Multifaceted neuroprotective effects of(-)-epigallocatechin-3-gallate(EGCG)in Alzheimer's disease:an overview of pre-clinical studies focused onβ-amyloid peptide

作     者：Kumju Youn Chi-Tang Ho Mira Jun Kumju Youn;Chi-Tang Ho;Mira Jun

作者机构：Department of Food Science and NutritionDong-A UniversityBusan 49315Korea Department of Food ScienceRutgers UniversityNJ 08901USA Department of Health SciencesThe graduate School of Dong-A UniversityBusan 49315Korea 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2022年第11卷第3期

页      面：483-493页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 09[农学] 090203[农学-茶学] 100203[医学-老年医学] 0902[农学-园艺学] 10[医学] 

基　　金：supported by Dong-A University。 

主　　题：Alzheimer’s disease β-Amyloid peptide Green tea EGCG Neuroinflammation 

摘      要：Alzheimer’s disease(AD)is the most common neurodegenerative disease characterized by cognitive decline and memory impairment.Many lines of evidence indicate that excessiveβ-amyloid peptide(Aβ)generation and aggregation play pivotal roles in the initiation of AD,leading to various biochemical alteration including oxidative damage,mitochondrial dysfunction,neuroinflammation,signaling pathway and finally resulting in neuronal death.AD has a complex pathogenic mechanism,and a single-target approach for anti-AD strategy is thus full of challenges.To overcome these limitations,the present study focused to review on one of multiple target-compounds,(-)-epigallocatechin-3-gallate(EGCG)for the prevention and treatment of AD.EGCG is a main bioactive polyphenol in green tea and has been reported to exert potent neuroprotective properties in a wide array of both cellular and animal models in AD.This review demonstrated multiple neuroprotective efficacies of EGCG by focusing on the involvement of Aβ-evoked damage and its Aβregulation.Furthermore,to understand its mechanism of action on the brain,the permeability of the blood-brain barrier was also discussed.