Circulating extracellular vesicles:friends and foes in neurodegeneration

作     者：Anna Picca Flora Guerra Riccardo Calvani Hélio JoséCoelho-Junior Cecilia Bucci Emanuele Marzetti Anna Picca;Flora Guerra;Riccardo Calvani;Hélio JoséCoelho-Junior;Cecilia Bucci;Emanuele Marzetti

作者机构：Fondazione Policlinico Universitario“Agostino Gemelli”IRCCSRomeItaly Aging Research CenterDepartment of NeurobiologyCare Sciences and SocietyKarolinska Institutet and Stockholm UniversityStockholmSweden Department of Biological and Environmental Sciences and TechnologiesUniversitàdel SalentoLecceItaly UniversitàCattolica del Sacro CuoreInstitute of Internal Medicine and GeriatricsRomeItaly 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第3期

页      面：534-542页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：partially funded by an Intramural Research Grant from the Università Cattolica del Sacro Cuore [D1 2020 to EM] the nonprofit research foundation “Centro Studi Achille e Linda Lorenzon”(to AP,EM,and RC) 

主　　题：Alzheimer's disease amyloid protein exosomes misfolded proteins mitochondrial-derived vesicles neuroinflammation Parkinson's disease quality control Tau protein α-synuclein 

摘      要：Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological *** this route,several molecules(e.g.,nucleic acids,proteins,metabolites) can be transferred to proximal and distant targets to convey specific *** vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating ***,circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded ***,the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic *** increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues,such as the brain,thereby serving as a brain liquid biopsy.The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized ***,we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases(i.e.,Parkinson s and Alzheimer s diseases).A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring.