Parabrachial neuron development: Effects of pre- and neonatal undernutrition in the rat

作     者：Carmen Torrero Mirelta Regalado Lorena Rubio Manuel Salas 

作者机构：Department of Developmental Neurobiology and Neurophysiology Institute of Neurobiology University of Mexico Queretaro Mexico. 

出 版 物：《Open Journal of Molecular and Integrative Physiology》 (分子和综合生理学期刊（英文）)

年 卷 期：2012年第2卷第4期

页      面：112-118页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Parabrachial Neurons Development Brainstem Undernutrition Rats 

摘      要：Pre-and neonatal fasting in the rat has been used as an experimental model to obtain information on how the newborn gustatory system can be damaged, in- terfering with the basic sensory and hedonic proc- esses to different tastants. Fasting during the prenatal period and for 24 days postnatally results in signifi- cant reductions of body and brain weight, number of branches, dendritic density, and cross-sectional area of the PBN multipolar neurons in the central lateral and central medial subnucleus particularly at post- natal days 20 and 30. Furthermore, the underfeeding paradigm affected more the middle portions of the dendritic tree than other parts of the neurons possibly disturbing the afferent characteristics of neuronal acti- vity propagation that may partly disrupt the elabora- tion of synaptic plasticity at later ages. These findings may play a role in the development of complex physio- logical phenomena such as food intake, taste discrimi- nation, learning taste aversion, and appetitive beha- vior.