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Placental tissues as sources of stem cells—Review

Open Journal of Animal Sciences 2012年第3期2卷 166-173页

作者： Renata Avancini fernandes Carolina Costola-Souza Carlos Alberto Palmeira Sarmento Leandro Goncalves Phelipe oliveira Favaron Maria Angelica Miglino Faculty of Veterinary Medicine and Animal Science University of Sao PauloSao PauloBrazil

Recently the fetal membranes are regarded to be abundant, ethically acceptable and easily accessible sources of mesenchymal stem cells, which cause only minor immunogenic troubles. In addition, these membranes have been studied as an alternative to adult and embryonic stem cells. The chorion develops firstly as a layer of simple avascular epithelium (trophoblast). The amnion, as the chorion is also an avascular membrane. It is derived from the ectoderm, and forms a very thin membrane which surrounded the embryo in development. The hypoblast and exocoelomic membrane together originates the yolk sac which late will give rise to the allantois. The study of the origin and development of these tissues is of vital importance for obtaining stem cells. Different cell lineages can be obtained from the fetal placental tissues: the hematopoietic lineage is found in the chorion, allantois and, yolk sac, and the mesenchymal lineage is found in the chorion and amnion. The properties and potential for differentiation of fetal stem cells isolated from placental tissues must be characterized in order for them to be used in the treatment of several diseases. The chorion, yolk sac, allantois, and amnion contain heterogeneous cell populations. However, few studies have focused on characterizing these alternative stem cells sources. The amnion has a significant advantage over the other fetal membranes, mainly due to its easily accessibility for collection in humans and rodents and also because it contains populations of pluripotent and multipotent cells. In some other species (dogs, ruminants, horses, cats, and swine) the allantoic fluid is more easily accessible, but there is little information regarding the characterization of the cell population. This review will address advances in the isolation of stem cells from fetal placental tissues and describe their characterization and possible use in cell therapy, as well as their origin and development.

关键词： Amnion Allantois Yolk Sac Chorion Stem Cells

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Nursing Diagnostics of Nutrition Domain of NANDA International in Hemodialysis Patients

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Open Journal of Nursing 2016年第3期6卷 204-212页

作者： Érida Maria Diniz Leite Sama Mikaella de oliveira Maria Isabel da Conceição Dias fernandes Maria das Graças Mariano Nunes Cyndi fernandes de Lima Ana Luisa Brandão de Carvalho Lira Department of Nursing Hospital Academic Onofre Lopes Natal Brasil Department of Nursing University of Rio Grande do Norte Natal Brasil

Introduction: The dialysis causes the loss of the nutrients and the elevation of catabolism, thus, patients in dialysis have at high risk for the loss of body reserves of protein and energy. Objective: To identify nursing diagnoses of nutrition domain of NANDA International in hemodialysis patients and to correlate them to the socioeconomic and clinical data. Design: Cross-sectional study. Setting: Performed in a large university hospital in northeastern Brazil. Participants: The first stage was carried out with 50 patients, selected with the following inclusion criteria: Being hospitalized and undergoing hemodialysis in that hospital;aged 18 years old or over;being conscious and oriented. Exclusion criteria were patients undergoing hemodialysis in that hospital with external service, pregnant women and patients being treated by plasmapheresis. In the second stage, participants were three nursing specialists in nephrology and nursing diagnoses. Methods: The defining characteristics of the nursing diagnoses inserted in the nutrition domain were observed in patients and then these data were judged by nurses, in order to identify diagnoses present in each patient. The Chi-square, Fisher’s exact and Mann-Whitney tests were used in the analysis of the relationship of socioeconomic and clinical data, with an adopted p value of p = 0.001), origin (p = 0.014), religion (p = 0.046) and income (p = 0.039), respectively. Conclusion: The variables that showed significant association were risk of impaired liver function and gender;imbalanced nutrition: More than body requirements and origin requirements;risk for deficient fluid volume and religion;and deficient fluid volume and income.

关键词： Nursing Nursing Diagnosis Risk Groups Nutrition Renal Dialysis

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Anxiety Disorder in Adolescent and the Importance of Primary Health Care to Identify This Illness

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Journal of Health Science 2018年第5期6卷 384-389页

作者： Daniel Ferreira Moraes de Sousa julia de Lima Cabra Mylena Varela Santos oliveira Lara Candida de Sousa Machado The Department of Medicine University of Rio Verde (UniRV) 75900 Brazil Medical School University of Rio Verde (UniRV) 75900 Brazil

Summary： Introduction： Adolescence, is a life stage characterized by constant emotional instability and psychological conflicts. Analyzing the age of psychological transition of these adolescents along with the environment demands that those ones live, in conclusion, there are conflicts between particularities of intern and extern environment, besides self-knowledge of these adolescents, ending up in what we call AD （anxiety disorder）. Objective： Raise reader’s awareness about the early recognition of ADs and stress. Methodology： Based on literature review. The virtual library Scielo and the Latin American Journal of Nursing were mainly consulted. Results： The AD is characterized as a mental health disturbance, which has as main symptoms feelings of preoccupation, anxiety or fear which are strong enough to interfere in daily activities. Its detection should be as early as possible, therefore, primary health care is the most efficient to prevent and detect this illness. Conclusion： It is possible to assure that primary health care （periodical medical check） has great impact on detecting and preventing the anxiety disorder in adolescent, since mental health professionals have used many working instruments which are useful for detecting this illness.

关键词： Anxiety primary health care depression

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River Network and the Risk of Flooding for the Railway and Subway Systems in the City of Sao Paulo, Brazil

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Journal of Geological Resource and Engineering 2016年第7期4卷 328-334页

作者： Daniel Nery dos Santos Marcos Antonio Maia de oliveira Alexandre Formigoni Joao Roberto Maiellaro Antonio Roberto Saad Marcelo Eloy fernandes Department of Logistics-NUPELOG Sao Paulo State Technological College Campus Guarulhos Sao Paulo Brazil Department of Geosciences University Guarulhos Campus Guarulhos Sao Paulo Brazil Department of lnformation Technology Management Sao Paulo State Technological College Campus Barueri Sao Paulo Brazil

This study investigated the risk of flooding along the Sao Paulo city＇s railway network and showed its latest technologies. To that end, we took into account topographic and hydrological features, as well as possible interferences of the flooding phenomenon with the optimal operation of the railway system. When preparing the maps and the flooding risk analysis, we used data from project SRTM （Shuttle Radar Topography Mission） integrated and processed in a GIS （geographical information system）, through version 2.14 of the geoprocessing software ＂QGis＂. Results showed risk exposure for logistics operations of the railway system for the transportation of passengers, especially in the Central and Eastern regions of the city, where there is a higher concentration of points of flooding, thus making it more difficult for passengers to come and go in the greatest city of Brazil.

关键词： Urban mobility rivers logistics Sao Paulo flooding railroads.

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Comparative Analysis of Two Methods for the Assessment of Aesthetic Impairment Involving Teeth

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Forensic Medicine and Anatomy Research 2022年第3期10卷 51-63页

作者： Mário Marques fernandes Luiz Eugênio Nigro Mazzilli José Cícero Dinato Rosane Pérez Baldasso Rogério Nogueira de oliveira Department of Community Dentistry School of Dentistry University of S&#227 o Paulo (FOUSP) S&#227 o Paulo Brasil Brazilian Dental Association Section of Rio Grande do Sul (ABORS) Porto Alegre Brasil

Objective: To analyze and compare the effectiveness of two methods designed for the assessment of esthetic impairment in patients with missing teeth. Material and Methods: Two methods were addressed in this study: 7-level scale (7LS) and AIPE-Odonto/Brasil. Both tools are designed to assess esthetic dental impairment in civil and criminal Courts. One-hundred and thirteen dentists used the tools to assess dental esthetic impairment in four mock cases (one male and three females). The outcomes of their analyses were compared with pre-established gold-standard scores. Chi-square test was used to investigate the influence of dentists’ sex, age, time of experience and forensic knowledge with their outcomes. Results: Dentists’ outcomes were closer to the expected gold-standard scores when AIPE-Odonto/Brasil was used compared to 7LS (p < 0.05). Dentists’ sex, time of experience and forensic knowledge were significantly associated with the scores obtained with both tools (p < 0.05). Conclusions: Comparatively, AIPE-Odonto/Brasil was more effective for the assessment of esthetic dental impairment involving missing teeth compared to the 7LS.

关键词： Dental Esthetics Wounds and Injuries Trauma Forensic Dentistry Facial Injuries

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Characterization of goat whey proteins and their bioactivity and toxicity assay

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Food Bioscience 2022年第2期46卷 833-843页

作者： Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes julia Mariano Caju de oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha Programa de P´os-Graduaç˜ao em Ciˆencia e Tecnologia de Alimentos Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil Departamento de Biologia Molecular Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil Centro de Desenvolvimento Tecnol´ogico Universidade Federal de PelotasRio Grande do SulBrazil Programa de P´os-Graduaç˜ao em Ciˆencias da Nutriç˜ao Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil

Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s ***,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute *** proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE *** activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for *** *** activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of *** highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical *** acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout ***,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without *** present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry.

关键词： Goat whey proteins Malignant cells Antimicrobial Antioxidant capacity Whey protein functionality

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Absence of Expression of OCT-2 in Gastric Cancer Cells

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American Journal of Molecular Biology 2014年第3期4卷 129-133页

作者： José Paulo Freire Maria Emilia oliveira Maria Conceicao Crujo Ana Rute fernandes José Crespo Mendes de Almeida Henrique Bicha Castelo Department of Surgery Hospital de Santa MariaFaculdade de Medicina de LisboaLisboaPortugal Department of Pathology Hospital de Santa MariaFaculdade de Medicina de LisboaLisboaPortugal

OCT-2, a member of the POU homeodomain family of transcription factors, has been implicated in gastric cancer lymph node metastasis on a single publication so far. Other members of the same family of transcription factors were found to have a role in intestinal metaplasia and gastric cancer (OCT-1) and in trophectoderm differentiation of embryonic stem cells (OCT3/4) via modulation ofCDX2. These findings prompted us to evaluate whether OCT-2 could in fact have a role in gastric oncogenesis and lymph node metastasis in human gastric cancer, designing an immunohistochemistry study of the putative expression of OCT-2 on human gastric cancer tissue of 69 surgical archival specimens of intestinal and diffuse type. We could not find expression of OCT-2 on any of our cancer tissues, metaplasia or normal gastric mucosa despite the expression of OCT-2 on tonsil lymphatic cells (tissue test) and normal lymph nodes. We concluded that, based on immunohistochemistry, OCT-2 does not have a role in gastric oncogenesis nor does have any relationship with lymph node metastasis in gastric cancer.

关键词： Gastric Cancer Lymph Node Metastasis OCT-2 Stem Cells

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Exercise training in hypertension:Role of microRNAs

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World Journal of Cardiology 2014年第8期6卷 713-727页

作者： Vander Josédas Neves Tiago fernandes Fernanda Roberta Roque Ursula Paula RenóSoci Stéphano Freitas Soares Melo Edilamar Menezes de oliveira Laboratory of Biochemistry and Molecular Biology of the Exercise School of Physical Education and SportUniversity of Sao PauloSao PauloSP 05508-900Brazil

Hypertension is a complex disease that constitutes an important public health problem and demands many studies in order to understand the molecular mechanisms involving his pathophysiology. Therefore, an increasing number of studies have been conducted and new therapies are continually being discovered. In this context, exercise training has emerged as an important non-pharmacological therapy to treat hypertensive patients, minimizing the side effects of pharmacological therapies and frequently contributing to allow pharmacotherapy to be suspended. Several mechanisms have been associated with the pathogenesis of hypertension, such as hyperactivity of the sympathetic nervous system and renin-angiotensin aldosterone system,impaired endothelial nitric oxide production, increased oxygen-reactive species, vascular thickening and stiffening, cardiac hypertrophy, impaired angiogenesis, and sometimes genetic predisposition. With the advent of microRNAs(miRNAs), new insights have been added to the perspectives for the treatment of this disease, and exercise training has been shown to be able to modulate the miRNAs associated with it. Elucidation of the relationship between exercise training and miRNAs in the pathogenesis of hypertension is fundamental in order to understand how exercise modulates the cardiovascular system at genetic level. This can be promising even for the development of new drugs. This article is a review of how exercise training acts on hypertension by means of specific miRNAs in the heart, vascular system, and skeletal muscle.

关键词： Exercise training Hypertension MicroRNA Heart Vascular system Macrocirculation Microcirculation Muscles Angiogenesis

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The Teaching of Sign Language in Undergraduate Nursing Courses: A Descriptive Study as an Attribute to the Integrality of Care

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Health 2015年第14期7卷 1824-1832页

作者： Wiliam César Alves Machado Carla oliveira Shubert Athaynne Ramos de Aguiar Prado Edicléa Mascarenhas fernandes Teresa Tonini Míriam Garcia Leoni Federal University of Rio de Janeiro State Rio de Janeiro Brazil Estácio de Sá University Rio de Janeiro Brazil Rio de Janeiro State University Rio de Janeiro Brazil

Background: Current and future generations of nurses must be prepared to communicate and properly care for deaf patients. The objective of this study is to describe how Brazilian Sign Language is taught in undergraduate Nursing courses. Method: This was a descriptive study with a qualitative approach, performed with fifteen professors from four universities, two public and two private and in the metropolitan region of Rio de Janeiro, through individual interviews with an analysis procedure guided by Content Analysis. Results: The teaching is restricted to the adoption of planned and established approaches to sign language and procedures to assess theoretical contents and practical domains sign language teaching exclusively in elective course often offered through the online platform. Conclusion: We conclude that professors are not prepared for the teaching of sign language and that curricula need to be appropriate to the demand of full and indistinct assistance to the population’s needs.

关键词： Undergraduate Nursing Programs Communication Barriers Deafness Sign Language

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Multi-Criteria Decision Support Methods for Renewable Energy Systems on Islands

Multi-Criteria Decision Support Methods for Renewable Energy...

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作者： C.Wimmler G.Hejazi E.de oliveira fernandes C.Moreira S.Connors the Faculty of Engineering University of Porto the Mechanical Engineering Department University of Porto the Electrical Engineering Department University of Porto the Massachusetts Institute of Technology

Islands often are confronted with severe energy challenges especially those far from the main land which operate as isolated energy *** those cases electricity,the queen of the energy vectors shall be obtained from diversified sources to alleviate the burden of the dependence on fossil ***,the generation of electricity from renewable energy sources in combination with electricity storage becomes an irrecusably challenge in the nearby *** a variety of criteria can be applied to identify the suitability of technologies,whereas no ideal family of criteria has been defined in the ***,decision support for energy planning and management is *** paper reviews the state-of-the-art of multi-criteria decision support methods applied to renewable energy and storage *** will be analyzed where the current focus is placed *** gaps of those analyzed studies will be evaluated and key aspects for future energy planning considerations for islands will be ***,an outlook for a newly developed concept for island energy planning will be ***,for most isolated islands renewable energy technologies in combination with storage devices are a desirable and valued solution for sustainable development.

关键词： Island energy planning multi-criteria decision support methods renewable energy technologies sustainable development

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