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Increased food intake after starvation enhances sleep in Drosophila melanogaster

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Journal of Genetics and Genomics 2017年第6期44卷 319-326页

作者： josue M.regalado McKenna B.Cortez Jeremy Grubbs Jared A.Link Alexander van der Linden Yong Zhang Department of Biology University of Nevada-Reno

Feeding and sleep are highly conserved,interconnected behaviors essential for *** has been shown to potently suppress sleep across species;however,whether satiety promotes sleep is still *** we use the fruit fly,Drosophila melanogaster,as a model organism to address the interaction between feeding and *** first monitored the sleep of flies that had been starved for 24 h and found that sleep amount increased in the first 4 h after flies were given *** sleep after starvation was due to an increase in sleep bout number and average sleep bout *** of translin or adipokinetic hormone,which fail to suppress sleep during starvation,still exhibited a sleep increase after starvation,suggesting that sleep increase after starvation is not a consequence of sleep loss during *** also found that feeding activity and food consumption were higher in the first 10-30 min after *** food consumption in starved flies to 30 min was sufficient to increase sleep for 1 *** flies ingested a comparable amount of food at differing sucrose concentrations,sleep increase after starvation on a lower sucrose concentration was *** together,our results suggest that increased food intake after starvation enhances sleep and reveals a novel relationship between feeding and sleep.

关键词： Drosophila Feeding Sleep Starvation Satiety

The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

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Particuology 2024年第6期89卷 1-10页

作者： Juan Enrique Barranco-García Carolina Caicedo Enrique Javier Jiménez-regalado Carlos Espinoza-González Graciela Morales Rocio Yaneli Aguirre-Loredo Abril Fonseca-García Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca Departamento de Química y BioquímicaAvenida Ing.Víctor Bravo Ahuja No.125Esquina Calzada Tecnológico68030OaxacaMexico Faculty of Engineering Unidad Central del Valle del Cauca(UCEVA)Carrera 17a 48-144763022TuluáColombia Centro de Investigación en Química Aplicada(CIQA) Blvd.Enrique Reyna Hermosillo 14025294SaltilloCoahuilaMexico Investigadoras por México CONAHCYT-CIQA Av.Insurgentes Sur 1562Col.Crédito Constructor03940Alcaldía Benito JuárezCDMXMexico

Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical *** paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer,commercially named Pluronic®*** aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying *** with a poloxamer concentration of 3%(w/v)demonstrated a notably higher yield,especially when compared to those with 0%and 1%*** with 3%and 5%(w/v)poloxamer displayed a narrower particle size distribution,with the 3%blend showing a superior yield attributed to arrangements of blend components that improve flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between *** with increased poloxamer content showed elevated thermal degradation temperatures,with the 3%blend registering a significant rise,opening avenues for encapsulating heat-sensitive *** study primarily focuses on the preparation and basic characterization of *** underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

关键词： Biopolymer Starch Chitosan Pluronic®F127 Microparticles Spray drying

Effects of Pre-and Neonatal Undernutrition on Long-Term Hearing Cognition of the Rat

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Journal of Behavioral and Brain Science 2022年第6期12卷 302-322页

作者： Manuel Salas Carmen Torrero Mirelta regalado Institute of Neurobiology Department of Developmental Neurobiology and Neurophysiology Universidad Nacional Autónoma de México Campus UNAM Juriquilla Querétaro México

Experimental evidence in the rat suggests that perinatal undernutrition, associated with sensory and hormonal deficiencies, interferes with brain network integrative actions. We review peripheral and central morpho-functional alterations related to early food restriction along with the auditory relays, and their connections with the limbic system, which are essential for motivation-emotional arousal. The findings indicated that different morpho-functional alterations in the auditory system permanently affect the brainstem, the reticular thalamic nucleus, and the prefrontal and auditory cortices. Moreover, data showed the noxious role of early food restriction and the external ear occlusion on the distal portions of dendritic arbor measurements, in the cochlea, nucleus ambiguous and motor cortical pyramids. These anatomical alterations also correlated with deficiencies in the dynamic motor and auditory cognitive brain plasticity. Food restriction-related deficiencies in the motor-emotional-behavioral arousal systems may be useful to understand long-term cognitive disorders in humans.

关键词： Perinatal Undernutrition Auditory Cognition Mother-Litter Bonds Rats

Endoscopic management of difficult laterally spreading tumors in colorectum

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World Journal of Gastrointestinal Endoscopy 2022年第3期14卷 113-128页

作者： Edgar Castillo-regalado Hugo Uchima Endoscopy Unit Department of GastroenterologyHospital Universitari Germans Trias i PujolBarcelona 08916Spain Endoscopic Unit Creu Groga Medical CenterCalella 08370Spain Endoscopic Unit Teknon Medical CenterBarcelona 08022Spain

Due to the advent of the screening programs for colorectal cancer and the era of quality assurance colonoscopy the number the polyps that can be considered difficult,including large(>20 mm)laterally spreading tumors(LSTs),has increased in the last *** LSTs should be assessed carefully,looking for suspicious areas of submucosal invasion(SMI),such as nodules or depressed areas,describing the morphology according to the Paris classification,the pit pattern,and vascular *** simplest,most appropriate and safest endoscopic treatment with curative intent should be *** LST-granular homogeneous type,piecemeal endoscopic mucosal resection should be the first option due to its biological low risk of ***-nongranular pseudodepressed type has an increased risk of SMI,and en bloc resection should be *** endoscopic mucosal resection is useful in situations where submucosal injection alters the operative field,e.g.,for the resection of scar lesions,with no lifting,adjacent tattoo,incomplete resection attempts,lesions into a colonic diverticulum,in ileocecal valve and lesions with intra-appendicular *** full thickness resection is very useful for the treatment of difficult to resect lesions of less than 20 up to 25 *** the indications,we highlight the treatment of polyps with suspected malignancy because the acquired tissue allows an exact histologic risk stratification to assign patients individually to the best treatment and avoid surgery for low-risk *** submucosal dissection is the only endoscopic procedure that allows completes en bloc resection regardless of the size of the *** should therefore be indicated in the treatment of lesions with risk of SMI.

关键词： Colorectal polyps Laterally spreading tumors Endoscopic mucosal resection Underwater endoscopic mucosal resection Endoscopic full thickness resection Endo

Involvement of ethylene receptors in the salt tolerance response of Cucurbita pepo

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Horticulture Research 2021年第1期8卷 1058-1071页

作者： Gustavo Cebrian Jessica Iglesias-Moya Alicia Garcia Javier MartInez Jonathan Romero Jose Javier regalado Cecilia Martinez Juan Luis Valenzuela Manuel Jamilena Department of Biology and Geology Agri-food Campus of International Excellence(CeiA3)and Research Center CIAMBITALUniversity of Almeria04120 AlmeriaSpain

Abiotic stresses have a negative effect on crop production,affecting both vegetative and reproductive *** plays a relevant role in plant response to environmental stresses,but the specific contribution of ethylene biosynthesis and signalling components in the salt stress response differs between Arabidopsis and rice,the two most studied model *** this paper,we study the effect of three gain-of-function mutations affecting the ethylene receptors CpETR1B,CpETR1A,and CpETR2B of Cucurbita pepo on salt stress response during germination,seedling establishment,and subsequent vegetative growth of *** mutations all reduced ethylene sensitivity,but enhanced salt tolerance,during both germination and vegetative growth,demonstrating that the three ethylene receptors play a positive role in salt *** salt stress,etr1b,etr1a,and etr2b germinate earlier than WT,and the root and shoot growth rates of both seedlings and plants were less affected in mutant than in *** enhanced salt tolerance response of the etr2b plants was associated with a reduced accumulation of Na^(+)in shoots and leaves,as well as with a higher accumulation of compatible solutes,including proline and total carbohydrates,and antioxidant compounds,such as *** membrane monovalent cation transporters,including Na^(+)/H^(+)and K^(+)/H^(+)exchangers(NHXs),K^(+)efflux antiporters(KEAs),high-affinity K^(+)transporters(HKTs),and K^(+)uptake transporters(KUPs)were also highly upregulated by salt in etr2b in comparison with *** aggregate,these data indicate that the enhanced salt tolerance of the mutant is led by the induction of genes that exclude Na+in photosynthetic organs,while maintaining K^(+)/Na^(+)homoeostasis and osmotic *** the salt response of etr mutants occurs via the ethylene signalling pathway,our data show that ethylene is a negative regulator of salt tolerance during germination and vegetative ***,the higher upregulation

关键词： subsequent aggregate likely

Problem Based Learning： Obtaining Enzyme Kinetics Parameters Integrating Linear Algebra, Computer Programming and Biochemistry Curriculum

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通讯和计算机（中英文版） 2010年第11期7卷 10-17页

作者： regalado Alejandro Baiez Juan Peralta Ever Environment Engineering Del Mar University Oaxaca Puerto Angel 70902 Mdxico Department of Food Faculty of Biological Sciences Nuevo Le6n Autonomous University Nuevo Le6n 66451 Mdxico

Parabrachial neuron development: Effects of pre- and neonatal undernutrition in the rat

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Open Journal of Molecular and Integrative Physiology 2012年第4期2卷 112-118页

作者： Carmen Torrero Mirelta regalado Lorena Rubio Manuel Salas Department of Developmental Neurobiology and Neurophysiology Institute of Neurobiology University of Mexico Queretaro Mexico.

Pre-and neonatal fasting in the rat has been used as an experimental model to obtain information on how the newborn gustatory system can be damaged, in- terfering with the basic sensory and hedonic proc- esses to different tastants. Fasting during the prenatal period and for 24 days postnatally results in signifi- cant reductions of body and brain weight, number of branches, dendritic density, and cross-sectional area of the PBN multipolar neurons in the central lateral and central medial subnucleus particularly at post- natal days 20 and 30. Furthermore, the underfeeding paradigm affected more the middle portions of the dendritic tree than other parts of the neurons possibly disturbing the afferent characteristics of neuronal acti- vity propagation that may partly disrupt the elabora- tion of synaptic plasticity at later ages. These findings may play a role in the development of complex physio- logical phenomena such as food intake, taste discrimi- nation, learning taste aversion, and appetitive beha- vior.

关键词： Parabrachial Neurons Development Brainstem Undernutrition Rats

Effects of Neonatal Undernutrition on Development of the Dorsolateral Prefrontal Cortex Pyramidal Cells in the Rat

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Journal of Behavioral and Brain Science 2014年第1期4卷 49-57页

作者： Carmen Torrero Mirelta regalado Lorena Rubio Manuel Salas Department of Developmental Neurobiology and Neurophysiology Institute of Neurobiology National Autonomous University of Mexico Campus UNAM Juriquilla Queretaro Mexico

The dorsolateral prefrontal cortex (dlPFC) of the rat plays a role in the encoding of neuronal signals involved in conflict-induced behavioral adjustment, working memory, planning and executive abilities, attentional control and other cognitive responses. In altricial species, early perinatal undernutrition interferes with the morphofunctional organization of a number of central nervous system (CNS) structures including the prefrontal cortex. The effects of neonatal undernutrition on dendritic arbor density, perikaryon measurements, and the number of spines (detected by rapid-Golgi) of basilar dendritic segments in layer III pyramidal neurons of the dlPFC were examined in male Wistar rats on postnatal (PDs) 12, 20, and 30. In the underfed (U) subjects the distal portions of the dendritic arbors had a consistent hipoplasia, mainly on PD 30, with reduced cross sectional area, perimeter, and spine densities on the basilar dendrites on all days studied. Thus, the alterations of the dlPFC pyramidal neurons may interfere with the plastic synaptic activity and cognitive performance of rats subjected to the stress of early underfeeding. Characterizing these anatomical alterations may help to understand the disrupted cognitive processes associated with neonatal undernutrition.

关键词： Neonatal Undernutrition Prefrontal Cortex Development Stressed Rats

Juvenile Play Behavior in Neonatally Underfed and Sensory Stimulated Wistar Rats

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Journal of Behavioral and Brain Science 2019年第10期9卷 362-374页

作者： Manuel Salas Mirelta regalado Carmen Torrero Minerva Ortiz-Valladares Department of Developmental Neurobiology and Neurophysiology Institute of Neurobiology University of Mexico Campus UNAM Juriquilla Queretaro Mexico

Play development in juvenile rats depends on specific sensory signals integrated at cortical, limbic and brain stem levels to modulate motoric, metabolic, motivational and social responses. Neonatal undernourishment disrupts the morphological and functional organization of the brain for adaptive responses including play performance. These alterations may be restored by preweaning exposure to sensory-enriched environments. This study was designed to determine in four experimental groups, Control (LC), Underfed (LU), Control Ligated/Stimulated (LCS), and Underfed Ligated/Stimulated (LUS), whether changes in juvenile play of neonatally underfed male rats by the nipple-ligated procedure of F0 dams and/or the handling of F1 rats may restore the deficiencies in juvenile play performance. The pinning frequency values in LC, LCS and LUS groups consistently increased until reaching a significant peak between postnatal days (PDs) 25 and 50 and then gradually declining until PD 60, when the play in pairs was significantly higher compared with the play in groups that follows the same sequence but with lower values in the stimulated groups. The results may reflect poor maternal care and lower somatosensory stimulation;and the sensory massage of LU F1 pups compared with the LC, LUS, and LCS rats. Fewer dorsal body contacts occurred in LU and LUS rats when playing in pairs than in groups. Results suggest that although handling has salutary effects on neuronal play structures, the reduced levels of total pinning and dorsal contacts, mainly in the play of rat pairs in LCS vs. LUS groups, were not fully recovered.

关键词： Juvenile Play Early Handling Neonatal Undernutrition Rats