Adhesive ginsenoside compound K patches for cartilage tissue regeneration

作     者：Jun-Ho Yang Hyun Ho Shin Donghyeon Kim Ji Hyun Ryu Eun-Jung Jin 

作者机构：Department of Biological SciencesCollege of Health SciencesWonkwang UniversityIksanJeonbuk 54538South Korea Department of Chemical EngineeringWonkwang UniversityIksanJeonbuk 54538South Korea Department of Carbon Convergence EngineeringWonkwang UniversityIksanJeonbuk 54538South Korea Integrated Omics InstituteWonkwang UniversityIksanJeonbuk 54538South Korea 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2023年第10卷第1期

页      面：1442-1450页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 

基　　金：supported by a National Research Foundation of Korea(NRF)grant funded by the Korean Government(MSIT)(2022R1A4A1031259 and 2021R1I1A3041149)to E.-J.J by a Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korean Government(Ministry of Science and ICT,Ministry of Health&Welfare)(22A0103L1)to J.H.R 

主　　题：ginsenoside compound K adhesive patch drug delivery hydrocaffeic acid-conjugated chitosan osteoarthritis 

摘      要：Biomaterial-based drug delivery systems have been developed to expedite cartilage regeneration;however,challenges related to drug recovery,validation,and efficient drug delivery *** instance,compound K(CK)is a major metabolite of ginsenosides that is known to protect against joint degeneration by inhibiting the production of inflammatory cytokines and the activation of immune ***,its effects on cartilage degradation and tissue regeneration remain ***,tissue-adhesive drug delivery depots that stably adhere to cartilage defects are required for CK *** this study,CK-loaded adhesive patches were reported to seal cartilage defects and deliver CK to defect sites,preventing cartilage degradation and accelerating cartilage tissue *** patches are stable and suitable for application in surgical procedures under physiological conditions and show excellent adhesiveness to cartilage *** addition,there were no significant differences in the adhesive polymeric networks before and after CK ***-loaded hydrocaffeic acid-conjugated chitosan patches significantly inhibited the stimulation of cartilage-degrading enzymes and apoptosis in osteoarthritic cartilage by releasing CK in cartilage ***,the NFkB signaling pathway of released CK from the adhesive patches in the treatment of osteoarthritis is ***,the CK-loaded adhesive patches are expected to significantly contribute to cartilage regeneration.