Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma

作     者：Areeg Elmusrati Justin Wang Cun-Yu Wang Areeg Elmusrati;Justin Wang;Cun-Yu Wang

作者机构：Laboratory of Molecular SignalingDivision of Oral Biology and MedicineSchool of DentistryUCLALos AngelesCAUSA Jonsson Comprehensive Cancer CenterUCLALos AngelesCAUSA 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2021年第13卷第3期

页      面：219-229页

核心收录：

学科分类：1003[医学-口腔医学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the NIH Grants R01DE029173 R01DE030445 and R01CA236878 

主　　题：squamous chemotherapy outside 

摘      要：Head and neck squamous cell carcinoma(HNSCC),an aggressive malignancy,is characterized by high morbidity and low survival rates with limited therapeutic options outside of regional surgery,conventional cytotoxic chemotherapy,and *** studies have supported the synergistic role of the tumor microenvironment(TME)in cancer *** immune system,in particular,plays a key role in surveillance against the initiation,development,and progression of *** understanding of how neoplastic cells evolve and evade the immune system whether through self-immunogenicity manipulation,or expression of immunosuppressive mediators,provides the foundation for the development of advanced ***,the crosstalk between cancer cells and the host immune system have a detrimental effect on the TME promoting angiogenesis,proliferation,and *** review provides a recent insight into the role of the key inflammatory cells infiltrating the TME,with a focus on reviewing immunological principles related to HNSCC,as cancer immunosurveillance and immune escape,including a brief overview of current immunotherapeutic strategies and ongoing clinical trials.