Effect of Dioscorea batatas on longitudinal bone growth rate in adolescent female rats

作     者：Hyun Soo KIM Donghun LEE Young-Sik KIM Jung-bin SONG Hyun Jung LEE Seunggyeong LEE Sung Hyun LEE Juyeon PARK Hocheol KIM 

作者机构：Department of Herbal Pharmacology College of Korean Medicine Kyung Hee University Seoul Kirea Korea Institute of Science and Technology for Eastern Medicine NeuMed Inc. Seoul Korea 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2015年第29卷第S1期

页      面：103-104页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The project supported by the Traditional Korean Medicine R&D program funded by the Ministry of Health&Welfare through the Korea Health Industry Development Institute(KHIDI)(HI14C0976) by Brain Korea 21plus project 

主　　题：Dioscorea batatas longitudinal bone growth rhGH te 

摘      要：OBJECTIVE The root of Dioscorea batatas,rich in steroidal saponins,alkaloids,tannins,phytosterols,and starch,is an herbal medicine of tonifying qi and nourishing stomach after invigorating spleen with a long history of safe use for treatment of chronic dysentery and weakness of the spleen and stomach in *** study was aimed to investigate the effect of *** on longitudinal bone growth rate in adolescent female *** *** was extracted with 30% EtOH for 3h at 90℃in a reflux *** two groups,we administered a twice daily dosage of *** extract(at 30 and 300mg·kg-1,respectively)per os for 4d,and in a control group,we administered vehicle only under the same *** human growth hormone(rhGH)was subcutaneously injected once *** rats were born at same day(33d-old).On day 3,tetracycline was injected intraperitoneally to form a fluorescent band on the growth *** The bone growth rate in groups administered *** 300mg·kg-1 and rhGH was significantly increased to 343.8±20.7,and 359.6±30.2μm·d-1 respectively from control group,320.7±23.2μm·*** difference was observed in the amount of food intake or mean body weight among all groups during the acclimation or administration *** These results suggest that *** extracts have the potential to induce height increase;however,further research,including clinical trials,is necessary.