Effects of Pre-and Neonatal Undernutrition on Long-Term Hearing Cognition of the Rat
Effects of Pre-and Neonatal Undernutrition on Long-Term Hearing Cognition of the Rat作者机构：Institute of Neurobiology Department of Developmental Neurobiology and Neurophysiology Universidad Nacional Autónoma de México Campus UNAM Juriquilla Querétaro México
出 版 物：《Journal of Behavioral and Brain Science》 (行为与脑科学期刊（英文）)
年 卷 期：2022年第12卷第6期
页 面：302-322页
学科分类：1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学]
主 题：Perinatal Undernutrition Auditory Cognition Mother-Litter Bonds Rats
摘 要：Experimental evidence in the rat suggests that perinatal undernutrition, associated with sensory and hormonal deficiencies, interferes with brain network integrative actions. We review peripheral and central morpho-functional alterations related to early food restriction along with the auditory relays, and their connections with the limbic system, which are essential for motivation-emotional arousal. The findings indicated that different morpho-functional alterations in the auditory system permanently affect the brainstem, the reticular thalamic nucleus, and the prefrontal and auditory cortices. Moreover, data showed the noxious role of early food restriction and the external ear occlusion on the distal portions of dendritic arbor measurements, in the cochlea, nucleus ambiguous and motor cortical pyramids. These anatomical alterations also correlated with deficiencies in the dynamic motor and auditory cognitive brain plasticity. Food restriction-related deficiencies in the motor-emotional-behavioral arousal systems may be useful to understand long-term cognitive disorders in humans.
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