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Adhesive ginsenoside compound K patches for cartilage tissue regeneration

Regenerative Biomaterials 2023年第1期10卷 1442-1450页

作者： jun-ho yang Hyun ho Shin Donghyeon Kim Ji Hyun Ryu Eun-jung Jin Department of Biological Sciences College of Health SciencesWonkwang UniversityIksanJeonbuk 54538South Korea Department of Chemical Engineering Wonkwang UniversityIksanJeonbuk 54538South Korea Department of Carbon Convergence Engineering Wonkwang UniversityIksanJeonbuk 54538South Korea Integrated Omics Institute Wonkwang UniversityIksanJeonbuk 54538South Korea

Biomaterial-based drug delivery systems have been developed to expedite cartilage regeneration;however,challenges related to drug recovery,validation,and efficient drug delivery *** instance,compound K(CK)is a major metabolite of ginsenosides that is known to protect against joint degeneration by inhibiting the production of inflammatory cytokines and the activation of immune ***,its effects on cartilage degradation and tissue regeneration remain ***,tissue-adhesive drug delivery depots that stably adhere to cartilage defects are required for CK *** this study,CK-loaded adhesive patches were reported to seal cartilage defects and deliver CK to defect sites,preventing cartilage degradation and accelerating cartilage tissue *** patches are stable and suitable for application in surgical procedures under physiological conditions and show excellent adhesiveness to cartilage *** addition,there were no significant differences in the adhesive polymeric networks before and after CK ***-loaded hydrocaffeic acid-conjugated chitosan patches significantly inhibited the stimulation of cartilage-degrading enzymes and apoptosis in osteoarthritic cartilage by releasing CK in cartilage ***,the NFkB signaling pathway of released CK from the adhesive patches in the treatment of osteoarthritis is ***,the CK-loaded adhesive patches are expected to significantly contribute to cartilage regeneration.

关键词： ginsenoside compound K adhesive patch drug delivery hydrocaffeic acid-conjugated chitosan osteoarthritis

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Effects of inter-electrode insertion on the performance and thermal flow fields of a hollow-electrode plasma torch

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Plasma Science and Technology 2020年第1期22卷 33-44页

作者： In-Mok yang jun-Seok NAM Min-Kyu ChoI jun-ho SEO Shi-Young yang Department of Applied Plasma Engineering Chonbuk National UniversityJeonju 54896Republic of Korea Graduate School of Flexible&Printable Electronics Chonbuk National UniversityJeonju 54896Republic of Korea

The effects of lntcr-ckxttxxk insertion on the performance of a hollow--electrode plasma torch have been investigated by numerical *** results revealed that when inter-dcctrodes arc inserted,the arc voltages and plasma powers increase due to the increase in the arc *** addition,it was predicted that thermal efficiency can be improved with the increase in plasma power by injecting plasma gases through the gaps between *** unique effects of inter-electrode insertion arc a result of the plasma temperatures adjusting themselves to increase arc voltages when the arc column is contracted radially by increasing gas-flow rate or decreasing inter-electrcxk diameter.

关键词： hollow-electrode plasma torch inter-electrodes numerical analysis torch performance

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Useful biomarkers for assessment of hepatitis C virus infection-associated autoimmune disorders

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World Journal of Gastroenterology 2014年第11期20卷 2962-2970页

作者： Deng-ho yang Ling-jun ho Jenn-Haung Lai Division of Rheumatology Immunology and AllergyDepartment of Internal MedicineTaichung Armed-Forces General Hospital Institute of Medicine Chung Shan Medical University Institute of Cellular and System Medicine National Health Research Institute Graduate Institute of Medical Science National Defense Medical Center Division of Allergy Immunology and RheumatologyDepartment of Internal MedicineChang Gung Memorial HospitalChang Gung University

During the course of chronic hepatitis C virus(HCV)infection,various extrahepatic manifestations of autoimmune disorders may occur,including arthralgia/arthritis,sicca complex,purpura,cutaneous ulcer,and thyroid *** addition,the prevalence of circulating autoantibodies is high among patients with HCV *** detected autoantibodies in HCVinfected patients include rheumatoid factor,antinuclear antibody,anti-SSA/anti-SSB antibody,cryoglobulin,antineutrophil cytoplasmic antibody,anti-smooth muscle antibody,anti-liver and anti-thyroid *** autoantibodies may be associated with underlying autoimmune disorders or liver inflammation in HCV infection.A possible reason for antibody production is overactivation and proliferation of B lymphocytes,via the interaction with the surface protein of *** immunotherapy can cause HCV flare-up or liver damage,overdiagnosis of HCV-related autoimmune symptoms as primary autoimmune disorders should be *** review describes biomarkers that are useful in clinically evaluating autoimmune manifestations and disorders associated with HCV infection.

关键词： Hepatitis C virus Autoantibody Autoimmune Biomarker Cytokine

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Management of Schemes and Threat Prevention in ICS Partner Companies Security

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Computers, Materials & Continua 2021年第12期69卷 3659-3684页

作者： Sangdo Lee jun-ho Huh Cyber Security Center Korea Midland Power Co.Ltd.BoryeongKorea Department of Data Informatics (National)Korea Maritime and Ocean UniversityBusanKorea

An analysis of the recent major security incidents related to industrial control systems,revealed that most had been caused by company ***,enterprise security management systems have been developed to focus on companies’***,several hacking incidents,involving major companies and public/financial institutions,were actually attempted by the cooperative firms or the outsourced manpower undertaking maintenance ***,institutions that operate industrial control systems(ICSs)associated with critical national infrastructures,such as traffic or energy,have contracted several cooperative ***,ICT’s importance is gradually increasing,due to outsourcing,and is the most vulnerable factor in *** paper proposes a virtualized security management scheme for the resident cooperative firms in the industrial control *** such companies often cannot afford adequate investment in security,the scheme is to let an ICS company provide the virtualized *** of its merits is the convenience of controlling a VDI server at the *** cooperative firms were classified,based on their respective security levels,and statistics were collected throughout a four-year period for the *** paper analyzes the policies and virtualization systems that have been applied to the security of the partner companies,which engaged in ICS security.A suitable model for ICS security was then proposed by analyzing their effects on the system efficiencies,based on the comparisons of the security inspection results obtained before and after *** proposed system is expected to contribute to industrial safety.

关键词： Nuclear power plant nuclear power plant security virtual machine SCADA ICS ISO27001 VDI based security software engineering

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Long-lasting,reinforced electrical networking in a high-loading Li_(2)S cathode for high-performance lithium–sulfur batteries

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Carbon Energy 2023年第8期5卷 1-14页

作者： Hun Kim Kyeong-jun Min Sangin Bang Jang-Yeon Hwang jung ho Kim Chong SYoon yang-Kook Sun Department of Energy Engineering Hanyang UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangjuRepublic of Korea Institute for Superconducting&Electronic Materials(ISEM) Australian Institute of Innovative Materials(AIIM)University of WollongongNew South WalesNorth WollongongAustralia Department of Materials Science and Engineering Hanyang UniversitySeoulRepublic of Korea

Realizing a lithium sulfide(Li_(2)S)cathode with both high energy density and a long lifespan requires an innovative cathode design that maximizes electrochemical performance and resists electrode ***,a high-loading Li_(2)S-based cathode with micrometric Li_(2)S particles composed of two-dimensional graphene(Gr)and one-dimensional carbon nanotubes(CNTs)in a compact geometry is developed,and the role of CNTs in stable cycling of high-capacity Li–S batteries is *** a dimensionally combined carbon matrix,CNTs embedded within the Gr sheets create robust and sustainable electron diffusion pathways while suppressing the passivation of the active carbon *** a unique point,during the first charging process,the proposed cathode is fully activated through the direct conversion of Li_(2)S into S_(8) without inducing lithium polysulfide *** direct conversion of Li_(2)S into S_(8) in the composite cathode is ubiquitously investigated using the combined study of in situ Raman spectroscopy,in situ optical microscopy,and cryogenic transmission electron *** composite cathode demonstrates unprecedented electrochemical properties even with a high Li_(2)S loading of 10 mg cm^(–2);in particular,the practical and safe Li–S full cell coupled with a graphite anode shows ultra-long-term cycling stability over 800 cycles.

关键词： carbon nanotubes electrical network high energy high loading Li_(2)S cathode lithium-sulfur batteries

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Adhesion and Suction Functions of the Tip Region of a Nectar-drinking Butterfly Proboscis

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Journal of Bionic Engineering 2017年第4期14卷 600-606页

作者： Seung Chul Lee jun ho Kim Sang Joon Lee Department of Mechanical Engineering Pohang University of Science and Technology Pohang 37673 Gyeongbuk Republic of Korea Center for Biofluid and Biomimic Research Pohang University of Science and Technology Pohang 37673 Gyeongbuk Republic of Korea

In this study, we investigated the dynamic functions of the tip region of the butterfly proboscis through which liquid is sucked during liquid feeding. The microstructures and flow patterns in the tip region of the proboscis were in vivo analyzed. The tip region can be divided into two functional sections： namely adhesion and suction sections. The liquid adheres to the adhesion section during liquid suction. Although the tip region has numerous slits connected to food canal of the proboscis, liquid is mainly sucked through the suction section, which section is submerged in the fluid pulled by the adhesion section and then successfully imbibes liquid. To check the dynamic functions of the tip region, we fabricated a suction tip model having adhesion and suction parts. The in vitro model experiments show that the hydrophilicity of the adhesion part and the existence of the suction inlet improve the liquid uptake driven by a suction pump. This study may provide insights for the biomimetic design of nectar-feeding butterflies.

关键词： butterfly proboscis nectar-feeding strategy suction

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A comparative study of interface reconstruction algorithms in molten metal flow

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China Foundry 2013年第1期10卷 50-56页

作者： Young-Sim Choi jun-ho hong ho-Young Hwang e-Design Center Korea Institute of Industrial TechnologyIncheon 406-840Korea

In the present research,two numerical schemes for improving the accuracy of the solution in the flow simulation of molten metal were *** method is the Piecewise Linear Interface Calculation(PLIC) method and the other is the Donor-Acceptor(D-A) *** verify the module of the interface reconstruction algorithms,simple problems were *** these validations,the accuracy and efficiency of these two methods were compared by simulating various real *** the numerical simulation of free surface flow,it is possible for the PLIC method to track very accurately the interface between *** PLIC method,however,has the weak point in that a lot of computational time is required,though it shows the more accurate interface *** Donor-Acceptor method has enough effectiveness in the macro-observation of a mold filling sequence though it shows inferior ***,for the problems that need the accurate solution,PLIC is more appropriate than *** accuracy may cause less efficiency in numerical *** method between D-A method and PLIC method should be chosen depends on the product.

关键词： interface reconstruction DA PLIC molten metal flow accuracy volume of fluid method

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Multifaceted neuroprotective effects of(-)-epigallocatechin-3-gallate(EGCG)in Alzheimer's disease:an overview of pre-clinical studies focused onβ-amyloid peptide

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Food Science and Human Wellness 2022年第3期11卷 483-493页

作者： Kumju Youn Chi-Tang ho Mira jun Department of Food Science and Nutrition Dong-A UniversityBusan 49315Korea Department of Food Science Rutgers UniversityNJ 08901USA Department of Health Sciences The graduate School of Dong-A UniversityBusan 49315Korea

Alzheimer’s disease(AD)is the most common neurodegenerative disease characterized by cognitive decline and memory *** lines of evidence indicate that excessiveβ-amyloid peptide(Aβ)generation and aggregation play pivotal roles in the initiation of AD,leading to various biochemical alteration including oxidative damage,mitochondrial dysfunction,neuroinflammation,signaling pathway and finally resulting in neuronal *** has a complex pathogenic mechanism,and a single-target approach for anti-AD strategy is thus full of *** overcome these limitations,the present study focused to review on one of multiple target-compounds,(-)-epigallocatechin-3-gallate(EGCG)for the prevention and treatment of *** is a main bioactive polyphenol in green tea and has been reported to exert potent neuroprotective properties in a wide array of both cellular and animal models in *** review demonstrated multiple neuroprotective efficacies of EGCG by focusing on the involvement of Aβ-evoked damage and its Aβ***,to understand its mechanism of action on the brain,the permeability of the blood-brain barrier was also discussed.

关键词： Alzheimer’s disease β-Amyloid peptide Green tea EGCG Neuroinflammation

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Study on accuracy of casting flow simulation

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China Foundry 2017年第5期14卷 333-338页

作者： Youngsim Choi jun-ho hong ho-Young Hwang Kyuhong Kim Dept.of Mechanical&Aerospace Engineering Seoul Nat.Univ.Republic of Korea Korea Institute of Industrial Technology(KITECH) Republic of Korea Institute of Advanced Aerospace Technology Seoul Nat.Univ.Republic of Korea

In the field of casting flow simulation, the application of body-fitted coordinate(BFC) has not been widely used due to the difficulty and low efficiency of grid generation, despite the availability of good quality analysis results. Cartesian coordinates, on the other hand, have been used predominantly in casting process simulations because of their relatively easy and fast grid generation. however, Cartesian grid systems cannot obtain accurate results because they cannot express the geometries properly. In this study, Cut Cell method was applied to solve this problem. The three-dimensional incompressible viscous governing equation was analyzed using a function defined for the volume and area of the casting in the cutting cell. Using the Cut Cell method, accurate flow analysis results were also obtained in the Cartesian grid systems. The tests of simple shape and the applications of actual casting product have been tried with Cut Cell method.

关键词： casting flow Cut Cell Cartesian coordinates body-fitted coordinates filling pattern conservationof momentum

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YouTube as a source of patient information on gallstone disease

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World Journal of Gastroenterology 2014年第14期20卷 4066-4070页

作者： jun Suh Lee ho Seok Seo Tae ho hong Department of Surgery Armed Forces Capital Hospital Department of Surgery Seoul St. Mary’s HospitalCollege of MedicineThe Catholic University of Korea

AIM: To investigate the quality of YouTube videos on gallstone disease and to assess viewer response according to quality.

关键词： YouTube Gallstone disease Gallstone Gallbladder Cholecystitis

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