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Role of serendipity in the discovery of classical antidepressant drugs:Applying operational criteria and patterns of discovery

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World Journal of Psychiatry 2022年第4期12卷 588-602页

作者： Francisco López-Muñoz Pilar D’Ocón Alejandro Romero JoséA Guerra CecilioÁlamo Faculty of Health University Camilo JoséCelaVillanueva de la Cañada 28692MadridSpain “Hospital 12 de Octubre”Research Institute(i+12) Avda.de Córdobas/nMadrid 28041Spain Department of Pharmacology Faculty of PharmacyUniversity of ValenciaAvda.Vicent Andres Estelless/nValencia 46100Spain Department of Pharmacology and Toxicology Faculty of Veterinary MedicineComplutense UniversityAvda.Puerta de Hierros/nMadrid 28040Spain Department of Pharmacology and Toxicology Faculty of PharmacyComplutense UniversityPl.de Ramón y Cajals/nMadrid 28040Spain Department of Biomedical Sciences(Pharmacology Area) Faculty of Medicine and Health SciencesUniversity of AlcaláCampus Científico-TecnológicoCrta.de Madrid-BarcelonaAlcaláde Henares 28871MadridSpain

The role played by serendipity in the origin of modern psychopharmacology has proven to be controversial in scientific *** its original meaning(Walpole),serendipity refers to discoveries made through a combination of accidents and *** have implemented an operational definition of serendipity based on finding something unexpected or unintended,regardless of the systematic process that led to the accidental observation,and we have established four different patterns of serendipitous *** this paper,we have analyzed the role of serendipity in the discovery and development of classical antidepressant drugs,tricyclic antidepressants and monoamine oxidase inhibitors as well as heterocyclic,“atypical”or“second generation”*** discovery of the antidepressant properties of imipramine and iproniazid,the prototypes of tricyclic antidepressants and monoamine oxidase inhibitors,respectively,fits the mixed type II pattern;initial serendipitous discoveries(imipramine was an antipsychotic and iproniazid was an antituberculosis agent)led secondarily to non-serendipitous *** the other components of these two families of drugs were developed specifically as antidepressants,modifying the chemical structure of the series leaders,thereby allowing all of them to be included in the type IV pattern,characterized by the complete absence of *** the heterocyclic drugs,mianserin(originally developed as an antihistamine)also falls into the type II pattern.

关键词： serendipity Antidepressants Imipramine Iproniazid Psychopharmacology History of neurosciences

serendipity in Recommender Systems:A Systematic Literature Review

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Journal of Computer Science & Technology 2021年第2期36卷 375-396页

作者： Reza Jafari Ziarani Reza Ravanmehr Department of Computer Engineering Central Tehran BranchIslamic Azad UniversityTehran ***Iran

A recommender system is employed to accurately recommend items,which are expected to attract the user's *** over-emphasis on the accuracy of the recommendations can cause information over-specialization and make recommendations boring and even *** and diversity are two partly useful solutions to these ***,novel and diverse recommendations cannot merely ensure that users are attracted since such recommendations may not be relevant to the user's ***,it is necessary to consider other criteria,such as unexpectedness and *** is a criterion for making appealing and useful *** usefulness of serendipitous recommendations is the main superiority of this criterion over novelty and *** bulk of studies of recommender systems have focused on serendipity in recent ***,a systematic literature review is conducted in this paper on previous studies of serendipity-oriented recommender ***,this paper focuses on the contextual convergence of serendipity definitions,datasets,serendipitous recommendation methods,and their evaluation ***,the trends and existing potentials of the serendipity-oriented recommender systems are discussed for future *** results of the systematic literature review present that the quality and the quantity of articles in the serendipity-oriented recommender systems are progressing.

关键词： systematic literature review recommender system serendipity evaluation metric evaluation method

Superconvergence for rectangular serendipity finite elements

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Science China Mathematics 2003年第1期46卷 1-10页

作者：陈传淼 Institute of Computation Hunan Normal University

Based on an orthogonal expansion and orthogonality correction in an element, superconvergenceat symmetric points for any degree rectangular serendipity finite element approximation to second order ellipticproblem is p... 详细信息

关键词： rectangular serendipity elements, superconvergence, symmetric points.

Coupling of serendipity, Affordance and Taxonomy in Digital Competence: HCI for Illiterates

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Journal of Software Engineering and Applications 2022年第7期15卷 248-261页

作者： Livaniaina Razanakolona Andrianjaka Miary Rapatsalahy Hajarisena Razafimahatratra Sorin Ilie Thomas Mahatody Noble Akam Laboratory for Mathematical and Computer Applied to the Development Systems (LIMAD) University of Fianarantsoa Fianarantsoa Madagascar Department of Computers and Information Technology University of Craiova Craiova Romania Laboratory for Mediations Informations Communication and Arts University of Bordeaux Montaigne France

This research work is the result of multidisciplinary research for the design of a digital learning tool from the basic level. Computer science guarantees the technical concepts of the development of the tool. At the same time, Information and Communication Science discipline describes the concepts of cognitive psychology with digital competence in computerization. The overall goal of this work is to provide an HCI component for basic level learning or HCI for the illiterate. It is about transforming a communication tool from a cognitive system to a digital learning tool adapted to the learner’s level of digital competence. The author relies on the UML class diagram to identify the affordance and serendipity of HCI property entities. The mathematical study of the similarity between these two properties allows us to update the learner’s profile. Stephanie’s approach was used when managing the learner’s profile and the digital competency taxonomy to classify the learner’s level of digital use. The principle of an expert system was taken up in this work to make the decision on the level of digital competence of the learner and to guide the solution so that the learning continues without interruption. This expert system integrates the data science of digital educational materials, defining its specificity. The algorithm of the realization summarizes the implementation of the whole approach. αβGasy@mobile is an application on Android for Malagasy language literacy. To learn the letter “l” with this application, the initially low-level learner had an intermediate assessment score after 2 hours of continuous learning. Self-constructivism has been developed and strengthened by the HCI illiterate component. We have hundreds of learners for the case study and used ten smartphones to 5 inches. On the selected samples, the results of the experiment are close to our objective. More precisely, the inactive time is almost non-existent, the learning time predefined in the system is

关键词： Affordance Component Guide ETL Expert System HCI-Illiterate serendipity

serendipity in anticancer drug discovery

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World Journal of Clinical Oncology 2012年第1期3卷 1-6页

作者： Emily Hargrave-Thomas Bo Yu Jóhannes Reynisson Auckland Bioengineering Institute The University of Auckland Auckland 1142 New Zealand School of Chemical Sciences The University of Auckland Auckland 1142 New Zealand

It was found that the discovery of 5.8%(84/1437) of all drugs on the market involved serendipity. Of these drugs, 31(2.2%) were discovered following an incident in the laboratory and 53(3.7%) were discovered in a clinical setting. In addition, 263(18.3%) of the pharmaceuticals in clinical use today are chemical derivatives of the drugs discovered with the aid of serendipity. Therefore, in total, 24.1%(347/1437) of marketed drugs can be directly traced to serendipitous events confirming the importance of this elusive phenomenon. In the case of anticancer drugs, 35.2%(31/88) can be attributed to a serendipitous event, which is somewhat larger than for all drugs. The therapeutic field that has benefited the most from serendipity are central nervous system active drugs reflecting the difficulty in designing compounds to pass the blood-brain-barrier and the lack of laboratory-based assays for many of the diseases of the mind.

关键词： Anticancer drugs Drug discovery and development serendipity

serendipity Blackmagic V3全新亮相Drupa 2004

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印刷技术 2004年第16期 76-77页

“serendipity”在技术创新中的合法性研究

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科学学研究 2021年第8期39卷 1528-1536页

作者：李天柱马佳宋丹荣辽宁科技大学工商管理学院辽宁鞍山114051 成都信息工程大学管理学院四川成都610103

serendipity理论为技术创新研究提供了新视角,但其合法性需要严格的证明。引入"映射"的概念,通过生物制药产业的典型案例对serendipity理论在技术创新研究中的应用合法性进行实证分析,通过检验对应要素和对应关系,确认serendipity理论... 详细信息

serendipity理论为技术创新研究提供了新视角,但其合法性需要严格的证明。引入"映射"的概念,通过生物制药产业的典型案例对serendipity理论在技术创新研究中的应用合法性进行实证分析,通过检验对应要素和对应关系,确认serendipity理论可以应用于技术创新研究,并归纳出serendipity理论在技术创新研究中的三条应用准则。以技术创新失败项目挽救为应用情境,进一步针对serendipity理论在技术创新研究中的应用提出若干具体思路。

关键词： serendipity 技术创新合法性映射失败挽救

Methods to Study serendipity

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Methods to Study Serendipity

UserFriendly2014暨UXPA中国第十...

作者： Xiaosong Zhou Xu Sun Sarah Sharples University of Nottingham

Despite the important role of serendipity in information research,its relevant studies within China are at a very early *** paper categorises current research methods of investigating serendipity in this *** use of social media has been highlighted and discussed as a research method in serendipity *** reviewing the research methods,we aim to help scholars and designers to conduct empirical studies to better understand this phenomenon.

关键词： serendipity research method social media

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serendipity与高分子化学

Serendipity与高分子化学