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Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model

World Journal of Gastroenterology 2020年第7期26卷 706-716页

作者： Jaeseung shin Haesung Yoon Yoon Jin Cha Kyunghwa Han Mi-jung Lee Myung-Joon Kim Hyun Joo shin Department of Radiology Severance HospitalResearch Institute of Radiological ScienceYonsei University College of MedicineSeoul 03722South Korea Department of Pathology Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273South Korea Department of Radiology Severance HospitalResearch Institute of Radiological ScienceCenter for Clinical Imaging Data ScienceSeoul 03722South Korea

BACKGROUND Hepatic sinusoidal obstruction syndrome(SOS)is caused by damage to hepatic sinusoidal endothelial cells that results in fibrous obliteration of intrahepatic venules and necrosis of *** the diagnosis is primarily based on nonspecific clinical features and invasive liver ***,noninvasive imaging methods are required for the early diagnosis and severity assessment of hepatic *** To determine the effectiveness of supersonic shear wave imaging(SSI)and dual energy computed tomography(DECT)for diagnosing hepatic SOS using a rabbit *** Among nine New Zealand white rabbits(3-4 kg,male),three in control group ingested normal saline for 20 d and six in the SOS group ingested 6-thioguanine(5 mg/kg/d)for 20 *** stiffness was measured using SSI on days 0,3,10,and *** the same days,liver perfusion was evaluated from virtual monochromatic images of 55 keV and iodine map using *** changes in the liver were assessed using *** pathology scores were compared between the two *** stiffness and perfusion parameters were compared according to the groups,days,and pathology *** Final pathology scores were significantly higher in the SOS than the control group(median 22 vs 2,P=0.024).No gross morphologic changes were seen in *** stiffness,Hounsfield Unit values,and iodine concentrations were higher in the SOS compared to the control group on days 10 and 20(all,P≤0.007).Compared to day 0,liver stiffness and perfusion parameters were higher on day 20 in the SOS group(all,P≤0.001).Correlation coefficients for liver stiffness(r=0.635),Hounsfield Unit values(r=0.587),and iodine concentration(r=0.611)with final pathology scores were positive without significance(all,P>0.05).CONCLUSION Liver stiffness and perfusion parameters were significantly increased in the livers of a rabbit SOS *** and DECT might aid in early diagnosis of hepatic SOS.

关键词： Hepatic sinusoidal obstruction syndrome Elasticity imaging techniques Iodine Computed tomography Liver Animals

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Is the AIM65 score useful in predicting outcomes in peptic ulcer bleeding?

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World Journal of Gastroenterology 2014年第7期20卷 1846-1851页

作者： Sung Hoon jung jung hwan Oh Hye Yeon Lee Joon Won Jeong Se Eun Go Chan Ran You Eun jung Jeon Sang Wook Choi Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 130-709South Korea

AIM:To evaluate the applicability of AIMS65 scores in predicting outcomes of peptic ulcer ***:This was a retrospective study in a single center between January 2006 and December *** enrolled 522 patients with upper gastrointestinal haemorrhage who visited the emergency *** patients were regarded as those who had rebleeding within 30 d from the first endoscopy as well as those who died within 30 d of visiting the Emergency room.A total of 149 patients with peptic ulcer bleeding were analysed,and the AIMS65 score was used to retrospectively predict the high-risk ***:A total of 149 patients with peptic ulcer bleeding were *** poor outcome group comprised 28 patients[male:23(82.1%)vs female:5(10.7%)]while the good outcome group included 121patients[male:93(76.9%)vs female:28(23.1%)].The mean age in each group was not significantly *** mean serum albumin levels in the poor outcome group were slightly lower than those in the good outcome group(P=0.072).For the prediction of poor outcome,the AIMS65 score had a sensitivity of35.5%(95%CI:27.0-44.8)and a specificity of 82.1%(95%CI:63.1-93.9)at a score of *** AIMS65 score was insufficient for predicting outcomes in peptic ulcer bleeding(area under curve=0.571;95%CI:0.49-0.65).CONCLUSION:The AIMS65 score may therefore not be suitable for predicting clinical outcomes in peptic ulcer *** albumin levels may be a risk factor associated with high mortality in peptic ulcer bleeding.

关键词： Gastrointestinal haemorrhage Peptic ulcer Mortality Morbidity Prognosis

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Acute esophageal obstruction after ingestion of psyllium seed husk powder:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2336-2340页

作者： Sujeong shin jung Ho Kim You Ho Mun Han Sol Chung Department of Emergency Medicine Yeungnam University School of Medicine and College of MedicineDaegu 42415South Korea

BACKGROUND Bezoar is a mass of hardened external material found in the gastrointestinal(GI)*** may form anywhere in the GI tract,but esophageal bezoar is rare because of the short esophageal transit *** seed husk is an indigestible natural derivative that is widely used as an herbal ***,we report a case of acute esophageal obstruction caused by a bezoar after ingestion of psyllium seed husk *** SUMMARY A 76-year-old male with Parkinson’s disease visited the emergency department with swallowing difficulty approximately 10 h after ingesting psyllium seed husk *** began a few hours after ingestion and progressed to severe *** were no abnormal findings on simple ***,a computed tomography scan revealed an approximately 2.0 cm×2.5 cm mass located near the gastro-esophageal *** grinding,the mass was removed using an endoscopic capture *** bezoars may cause life-threatening *** with Parkinson’s disease may have esophageal motility dysfunction,which may increase esophageal transit *** our patient had Parkinson’s disease,this effect may have contributed to the formation of the *** Attention should be paid to using bulk-laxatives,and an appropriate specified regimen will be needed when marketed as a dietary supplement.

关键词： Bezoar Esophagus Obstruction Parkinson’s disease Psyllium Case report

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Anti-scarring effects of butaprost on human subconjunctival Tenon's fibroblasts

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1028-1033页

作者： Jong Hoon shin Je Hyun Seo Jae Ho jung Tae Woo Kim Department of Ophthalmology Pusan National University Hospital Department of Ophthalmology Pusan National University Yangsan Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Department of Ophthalmology Seoul National University College of MedicineSeoul National University Bundang Hospital

AIM： To investigate the toxicity of the E-prostanoid 2（EP2） receptor agonist, butaprost against human subconjunctival（Tenon＇s capsule） fibroblasts, and to determine the underlying mechanism. METHODS： We isolated Tenon＇s fibroblasts from the subconjunctival area of healthy subjects and evaluated the types of EP receptors expressed using quantitative realtime reverse transcription polymerase chain reaction（RTPCR）. The toxicity of butaprost against the fibroblasts was evaluated using methyl thiazolyl tetrazolium and lactic dehydrogenase assays. The inhibition of conjunctival fibroblast proliferation by butaprost was assessed by measuring α-actin levels. The underlying mechanism was assessed by measuring intracellular cyclic adenosine monophosphate（c AMP） levels. Intergroup differences were statistically analyzed using an independent t-test. Densitometry of the Western blot bands was performed using the Image J software. RESULTS： Quantitative real-time RT-PCR revealed that the fibroblast EP2 receptor levels were higher than those of the other EP receptors. Butaprost did not show toxicity against Tenon＇s tissue, but inhibited conjunctival fibroblast proliferation by reducing collagen synthesis. EP2 receptor activation enhanced the c AMP cascade, which might be an important mechanism underlying this ***： Butaprost effectively reduces the subconjunctival scarring response. Given the significanceof wound healing modulation in blebs, butaprost＇s inhibitory effect on subconjunctival Tenon＇s fibroblasts may be beneficial in managing postoperative scarring in glaucoma surgery.

关键词： butaprost Tenon's capsule trabeculectomy fibroblasts

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Sequence Information on Simple Sequence Repeats and Single Nucleotide Polymorphisms through Transcriptome Analysis of Mungbean

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Journal of Integrative Plant Biology 2011年第1期53卷 63-73页

作者： Kyaw Thu Moe Jong-Wook Chung Young-Il Cho jung-Kyung Moon Ja-hwan Ku Jin-Kyo jung jungran Lee Yong-Jin Park Department of Plant Resources College of Industrial SciencesKongju National University The Rural Development Administration(RDA) Legume Bio-Resource Center of Green Manure(LBRCGM) Kongju National University

Mungbean （Vigna radiata （L.） Wilczek） is a unique species in its ability to fix atmospheric nitrogen, with early maturity, and relatively good drought resistance. We used 454 sequencing technology for transcriptome sequencing. A total of 150 159 and 142 993 reads produced 5 254 and 6 374 large contigs （〉_500 bp） with an average length of 833 and 853 for Sunhwa and Jangan, respectively. Functional annotation to known sequences yielded 41.34% and 41.74% unigenes for Jangan and Sunhwa. A higher number of simple sequence repeat （SSR） motifs was identified in Jangan （1 630） compared with that of Sunhwa （1 334）. A similar SSR distribution pattern was observed in both varieties. A total of 8 249 single nucleotide polymorphisms （SNPs） and indels with 2 098 high-confidence candidates were identified in the two mungbean varieties. The average distance between individual SNPs was -860 bp. Our report demonstrates the utility of transcriptomic data for implementing a functional annotation and development of genetic markers. We also provide large resource sequence data for mungbean improvement programs.

关键词： Sequence Information on Simple Sequence Repeats and Single Nucleotide Polymorphisms through Transcriptome Analysis of Mungbean SNPs

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Interstitial tissue-specific gene expression in mouse testis by intra-tunica albuguineal injection of recombinant baculovirus

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Asian Journal of Andrology 2009年第3期11卷 342-350页

作者： Hyun jung Park Won Young Lee Jin Hoi Kim Jae hwan Kim Hun Jong jung Nam Hyung Kim Bo Kyung Kim Hyuk Song Department of Animal Science College of Natural Science Konkuk University Chung-ju 380-701 Korea CHA Stem Cell Institute Graduate School of Life Science and Biotechnology Pochon CHA University Seoul 135-907 Korea Department of Animal Biotechnology College of Animal Biotechnology Konkuk University Seoul 143-701 Korea Occupation and Environment Department Medical School Konkuk University Chung-ju 380-704 Korea Department of Animal Science College of Agriculture Chungbuk National University Choung-ju Chung-buk 361-763 Korea Department of Physiology Medical School Konkuk University Chung-ju 380-701 Korea

The purpose of this study is to establish a gene delivery system for interstitial tissue-specific protein expression in mice testes using modified recombinant baculovirus. Green fluorescent protein （GFP）-expressing recombinant baculovirus （GFP-baculovirus）, in which the insect cell-specific polyhedron promoter was replaced by the cytomegalovirus （CMV）-IE promoter, was used to transfect testicular cells in vitro, and for intra-tunica albuguineal injection of the interstitial tissue of the testis. GFP expression was monitored in frozen testes sections by fluorescence microscopy. Expression of GFP in testicular tissues was also assessed by reverse transcription polymerase chain reaction （RT-PCR）, and protein expression was assessed by Western blot. Testicular cells in vitro were infected efficiently by modified recombinant GFP-baculovirus. lntra-tunica albuguineal injection of GFP- baculovirus into the mouse testis resulted in a high level of GFP expression in the interstitial tissues. RT-PCR analysis clearly showed GFP gene expression in the testis, particularly interstitial tissues. Intra-tunica albuguineal injection of a modified baculovirus that encoded recombinant rat insulin-like growth factor binding protein （IGFBP）-5 resulted in an increase in IGFBP-5 in testis and semen. In conclusion, we have developed an efficient delivery system for gene expression in vivo in testicular cells, particularly cells of the interstitial tissue using intratunica albuguineal injection of a modified recombinant baculovirus. This method will be particularly relevant for application that requires gene delivery and protein expression in the testicular cells of the outer seminiferous tubule of the testis.

关键词： intra-tunica albuguineal injection recombinant baculovirus testis gene delivery

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CXC chemokines and chemokine receptors in gastric cancer: From basic findings towards therapeutic targeting

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World Journal of Gastroenterology 2014年第7期20卷 1681-1693页

作者： Hyo Jin Lee Ik-Chan Song hwan-jung Yun Deog-Yeon Jo Samyong Kim Division of Hematology/Oncology Department of Internal MedicineSchool of Medicine Chungnam National University and Chungnam National University HospitalDaejeon 301-721South Korea Cancer Research Institute Chungnam National UniversityDaejeon 301-721South Korea Division of Hematology/Oncology Department of Internal MedicineChungnam National University HospitalDaejeon 301-721South Korea

Gastric cancer is the fourth most common cancer,and the second-highest cause of cancer-related deaths *** extensive research to identify novel diagnostic and therapeutic agents,patients with advanced gastric cancer suffer from a poor quality of life and poor prognosis,and treatment is dependent mainly on conventional cytotoxic *** improve the quality of life and survival of gastric cancer patients,a better understanding of the underlying molecular pathologies,and their application towards the development of novel targeted therapies,is urgently *** are a group of small proteins associated with cytoskeletal rearrangements,the directional migration of several cell types during development and physiology,and the host immune response via interactions with G-protein coupled *** is also growing evidence to suggest that chemokines not only play a role in the immune system,but are also involved in the development and progression of *** gastric cancer,CXC chemokines and chemokine receptors regulate the trafficking of cells in and out of the tumor *** chemokines and their receptors can also directly influence tumorigenesis by modulating tumor transformation,survival,growth,invasion and metastasis,as well as indirectly by regulating angiogenesis,and tumor-leukocyte *** this review,we will focus on the roles of CXC chemokines and their receptors in the development,progression,and metastasis of gastric tumors,and discuss their therapeutic potential for gastric cancer.

关键词： Chemokine Chemokine receptor Gastric neoplasm Therapeutic target

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Measuring nasolacrimal duct volume using computed tomography images in nasolacrimal duct obstruction patients in Korean

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 100-105页

作者： Jin-hwan Park jung-Ah Huh Jun-Feng Piao Hwa Lee Se-Hyun Baek Department of Ophthalmology Korea University College of Medicine

AIM: To investigate nasolacrimal duct(NLD) volume in Korean patients and to examine the correlation between NLD volume and obstruction. METHODS: Of patients who underwent orbital computed tomography from March 2013 to January 2016, patients diagnosed with NLD obstruction were classified into the patient group and patients without obstruction were classified into the control group. The NLD volume was measured using the Image J program, which showed the NLD in axial,coronal, and sagittal images on computed tomography. RESULTS: The average value of men's NLD volume,265.33±90.57 mm3, was significantly larger than women's,211.87±68.61 mm3(P=0.009). In the patient group, the NLD volume of the obstructed eyes, 242.49±82.93 mm3,and the non-obstructed eyes, 225.20±73.20 mm3, were significantly higher than the control group, 217.61±82.04 mm3(P<0.001, P<0.001). CONCLUSION: The NLD volume is larger in men than in women in Korean adults. If there is NLD obstruction in women, the NLD volume is larger and it is judged that inflammatory reaction caused a chronic change in the bone around the NLD and affect the measurement of NLD volume.

关键词： computed tomography nasolacrimal duct obstruction nasolacrimal duct volume

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The Conserved Proline Residue in the LOB Domain of LBD18 Is Critical for DNA-Binding and Biological Function

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Molecular Plant 2013年第5期6卷 1722-1725页

作者： Han Woo Lee Min-jung Kimb MoungYeon Park Kyung-hwan Han jungmook Kim Department of Bioenergy Science and Technology Chonnam National University Gwangju 500-757 Korea Department of Plant Biotechnology Chonnam National University Gwangju 500-757 Korea Department of Horticulture and Department of Forestry Michigan State University East Lansing MI 48824-1222 USA Kumho Life Science Laboratory Chonnam National University Buk-Gu Gwangju 500-757 Korea

Dear Editor, The LATERAL ORGAN BOUNDARIES DOMAIN （LBD）/ ASYMMETRICLEAVES2-LIKE （ASL） genes （hereafter referred to as LBD） encode proteins containing a conserved plant-specific LOB domain and play roles in lateral organ development （Iwakawa et al., 2002; Shuai et al., 2002; Majer and Hochholdinger, 2011）. The LOB domain is approximately 100 amino acids in length and contains a conserved four-Cys motif （CX2CX6CX3C）, the Gly-Ala-Ser block （GAS）, and the leucine-zipper-like coiled-coil motif （LX6LX3LX6L）（Shuai et al., 2002）. The leucine-zipper-like coiled-coil motif in the LOB domain is predicted to function in protein dimerization. LOB, AS2, and LBD4 preferentially bind unique DNA sequences in electrophoretic mobility shift assays （EMSAs）（Husbands et al., 2007）. The LOB domain of AS2 cannot be functionally replaced by those of other members of the LOB family,

关键词： LOB 生物学功能 DNA结合保守脯氨酸亮氨酸拉链残基器官发育

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Stone extraction balloon-guided repeat self-expanding metal stent placement

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World Journal of Gastroenterology 2010年第24期16卷 3087-3090页

作者： Hyung Hun Kim Jeong Seop Moon Soo Hyung Ryu jung hwan Lee You Sun Kim Division of Gastroenterology Department of Internal MedicineSeoul Paik Hospital Inje University College of Medicine

Self-expanding metal stent (SEMS) placement offers safe and effective palliation in patients with upper gastrointestinal obstruction due to a malignancy. Well described complications of SEMS placement include tumor growth, obstruction, and stent migration. SEMS occlusions are treated by SEMS redeployment, argon plasma coagulation application, balloon dilation, and surgical bypass. At our center, we usually place the second SEMS into the first SEMS if there is complete occlusion by the tumor. We discovered an unusual complication during SEMS redeployment. The guide-wire passed through the mesh of the first SEMS and caused the second SEMS to become entangled with the first SEMS. This led to the distortion and malfunction of the second SEMS, which worsened the gastric outlet obstruction. For lowering the risk of entanglement, we studied stone extraction balloon-guided repeat SEMS placement. This is the first report of a SEMS entangled by the mesh of the first SEMS and stone extraction balloon-guided repeat SEMS placement for lowering the risk of this complication.

关键词： Gastric outlet obstruction Self-expanding metal stent

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