The relationship between chimeric RNAs and gene fusions:Potential implications of reciprocity in cancer

作     者：Justin Elfman Lam-Phong Pham Hui Li Justin Elfman;Lam-Phong Pham;Hui Li

作者机构：Department of Biochemistry and Molecular GeneticsSchool of MedicineUniversity of VirginiaCharlottesvilleVA22904 USA Department of PathologySchool of MedicineUniversity of VirginiaCharlottesvilleVA22904 USA 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2020年第47卷第7期

页      面：341-348页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：NIGMS grant GM132138 

主　　题：cancer diagnosis horse 

摘      要：Gene fusions have long been considered hallmarks of *** into characterization of their prevalence,cause,and function have provided significant progress toward improvements in diagnosis,prognosis assessment,and treatment of numerous *** recently,detection of intergenically spliced chimeric RNAs in cancer has spurred efforts to characterize these transcripts,anticipating similar successes in translation to the *** of chimeric RNAs in normal cells,especially those which precede canonical translocations such as PAX3-F0X01 and JAZF1-JJAZ1,suggests that these physiologically regulated transcripts may function as proto-oncogenic factors,in that their dysregulation can lead to cancer *** findings have given rise to conjecture regarding chimeric RNAguided rearrangements giving rise to fusion genes,termed the cart-before-the-horse ***,we provide context for the relationship between gene fusions,chimeric RNAs,and cancer;assemble evidence in support of the cart-before-the-horse hypothesis;and discuss potential advantages of targeting chimeric RNAs in cancer treatment.