Role of serendipity in the discovery of classical antidepressant drugs:Applying operational criteria and patterns of discovery
作者机构：Faculty of HealthUniversity Camilo JoséCelaVillanueva de la Cañada 28692MadridSpain “Hospital 12 de Octubre”Research Institute(i+12)Avda.de Córdobas/nMadrid 28041Spain Department of PharmacologyFaculty of PharmacyUniversity of ValenciaAvda.Vicent Andres Estelless/nValencia 46100Spain Department of Pharmacology and ToxicologyFaculty of Veterinary MedicineComplutense UniversityAvda.Puerta de Hierros/nMadrid 28040Spain Department of Pharmacology and ToxicologyFaculty of PharmacyComplutense UniversityPl.de Ramón y Cajals/nMadrid 28040Spain Department of Biomedical Sciences(Pharmacology Area)Faculty of Medicine and Health SciencesUniversity of AlcaláCampus Científico-TecnológicoCrta.de Madrid-BarcelonaAlcaláde Henares 28871MadridSpain
出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)
年 卷 期：2022年第12卷第4期
页 面：588-602页
核心收录：
学科分类：1002[医学-临床医学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题：Serendipity Antidepressants Imipramine Iproniazid Psychopharmacology History of neurosciences
摘 要：The role played by serendipity in the origin of modern psychopharmacology has proven to be controversial in scientific *** its original meaning(Walpole),serendipity refers to discoveries made through a combination of accidents and *** have implemented an operational definition of serendipity based on finding something unexpected or unintended,regardless of the systematic process that led to the accidental observation,and we have established four different patterns of serendipitous *** this paper,we have analyzed the role of serendipity in the discovery and development of classical antidepressant drugs,tricyclic antidepressants and monoamine oxidase inhibitors as well as heterocyclic,“atypicalor“second generation*** discovery of the antidepressant properties of imipramine and iproniazid,the prototypes of tricyclic antidepressants and monoamine oxidase inhibitors,respectively,fits the mixed type II pattern;initial serendipitous discoveries(imipramine was an antipsychotic and iproniazid was an antituberculosis agent)led secondarily to non-serendipitous *** the other components of these two families of drugs were developed specifically as antidepressants,modifying the chemical structure of the series leaders,thereby allowing all of them to be included in the type IV pattern,characterized by the complete absence of *** the heterocyclic drugs,mianserin(originally developed as an antihistamine)also falls into the type II pattern.
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