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Prognosis of metastatic splenic hilum lymph node in patients with gastric cancer after total gastrectomy and splenectomy

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World Journal of Hepatology 2010年第2期2卷 81-86页

作者： Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Takuya Imaizumi junya Kizaki Kazuo Shirouzu Department ofSurgery Kurume University School of MedicineFukuoka830-0011Japan

AIM:To clarify the significance of combined resection of the spleen to dissect the No.10 lymph node(LN). METHODS:We studied 191 patients who had undergone total gastrectomy with splenectomy,excluding non-curative cases,resection of multiple gastric cancer, and those with remnant stomach *** clinico-pathological factors were evaluated for any independent contributions to No.10 LN metastasis,usingχ 2 test. Significant factors were extracted for further analysis, carried out using a logistic regression ***,lymph node metastasis was evaluated for any independent contribution to No.10 LN metastasis,using the same *** cumulative survival rate was calculated using the Kaplan-Meier *** significance of any difference between the survival curves was determined using the Cox-Mantel test,and any difference was considered significant at the 5%level. RESULTS:From the variables considered to be potentially associated with No.10 LN metastasis,age, depth,invasion of lymph vessel,N factor,the numberof lymph node metastasis,Stage,the number of sites, and location were found to differ significantly between those with metastasis(the Positive Group)and those without(the Negative Group).A logistic regression analysis showed that the localization and Stage were significant parameters for No.10 LN *** was no case located on the lesser curvature in the Posi-tive *** numbers of No.2,No.3,No.4sa,No. 4sb,No.4d,No.7,and No.11 LN metastasis were each found to differ significantly between the Positive Group and the Negative Group.A logistic regression analysis showed that No.4sa,No.4sb,and No.11 LN metastasis were each a significant parameter for No.10 LN *** was no significant difference in survival curves between the Positive Group and the Negative Group. CONCLUSION:Splenectomy should be performed to dissect No.10 LN for cases which have No.4sa,No. 4sb or No.11 LN ***,in cases where the tumor is located on th

关键词： Gastric cancer Lymph node metastasis Lymphadenectomy,Splenectomy Total gastrectomy

Wuling powder alleviates depressive-like behavior by attenuating endoplasmic reticulum stress in the mouse hippocampus

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Journal of Chinese Pharmaceutical Sciences 2024年第9期33卷 783-794页

作者： Lu Feng Wei Huang Ji Zheng Dongmei Li Mingyang Wang junya Liu Shujie Fan Chao Ji Nan yang Yanyong Liu Department of Pharmacology Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

The response to endoplasmic reticulum(ER)stress has been noted in both human depression cases and depression models in *** powder,derived from the mycelium of the esteemed fungus Xylaria Nigripes(Kl.)Sacc,has demonstrated efficacy in alleviating depressive *** purpose of this research was to explore the antidepressant properties of Wuling powder and its basic molecular effects,particularly regarding alterations in ER stress.A model of social defeat stress was created by introducing a mouse to the cage of an unfamiliar,hostile mouse for intervals of 5–10 min daily over a span of 10 ***,the mice received oral doses of Wuling powder for 2 *** social approach-avoidance assay was employed to evaluate signs of depression-like ***,protein and gene expressions linked to ER stress triggered by social defeat were analyzed through Western blotting analysis and quantitative real-time *** behavioral tests indicated that Wuling powder ameliorated behaviors associated with depression due to social defeat *** with Wuling powder markedly reduced the increased levels of the 78-k Da glucose-regulated protein and protein disulfide isomerase caused by social defeat *** also diminished the expression of inositol-requiring enzyme 1α(IRE1α)and spliced X box-binding protein-1(s XBP1)at the protein and m RNA ***,Wuling treatment notably decreased the levels of phosphorylated eukaryotic initiation factor 2 alpha kinase(P-e IF2α),activating transcription factor 4(ATF4)and C/EBP homologous protein(CHOP),simultaneously enhancing the ratio of B-cell lymphoma 2(Bcl-2)to Bcl-2-associated X protein(Bax).These results suggested that Wuling powder could alleviate ER stress and inhibit cell apoptosis in the hippocampus by inhibiting protein translation and synthesis,thereby attenuating depressive-like behavior.

关键词： Depression Wuling powder Endoplasmic reticulum stress Unfolded protein response

Myelin protein zero (P0)- and Wnt1-Cre marked muscle resident neural crest-derived mesenchymal progenitor cells give rise to heterotopic ossification in mouse models

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Genes & Diseases 2023年第3期10卷 731-734页

作者： Chengzhu Zhao Yoshiko Inada Kazuya Sekiguchi Kyosuke Hino Megumi Nishio Yasuhiro Yamada Shuichi Matsuda junya Toguchida Makoto Ikeya Department of Clinical Application Center for iPS Cell Research and Application(CiRA)Kyoto UniversitySakyo-kuKyoto 606-8507Japan Laboratory of Skeletal Development and Regeneration Institute of Life SciencesChongqing Medical UniversityChongqing 400016China Department of Cell Growth and Differentiation Center for iPS Cell Research and Application(CiRA)Kyoto UniversitySakyo-kuKyoto 606-8507Japan Department of Orthopaedic Surgery Graduate School of MedicineKyoto UniversitySakyo-kuKyoto 606-8507Japan Regenerative&Cellular Medicine Kobe Center Sumitomo Pharma Co.Ltd.Konohana-kuOsaka 554-0022Japan Division of Stem Cell Pathology Center for Experimental Medicine and Systems BiologyInstitute of Medical ScienceUniversity of TokyoMinato-kuTokyo 108-8639Japan Department of Regeneration Sciences and Engineering Institute for Frontier Life and Medical SciencesKyoto UniversitySakyo-kuKyoto 606-8507Japan

Heterotopic ossification(HO)describes bone formation at non-skeletal sites and results from traumatic injury,surgery,or genetic disease such as fibrodysplasia ossificans progressiva(FOP).1,2 Although it is known that BMP signaling regulates HO,knowledge about the developmental origin of the osteogenic progenitors responsible for the BMP-associated metamorphosis is comparably *** the use of transgenic mice and labelled neural crest-derived cell,3 we found myelin protein zero(P0,or MPZ)-and Wnt1-lineage cells give rise to BMP-7 induced adult ectopic cartilage and bone.

关键词： progenitor ossification neural

Space aquatic chemistry:A roadmap for drinking water treatment in microgravity

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Environmental Science and Ecotechnology 2024年第3期19卷 26-28页

作者： Baiwen Ma Yaohui Bai Chengzhi Hu Beizhen Xie junya Zhang Mathias Ulbricht Libing Zheng Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Lehrstuhl für Technische Chemie II Universität Duisburg-EssenEssen45117Germany Institute of Environmental Biology and Life Support Technology School of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China Department of Water Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Department of Isotope Biogeochemistry Helmholtz Centre for Environmental Research-UFZLeipzig04318Germany

Rapid advancement in aerospace technology has successfully enabled long-term life and economic activities in space,particularly in Low Earth Orbit(LEO),extending up to 2000 km from the mean sea ***,the sustainance of the LEO Economy and its Environmental Control and Life Support System(ECLSS)still relies on a regular cargo supply of essential commodities(e.g.,water,food)from Earth,for which there still is a lack of adequate and sustainable *** key challenge in this context is developing water treatment technologies and standards that can perform effectively under microgravity *** this technical challenge will be a milestone in providing a scientific basis and the necessary support mechanisms for establishing permanent bases in outer space and *** identify clues towards solving this challenge,we looked back at relevant scientific research exploring novel technologies and standards for deep space exploration,also considering feedback for enhancing these technologies on *** our findings,we share our outlook for the future of drinking water treatment in *** also bring up a new concept for space aquatic chemistry,considering the closed environment of engineered systems operating in microgravity.

关键词： Microgravity Drinking water treatment Water quality Challenges Strategies

Characterization of the Long-Term Interaction between Intracellular Reactive Oxygen Species and Oxidative DNA Damage in Murine Lin<sup>-</sup>/Sca-1<sup>+</sup>Cells Exposed to Ionizing Radiation

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 95-105页

作者： junya Ishikawa Taro Morisaki Department of Medical Radiologic Technology Kyorin University Mitaka Japan Department of Environmental Health Science Oita University of Nursing and Health Sciences Oita Japan

Mutations in the Sfpi1 gene are essential for the development of radia-tion-induced acute myeloid leukemia. In this study, we investigated long-term interaction among immature hematopoietic cell number, intra-cellular reactive oxygen species contents, and oxidative DNA damage fre-quency after irradiation. Lin-/Sca-1+ cells were isolated from C3H/HeN mice on days 1 - 400 after 0 - 3 Gy total body irradiation. On days 1 - 7, the number of surviving cells decreased and reached a minimum;however, the number of cells gradually recovered until day 200. Intracellular reactive oxygen species contents significantly increased from day 1 to day 30. In addition, the frequency of oxidative DNA damage tended to increase from day 1 and day 30, and that at day 30 was significantly increased in the 3 Gy group compared with that in the control group. In contrast, decreased cell number, increased intracellular reactive oxygen species content, and decreased oxidative DNA damage frequency were observed on day 400. These results suggested that oxidative DNA damage was involved in intracellular reactive oxygen species generation induced by cell proliferation to compensate for cell death after irradiation.

关键词： Acute Myeloid Leukemia Oxidative DNA Damage Reactive Oxygen Species

Association of serum lipids and severity of epithelial ovarian cancer：an observational cohort study of 349 Chinese patients

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The Journal of Biomedical Research 2018年第5期32卷 336-342页

作者： Yi Zhang Jing Wu junya Liang Xing Huang Lei Xia Dawei Ma Xinyu Xu Pingping Wu Department of Pathology Jiangsu Institute of Cancer Research the Affiliated Cancer Hospital of Nanjing Medical University Nanjing Jiangsu 210009 China Department of Radiation Oncology Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research the Affiliated Cancer Hospital of Nanjing Medical University Nanjing Jiangsu 210009 China The School of Public Health Nanjing Medical University Nanjing Jiangsu 211166 China Department of Oncology Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research the Affiliated Cancer Hospital of Nanjing Medical University Nanjing Jiangsu 210009 China.

While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who received treatment at Jiangsu Cancer Hospital, China between 2011 and 2017. We analyzed age at diagnosis, blood pressure, plasma glucose content, body mass index（BMI）, lipid levels and clinical parameters. Severity of epithelial ovarian cancer was classified according to the International Federation of Gynecology and Obstetrics（FIGO） grading system. Univariate analysis of the clinical factors according to the severity of epithelial ovarian cancer was followed by logistic regression analysis to identify clinical factors significantly associated with epithelial ovarian cancer severity. Univariate analysis indicated that age,BMI, triglyceride（TG）, and high density lipoproteins（HDL） differed significantly among different stages of epithelial ovarian cancer（P〈0.05）. In the logistic regression model, elevated TG（OR： 1.883; 95% CI= 1.207-2.937）, and low HDL（OR： 0.497; 95% CI = 0.298-0.829） levels were significantly associated with the high severity epithelial ovarian cancer. Our data indicate that high TG and low HDL levels correlate with a high severity of epithelial ovarian cancer. These data provide important insight into the potential relationship between the lipid pathway and epithelial ovarian cancer phenotype and development.

关键词： triglycerides epithelial ovarian cancer high density lipoproteins dyslipidemia clinical data statistics

碱金属硝酸盐对促进LDH基材料吸附CO_2性能的影响

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环境工程学报 2018年第12期12卷 3379-3388页

作者：王君雅羊莹宁平昆明理工大学环境科学与工程学院昆明650500

为进一步提高LDH基材料的CO_2吸附性能以及吸-脱循环稳定性能,采用浸渍法将碱金属硝酸盐负载在LDH基材料上,分别探究了Mg/Al比、合成pH、碱金属硝酸盐种类和负载量等对其CO_2吸附性能的影响。结果表明,当LDH中Mg/Al比例为20,合成pH为10... 详细信息

为进一步提高LDH基材料的CO_2吸附性能以及吸-脱循环稳定性能,采用浸渍法将碱金属硝酸盐负载在LDH基材料上,分别探究了Mg/Al比、合成pH、碱金属硝酸盐种类和负载量等对其CO_2吸附性能的影响。结果表明,当LDH中Mg/Al比例为20,合成pH为10,负载30%Li0.3Na0.18K0.52NO3后,在最佳煅烧温度500℃,最佳吸附温度260℃的条件下,其CO_2吸附量最大可达到4.64 mmol·g-1。另外,该材料在经历了10个吸-脱附循环过程后,表现出较好的循环稳定性能。通过分析可知,碱金属硝酸盐没有参与CO_2吸附反应,碱金属硝酸盐的负载对LDH的CO_2吸附性能有极大地促进作用。

关键词：类水滑石 CO2吸附碱金属硝酸盐循环稳定性能

Characterisation of IL-21 and IL-21Rαin grass carp:IL-21-producing cells are upregulated during Flavobacterium columnare infection

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Aquaculture and Fisheries 2024年第2期9卷 126-135页

作者： Jiawen Xu junya Wang Qingyu Min Wei Wang Yuting Qin Lina Lei Qian Gao Jun Zou Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai201306China International Research Center for Marine Biosciences at Shanghai Ocean University Ministry of Science and TechnologyShanghai201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266200China

Interleukin-21(IL-21)is produced mainly by activated CD4^(+)T cells and promotes the proliferation,survival and differentiation of immune *** study characterised a high affinity binding receptor of IL-21(IL-21 Rα)from grass carp(Ctenopharyngodon idella,Ci)and analyzed the expression of CiIL-21 and CiIL-21 Rα.It has been shown that they were modulated by PAMPs and during infection with bacterial and viral *** CiIL-21 protein produced in bacteria was active in inducing the expression of genes involved in Th responses.A monoclonal CiIL-21 antibody was generated against the rCiIL-21 and showed good reactive specificity with the rCiIL-21 proteins expressed in *** cells,and HEK293 T cells and the native protein from PHA-stimulated kidney *** addition,the IL-21-producing cells detected by the CiIL-21 monoclonal antibody were found to be increased to in the kidney,spleen and hindgut after infection with Flavobacterium *** data indicate that IL-21 is involved in the regulation of immune response to bacterial and viral infection.

关键词： IL-21 IL-21Rα Gene expression IL-21-Producing cell Bacterial and viral infection Fish

Enhanced editing efficiency in Arabidopsis with a LbCas12a variant harboring D156R and E795L mutations

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aBIOTECH 2024年第2期5卷 117-126页

作者： Cuiping Xin Dexin Qiao junya Wang Wei Sun Zhenghong Cao Yu Lu Yuanyuan Jiang Yiping Chai Xue-Chen Wang Qi-jun Chen State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193People’s Republic of China

Cas12a(Cpf1),a Class 2 Type V CRISPR/Cas nuclease,has several unique attributes for genome editing and may provide a valuable alternative to ***,a low editing efficiency due to temperature sensitivity and insufficient cleavage activity of the Cas12a nuclease are major obstacles to its broad *** this report,we generated two variants,ttAsCas12 Ultra and ttLbCas12a Ultra harboring three(E174R,M537R,and F870L)or two(D156R and E795L)mutations,respectively,by combining the mutations from the temperature-tolerant variants ttAsCas12a(E174R)and ttLbCas12a(D156R),and those from the highly active variants AsCas12a Ultra(M537R and F870L)and LbCas12a Ultra(E795L).We compared editing efficiencies of the five resulting Cas12a variants(LbCas12a,ttLbCas12a,ttLbCas12a Ultra,AsCas12a Ultra,and ttAsCas12 Ultra)at six target sites of four genes in Arabidopsis(Arabidopsis thaliana).The variant ttLbCas12a Ultra,harboring the D156R and E795L mutations,exhibited the highest editing efficiency of all variants tested in Arabidopsis and can be used to generate homozygous or biallelic mutants in a single generation in Arabidopsis plants grown at 22 *** addition,optimization of ttLbCas12a Ultra,by varying nuclear localization signal sequences and codon usage,further greatly improved editing ***,our results indicate that ttLbCas12a Ultra is a valuable alternative to Cas9 for editing genes or promoters in Arabidopsis.

关键词： Genome editing CRISPR/Cas Cas12a ttLbCas12a ultra Arabidopsis