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When the left side knows something happened to the right–sensing injury in neurons contralateral and remote to injury

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Neural Regeneration Research 2020年第10期15卷 1854-1855页

作者： Valerie M.K.Verge jovan c.d.hasmatali Vikram Misra department of Anatomy Physiology and PharmacologyCameco MS Neuroscience Research CenterUniversity of SaskatchewanSaskatoonSaskatchewanCanada department of critical care Medicine Rady Faculty of Health SciencesUniversity of ManitobaWinnipegManitobaCanada department of Veterinary Microbiology University of SaskatchewanSaskatoonSaskatchewanCanada

How sensory neurons encode axonal injury signals has been a longstanding area of neurological *** into the cellular and transcriptional changes in the injured neurons have driven many new therapeutic strategies to improve *** contrast,less focus has been centered on the systemic or transneuronal changes that may arise from these injuries and how they may impact or factor into the alterations in gene expression,physiology and neuropathology,such as mirror image pain,arising in regions either directly contralateral or those remote to the injury *** in this area is clinically *** patients with chronic unilateral pain due to multiple pathologies,many of which involve nerve trauma,there is a very high incidence of bilateral sensory abnormalities reported with 33–50%of patients with mechanical abnormalities reporting contralateral sensory abnormalities(Konopka et al.,2012).This has implications when evaluating sensory abnormalities or pain states in patients,as the contralateral side is often used as the non-affected ***,the bilateral nature of these sensory abnormalities,albeit usually less severe on the contralateral side,support that a systemic or central nervous system component is involved in this aspect of the *** highlights the need to better understand the mechanisms underlying these bilateral responses as this will likely impact therapeutic treatments for these patients.

关键词： injuries injury something

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Impact of Microstructural and Surface Modifications on the Ti-45Nb Alloy’s Response to Bio-Environment

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1215-1230页

作者： Ivana cvijović-Alagić Slađana Laketić MilošMomčilović jovan ciganović Jelena Bajat Vesna Kojić Vinča Institute of Nuclear Sciences-National Institute of the Republic of Serbia University of BelgradeMike Petrovića Alasa 12-1411000BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411000BelgradeSerbia Oncology Institute of Vojvodina Faculty of MedicineUniversity of Novi SadPut Doktora Goldmana 4Sremska Kamenica21204Sremska KamenicaSerbia

The Ti-45Nb (mass%) alloy’s corrosive and biocompatible response in simulated physiological conditions was investigated before and after its additional high-pressure torsion (HPT) and laser irradiation processing. The grain size reduction from 2.76 µm to ~ 200 nm and the appearance of laser-induced morphologically altered and highly oxidized surface led to the significant improvement of alloy corrosion resistance and cell–implant interaction. Moreover, an additional increase of the laser pulse energy from 5 to 15 mJ during the alloy irradiation in the air led to an increase in the surface oxygen content from 13.64 to 23.89% accompanied by an increase of excellent cell viability from 127.18 to 134.42%. As a result of the controlled alloy microstructural and surface modifications, the formation of protective bi-modal mixed Ti- and Nb-oxide external scale was enabled. The presence of this surface oxide scale enhanced the alloy’s resistance to corrosion deterioration and simultaneously boosted cell viability and proliferation.

关键词： Ti-45Nb alloy High-pressure torsion Laser surface scanning corrosion resistance Biocompatible properties

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基于氯化胆碱的低共熔体系在Au上电沉积无枝晶Zn

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Transactions of Nonferrous Metals Society of china 2024年第7期34卷 2367-2380页

作者： Vesna S.cVETKOVIĆ Nebojša d.NIKOLIĆ Tanja S.BARUdŽIJA Silvana B.dIMITRIJEVIĆ jovan N.JOVIĆEVIĆ department of Electrochemistry Institute of ChemistryTechnology and MetallurgyUniversity of BelgradeNjegoševa 1211000 BelgradeSerbia Institute for Nuclear Sciences Vinča University of BelgradeP.O.Box 52211001 BelgradeSerbia Mining and Metallurgy Institute Zeleni bulevar 3519210 BorSerbia

以氯化胆碱和乙二醇混合液为低共熔溶剂,不使用其他添加剂,电化学沉积无枝晶Zn/Au合金。在不同的Zn(Ⅱ)浓度下,采用恒电位电沉积法在相对较低的Zn电沉积过电位下进行电沉积。通过循环伏安法(cV)和计时安培法(cA)揭示Zn电沉积的电化学机... 详细信息

以氯化胆碱和乙二醇混合液为低共熔溶剂,不使用其他添加剂,电化学沉积无枝晶Zn/Au合金。在不同的Zn(Ⅱ)浓度下,采用恒电位电沉积法在相对较低的Zn电沉积过电位下进行电沉积。通过循环伏安法(cV)和计时安培法(cA)揭示Zn电沉积的电化学机理。采用扫描电子显微镜和X射线衍射分析(XRd)对沉积层的形貌和结构进行表征,并用能谱仪对沉积层进行元素分析。cV结果表明,Zn的电沉积始于Zn欠电位沉积区,并一直持续到Zn过电位沉积(OPd)区。随着Zn(Ⅱ)浓度的增加,Zn/Zn(Ⅱ)电偶的沉积电位向更高的正值偏移。cA分析表明,在Zn的OPd区开始三维渐进形核,随后形成三维生长。形貌分析表明,电沉积始于致密Zn岛的形成,随后形成无枝晶Zn/Au合金。XRd分析表明,其物相为金属Zn、立方AuZn3和Au Zn金属间化合物。

关键词：锌电沉积低共熔溶剂锌金合金形貌结构

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The diagenesis of Plant Lipids during the Formation of the Krepoljin coal Basin(Serbia)—Using Multivariate Statistical Analysis in the Saturated Biomarkers

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Acta Geologica Sinica(English Edition) 2008年第6期82卷 1168-1178页

作者： Gordana dEVI Branimir jovanIEVI center of chemistry IChTMNjegoeva 1211000 BelgradeSerbia Faculty of chemistry University of BelgradePOB 15811001 BelgradeSerbia

The composition of the saturated hydrocarbon fraction of soluble organic matter （bitumen） from the Krepoljin brown coal basin （East Serbia） of Miocene age was investigated. The Krepoljin basin is especially interesting from a geochemical point of view. Namely, by the end of Tertiary Period, the basin was covered by powerful Mesozoic formations of great possibilities, the bedding became hermetically enclosed and protected from subsequent external influences. The nature of early diagenetic processes in the environment with abundant accumulation of organic substance is defined by the molecular content of bitumen through the connections of molecular structures to potential precursors in paleoplant phylla, as well as by the degree of their diagenetic transformations. The hierarchy of parameters based on molecules of saturated hydrocarbons was determined by applying the principal component analysis to the soluble organic matter. The most significant, most ＂loadings＂ values of component cI, are the plant types such as precursors or participants in early diagenetic transformations of steranes cs27-algal precursor material, cs28-moulds, cs29-higher land and water plants; resinous from the group of higher plant gymnosperms （G）; also triterpanes a and β-amirindicotyledonous angiosperms （A） and bacterial and/or terrestrial plants population represented by hopanes/moretanes; as well as the parameters which describe the degree of diagenetic/maturation transformation of precursor biomass, and based on next reactions：（1） shifting of methyl group, influenced by the inorganic sediment constitutents, sterane-rearranged steranes, （2） isomerization in the ring system, ααα→βββ c29 sterane as well as （3） isomerization on chiral center of the side chain sequence R→S c29 sterane S/（S＋R）. Additionally, a pyrite-derived inhibitory effect on the rearrangment of c29 steranes must be taken into account, but not on triterpanes reaction. Non- appearance of statistically important correlations, be

关键词： brown coal diagenetic transformations of saturated biomarkers diagenetic transformations of saturated biomarkers steranes diterpanes and triterpanes principal component

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Geochemistry of Sediments from the Lopare Basin(Bosnia and Herzegovina):Implications for Paleoclimate,Paleosalinity,Paleoredox and Provenance

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Acta Geologica Sinica(English Edition) 2020年第5期94卷 1591-1618页

作者： AleksandraŠAJNOVIĆ Nenad GRBA Franz NEUBAUER Milica KAŠANIN-GRUBIN Ksenija STOJANOVIĆ Nenad PETKOVIĆ Branimir jovanČIĆEVIĆ University of Belgrade Center of ChemistryICTMStudentski trg 12-1611000 BelgradeSerbia University of Novi Sad Faculty of SciencesDepartment of ChemistryBiochemistry and Environmental ProtectionTrg Dositeja Obradovica 321000 Novi SadSerbia Paris Lodron University of Salzburg Department of Geography and GeologyHellbrunnerstrasse 345020 SalzburgAustria University of Belgrade Faculty of ChemistryStudentski trg 12-1611000 BelgradeSerbia Rio Tinto–Rio Sava Exploration Takovska 4511000 BelgradeSerbia

A combined inorganic and organic geochemical study was carried out on marls and mudstones collected from the Lower Miocene Lopare Basin,Bosnia and Herzegovina.A total of 46 samples collected from two boreholes,Pot 1(depth of 193 m)and Pot 3(depth of 344 m),showed that element abundances like boron(B),lithium(Li),strontium(Sr),uranium(U),chromium(cr),nickel(Ni),magnesium(Mg),sodium(Na)and calcium(ca)are much higher than average than in the upper continental crust(Ucc).chemical composition indicates at least two sources:(i)Mesozoic ophiolites occurring in the north of the investigated area,and(ii)dacito-andesitic pyroclastics(Mesozoic to cenozoic).Lopare Basin sedimentation was influenced by strong evaporation resulting in a partly hypersaline lake,which formed during a warm climatic period,probably during the Miocene climatic Optimum.A brief episode of humid climate conditions resulted in the basin fillingup and deposition of felsic sediments enriched in thorium(Th).Organic geochemistry shows that the majority of studied sediments contains predominantly immature to marginally mature algal organic matter(OM).The biomarker patterns are generally in agreement with the geological history of the Lopare Basin and inorganic and mineralogical ***,the molecular distribution of n-alkanes as reliable climatic andδ-MTTc as paleosalinity indicators do not support this conclusion.

关键词： geochemistry provenance analysis paleoenvironmental conditions salinity/hypersalinity biomarker Lopare Basin Bosnia and Herzegovina

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A cadaveric breast cancer tissue phantom for phase-contrast X-ray imaging applications

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Animal Models and Experimental Medicine 2023年第5期6卷 427-432页

作者： cody c.Rounds chengyue Li Wei Zhou Kenneth M.Tichauer jovan G.Brankov Biomedical Engineering Illinois Institute of TechnologyChicagoIllinoisUSA Medical Imaging Research center Illinois Institute of TechnologyChicagoIllinoisUSA Electrical and computer Engineering Illinois Institute of TechnologyChicagoIllinoisUSA

Background:As mammography X-ray imaging technologies advance and provide elevated contrast in soft tissues,a need has developed for reliable imaging phantoms for use in system design and component *** advanced imaging modalities such as refraction-based methods,it is critical that developed phantoms capture the biological details seen in clinical precancerous and cancerous cases while minimizing artifacts that may be caused due to phantom *** work presents the fabrication of a breast tissue imaging phantom from cadaveric breast tissue suitable for use in both transmission and refraction-enhanced imaging ***:Human cancer cell tumors were grown orthotopically in nude athymic mice and implanted into the fixed tissue while maintaining the native tumor/adipose tissue ***:The resulting human–murine tissue hybrid phantom was mounted on a clear acrylic housing for absorption and refraction X-ray *** breast tomosynthesis was also ***:Both attenuation-based imaging and refraction-based imaging of the phantom are presented to confirm the suitability of this phantom's use in both imaging modalities.

关键词： breast tumors digital mammography imaging phantoms orthotopic animal models phasecontrast X-ray imaging

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FOXO3a as a sensor of unilateral nerve injury in sensory neurons ipsilateral, contralateral and remote to injury

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Neural Regeneration Research 2020年第12期15卷 2353-2361页

作者： jovan cdhasmatali Jolly de Guzman Jayne MJohnston Hossein Noyan Bernhard HJuurlink Vikram Misra Valerie MKVerge department of Anatomy Physiologyand PharmacologyUniversity of SaskatchewanSaskatoonSKCanada cameco MS Neuroscience Research center University of SaskatchewanSaskatoonSKCanada department of Veterinary Microbiology University of SaskatchewanSaskatoonSKCanada

Emerging evidence supports that the stress response to peripheral nerve injury extends beyond the injured neuron,with alterations in associated transcription factors detected both locally and remote to the ***-induced nuclear translocation of the transcription factor forkhead class box O3a(FOXO3a)was initially linked to activation of apoptotic genes in many neuronal ***,a more complex role of FOXO3a has been suggested in the injury response of sensory neurons,with the injured neuron expressing less *** elucidate this response and test whether non-injured sensory neurons also alter FOXO3a expression,the temporal impact of chronic unilateral L4–6 spinal nerve transection on FOXO3a expression and nuclear localization in adult rat dorsal root ganglion neurons ipsilateral,contralateral or remote to injury relative to na?ve controls was *** na?ve neurons,high cytoplasmic and nuclear levels of FOXO3a colocalized with calcitonin gene related peptide,a marker of the nociceptive *** hour post-injury,an acute increase in nuclear FOXO3a in small size injured neurons occurred followed by a significant decrease after 1,2 and 4 days,with levels increasing toward pre-injury levels by 1 week post-injury.A more robust biphasic response to the injury was observed in uninjured neurons contralateral to and those remote to *** levels of FOXO3a peaked at 1 day,decreased by 4 days,then increased by 1 week post-injury,a response mirrored in c4 dorsal root ganglion neurons remote to *** altered expression contralateral and remote to injury supports that spinal nerve damage has broader systemic impacts,a response we recently reported for another stress transcription factor,Luman/*** early decreased expression and nuclear localization of FOXO3a in the injured neuron implicate these changes in the cell body response to injury that may be ***,the broader systemic changes support the existence of stress/inj

关键词： cell body response contralateral response dorsal root ganglion peripheral nerve injury plasticity sciatic nerve sensory neuron stress systemic transcription factor unilateral peripheral nerve injury

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Aluminium electrodeposition under novel conditions from Alcl3-urea deep eutectic solvent at room temperature

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Transactions of Nonferrous Metals Society of china 2020年第3期30卷 823-834页

作者： Vesna ScVETKOVIĆ Nataša MVUKIĆEVIĆ Niko JOVIĆEVIĆ Jasmina SSTEVANOVIĆ jovan NJOVIĆEVIĆ Institute of chemistry Technology and MetallurgyNational InstituteDepartment of ElectrochemistryUniversity of BelgradeBelgradeSerbia Nissan Technical center North America Inc.39001 Sunrise DriveFarmington HillsMI 48331-3487USA

The electrodeposition of aluminium on glassy carbon and aluminium substrates from Alcl3-urea deep eutectic solvent(dES) system at near room temperatures was investigated,without additional purification of the chemicals used to prepare the electrolyte and without rigorous control of moisture and oxygen present in the working *** effects of changing temperature,working potential,controlled deposition current density and deposition time on the morphology of deposited aluminium without stirring of the electrolyte were *** potentiostatic and galvanostatic techniques,aluminium was electrodeposited from the deep eutectic solvent(n(Alcl3):n(urea)=1.6:1) onto glassy carbon and aluminium substrates at temperatures ranging from 25 to 50℃.Using SEM,EdS and XRd techniques,substrates were studied and confirmed the presence of aluminium deposits following both potentiostatic and galvanostatic *** shape and size of Al grains deposited depended on the time of deposition and varied in size from nanometers to micrometers and in shape from regular crystal forms to needle-like and flake-like structures.

关键词： aluminium electrodeposition deep eutectic solvent(dES) Alcl3-urea

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Transcatheter Ventricular Septal defect closure with Nit-Occlud LêVSd device—Five Years’Experience and Literature Review

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congenital Heart disease 2023年第3期18卷 361-371页

作者： Ivana B.cerović Vladislav A.Vukomanović jovan Lj.Košutić Mila S.Stajević Sanja S.Ninić Saša S.Popović Ivan d.dizdarević Staša d.Krasić Sergej M.Prijić cardiology department Mother and Child Health Institute of Serbia“Dr VukanČupić”Belgrade11070Serbia Faculty of Medicine University of BelgradeBelgrade11070Serbia

Introduction:Transcatheter closure is an alternative to ventricular septal defect(VSd)occlusion ***-Occlud LêVSd coil is a new device yet to be *** study aimed to evaluate immediate and midterm results after transcatheter closure with the Nit-Occlud LêVSd ***:The retrospective analysis included 30 patients with VSd referred for closure during the period from October 2015 to december ***:At the time of intervention,the patients’mean age and body weights were 7.5±5.6 years and 29.3±19.1 *** majority of the defects had perimembranous location(24/30),four defects had muscular and two outlet subaortic *** mean effective right-side diameter of the VSds was 3.6±1.3 *** ventricular fibrillation,device embolization,and hemolysis developed in different patients and were successfully *** of the patients had a complete atrioventricular *** coil was successfully placed in 25/30(83.3%)*** majority of the devices were 10 mm×6 mm(11/25)and 12 mm×8 mm(8/25)in *** patients required the implantation of a second *** follow-up period was 2.1±1.4 *** VSd closure was achieved in 48%of cases immediately after the intervention,74%during 2.1±1.6 months after the procedure,and 81%over *** remaining patients had a trivial residual *** the follow-up,approximately one-third of patients developed trivial aortic and mitral valve regurgitation,and half of the patients acquired trace/mild tricuspid ***(z-score)left ventricular end-diastolic diameter(0.15±0.37 vs.0.92±0.82,p=0.005)and left atrium dimension(0.47±0.58 vs.1.89±1.11,p=0.005),as well as the left atrium to aortic root ratio(1.2±0.1 vs.1.4±0.2,p=0.005)showed a significant decrease over follow-up related to the period before ***:Intervention with Nit-OccludLêVSd coil showed appropriate results regarding VSd closure rate,complications,and chamber *** introduction of t

关键词： Ventricular septal defect transcatheter device children

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Single-shot mid-infrared incoherent holography using Lucy-Richardson-Rosen algorithm

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Opto-Electronic Science 2022年第3期1卷 1-8,I0001页

作者： Vijayakumar Anand Molong Han jovan Maksimovic Soon Hock Ng Tomas Katkus Annaleise Klein Keith Bambery Mark J.Tobin Jitraporn Vongsvivut Saulius Juodkazis Optical Sciences center and ARc Training centre in Surface Engineering for Advanced Materials(SEAM) School of ScienceComputing and Engineering TechnologiesOptical Sciences CenterSwinburne University of TechnologyHawthornMelbourneVictoria 3122Australia Institute of Physics University of Tartu50411 TartuEstonia Infrared Microspectroscopy(IRM)Beamline ANSTO-Australian SynchrotronClaytonVictoria 3168Australia Tokyo Tech World Research Hub Initiative(WRHI) School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1OokayamaMeguro-kuTokyo 152-8550Japan

In recent years,there has been a significant transformation in the field of incoherent imaging with new possibilities of compressing three-dimensional(3d)information into a two-dimensional intensity distribution without two-beam interference(TBI).Most of the incoherent 3d imagers without TBI are based on scattering by a random phase mask exhibiting sharp autocorrelation and low cross-correlation along the ***,during reconstruction,high lateral and axial resolutions are *** based on scattering requires an astronomical photon budget and is therefore precluded in many power-sensitive *** this study,a proof-of-concept 3d imaging method without TBI using deterministic fields has been demonstrated.A new reconstruction method called the Lucy-Richardson-Rosen algorithm has been developed for this imaging *** believe that the proposed approach will cause a paradigm-shift in the current state-of-the-art incoherent imaging,fluorescence microscopy,mid-infrared fingerprinting,astronomical imaging,and fast object recognition applications.

关键词： imaging holography mid-infrared spectroscopy incoherent optics computational optics mid-infrared imaging

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