检索结果-南通市图书馆

Role of serendipity in the discovery of classical antidepressant drugs:Applying operational criteria and patterns of discovery

引用

World Journal of Psychiatry 2022年第4期12卷 588-602页

作者： Francisco López-Muñoz Pilar D’Ocón Alejandro Romero joséa guerra CecilioÁlamo Faculty of Health University Camilo JoséCelaVillanueva de la Cañada 28692MadridSpain “Hospital 12 de Octubre”Research Institute(i+12) Avda.de Córdobas/nMadrid 28041Spain Department of Pharmacology Faculty of PharmacyUniversity of ValenciaAvda.Vicent Andres Estelless/nValencia 46100Spain Department of Pharmacology and Toxicology Faculty of Veterinary MedicineComplutense UniversityAvda.Puerta de Hierros/nMadrid 28040Spain Department of Pharmacology and Toxicology Faculty of PharmacyComplutense UniversityPl.de Ramón y Cajals/nMadrid 28040Spain Department of Biomedical Sciences(Pharmacology Area) Faculty of Medicine and Health SciencesUniversity of AlcaláCampus Científico-TecnológicoCrta.de Madrid-BarcelonaAlcaláde Henares 28871MadridSpain

The role played by serendipity in the origin of modern psychopharmacology has proven to be controversial in scientific *** its original meaning(Walpole),serendipity refers to discoveries made through a combination of accidents and *** have implemented an operational definition of serendipity based on finding something unexpected or unintended,regardless of the systematic process that led to the accidental observation,and we have established four different patterns of serendipitous *** this paper,we have analyzed the role of serendipity in the discovery and development of classical antidepressant drugs,tricyclic antidepressants and monoamine oxidase inhibitors as well as heterocyclic,“atypical”or“second generation”*** discovery of the antidepressant properties of imipramine and iproniazid,the prototypes of tricyclic antidepressants and monoamine oxidase inhibitors,respectively,fits the mixed type II pattern;initial serendipitous discoveries(imipramine was an antipsychotic and iproniazid was an antituberculosis agent)led secondarily to non-serendipitous *** the other components of these two families of drugs were developed specifically as antidepressants,modifying the chemical structure of the series leaders,thereby allowing all of them to be included in the type IV pattern,characterized by the complete absence of *** the heterocyclic drugs,mianserin(originally developed as an antihistamine)also falls into the type II pattern.

关键词： Serendipity Antidepressants Imipramine Iproniazid Psychopharmacology History of neurosciences

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New-onset diabetes after kidney transplantation:Incidence and associated factors

引用

World Journal of Diabetes 2018年第7期9卷 132-137页

作者： Vania Gomes Florbela Ferreira joséguerra Maria Joao Bugalho Endocrinology Diabetes and Metabolism DepartmentSanta Maria HospitalLisbon 1649-035Portugal Nephrology and Kidney Transplantation Department Santa Maria HospitalLisbon 1649-035Portugal

AIM To determine the incidence and associated factors of new-onset diabetes after transplantation(NODAT) in a Portuguese central hospital. METHODS This single-center retrospective study involved consecutive adult nondiabetic transplant recipients, who had undergone kidney transplantation between January 2012 and March 2016. NODAT was diagnosed according to the criteria of the American Diabetes Association. Data were collected from an institutional database of the Nephrology and Kidney Transplantation Department(Santa Maria Hospital, Lisbon, Portugal) and augmented with data of laboratorial parameters collected from the corresponding patient electronic medical records. Exclusion criteria were preexisting diabetes mellitus, missing information and follow-up period of less than 12 mo. Data on demographic and clinical characteristics as well as anthropometric and laboratorial parameters were also collected. Patients were divided into two groups: With and without NODAT-for statistical *** A total of 156 patients received kidney transplantduring the study period, 125 of who were included in our analysis. NODAT was identified in 27.2% of the patients(n = 34; 53% female; mean age: 49.5 ± 10.8 years; median follow-up: 36.4 ± 2.5 mo). The incidence in the first year was 24.8%. The median time to diagnosis was 3.68 ± 5.7 mo after transplantation, and 76.5% of the patients developed NODAT in the first 3 mo. In the group that did not develop NODAT(n = 91), 47% were female, with mean age of 46.4 ± 13.5 years and median follow-up of 35.5 ± 1.6 mo. In the NODAT group, the pretransplant fasting plasma glucose(FPG) levels were significantly higher [101(96.1-105.7) mg/d L vs 92(91.4-95.8) mg/d L, P = 0.007] and pretransplant impaired fasting glucose(IFG) was significantly more frequent(51.5% vs 27.7%, P = 0.01). Higher pretransplant FPG levels and pretransplant IFG were found to be predictive risk factors for NODAT development [odds ratio(OR): 1.059, P = 0.003; OR: 2.77

关键词： New-onset diabetes after transplant Incidence Kidney transplantation Impaired fasting glucose Immunosuppression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Mushroom Extract Hericium erinaceus on Spatial Memory and Morphology of Neurons in the CA1 and CA3 Regions of the Hippocampus in Ovariectomized Rats

引用

Open Journal of Veterinary Medicine 2024年第7期14卷 163-179页

作者： Lucia Garcia-Delgado Mariana Monserrath Verdía-Venegas Jacinto Bañuelos-Pineda Esther Albarrán-Rodríguez Guillermo Nolasco-Rodriguez josé Ricardo Cuellar-Pérez Sergio Fausto-guerra Manuel Rosales-Cortés Master in Behavioral Sciences Institute of Neurosciences University of Guadalajara Zapopan Mexico Department of Veterinary Medicine Division of Veterinary Sciences CUCBA University of Guadalajara Zapopan Mexico Botany and Zoology Laboratory CUCBA University of Guadalajara Zapopan Mexico

Various studies indicate that low levels of estradiol negatively impact cognitive abilities. Extracts from the fungus Hericium erinaceus (HE) contain bioactive components that promote the proper functioning of the nervous system and potential effects on protection against neurodegenerative diseases, including dementia and motor dysfunctions. The objective was to evaluate the effects of the administration of the HE mushroom extract on visuospatial memory and morphology of neurons in the CA1 and CA3 regions of the hippocampus in ovariectomized rats. 40 young Wistar rats weighing 90 ± 10 g BW were used, which were distributed into four groups of 10 animals;Control Group, non-ovariectomized and untreated rats;Group E2, ovariectomized rats treated with estradiol (2 μg/kg/body weight);Group HE, ovariectomized rats treated with the extract of the fungus Hericium erinaceus (0.5 mg/kg body weight) and Group Ovx/ST, ovariectomized rats, without treatment. The animals were tested in the Barnes and Open Field maze, then they were sacrificed, and their brains were obtained to perform a histological analysis of neuronal morphology in the CA1 and CA3 areas of the hippocampus. The most outstanding results showed that the Ovx/ST group recorded the longest time to arrive at the escape box and stay in the Barnes maze. A correlation was observed between neuronal damage and function;in the groups that did not present satisfactory performance in the maze tests, morphological alterations were identified such as the presence of some neuronal somata with degeneration characteristics such as pyknosis, nuclear basophilia and shrinkage of the cells. Its soma, as well as a decrease in the nuclear area of CA1 and CA3 neurons. It is concluded that the fungus Hericium erinaceus exerted a neuroprotective effect on the neuronal bodies of the hippocampus, associated with better performance in the visuospatial recognition memory test.

关键词： Ovariectomized Rats Ovarian Hypofunction Estradiol Hericium erinaceus Barnes Circular Labyrinth Open Field Labyrinth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

濒危帽贝铁锈笠螺的活动节律和采食行为的初步观察(英文)

引用

动物学报 2007年第1期53卷 179-183页

作者： Free ESPINOSA Alexandre R.GONZLEZ Manuel J.MAESTRE Darren FA josé M.guerra-GARCíA josé C.GARCíA-GóMEZ Gibraltar Museum 18-20 Bomb House LaneGibraltarUK Laboratorio de Biología Marina Departamento de Fisiología y ZoologíaAvda.Reina Mercedes6.41012 SevillaSpain

铁锈笠螺是地中海最濒危的海洋无脊椎动物,对其生物学知之甚少,缺少对其活动节律和采食行为的了解。使用环氧树脂Eporai1127(原位标记了20个不同外壳长度的个体,并在每个外壳上标有不同的数字,作者在白昼或黑夜的高潮和低潮期收集了有... 详细信息

铁锈笠螺是地中海最濒危的海洋无脊椎动物,对其生物学知之甚少,缺少对其活动节律和采食行为的了解。使用环氧树脂Eporai1127(原位标记了20个不同外壳长度的个体,并在每个外壳上标有不同的数字,作者在白昼或黑夜的高潮和低潮期收集了有关数据。可能由于云斑厚纹蟹(Pachygrapsus marmoratus)的捕食影响,铁锈笠螺白天的活动和运动多于夜间,但铁锈笠螺采食行为似乎仅限于高潮期。此外,汹涌的海面条件诱导了铁锈笠螺的活动和运动。

关键词：濒危帽贝铁锈笠螺活动环境因子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Generating oligodendroglia from adult mesenchymal cells for transplantation:cell reprogramming or direct lineage conversion?

引用

Neural Regeneration Research 2023年第7期18卷 1493-1494页

作者： Jorge Pascual-guerra joséA.Rodríguez-Navarro Carlos L.Paíno Service of Neurobiology-Research Ramón y Cajal University Hospital-IRYCISMadridSpain Department of Cellular Biology Complutense UniversityMadridSpain

Cell replacement therapy has long been proposed as a treatment for the damaged nervous *** of the most challenging aspects of such a strategy,however,is finding sources of donor cells for *** neural cells are rarely an option as every cell in the nervous system has a defined function that would be lost if that cell was to be *** possibility would be sourcing precursor or differentiated cells from fetal tissues;however,aside from ethical issues,heterologous cells are at risk of immunological rejection in the long *** improvements over the past 15 years have led to the possibility that autologous non-neural cells could be used for cell transplantation through their conversion into neural derivatives.

关键词： neural programming removed

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Circulating extracellular vesicles:friends and foes in neurodegeneration

引用

Neural Regeneration Research 2022年第3期17卷 534-542页

作者： Anna Picca Flora guerra Riccardo Calvani Hélio joséCoelho-Junior Cecilia Bucci Emanuele Marzetti Fondazione Policlinico Universitario“Agostino Gemelli”IRCCS RomeItaly Aging Research Center Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet and Stockholm UniversityStockholmSweden Department of Biological and Environmental Sciences and Technologies Universitàdel SalentoLecceItaly UniversitàCattolica del Sacro Cuore Institute of Internal Medicine and GeriatricsRomeItaly

Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological *** this route,several molecules(e.g.,nucleic acids,proteins,metabolites) can be transferred to proximal and distant targets to convey specific *** vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating ***,circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded ***,the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic *** increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues,such as the brain,thereby serving as a "brain liquid biopsy".The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized ***,we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases(i.e.,Parkinson's and Alzheimer's diseases).A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring.

关键词： Alzheimer's disease amyloid protein exosomes misfolded proteins mitochondrial-derived vesicles neuroinflammation Parkinson's disease quality control Tau protein α-synuclein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Litter decomposition and nutrient release for two tropical N-fixing species in Rio de Janeiro,Brazil

引用

Journal of Forestry Research 2022年第2期33卷 487-496页

作者： David Pessanha Siqueira Giovanna Campos Mamede Weiss de Carvalho joséGabriel de Souza Silva Marcos Vinicius Winckler Caldeira Deborah guerra Barroso Laboratório de Fitotecnia Universidade Estadual do Norte Fluminense Darcy RibeiroAvenida Alberto Lamego2000Campos dos GoytacazesRio de JaneiroBrazil Departamento de Ciências Florestais e da Madeira Universidade Federal do Espírito SantoAvenida Governador Lindenberg316Jerônimo MonteiroEspírito SantoBrazil Department of Geosciences and Natural Resources Management University of CopenhagenRolighedsvej 23Frederisksberg CDenmark

Litter production and decomposition are critical to forest productivity,nutrient cycling,and carbon seques-tration in tropical woody ***,nutrient release and leaf litter stoichiometry in tropical legume tree plantations over the long term after outplanting are poorly understood or even *** improving our under-standing of the pattern of changes in the decomposition of N-fixing leaf litters and their possible impact on carbon stor-age,we measured litter production,mass loss and nutrient release for 240 d during litter decomposition for two tropical legume tree species(Plathymenia reticulata and Hymenaea courbaril),in Rio de Janeiro,*** production for *** was 5.689 kg ha^(−1) a^(−1) and 3.231 kg ha^(−1) a^(−1) for *** patterns of mass loss rates were similar;however,nutrient release was greater for ***,while *** showed immobilization of nutrients,especially for N,which increased by almost 20%in the early phase of decomposition followed by gradual *** from the N-fixing species did differ in nutrient chemistries over time,which was not surprising given that initial nutrient concentrations varied broadly,except for C and *** of the nutrient concentrations increased as the remaining litter mass decreased in both species,except for C and *** C:N and N:P ratios differed between the species,but N:P did not correlate to mass *** species had N-rich leaves,but *** decomposition was very likely P-limited,while *** seemed to be co-limited by N and *** results showed different patterns in nutrient release and the stoichi-ometry involved in the decomposition dynamics of the two tropical N-fixing species,even though they have similar litter decay *** species,but especially ***,may help re-establish nutrient cycling in disturbed ecosystems.

关键词： Nutrient dynamics Legume species Litter chemistry Ecological stoichiometry Tropical forest

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vegetative propagation of Apuleia leiocarpa(Vogel)***

引用

Journal of Forestry Research 2022年第2期33卷 455-462页

作者： joséGabriel de Souza Silva Diêgo Faustolo Alves Bispo David Pessanha Siqueira Giovanna Campos Mamede Weiss de Carvalho Deborah guerra Barroso Laboratório de Fitotecnia Universidade Estadual do Norte Fluminense Darcy RibeiroAvenida Alberto LamegoCampos dos GoytacazesRJ 2000Brazil

Apuleia leiocarpa is an environmentally and economically significant Atlantic Forest species threat-ened by ongoing *** vegetative propagation of the species could be a step forward to enable implanta-tion of clonal seed orchards and multiplication of selected trees but remains unknown to *** study assessed the mini-cutting technique for propagation of *** and determined the time required for rooting and viable mini-cutting type and *** results show that it is possible to propagate *** with mini-cuttings derived from mini-stumps produced with seeds;the mini-stumps pre-sented regrowth capacity and remained constantly produc-tive for 1 year;10-cm *** mini-cuttings should remain under misting conditions for at least 40 days,and the vegetative propagation of *** with intermediate 7-to 10-cm mini-cuttings resulted in more vigorous clonal seedlings than smaller mini-cuttings.

关键词： Mini-cutting Tropical woody species Adventitious rooting Fabaceae

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

What is the prognosis of emphysematous pyelonephritis associated with extended-spectrum beta-lactamases producing microorganisms?

引用

Asian Journal of Urology 2022年第2期9卷 146-151页

作者： joséIván Robles-Torres Marco Alberto Ocaña-Munguía joséGustavo Arrambide-Herrera Adrián Mauricio Martínez-Fernández Rodrigo Romero-Mata Lauro Salvador Gómez-guerra Urology Department Hospital Universitario"Dr.Jose´Eleuterio Gonza´lez"Universidad Auto´noma de Nuevo LeonMonterreyNuevo LeonMexico

Objective:To describe the microbiological characteristics in emphysematous pyelonephritis(EPN),demonstrate the frequency of extended-spectrum beta-lactamase(ESBL)microorganisms,and determine if these microorganisms are associated with the prognosis of patients with ***:We conducted a retrospective study in patients with a diagnosis of EPN in a tertiary care hospital of the northeast region of Mexico during the period from January 2011 to January *** variables were analyzed to determine association with the presence of ESBL-producing *** significance was set with p<***:A total of 63 patients were included;55(87.3%)of them were females,with a median age of 55(interquartile range:45-65)*** management was indicated in 38.1%;42.9%were treated with ureteral stent;12.7%with open or percutaneous drainage;15.8%with early nephrectomy;and 9.5%with delayed *** mortality was 13(20.6%)cases;23(36.5%)cases required admission to the intensive care *** most frequent microorganism isolated was Escherichia coli(n=34,53.9%).ESBL microorganisms were found in 31.7%of the *** significant association of ESBL was found with admission to the intensive care unit,or with increased ***:To our knowledge,this is the first study that evaluates ESBL microorganisms as a prognostic factor in *** factors associated with a poor prognosis in patients with EPN have been *** microbiological factors,specifically ESBL-producing bacteria,do not seem to influence in the prognosis of these patients.

关键词： Emphysematous pyelonephritis Extended spectrum betalactamase Mortality Intensive care unit admission

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Urethroplasty in a post irradiation urethral stricture-a review

引用

Plastic and Aesthetic Research 2022年第1期9卷 133-139页

作者： Carlos guerra Sergio Davila Slavica Pusica Predrag Aleksic Department of Urology Belgrade Center for Genitourinary Reconstructive SurgeryBelgrade 11000Serbia Department of Urology Hospital Universitario“Dr.JoséEleuterio González”MonterreyNuevo Leon 64460Mexico Department of Urology Medical Military AcademyBelgrade 11000Serbia

Radiotherapy-induced urethral strictures(RIUS)decrease quality of life and present a great challenge for surgical reconstruction,especially due to proximal location,compromised vascular supply,and poor wound *** is unclear whether urethroplasty is an option in cases with stricture resulting from exposure to pelvic *** review the pathophysiology,diagnostic workup,and disease-specific aspects of ***,we discuss several management alternatives such as excision and primary anastomosis,as well as techniques for open reconstruction with *** most extensive techniques in the treatment of strictures include,for example,those using gracilis muscle flaps,as they can involve periurethral tissue to provide sufficient vascularity for excellent post-surgery urethral *** brief,RIUS represent a significant *** carefully chosen patients,urethroplasty should be considered as a feasible and durable ***,medical practitioners should always take into consideration that the results of urethroplasty in RIUS are not comparable to urethroplasties without a radiation background.

关键词： Urethra stricture radiotherapy urethroplasty buccal mucosa graft gracilis muscle flap stricture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：