The protein-protein interaction landscape of transcription factors during gynoecium development in Arabidopsis

作     者：Humberto Herrera-Ubaldo Sergio E.Campos Pablo López-Gómez Valentín Luna-García Víctor M.Zúñiga-Mayo Gerardo E.Armas-Caballero Karla L.González-Aguilera Alexander DeLuna Nayelli Marsch-Martínez Carlos Espinosa-Soto Stefan de Folter Humberto Herrera-Ubaldo;Sergio E.Campos;Pablo López-Gómez;Valentín Luna-García;Víctor M.Zúñiga-Mayo;Gerardo E.Armas-Caballero;Karla L.González-Aguilera;Alexander DeLuna;Nayelli Marsch-Martínez;Carlos Espinosa-Soto;Stefan de Folter

作者机构：Unidad de Genómica Avanzada(UGA-LANGEBIO)Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN)IrapuatoGuanajuato 36824México Departamento de Biotecnología y BioquímicaUnidad IrapuatoCINVESTAV-IPNIrapuatoGuanajuato 36824México Instituto de FísicaUniversidad de San Luis PotosíSan Luis PotosíSLP 78290México Present address:Department of Plant SciencesUniversity of CambridgeCambridgeUK Present address:Department of Molecular and Cellular BiologyUniversity of California DavisDavisCAUSA Present address:CONACYTInstituto de FitosanidadColegio de PostgraduadosCampus MontecilloTexcocoMéxico 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2023年第16卷第1期

页      面：260-278页

核心收录：

学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学] 

基　　金：H.H.-U.,V.L.-G.,and P.L.-G.were supported by the Mexican National Council of Science and Technology(CONACyT)with a Ph.D.fellowship(243380,487657,and 747095,respectively) Work in the S.d.F.laboratory was financed by the CONACYT grants CB-2012-177739,FC-2015-2/1061,and CB-2017-2018-A1-S-10126,and N.M.-M.by the CONACYT grant CB-2015-255069.S.d.F.is grateful for the Fellowship of the Marcos Moshinsky Foundation(2018) participation in the European Union projects H2020-MSCA-RISE-2020 EVOfruland project(101007738)and H2020-MSCA-RISE-2019 MAD project(872417) 

主　　题：interactome networks transcription factors gynoecium development 

摘      要：Flowers are composed of organs whose identity is defined by the combinatorial activity of transcription factors(TFs).The interactions between MADS-box TFs and protein complex formation have been schematized in the floral quartet model of flower *** gynoecium is the flower’s female reproductive part,crucial for fruit and seed production and,hence,for reproductive *** the establishment of carpel identity,many tissues arise to form a mature *** have been described as regulators of gynoecium development,and some interactions and complexes have been ***,broad knowledge about the interactions among these TFs and their participation during development remains *** this study,we used a systems biology approach to understand the formation of a complex reproductive unit—as the gynoecium—by mapping binary interactions between well-characterized *** analyzed almost 4500 combinations and detected more than 250 protein-protein interactions(PPIs),resulting in a process-specific interaction *** analyses suggest hidden functions and novel roles for many *** addition,we observed a close relationship between TFs involved in auxin and cytokinin-signaling pathways and other ***,we analyzed the network by combining PPI data,expression,and genetic data,which helped us to dissect it into several dynamic spatio-temporal subnetworks related to gynoecium development ***,we generated an extended PPI network that predicts new players in gynoecium *** together,all these results serve as a valuable resource for the plant community.