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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： T.i.TOLUWALOJU C.K.THEiN D.HALiM Department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo China Beacons of Excellence Research and innovation institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered-dual response(LEDAR)Coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vertical guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEDAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio Coulomb damping preload tension/compression isolation band/depth offset potential

Deep bed filtration model for cake filtration and erosion

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 355-372页

作者： L.i.KUZMiNA Y.V.OSiPOV A.R.PESTEREV Department of Applied Mathematics HSE UniversityMoscow 101000Russia Department of Computer Science and Applied Mathematics Moscow State University of Civil EngineeringMoscow 129337Russia

Many phenomena in nature and technology are associated with the filtration of suspensions and colloids in porous media. Two main types of particle deposition,namely, cake filtration at the inlet and deep bed filtration throughout the entire porous medium, are studied by different models. A unified approach for the transport and deposition of particles based on the deep bed filtration model is proposed. A variable suspension flow rate, proportional to the number of free pores at the inlet of the porous medium, is considered. To model cake filtration, this flow rate is introduced into the mass balance equation of deep bed filtration. For the cake filtration without deposit erosion,the suspension flow rate decreases to zero, and the suspension does not penetrate deep into the porous medium. in the case of the cake filtration with erosion, the suspension flow rate is nonzero, and the deposit is distributed throughout the entire porous medium. An exact solution is obtained for a constant filtration function. The method of characteristics is used to construct the asymptotics of the concentration front of suspended and retained particles for a filtration function in a general form. Explicit formulae are obtained for a linear filtration function. The properties of these solutions are studied in detail.

关键词： deep bed filtration cake filtration porous medium particle deposition and erosion analytical solution concentration front

Phase composition,conductivity,and sensor properties of cerium-doped indium oxide

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Nano Materials Science 2024年第2期6卷 193-200页

作者： M.i.ikim G.N.Gerasimov V.F.Gromov O.J.ilegbusi L.i.Trakhtenberg N.N.Semenov Federal Research Center for Chemical Physics of RAS MoscowRussia University of Central Florida OrlandoFLUSA Moscow institute of Physics and Technology(State University) DolgoprudnyMoscow RegionRussia Lomonosov Moscow State University MoscowRussia

The hydrothermal synthesis of in_(2)O_(3)and CeO_(2)–in_(2)O_(3)is investigated as well as the properties of sensor layers based on these *** the synthesis of in_(2)O_(3),intermediate products in(OH)_(3)and inOOH are formed,which are the precursors of stable cubic(c-in_(2)O_(3))and metastable rhombohedral(rh-in_(2)O_(3))phases,respectively.A transition from c-in_(2)O_(3)to rh-in_(2)O_(3)is observed with the addition of CeO_(2).The introduction of cerium into rh-in_(2)O_(3)results in a decrease in the sensor response to hydrogen,while it increases in composites based on c-in_(2)O_(3).The data on the sensor activity of the composites correlate with XPS results in which CeO_(2)causes a decrease in the concentrations of chemisorbed oxygen and oxygen vacancies in rh-in_(2)O_(3).The reverse situation is observed in composites based on c-in_(2)O_(3).Compared to in_(2)O_(3)and CeO_(2)–in_(2)O_(3)obtained by other methods,the synthesized composites demonstrate maximum response to H_(2)at low temperatures by 70–100℃,and have short response time(0.2–0.5 s),short recovery time(6–7 s),and long-term stability.A model is proposed for the dependence of sensitivity on the direction of electron transfer between in_(2)O_(3)and CeO_(2).

关键词： Cerium oxide indium oxide Nanocomposite Hydrothermal method Cubic phase Rhombohedral phase Sensor response Conductivity Hydrogen Response/recovery time

Pharmacokinetics and Bioequivalence Evaluation of Two Rosuvastatin Calcium 20 mg Tablets: A Single Oral Dose, Randomized-Sequence, Open-Label, Two-Period Crossover Study in Healthy Volunteers under Fasting Conditions

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Journal of Biosciences and Medicines 2024年第6期12卷 230-243页

作者： Evelyn Pena Alfredo inatti josé Gregorio Chacón Department of Clinical Research Industrias Biocontrolled C.A. Caracas Venezuela

Objectives: To compare the rate and extent of absorption of Racor® 20 mg (Rosuvastatin calcium 20 mg) tablet of Laboratorios Leti, S.A.V., with Crestor® 20 mg (Rosuvastatin calcium 20 mg) tablet of AstraZeneca, UK Limited in healthy adult human subjects under fasting conditions. Method: This was an open label, analyst blind, balanced, randomized, two-treatment, two-period, two-sequence, single oral dose, crossover, bioequivalence study in healthy, adult, human subjects under fasting condition. Twenty-four (24) subjects were planned as per the protocol and all subjects completed both periods of the study. The concentrations of Rosuvastatin in plasma were quantitated using a validated LC-MS/MS method of analysis and plasma levels were submitted for statistical analysis. Cmax, AUC0-t, AUC0-∞, Tmax, t1/2, Kel (hrs-1), percent AUC extrapolated [100 * (AUC0-∞ - AUC0-t)/AUC0-∞] (AUC_%Extrapobs) were calculated for rosuvastatin in plasma using SAS® version 9.1.3, SAS institute. inc. ***. ANOVA, 90% confidence interval using Schuirmann’s two one-sided test for bioequivalence, power and ratio analysis, for lntransformed pharmacokinetic parameters Cmax, AUC0-t and AUC0-∞ were computed and reported for Rosuvastatin in plasma for BE. Results: Data showed that 90% confidence intervals for the test/reference geometric mean ratios (GMR) of Cmax (95.01 - 112.66), AUC0-t (93.38 - 111.67) and AUC0-∞ (93.65 - 111.29) were within the BE (80% - 125%) acceptance range. Conclusions: Two products formulation, reference (R) Crestor® (rosuvastatin calcium) of AstraZeneca and test (T), Racor® (rosuvastatin calcium) of Laboratorios Leti S.A.V., with a single dose of 20 mg, under fasting conditions were bioequivalent. No severe, serious or unexpected adverse events (AEs) were reported in this study.

关键词： Bioequivalence Rosuvastatin Pharmacokinetics

Severe aspiration pneumonia in the elderly

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Journal of intensive Medicine 2024年第3期4卷 307-317页

作者： Sebastian Ocrospoma Marcos i.Restrepo Division of Pulmonary Diseases&Critical Care Medicine University of Texas Health San AntonioSan AntonioTXUSA Section of Pulmonary&Critical Care Medicine South Texas Veterans Health Care SystemSan AntonioTXUSA

The global population is aging at an unprecedented rate,resulting in a growing and vulnerable elderly population in need of efficient comprehensive healthcare services that include long-term care and skilled nursing *** this context,severe aspiration pneumonia,a condition that carries substantial morbidity,mortality,and financial burden,especially among elderly patients requiring admission to the intensive care unit,has attracted greater *** pneumonia is defined as a pulmonary infection related to aspiration or dysphagia in *** episodes of coughing on food or liquid intake,a history of relevant underlying conditions,abnormalities on videofluoroscopy or water swallowing,and gravity-dependent shadow distribution on chest imaging are among the clues that suggest *** with aspiration pneumonia tend to be elderly,frail,and suffering from more comorbidities than those without this ***,we comprehensively address the epidemiology,clinical characteristics,diagnosis,treatment,prevention,and prognosis of severe aspiration community-acquired pneumonia in the elderly to optimize care of this high-risk demographic,enhance outcomes,and minimize the healthcare costs associated with this *** preventive measures and effective management strategies is vital in ensuring the well-being of our aging population.

关键词： Aspiration pneumonia Aged Critical illness Swallowing disorders Frailty Antibacterial agents

Driving factors behind multiple populations

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 172-181页

作者： Ruoyun Huang Baitian Tang Chengyuan Li Doug Geisler Mario Mateo Ying-Yi Song Holger Baumgardt Julio A.Carballo-Bello Yue Wang Jundan Nie Bruno Dias joséG.Fernández-Trincado School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China Departamento de Astronomía Universidad de ConcepcionConcepcionChile instituto de investigación Multidisciplinario en Ciencia y Tecnología Universidad de La SerenaLa SerenaChile Departamento de Astronomía Facultad de CienciasUniversidad de La SerenaChile Department of Astronomy University of MichiganAnn Arbor 48109USA David A.Dunlap Department of Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada Dunlap institute for Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada School of Mathematics and Physics The University of QueenslandSt.Lucia QLD 4072Australia instituto de Alta investigación Universidad de TarapacáAricaChile CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China instituto de Astrofísica Departamento de Ciencias FísicasFacultad de Ciencias ExactasUniversidad Andres BelloSantiagoChile instituto de Astronomía Universidad Católica del NorteAntofagastaChile

Star clusters were historically considered simple stellar populations,with all stars sharing the same age and initial chemical ***,the presence of chemical anomalies in globular clusters(GCs),called multiple stellar populations(MPs),has challenged star formation theories in dense *** studies show that mass,metallicity,and age are likely controlling parameters for the manifestation of *** the limit between clusters with/without MPs in physical parameter space is crucial to reveal the driving mechanism behind their *** this study,we look for MP signals in Whiting 1,which is traditionally considered a young *** the Magellan telescope,we obtained low-resolution spectra withinλλ=3850-5500?for eight giants of Whiting *** measured the C and N abundances from the CN and CH spectral indices.C and N abundances have variations comparable with their measurement errors(~0.1 dex),suggesting that MPs are absent from Whiting *** these findings with literature studies,we propose a limit in the metallicity *** compactness index parameter space,which relatively clearly separates star clusters with/without MPs(GCs/open clusters).This limit is physically *** a larger scale,the galactic environment determines cluster compactness and metallicity,leading to metal-rich,diffuse,old clusters formed ex *** proposed limit also impacts our understanding of the formation of the Sagittarius dwarf galaxy:star clusters formed after the first starburst(age≤8-10 Gyr).These clusters are simple stellar populations because the enriched galactic environment is no longer suitable for MP formation.

关键词： stellar galactic galaxy

Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

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integrative Zoology 2024年第3期19卷 400-416页

作者： Paulo MEJiA Gustavo Lima URBiETA Bruna da Silva XAViER isaíJorge de CASTRO joséJúlio DE TOLEDO Gustavo GRACiOLLi Lucio AndréViANA DiAS William Douglas CARVALHO Programa de Pós-Graduação em Biodiversidade Tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Programa de Pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de Mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Programa de Pós-Graduação em Biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestrial Ecology Group(TEG-UAM) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de investigación en Biodiversidad y Cambio Global(CiBC-UAM) Universidad Autónoma de MadridMadridSpain

Bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the Brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

Post processing of additive manufactured Mg alloys:Current status,challenges,and opportunities

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Journal of Magnesium and Alloys 2024年第4期12卷 1283-1310页

作者： Nooruddin Ansari Fatima Ghassan Alabtah Mohammad i.Albakri Marwan Khraisheh Mechanical Engineering Program Texas A&M University at QatarP.O.Box 23874DohaQatar

Magnesium(Mg)and its alloys are emerging as a structural material for the aerospace,automobile,and electronics industries,driven by the imperative of weight *** are also drawing notable attention in the medical industries owing to their biodegradability and a lower elastic modulus comparable to *** ability to manufacture near-net shape products featuring intricate geometries has sparked huge interest in additive manufacturing(AM)of Mg alloys,reflecting a transformation in the manufacturing ***,AM of Mg alloys presents more formidable challenges due to inherent properties,particularly susceptibility to oxidation,gas trapping,high thermal expansion coefficient,and low solidification *** leads to defects such as porosity,lack of fusion,cracking,delamination,residual stresses,and inhomogeneity,ultimately influencing the mechanical,corrosion,and surface properties of AM Mg *** address these issues,post-processing of AM Mg alloys are often needed to make them suitable for *** present article reviews all post-processing techniques adapted for AM Mg alloys to date,including heat treatment,hot isostatic pressing,friction stir processing,and surface *** utilization of these methods within the hybrid AM process,employing interlayer post-processing,is also *** post-processing conditions are reported,and their influence on the microstructure,mechanical,and corrosion properties are ***,future prospects and research directions are proposed.

关键词： Magnesium alloy Additive manufacturing Post-processing Heat treatment HiP

Gut microbiome:A revolution in typeⅡdiabetes mellitus

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World Journal of Diabetes 2024年第9期15卷 1874-1888页

作者： Madhan Jeyaraman Tejaswin Mariappan Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Gabriel Silva Santos Lucas Furtado da Fonseca joséFábio Lana Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Community Medicine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

TypeⅡdiabetes mellitus(T2DM)has experienced a dramatic increase globally across countries of various income levels over the past three *** persistent prevalence of T2DM is attributed to a complex interplay of genetic and environmental *** numerous pharmaceutical therapies have been developed,there remains an urgent need for innovative treatment approaches that offer effectiveness without significant adverse *** this context,the exploration of the gut microbiome presents a promising *** has increasingly shown that the gut microbiome of individuals with T2DM exhibits distinct differences compared to healthy individuals,suggesting its potential role in the disease’s pathogenesis and *** emerging field offers diverse applications,particularly in modifying the gut environment through the administration of prebiotics,probiotics,and fecal microbiome *** interventions aim to restore a healthy microbiome balance,which could potentially alleviate or even reverse the metabolic dysfunctions associated with *** current results from clinical trials have not yet shown dramatic effects on diabetes management,the groundwork has been laid for deeper *** and future clinical trials are critical to advancing our understanding of the microbiome’s impact on *** further elucidating the mechanisms through which microbiome alterations influence insulin resistance and glucose metabolism,researchers can develop more targeted *** potential to harness the gut microbiome in developing new therapeutic strategies offers a compelling prospect to transform the treatment landscape of T2DM,potentially reducing the disease’s burden significantly with approaches that are less reliant on traditional pharmaceuticals and more focused on holistic,systemic health improvements.

关键词： TypeⅡdiabetes Gut microbiome Probiotics Prebiotics Fecal microbiota transplantation

Effectiveness of external prestressing in enhancing the non-ductile hanger failure mechanism in reinforced concrete inverted T-beams

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1050-1065页

作者： Ahmed M.ATTA Reda N.BEHiRY Mohammed i.HARAZ Structural Engineering Department Faculty of EngineeringTanta UniversityTanta 33511Egypt Nile Higher institute for Engineering and Technology Mansoura 11001Egypt

Recently,inverted T-beams have been used in reinforced concrete(RC)bridges to support transverse precast *** T-beams,contrary to practice with conventional beams,are loaded on the flanges upper *** loading configuration causes hanger failure due to the generation of vertical tensile stresses near the bottom of the *** key purpose of this study is to investigate the efficiency of vertical external prestressing stainless-steel bars in mitigating non-ductile hanger failure in reinforced concrete inverted *** experimental study on six inverted-T beams,including two un-strengthened specimens,was carried *** study showed that the value of the prestressing level had a considerable impact on the performance of hanger mechanism in relation to crack pattern,ultimate loads,cracking behavior,load-deflection,strains,and *** experimental results indicated that the suggested method for strengthening inverted T-beams had efficacy in reducing the seriousness of the non-ductile hanger failure and resulted in a strength increase of up to 53% when compared to that of the un-strengthened ***,two analytical models for estimating the hanger capacity and the average crack width of the strengthened RC inverted T-beams were *** models that were proposed exhibited a high degree of agreement with the experimental results.

关键词： RC bridges inverted T-beams strengthening hanger failure external prestressing