Effects of Angelica sinensis on longitudinal bone growth rate in adolescent female rats

作     者：Hai-ling GUO Donghun LEE Young-Sik KIM Jung-bin SONG Hyun Soo KIM Hyun Jung LEE Sung Hyun LEE Juyeon PARK Hocheol KIM 

作者机构：Department of Herbal Pharmacology College of Korean Medicine Kyung Hee University Seoul Kirea Korea Institute of Science and Technology for Eastern Medicine NeuMed Inc. Seoul Korea 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2015年第29卷第S1期

页      面：103-103页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The project supported by the Traditional Korean Medicine R&D program funded by the Ministry of Health&Welfare through the Korea Health Industry Development Institute(KHIDI)(HI14C0976) by Brain Korea 21plus project 

主　　题：Angelica sinensis longitudinal bone growth rate he 

摘      要：OBJECTIVE To investigate the effect of *** on longitudinal bone growth rate in adolescent female *** *** was extracted with 30% EtOH for 3h at 90℃in a reflux *** Sprague-Dawley rats(33d-old)were randomly divided into three groups:control(vehicle),recombinant human growth hormone(rhGH;20μg·kg-1·d-1),and ***(300mg·kg-1·d-1).*** extracts or vehicle was administered orally twice daily for *** bone growth rate in newly synthesized bone was observed using tetracycline labeling(20mg·kg-1,intraperitoneally).RESULTS *** significantly increased longitudinal bone growth rate in adolescent female rats at 300mg·kg-1(6.1%,357.34±32.67μm·d-1)compared to control group(336.80±14.47μm·d-1).CONCLUSION *** extract significantly increased longitudinal bone growth rate and growth plate height in adolescent female *** results suggest that *** could be helpful for increasing bone growth rate in children who have growth retardation.