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Real-world treatment patterns and disease control over one year in patients with inflammatory bowel disease in Brazil

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World Journal of gastroenterology 2021年第23期27卷 3396-3412页

作者： Ligia Yukie sassaki sender J Miszputen Roberto Luiz Kaiser Junior Wilson R Catapani Mauro Bafutto António s scotton Cyrla Zaltman Julio pinheiro Baima Hagata s Ramos Mikaell Alexandre gouvea faria Carolina D gonçalves Isabella Miranda guimaraes Cristina flores Heda M B s Amarante Rodrigo Bremer Nones JoséMiguel Luz parente Murilo Moura Lima Júlio maria Chebli maria de Lourdes Abreu ferrari julia f campos.maria g p s.nna Odery Ramos Rogério serafim parra Jose J R da Rocha Omar feres Marley R feitosa Rosana fusaro Caratin juliana Tosta senra genoile Oliveira santana Department of Internal Medicine Botucatu Medical School at Sao Paulo State University(UNESP)Botucatu 18618-687São PauloBrazil Department of gastroenterology Escola Paulista de MedicinaSao PauloSão Paulo 18618-687São PauloBrazil Department of proctology Kaiser Day HospitalSão Jose do Rio Preto 15015-110São PauloBrazil Department of gastroenterology Faculdade de Medicina do ABCSanto Andre 09060-870São PauloBrazil Department of gastroenterology Faculdade de MedicinaGoiania 74535-170GoiásBrazil Department of gastroenterology CMIP Centro Mineiro de PesquisaJuiz de Fora 36010-570Minas GeraisBrazil Department of Internal Medicine Federal University of Rio de JaneiroRio de Janeiro 21941-913Rio de JaneiroBrazil Department of gastroenterology Escola Paulista de MedicinaSão Paulo 04023-900São PauloBrazil Hospital de Clínicas de porto Alegre Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Hospital de Clinicas da Universidade federal do paraná Hospital de Clinicas da Universidade Federal do ParanáCuritiba ParanáParanáBrazil gastroenterology Department Hospital Nossa Senhora das GraçasCuritiba 80810-040ParanáBrazil Department of general Medicine Universidade Federal do PiauíTeresina 64049-550PiauíBrazil gastroenterology Hospital Universitario da Universidade Federal do PiauiTeresina 64049-550PiauíBrazil Department of Medicine University Hospital of Federal University of Juiz de ForaJuiz de ForaJuiz de Fora 36036-247Minas GeraisBrazil Department of Clinical Medicine Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Hospital de Clinicas da Universidade federal do paraná Hospital de Clinicas da Universidade Federal do ParanáCuritiba 80060-900ParanáBrazil Department of surgery and Anatomy Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirão Preto 14048-900São PauloBrazil scientific Affairs Takeda Pharmaceuticals BrazilSao Paulo 04709-011Brazil Clinical Research Takeda PharmaceuticalsSão Paulo 04709-011Sã

BACKgROUND Crohn’s disease(CD)and ulcerative colitis(UC)are inflammatory bowel diseases(IBDs)with a remission-relapsing presentation and symptomatic exacerbations that have detrimental impacts on patient quality of life and are associated with a high cost burden,especially in patients with moderate-to-severe *** Real-world Data of Moderate-to-severe Inflammatory Bowel Disease in Brazil(RIsE BR)study was a noninterventional study designed to evaluate disease control,treatment patterns,disease burden and health-related quality of life in patients with moderate-to-severe active *** report findings from the prospective follow-up phase of the RIsE BR study in patients with active UC or *** To describe the 12-mo disease evolution and treatment patterns among patients with active moderate-to-severe IBD in *** This was a prospective,noninterventional study of adult patients with active Crohn’s disease(CD:Harvey-Bradshaw Index≥8,CD Activity Index≥220),inadequate CD control(i.e.,calprotectin>200μg/g or colonoscopy previous results),or active ulcerative colitis(UC:partial Mayo score≥5).Enrollment occurred in 14 centers from October 2016 to february *** proportion of active IBD patients after 9-12 mo of follow-up,Kaplan-Meier estimates of the time to mild or no activity and a summary of treatment initiation,discontinuation and dose changes were *** The study included 118 CD and 36 UC patients,with mean±sD ages of 43.3±12.6 and 44.9±16.5 years,*** most frequent drug classes at index were biologics for CD(62.7%)and 5-aminosalicylate derivates for UC patients(91.7%).During follow-up,65.3%of CD and 86.1%of UC patients initiated a new treatment at least ***/dose changes occurred in 68.1%of CD patients[median 2.0(IQR:2-5)]and 94.3%of UC patients[median 4.0(IQR:3-7)].On average,CD and UC patients had 4.4±2.6 and 5.0±3.3 outpatient visits,*** median time to first mild or no activity was 319(IQR:239-3

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel diseases prospective study

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Characterization of goat whey proteins and their bioactivity and toxicity assay

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food Bioscience 2022年第2期46卷 833-843页

作者： maria Isabel ferreira campos paula perazzo de souza Barbosa Laura Junqueira Camargo Luciano Da silva pinto Bianca Mataribu Catarina serr˜ao Luis fernando Marques-santos Jos´e Hon´orio Lopes julia mariano Caju de Oliveira Carlos Alberto de Almeida gadelha Tatiane santi-gadelha programa de p´os-graduaç˜ao em Ciˆencia e Tecnologia de Alimentos Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil Departamento de Biologia Molecular Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil Centro de Desenvolvimento Tecnol´ogico Universidade Federal de PelotasRio Grande do SulBrazil programa de p´os-graduaç˜ao em Ciˆencias da Nutriç˜ao Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil

goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s ***,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute *** proteins were quantified and identified by Bradford,Kjehdal and sDs-pAgE *** activity was performed against Listeria monocytogenes,salmonella spp.,staphylococcus aureus,pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for *** *** activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of *** highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DppH radical *** acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout ***,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without *** present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry.

关键词： goat whey proteins Malignant cells Antimicrobial Antioxidant capacity Whey protein functionality

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significant association between ABO blood group and pancreatic cancer

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World Journal of gastroenterology 2010年第44期16卷 5588-5591页

作者： julia B greer Mark H Yazer Jay s Raval M Michael Barmada Randall E Brand David C Whitcomb Department of Medicine Division of GastroenterologyHepatology and NutritionUniversity of Pittsburgh School of Medicine Department of pathology University of Pittsburgh School of Medicine The Institute for Transfusion Medicine Department of Human genetics Graduate School of Public HealthUniversity of Pittsburgh University of pittsburgh Cancer Institute

AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United ***:Using the University of pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion service) in pittsburgh,pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group *** ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to pittsburgh's Central Blood Bank between 1979 and ***:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,p=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,p=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall p trend value comparing patient to donor blood groups was ***:The ABO blood group is associated with pancreatic cancer *** studies should examine the mechanism linking pancreatic cancer risk to ABO blood group.

关键词： ABO blood group pancreatic adenocarcinoma surveillance Risk reduction Epidemiology

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Inter- and intraobserver agreement in computed tomography enterography in inflammatory bowel disease

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World Journal of gastroenterology 2016年第45期22卷 10002-10008页

作者： Natally Horvat Camila Carlos Tavares Adriana Ribas Andrade julia campos sim?es Cabral Hilton Muniz Le?o filho Angela Hissae Motoyama Caiado serli Kiyomi Nakao Ueda André Zonetti de Arruda Leite Aytan Miranda sipahi Manoel de souza Rocha Radiology Department Hospital das Clínicas da Faculdade de Medicina da Universidade de S?o Paulo gastroenterology Department Lim 07 Hospital da Clínicas da Faculdade de Medicina da Universidade de S?o Paulo

AIM To evaluate intra- and interobserver agreement in imaging features in inflammatory bowel disease and comparison with fecal calprotectin(fC) *** Our institutional computed tomography enterography(CTE) database was retrospectively queried to identify patients who underwent CTE from January 2014 to June 2015. patient inclusion criteria were confirmed inflammatory bowel disease(IBD) and fC collected fter CTE without any change in clinical treatment or surgical treatment during this interval. The exclusion criterion was poor image quality. Two blinded abdominal radiologists, with 12 and 3 years of experience analyzed the CTE regarding localization(small bowel, colonic, both, or no disease detected);type of IBD(inflammatory, stenosing, fistulizing, > 1 pattern, or normal); and signs of active disease(present or absent). In 42 of 44 patients evaluated, routine CTE reports were made by one of the readers who reevaluated the CTEs ≥ 6 mo later, to determine the intraobserver agreement. fC was considered a sign of disease activity when it was higher than 250 μg/*** forty-four patients with IBD(38 with Crohn's disease and 6 with ulcerative colitis) were included. There was a moderate interobserver agreement regarding localization of IBD(k = 0.540), type of disease(k = 0.410) and the presence of active signs in CTE(k = 0.419). There was almost perfect intraobserver agreement regarding localization, type and signs of active disease in IBD. The k values were 0.902, 0.937 and 0.830, respectively. After a consensus between both radiologists regarding inflammatory activity in CTE, we found that 24(85.7%) of 28 patients who were classified with active disease had elevated fC, and six(37.5%) of 16 patients without inflammatory activity in CTE had elevated fC(p = 0.003). The correlation between elevated fC and the presence of active disease in CTE was significant(k = 0.495, p = 0.001).CONCLUsION We found almost perfect intraobserver and moderate interobserve

关键词： Crohn’s disease Ulcerative colitis Computed tomography fecal calprotectin Inflammatory bowel disease activity

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Novel pectin/Chia-Mucilage Membranes:Human serum Albumin Adsorption,Biocompatibility,and physical-Chemical properties

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Journal of Renewable Materials 2023年第6期11卷 2647-2663页

作者： s.E.Burruel-Ibarra R.A.Esquer-Osuna R.g.Valdez-Melchor D.A.Cuevas-Acuña L.Quihui-Cota J.Juárez J.C.campos-garcía E.Valbuena-gregorio M.A.López-Mata Departamento de Investigación en polímeros y Materiales Universidad de SonoraHermosilloSonoraMéxico Departamento de Ciencias de la salud Campus CajemeUniversidad de SonoraCd.ObregónSonoraMéxico Departamento de Nutrición pública y salud Coordinación de NutriciónCentro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico Departamento de física Universidad de SonoraHermosilloSonoraMéxico

This study aimed to characterize the physical-chemical and biological properties of pectin(pC)/chia seed mucilage(CM)***/CM[100/0(control),80/20%,60/40%,and 40/60%w/w]membranes were prepared using the casting *** membranes(pC/CM)were thin,yellow,lightly opaque(≈10%)and capable of blocking light UVB(between 66 at 52%).sEM analysis showed the presence of aggregates in the shape of a sphere(≈13μm)and ovoid(≈25μm).The proportion of 80/20 showed an increase in tensile strength(29%)and elastic modulus(19%)when compared to the *** analysis exhibited intermolecular interactions between pCpC,pC-CM,and CM-CM in the *** thermal analysis(600°C)showed a slight improvement in the percentage of residual mass-loss of 3.31%(80/20)that *** 40/60 membrane showed the lowest percentage of hemolysis(2.94%)but limited human albumin adsorption *** results suggested that the blend pC/CM may be considered as a biomaterial for medical applications.

关键词： pectin chia mucilage membrane hemolysis albumin biomaterial

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gene variants of the phosphatidylcholine synthesis pathway do not contribute to RDs in the Chinese population

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World Journal of pediatrics 2018年第1期14卷 52-56页

作者： Yu-Jun Chen julia Meyer Jennifer A.Wambach Kelcey Depass Daniel J.Wegner Xin fan Qun-Yuan Zhang Heins Hillary f.sessions Cole Aaron Hamvas Neonatology the First Affliated Hospital of GuangxiMedical UniversityNanningChina Division of Newborn Medicine Edward MallinckrodtDepartment of PediatricsWashington University Schoolof MedicineSt.LouisUSA

Background To determine population-based prevalence and disease contribution of phosphatidylcholine synthetic pathway-associated gene variants in a native southern Chinese cohort. Methods We used bloodspots from 2010 that were obtained from the guangxi Neonatal screening Center in Nannning China and included the Han (n = 443) and Zhuang (n = 313) ethnic groups. We sequenced the exons of cholinephosphate cytidylyltransferase (pCYT1B) lysophospholipid acyltransferase 1 (LpCAT1), and cholinephosphotransferase (CHpT1) genes, and analyzed both rare and common exonic variants. Results We obtained five mutations (g199D, A299V, g434C, Y490C, L312s) with eight alleles in the three candidate genes. The collapsed minor allele frequency for candidate genes was not significantly different between the Han and Zhuang popula-tions (0.0045 vs. 0.0064, respectively,p = 0.725). The combined Han and Zhuang pool collapsed carrier frequency of rare mutation allele was found to be 1.06%, which is much higher than previously reported for the Missouri population (0.1%). further, we detected six exonic common variants (three in LpCAT1 and three in CHpT1), with three non-synonymous vari-ants (f162s, f341L, M427K) among them. Two of the non-synonymous exonic variants (f341L, M427K) were not found in CHB;f341L was also not previously reported in exome sequencing project. Conclusions The population-based frequency of mutations in the phosphatidylcholine synthesis pathway-associated genes pCYT1B LpCAT1,CHpT1 is low in southern Chinese newborns and there is no evidence of contribution to population-based disease burden of respiratory distress syndrome. As a population-based study of rare mutations and common variants, this work is valuable in directing future research.

关键词： genetic epidemiology Human population genetics Neonatal respiratory distress syndrome pulmonary surfactant

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Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration

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National science Review 2021年第2期8卷 60-73页

作者： philippe Ciais Yitong Yao Thomas gasser Alessandro Baccini Yilong Wang Ronny Lauerwald shushi peng Ana Bastos Wei Li peter A.Raymond Josep g.Canadell glen p.peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann goulven Laruelle Alexandra g.Konings Anthony W.King Yi Liu sebastiaan Luyssaert fabienne Maignan prabir K.patra Anna peregon pierre Regnier julia pongratz Benjamin poulter Anatoly shvidenko Riccardo Valentini Rong Wang grégoire Broquet Yi Yin Jakob Zscheischler Bertrand guenet Daniel s.goll Ashley-p.Ballantyne Hui Yang Chunjing Qiu Dan Zhu state Key Laboratory of soil Erosion and Dryland farming on the Loess plateau Northwest A&F University CsIRO Oceans and Atmosphere 15. Institute for geology CEN—Center for Earth System Research and SustainabilityUniversity of Hamburg 16. Department of Earth System ScienceStanford University 17. Department of Earth System ScienceStanford UniversityStanford 18. School of Geographical SciencesNanjing University of Information Science and Technology 19. Department of Ecological SciencesVrije Universiteit Amsterdam 20. Research Institute for Global ChangeJAMSTEC Laboratoire des sciences du Climat et de l'Environnement CEA-CNRS-UVSQ-UPSACLAY Center for Environmental Remote sensing Chiba University Institute of soil science and Agrochemistry Siberian Branch of the Russian Academy of Sciences (SB RAS) Tuva state University Republic of Tuva Max planck Institute for Meteorology NAsA goddard space flight Center Biospheric Sciences Lab. 26. Department for Innovation in BiologicalAgro-food and Forest systems (DIBAF)University of Tuscia RUDN University Department of Environmental science and Engineering Shanghai Key Laboratory of Atmospheric Particle Pollution and PreventionInstitute of Atmospheric SciencesFudan University 29. Division of Geological and Planetary SciencesCalifornia Institute of Technology 30. Climate and Environmental Physics and Oeschger Centre for Climate Change ResearchUniversity of Bern 31. Department of Ecosystem and Conservation Sci

Resolving regional carbon budgets is critical for informing land-based mitigation policy. for nine regions covering nearly the whole globe, we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing. The net land–atmospheric carbon exchange(NEE) was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade, and riverine-carbon export to the ocean. summing up NEE from all regions, we obtained a global ‘bottom-up’ NEE for net land anthropogenic CO2uptake of –2.2 ± 0.6 pg C yr-1consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009. This estimate is so far the most comprehensive global bottom-up carbon budget accounting, which set up an important milestone for global carbon-cycle studies. By decomposing NEE into component fluxes, we found that global soil heterotrophic respiration amounts to a source of CO2of 39 pg C yr-1with an interquartile of 33–46 pg C yr-1—a much smaller portion of net primary productivity than previously reported.

关键词： carbon budget human appropriation of ecosystems soil carbon

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Virulence factor profile of staphylococcus aureus Isolated from Bovine Milk from Brazil

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food and Nutrition sciences 2014年第15期5卷 1496-1505页

作者： Verena M.santos Hellen B.Martins Izadora s.Rezende Maysa s.Barbosa Ewerton f.Andrade simone g.souza guilherme B.campos pollianna s.Oliveira Daniel s.sousa Danilo C.C.Da silva Aline T.Amorim Jorge Timenetsky Mariluze p.Cruz Regiane Yatsuda Lucas M.Marques Instituto Multidisciplinar em saúde Núcleo de Tecnologia em SaúdeUniversidade Federal da BahiaVitoria da ConquistaBrazil Instituto de Ciências Biomédicas Departamento de MicrobiologiaUniversidade de Sao PauloSao PauloBrazil

This study investigates the biofilm formation, presence and distribution of virulence genes and the capacity to induce an inflammatory response in strains of staphylococcus aureus isolated from milk samples in Bahia, Brazil. A total of 132 samples of raw milk were collected from four dairy farms (designated A to D) located in southwestern Bahia, in the municipality of Vitória da Conquista, from October/2009 to september/2010. After processing of the samples, 94 (71.2%) s. aureus isolates were obtained. These strains were subjected to the antibiogram method MIC (Minimum Inhibitory Concentration). As for the pathogenicity, tests were performedin vitrobiofilm formation induced by glucose. Moreover, we performed pCR for their virulence genes: sea (enterotoxin A), seb (B), sec (C), pvl (panton-Valentine Leukocidin), clfA (Clumping factor A) and spa (protein A) and analysis of cytokine induction in the inflammatory response of J774 macrophages by exocellular lipoteichoic acid. No isolates were resistant to oxacillin and vancomycin. In biofilm production, 5.31% (5/94) isolates did not produce biofilm, 5.31% (5/94) of the samples were poor producers, 15.96% (15/94) strains were moderate producers, 18.09% (17/94) were producers and 55.32% (55/94) of isolates were strong biofilm producers. One (1.06%) isolate expressed the seb gene, one (1.06%) sec, 18 (19.2%) cflA and 44 (46.8%) had spa. There was no expression of sea and pvl between isolates analyzed. The analysis of cytokine induction in the inflammatory response did not show statistical difference in the levels of IL-6, TNf-α and IL-10 induction. However, there was statistical difference in IL-1 induction between isolates from different farms. Thus, it appears that the results obtained in this study show significant effects for the region studied, since it is an important dairy region, hence the need for further studies, with the intent of attracting funding that contributes to improving prevention and control in both dai

关键词： Milk staphylococcus aureus Resistance Virulence factors

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The protein-protein interaction landscape of transcription factors during gynoecium development in Arabidopsis

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Molecular plant 2023年第1期16卷 260-278页

作者： Humberto Herrera-Ubaldo sergio E.campos pablo López-gómez Valentín Luna-garcía Víctor M.Zúñiga-Mayo gerardo E.Armas-Caballero Karla L.gonzález-Aguilera Alexander DeLuna Nayelli Marsch-Martínez Carlos Espinosa-soto stefan de folter Unidad de genómica Avanzada(UgA-LANgEBIO) Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN)IrapuatoGuanajuato 36824México Departamento de Biotecnología y Bioquímica Unidad IrapuatoCINVESTAV-IPNIrapuatoGuanajuato 36824México Instituto de física Universidad de San Luis PotosíSan Luis PotosíSLP 78290México present address:Department of plant sciences University of CambridgeCambridgeUK present address:Department of Molecular and Cellular Biology University of California DavisDavisCAUSA present address:CONACYT Instituto de FitosanidadColegio de PostgraduadosCampus MontecilloTexcocoMéxico

flowers are composed of organs whose identity is defined by the combinatorial activity of transcription factors(Tfs).The interactions between MADs-box Tfs and protein complex formation have been schematized in the floral quartet model of flower *** gynoecium is the flower’s female reproductive part,crucial for fruit and seed production and,hence,for reproductive *** the establishment of carpel identity,many tissues arise to form a mature *** have been described as regulators of gynoecium development,and some interactions and complexes have been ***,broad knowledge about the interactions among these Tfs and their participation during development remains *** this study,we used a systems biology approach to understand the formation of a complex reproductive unit—as the gynoecium—by mapping binary interactions between well-characterized *** analyzed almost 4500 combinations and detected more than 250 protein-protein interactions(ppIs),resulting in a process-specific interaction *** analyses suggest hidden functions and novel roles for many *** addition,we observed a close relationship between Tfs involved in auxin and cytokinin-signaling pathways and other ***,we analyzed the network by combining ppI data,expression,and genetic data,which helped us to dissect it into several dynamic spatio-temporal subnetworks related to gynoecium development ***,we generated an extended ppI network that predicts new players in gynoecium *** together,all these results serve as a valuable resource for the plant community.

关键词： interactome networks transcription factors gynoecium development

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MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

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Cellular & Molecular Immunology 2022年第2期19卷 234-244页

作者： Yeonsu Kim Xiaoyan Zheng Kathrin Eschke M.Zeeshan Chaudhry federico Bertoglio Adriana Tomić Astrid Krmpotić Markus Hoffmann Yotam Bar-On julia Boehme Dunja Bruder Thomas Ebensen Linda Brunotte stephan Ludwig Martin Messerle Carlos guzman Ofer Mandelboim Michael Hust stefan pöhlmann stipan Jonjić LukaČičin-Šain Department of Viral Immunology Helmholtz Centre for Infection Research(HZI)BraunschweigGermany Department of Biotechnology Institut für BiochemieBiotechnologie und BioinformatikTechnischen Universität BraunschweigBraunschweigGermany Oxford Vaccine group University of OxfordOxfordUK Center for proteomics University of RijekaFaculty of MedicineRijekaCroatia Infection Biology Unit German Primate CenterGöttingenGermany faculty of Biology and psychology Georg-August-University GöttingenGöttingenGermany Department of Immunology Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael Infection Immunology Institute for Medical Microbiology and Hospital HygieneHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke-University MagdeburgMagdeburgGermanyImmune RegulationHelmholtz Centre for Infection ResearchBraunschweigGermany Department of Vaccinology and Applied Microbiology Helmholtz Centre for Infection ResearchBraunschweigGermany Institute of Virology Medical University MünsterMünsterGermany Institute of Virology Hannover Medical School(MHH)HannoverGermany german Centre for Infection Research(DZIf) Hannover-Braunschweig SiteHannoverGermany Centre for Individualized Infection medicine(CiiM) a joint venture of HZI and MHHHannoverGermany

global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and *** remains a medical need for vaccines against these ***(cytomegalovirus)is aβ-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8+T cells are maintained for a ***,CMV has been proposed and investigated as a novel vaccine vector for expressing antigenic peptides or proteins to elicit protective cellular immune responses against numerous *** generated two recombinant murine CMV(MCMV)vaccine vectors expressing hemagglutinin(HA)of influenza A virus(MCMV^(HA))or the spike protein of severe acute respiratory syndrome coronavirus 2(MCMV^(s)).A single injection of MCMVs expressing either viral protein induced potent neutralizing antibody responses,which strengthened over ***,MCMV^(HA)-vaccinated mice were protected from illness following challenge with the influenza virus,and we excluded that this protection was due to the effects of memory T ***,we show here that MCMV vectors induce not only long-term cellular immunity but also humoral responses that provide long-term immune protection against clinically relevant respiratory pathogens.

关键词： Vaccine vector sARs-CoV-2 Influenza Cytomegalovirus humoral imunity

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