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Lactobacillus salivarius HHuMin-U Activates Innate Immune Defense against Norovirus Infection through TBK1-IRF3 and NF-κB Signaling Pathways

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Research 2023年第3期2022卷 229-241页

作者： Da Hyun Kim Minju Jeong Jae Hwan Kim Joe Eun Son John JYlee Sang-jun Park juyeon lee Minwoo Kim Jong-Won Oh Myeong Soo Park Sanguine Byun Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea Program in Developmental and Stem Cell Biology The Hospital for Sick ChildrenTorontoOntarioCanada Research Center BIFIDO Co.Ltd.Hanam 12930Republic of Korea

The composition of commensal bacteria plays a critical role in controlling immune responses in the *** have shown that specific bacterial strains may have the capacity to enhance host immune defense against gastrointestinal viral *** norovirus is known to be the most common cause of gastroenteritis,leading to an estimated 200,000 deaths every year,identification of bacterial strains with protective effects against norovirus infection remains ***,we discovered Lactobacillus salivarius HHuMin-U(HHuMin-U)as a potent antiviral strain against norovirus ***-U significantly suppressed murine norovirus replication and lowered viral RNA titers in *** transcriptome sequencing(RNA sequencing)analysis revealed that HHuMin-U markedly enhanced the expression level of antiviral interferon-stimulated genes compared to mock ***-U treatment dose-dependently induced type I interferons(IFN-αand IFN-β)and tumor necrosis factor-αproduction in mouse and human macrophages,promoting antiviral innate responses against norovirus *** on the molecular mechanism demonstrated that HHuMin-U can activate nuclear factorκB and TANK-binding kinase 1(TBK1)–interferon regulatory factor 3 signaling pathways,leading to the phosphorylation of signal transducer and activator of transcription 1 and signal transducer and activator of transcription 2,the key mediators of interferon-stimulated ***,oral administration of HHuMin-U increased IFN-βlevels in the ileum of mice and altered the gut microbiome *** results suggest the species/strain-specific importance of gut microbial composition for antiviral immune responses and the potential use of HHuMin-U as a probiotic agent.

关键词： TBK1 interferon protective

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Fabrication of fully aligned self-assembled cell-laden collagen filaments for tissue engineering via a hybrid bioprinting process

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Bioactive Materials 2024年第6期36卷 14-29页

作者： juyeon Kim Hyeongjin lee Gyudo lee Dongryeol Ryu GeunHyung Kim Department of Precision Medicine Sungkyunkwan University School of Medicine(SKKU-SOM)Suwon16419Republic of Korea Department of Biotechnology and Bioinformatics Korea UniversitySejongRepublic of Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and TechnologyGwangjuRepublic of Korea

Cell-laden structures play a pivotal role in various tissue engineering applications,particularly in tissue *** between cells within bioprinted structures are crucial for successful tissue development and regulation of stem cell fate through intricate cell-to-cell signaling *** this study,we developed a new technique that combines polyethylene glycol(PEG)-infused submerged bioprinting with a stretching *** approach facilitated the generation of fully aligned collagen structures consisting of myoblasts and a low concentration(2 wt%)of collagen to efficiently encourage muscle tissue *** adjusting several processing parameters,we obtained biologically safe and mechanically stable cell-laden collagen filaments with uniaxial ***,the cell filaments exhibited markedly elevated cellular activities compared to those exhibited by conventional bioprinted filaments,even at similar cell ***,when we implanted structures containing adipose stem cells into mice,we observed a significantly increased level of myogenesis compared to that in normally bioprinted ***,this promising approach has the potential to revolutionize tissue engineering by fostering enhanced cellular interactions and promoting improved outcomes in regenerative medicine.

关键词： Polyethylene glycol Dehydration Collagen Bioink Submerged bioprinting Muscle

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Effect of Dioscorea batatas on longitudinal bone growth rate in adolescent female rats

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中国药理学与毒理学杂志 2015年第S1期29卷 103-104页

作者： Hyun Soo KIM Donghun lee Young-Sik KIM Jung-bin SONG Hyun Jung lee Seunggyeong lee Sung Hyun lee juyeon PARK Hocheol KIM Department of Herbal Pharmacology College of Korean Medicine Kyung Hee University Seoul Kirea Korea Institute of Science and Technology for Eastern Medicine NeuMed Inc. Seoul Korea

OBJECTIVE The root of Dioscorea batatas,rich in steroidal saponins,alkaloids,tannins,phytosterols,and starch,is an herbal medicine of tonifying qi and nourishing stomach after invigorating spleen with a long history of safe use for treatment of chronic dysentery and weakness of the spleen and stomach in *** study was aimed to investigate the effect of *** on longitudinal bone growth rate in adolescent female *** *** was extracted with 30% EtOH for 3h at 90℃in a reflux *** two groups,we administered a twice daily dosage of *** extract(at 30 and 300mg·kg-1,respectively)per os for 4d,and in a control group,we administered vehicle only under the same *** human growth hormone(rhGH)was subcutaneously injected once *** rats were born at same day(33d-old).On day 3,tetracycline was injected intraperitoneally to form a fluorescent band on the growth *** The bone growth rate in groups administered *** 300mg·kg-1 and rhGH was significantly increased to 343.8±20.7,and 359.6±30.2μm·d-1 respectively from control group,320.7±23.2μm·*** difference was observed in the amount of food intake or mean body weight among all groups during the acclimation or administration *** These results suggest that *** extracts have the potential to induce height increase;however,further research,including clinical trials,is necessary.

关键词： Dioscorea batatas longitudinal bone growth rhGH te

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Reflectance and Dielectric Properties of B_2O_3-ZnO-BaO-P_2O_5 Glass with Oxide Fillers

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Journal of Wuhan University of Technology(Materials Science) 2007年第B12期22卷 779-782页

作者： Jungki lee juyeon Won Seongjin Hwang Hyungsun Kim School of Materials Engineering Inha UniversityIncheon 402751Korea

To improve the reflectance of white dielectrics, titania has been used commercially as a filler in a glass matrix despite its high dielectric constant. However, calcite has some advantages over titania as a filler, such as its low dielectric constant and the low price of the raw material. We fabricated composites with titania and calcite as the filler in a B2O3-ZnO-BaO-P2O5 （BZBP） glass matrix and investigated their dielectric constants and reflectances with an LCR meter and UV-visible spectrometer, respectively. The reflectance of the composites containing calcite and titania as a filler in the BZBP glass was approximately 80%. However, the dielectric constant varied significantly with the filler （titania： 10.82±0.45, calcite： 3.75±0.06）. From our results, we conclude that it is possible to develop a profitable and highly efficient white dielectric using calcite as a filler for plasma display panels.

关键词： calcite titania reflectance dielectric constant

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Inhibitory activity of Cinnamomum Cassia extract on hypersensitivity in mice

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中国药理学与毒理学杂志 2015年第S1期29卷 67-67页

作者： Seunggyeong lee Jungbin SONG Donghun lee Young Sik KIM HyunSoo KIM Hailing GUO juyeon PARK Hocheol KIM Department of Herbal Pharmacology College of Korean Medicine Kyung Hee University Seoul Korea Institute of Science and Technology for Eastern Medicine NeuMed Inc. Seoul Republic of Korea

OBJECTIVE Cinnamomum cassia has been used in traditional medicine in East Asian countries to treatallergic *** studies have demonstrated that *** the development of mite antigen-induced skin lesions in NC/Nga mice by suppressing the Thelper 2cell *** objective of this study is to investigate whether *** has an efficient inhibition on systemic anaphylaxis and contact hypersensitivity in *** To induce systemic anaphylaxis,mice were injected intraperitoneally with compound 48/*** was monitored for 1h after the *** hypersensitivity reaction was induced by topical application of 2,4-dinitrofluorobenzene(DNFB)to the ears of *** DNFBchallenge,ear thickness was measured 0,24 and *** We discovered that *** significantly inhibited compound 48/80-induced anaphylaxis and DNFB-induced ear *** 48/80-induced anaphylaxiswas completely inhibited at the dose of 60mg·kg-1 body *** swelling at 24 h after DNFB-challenge was significantly less than that in the control group(0.16±0.03 vs.0.32±0.03 mm,P<0.01),while *** was administered at the dose of 200mg·*** These findings indicate that *** allergic reactions,thus has potential value for mitigation of atopic dermatitis.

关键词： Cinnamomum Cassia hypersensitivity,contact hyperse

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Effects of Angelica sinensis on longitudinal bone growth rate in adolescent female rats

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中国药理学与毒理学杂志 2015年第S1期29卷 103-103页

作者： Hai-ling GUO Donghun lee Young-Sik KIM Jung-bin SONG Hyun Soo KIM Hyun Jung lee Sung Hyun lee juyeon PARK Hocheol KIM Department of Herbal Pharmacology College of Korean Medicine Kyung Hee University Seoul Kirea Korea Institute of Science and Technology for Eastern Medicine NeuMed Inc. Seoul Korea

OBJECTIVE To investigate the effect of *** on longitudinal bone growth rate in adolescent female *** *** was extracted with 30% EtOH for 3h at 90℃in a reflux *** Sprague-Dawley rats(33d-old)were randomly divided into three groups:control(vehicle),recombinant human growth hormone(rhGH;20μg·kg-1·d-1),and ***(300mg·kg-1·d-1).*** extracts or vehicle was administered orally twice daily for *** bone growth rate in newly synthesized bone was observed using tetracycline labeling(20mg·kg-1,intraperitoneally).RESULTS *** significantly increased longitudinal bone growth rate in adolescent female rats at 300mg·kg-1(6.1%,357.34±32.67μm·d-1)compared to control group(336.80±14.47μm·d-1).CONCLUSION *** extract significantly increased longitudinal bone growth rate and growth plate height in adolescent female *** results suggest that *** could be helpful for increasing bone growth rate in children who have growth retardation.

关键词： Angelica sinensis longitudinal bone growth rate he

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