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Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma

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International Journal of Oral Science 2021年第3期13卷 219-229页

作者： Areeg Elmusrati justin Wang Cun-Yu Wang Laboratory of Molecular Signaling Division of Oral Biology and MedicineSchool of DentistryUCLALos AngelesCAUSA Jonsson Comprehensive Cancer Center UCLALos AngelesCAUSA

Head and neck squamous cell carcinoma(HNSCC),an aggressive malignancy,is characterized by high morbidity and low survival rates with limited therapeutic options outside of regional surgery,conventional cytotoxic chemotherapy,and *** studies have supported the synergistic role of the tumor microenvironment(TME)in cancer *** immune system,in particular,plays a key role in surveillance against the initiation,development,and progression of *** understanding of how neoplastic cells evolve and evade the immune system whether through self-immunogenicity manipulation,or expression of immunosuppressive mediators,provides the foundation for the development of advanced ***,the crosstalk between cancer cells and the host immune system have a detrimental effect on the TME promoting angiogenesis,proliferation,and *** review provides a recent insight into the role of the key inflammatory cells infiltrating the TME,with a focus on reviewing immunological principles related to HNSCC,as cancer immunosurveillance and immune escape,including a brief overview of current immunotherapeutic strategies and ongoing clinical trials.

关键词： squamous chemotherapy outside

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New Characterizations of the dual Spaces of Hardy-amalgam Spaces

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Acta Mathematica Sinica,English Series 2022年第3期38卷 519-546页

作者： Zobo Vincent de Paul ABLE justin FEUTO Laboratoire de Mathématiques Fondamentales UFR Mathématiques et InformatiqueUniversitéFélixHouphouët-Boigny Abidjan-Cocody22B.P.582Abidjan 22Côte d’Ivoire Laboratoire de Mathématiques Fondamentales UFR Mathématiques et InformatiqueUniversitéFélixHouphouët-Boigny Abidjan-Cocody22B.P.1194Abidjan 22Côte d’Ivoire

In this paper,carrying on with our study of the Hardy-amalgam spaces H^((q,p)) and H^((q,p))_(loc)(0dual spaces whenever 0d q≤p<∞.Moreover,when 0 详细信息

In this paper,carrying on with our study of the Hardy-amalgam spaces H^((q,p)) and H^((q,p))_(loc)(0dual spaces whenever 0d q≤pde with those obtained in our earlier papers.

关键词： Amalgam spaces Hardy-amalgam spaces duality Pseudo-differential operators

dynamic performance and reflection sensitivity of quantum dot distributed feedback lasers with large optical mismatch

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Photonics Research 2021年第8期9卷 1550-1558页

作者： BOZHANG dONG JIANAN dUAN HEMING HUANG justin CNORMAN KENICHI NISHI KEIZO TAKEMASA MITSURU SUGAWARA JOHN EBOWERS FRédéRIC GRILLOT LTCI Telecom ParisInstitut Polytechnique de Paris19 Place Marguerite Perey91120 PalaiseauFrance Institute for Energy Efficiency University of CaliforniaSanta BarbaraCalifornia 93106USA Materials department University of CaliforniaSanta BarbaraCalifornia 93106USA Qd Laser Inc.KawasakiKanagawa 210-0855Japan department of Electrical and Computer Engineering University of CaliforniaSanta BarbaraCalifornia 93106USA Center for High Technology Materials University of New-MexicoAlbuquerqueNew Mexico 87106USA Current address:State Key Laboratory on Tunable Laser Technology School of Electronic and Information EngineeringHarbin Institute of TechnologyShenzhen 518055China

This work reports on a high-efficiency In As/Ga As distributed feedback quantum dot *** large optical wavelength detuning at room temperature between the lasing peak and the gain peak causes the static,dynamic,and nonlinear intrinsic properties to all improve with temperature,including the lasing efficiency,the modulation dynamics,the linewidth enhancement factor,and consequently the reflection *** reported show an optimum operating temperature at 75°C,highlighting the potential of the large optical mismatch assisted single-frequency laser for the development of uncooled and isolator-free high-speed photonic integrated circuits.

关键词： mismatch optical tuning

Strategies to promote the maturation of ALS-associated SOd1 mutants: small molecules return to the fold

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Neural Regeneration Research 2019年第9期14卷 1511-1512页

作者： Luke McAlary justin J.Yerbury Illawarra Health and Medical Research Institute WollongongNSWAustralia School of Chemistry and Molecular Bioscience Molecular HorizonsFaculty of ScienceMedicine and HealthUniversity of WollongongNSWAustralia

(Cu)^IIATSM(CuATSM)promotes the proper folding of familial amyotrophic lateral sclerosis(fALS)-associated copper,zinc superoxide dismutase(SOd1):ALS is a progressive neurodegenerative disease that affects motor neurons in the cortex and spinal cord,resulting in paralysis and ultimately *** majority of cases are sporadic and the remainder are fALS where a subset of cases are associated with over 160,mostly missense,mutations in the SOd1 enzyme ***,these mutations impede the correct folding of SOd1 by disrupting either metal binding,disulfide formation,and/or dimerization,leading to the accumulation of misfolded SOd1 which can form the intracellular inclusions observed in patient tissue.

关键词： (Cu)^IIATSM(CuATSM) familial amyotrophic patient tissue

designed in China： A Legal Frontier

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Fudan Journal of the Humanities and Social Sciences 2017年第3期10卷 395-408页

作者： justin Yee Queen's University 99 University Ave Kingston ON K7L 3N6 Canada

China＇s ＂Five-Year Plan＂ is a national strategy document developed by the country＇s top leaders. Manifest in its guidelines was a concept that the developed world has traditionally and freely acknowledged, but that China has only recently become an acquaintance with. Specifically, the plan labels innovation as one of its focus areas, with a goal to move up in the value chain of global economic powers by abandoning old heavy industry and building up bases of modern information-intensive infrastructure. These objectives are to be facilitated by actions which include the strengthening of intellectual property rights protection and enforcement and represents another notch on China＇ s growing shelf of advancements in the area. This paper will discuss the current state of China＇s intellectual property legal framework, the increasing awareness amongst Chinese leadership to bolster the framework and the barriers which will inevitably form in the eye of progress. The analysis will delve into the history of intellectual property in China and culminate with a glance into today＇s political and cultural landscape. The goal of this paper is to examine the importance of devising a stable legal framework in order for China to successfully adhere with the innovation aspect of its current Five-Year Plan.

关键词： Intellectual property Copyright Patent Trademark China

On the Centre of Mass Motion in Human Walking

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International Journal of Automation and computing 2017年第5期14卷 542-551页

作者： justin Carpentier Mehdi Benallegue Jean-Paul Laumond LAAS-CNRS University of Toulouse Humanoids Research Group National Institute of Advanced Industrial Science and Technology

The center of mass （CoM） is a key descriptor in the understanding and the analysis of bipedal locomotion. Some approaches are based on the premise that humans minimize the CoM vertical displacement. Other approaches express walking dynamics through the inverted pendulum model. Such approaches are contradictory in that they lead to two conflicting patterns to express the CoM motion： straight line segments for the first approaches and arcs of a circle for the second ones. In this paper, we show that CoM motion is a trade-off between both patterns. Specifically, CoM follows a ＂curtate cycloid＂, which is the curve described by a point rigidly attached to a wheel rolling on a flat surface. We demonstrate that all the three parameters defining a curtate cycloid only depend on the height of the subjects.

关键词： Human locomotion analytical model centre of mass locomotion signature synergies.

State,Society and Environmental Security in International Relations Theory

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Fudan Journal of the Humanities and Social Sciences 2023年第2期16卷 171-190页

作者： justin Joseph department of Political Science School of Liberal Arts and Applied ScienceHindustan Institute of Technology and Science(HITS)ChennaiIndia

As emerging non-traditional security issues in global politics such as environmental crises offer new avenues of research on the state-society behaviour in non-western political orders,this study applies an integrated conceptual framework of Copenhagen School’s securitization,constructivism and green theory in international relations theory(IRT).One of the key objectives of the study includes to provide a theoretical explanation on the role of non-state agencies in ameliorating the environmental *** the support of an illustrative case study,the researcher argues in line with the finding of Acharya and Buzan(2007)that there is no need to replace Western IRTs,but they should be enriched with more voices from non-western political *** other words,the emerging non-traditional issues in global politics are not“noises”to weaken existing IRTs but“voices”to strengthen their theoretical foundation.

关键词： IR theory Non-western polities Securitization Audience China

Proteoglycans: Road Signs for Neurite Outgrowth

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Neural Regeneration Research 2014年第4期9卷 343-355页

作者： justin A.Beller diane M.Snow Spinal Cord and Brain Injury Research Center The University of Kentucky

Proteoglycans in the central nervous system play integral roles as ＂traffic signals＂ for the direction of neurite outgrowth. This attribute of proteoglycans is a major factor in regeneration of the injured central nervous system. In this review, the structures of proteoglycans and the evidence suggesting their involvement in the response following spinal cord injury are presented. The review further describes the methods routinely used to determine the effect proteoglycans have on neurite outgrowth. The effects of proteoglycans on neurite outgrowth are not completely understood as there is disagreement on what component of the molecule is interacting with growing neurites and this ambiguity is chronicled in an historical context. Finally, the most recent findings suggesting possible receptors, interactions, and sulfation patterns that may be important in eliciting the effect of proteoglycans on neurite outgrowth are discussed. A greater understanding of the proteoglycan-neurite interaction is necessary for successfully promoting regeneration in the iniured central nervous system.

关键词： chondroitin sulfate proteoglycans heparan sulfate proteoglycans glycosaminoglycans protein core extracellular matrix neuronal growth cones axon outgrowth and regeneration spinalcord injury glial scar tissue culture

Representing the retinal line spread shape with mathematical functions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第12期9卷 996-1002页

作者： Yi-rong YANG justin WANEK Mahnaz SHAHIdI department of Bioengineering University of lllinois at Chicago IL 60607 USA department of Ophthalmology and Visual Sciences University of Illinois at Chicago IL 60607 USA

Objective: To report a mathematical function that characterizes the double-pass line spread function (LSF) of the human eye. determining analytical functions that represent the double-pass LSF is important because it allows modeling the optical performance of the eye. Methods: Optical section retinal images, generated in normal human eyes using a modified slit-lamp biomicroscope, were analyzed to derive the double-pass LSF by plotting the intensity distribution of laser light reflected/ scattered from the vitreoretinal interface. Three mathematical functions (Lorentzian, Gaussian, exponential) were fitted to the double-pass LSF and the root mean square error (RMSE) was calculated to provide a measure of the goodness of fit. Results: The Lorentzian function provided the best representation of the double-pass LSF of normal human eyes. The full width at half maximum (FWHM) of the Lorentzian fitted curve was positively correlated with age, indicating that the double-pass LSF broadens with age. Furthermore, the goodness of fit of the Lorentzian function was significantly better in younger subjects as compared with older subjects, suggesting that the fitted function to the double-pass LSF may vary according to age. Conclusion: The results demonstrate an age-related change in the double-pass LSF width and the goodness of fit of the Lorentzian function.

关键词： Retina double-pass line spread function (LSF) Lorentzian Gaussian Exponential