When the left side knows something happened to the right–sensing injury in neurons contralateral and remote to injury

作     者：Valerie M.K.Verge Jovan C.D.Hasmatali Vikram Misra 

作者机构：Department of AnatomyPhysiology and PharmacologyCameco MS Neuroscience Research CenterUniversity of SaskatchewanSaskatoonSaskatchewanCanada Department of Critical Care MedicineRady Faculty of Health SciencesUniversity of ManitobaWinnipegManitobaCanada Department of Veterinary MicrobiologyUniversity of SaskatchewanSaskatoonSaskatchewanCanada 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第10期

页      面：1854-1855页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by Canadian Institutes of Health Research(CIHR)grants No.74747 and 14238 to VMKV Natural Sciences and Science and Engineering Research Council(NSERC)of Canada grant to VM JCDH was supported by University of Saskatchewan College of Graduate and Postdoctoral Studies Scholarships 

主　　题：injuries injury something 

摘      要：How sensory neurons encode axonal injury signals has been a longstanding area of neurological *** into the cellular and transcriptional changes in the injured neurons have driven many new therapeutic strategies to improve *** contrast,less focus has been centered on the systemic or transneuronal changes that may arise from these injuries and how they may impact or factor into the alterations in gene expression,physiology and neuropathology,such as mirror image pain,arising in regions either directly contralateral or those remote to the injury *** in this area is clinically *** patients with chronic unilateral pain due to multiple pathologies,many of which involve nerve trauma,there is a very high incidence of bilateral sensory abnormalities reported with 33–50%of patients with mechanical abnormalities reporting contralateral sensory abnormalities(Konopka et al.,2012).This has implications when evaluating sensory abnormalities or pain states in patients,as the contralateral side is often used as the non-affected ***,the bilateral nature of these sensory abnormalities,albeit usually less severe on the contralateral side,support that a systemic or central nervous system component is involved in this aspect of the *** highlights the need to better understand the mechanisms underlying these bilateral responses as this will likely impact therapeutic treatments for these patients.