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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne Skøttrup mørkholt Jacek Lichota Preben Bruun-Nyzell mads Christian andersen Nanna marie Juhl Kristensen Amanda Krøger Johansen mikela Reinholdt Zinn Hulda maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

Dehydration melting and Proterozoic Granite Petrogenesis in a Collisional Orogen——A Case from the Svecofennian of Southern Finland

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Journal of Earth Science 2021年第6期32卷 1289-1299页

作者： Tom andersen O.Tapani Rämö Department of Geosciences University of OsloN-0316OsloNorway Department of Geosciences and Geography Geology and Geophysics Research ProgramUniversity of Helsinki00014HelsinkiFinland

Dehydration melting of metasupracrustal rocks at mid-to deep-crustal levels can generate water undersaturated granitic *** this study,we evaluate the potential of~1.89–1.88 Ga metasupracrustal rocks of the Precambrian of southern Finland as source rocks for the 1.86–1.79 Ga late-orogenic leucogranites in the region,using the Rhyolite-mELTS *** close in composition to leucogranite is produced over a range of realistic pressures(5 to 8 kbar)and temperatures(800 to 850℃),at 20%–30%of partial melting,allowing separation of melt from unmelted *** solid residue is a dry,enderbitic to charnoenderbitic ganulite depleted in incompatible components,and will only yield further melt above 1000–1050℃,when rapidly increasing fractions of increasingly calcic(granodioritic to tonalitic)melts are *** solid residue after melt extraction is incapable of producing syenogranitic magmas similar to the mid-Proterozoic,A-type rapakivi granites on further *** granitic fraction of the syenogranitic rapakivi complexes must thus have been formed by a different chain of processes,involving mantle-derived mafic melts and melts from crustal rock types not conditioned by the preceding late-orogenic Svecofennian anatexis.

关键词： leucogranite rapakivi granite anatexis restite depleted granulite Finland

Characterization of TGFβ-specific CD4+T cells through the modulation of TGFβexpression in malignant myeloid cells

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Cellular & molecular Immunology 2021年第11期18卷 2575-2577页

作者： Rasmus Erik Johansson mortensen morten Orebo Holmström mads Hald andersen National Center for Cancer Immune Therapy Department of OncologyCopenhagen University HospitalHerlevDenmark Institute for Immunology and microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor beta(TGFβ)is a pleiotropic cytokine with functions related to angiogenesis,tumor suppression,and immune tolerance[1].TGFβis involved in tumor immune escape and is a target for cancer immune therapy[1].We have reported that healthy donors and cancer patients harbor CD8^(+)cytotoxic T lymphocytes(CTLs)that are specific to TGFβ-derived epitopes and that these CD8^(+)CTLs kill malignant myeloid cells in a TGFβ-dependent manner[2].

关键词： TGFβ malignant myeloid

Hard-thermal-loop QED thermodynamics

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Chinese Physics C 2010年第9期34卷 1527-1529页

作者：苏楠 Jens O.andersen michael Strickland Frankfurt Institute for Advanced Studies Department of Physics Norwegian University of Science and Technology Department of Physics Gettysburg College

The weak-coupling expansion for thermodynamic quantities in thermal field theories is poorly convergent unless the coupling constant is *** discuss the calculation of the free energy for a hot gas of electrons and photons to three-loop order using hard-thermal-loop perturbation theory （HTLpt）.We show that the hard-thermal-loop perturbation reorganization improves the convergence of the successive approximations to the QED free energy at large coupling,e ～ *** reorganization is gauge invariant by construction,and due to the cancellations among various contributions,we obtain a completely analytic result for the resummed thermodynamic potential at three loops.

关键词： resummation hard-thermal-loop thermal field theory QED free Energy

A machine learning approach for regional geochemical data:Platinum-group element geochemistry vs geodynamic settings of the North Atlantic Igneous Province

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Geoscience Frontiers 2021年第3期12卷 42-59页

作者： Jordan J.Lindsay Hannah S.R.Hughes Christopher m.Yeomans Jens C.Ø.andersen Iain mcDonald Camborne School of mines University of ExeterPenryn CampusPenrynCornwall TR109FEUnited Kingdom School of Earth and Ocean Sciences Main CollegeCardiff UniversityPark PlaceCardiff CF103ATUnited Kingdom

Whilst traditional approaches to geochemistry provide valuable insights into magmatic processes such as melting and element fractionation,by considering entire regional data sets on an objective basis using machine learning algorithms(mLAs),we can highlight new facets within the broader data structure and significantly enhance previous geochemical *** platinum-group element(PGE)budget of lavas in the North Atlantic Igneous Province(NAIP)has been shown to vary systematically according to age,geographic location and geodynamic *** the large multi-element geochemical data set available for the region,mLAs were employed to explore the magmatic controls on these shifting *** key advantage of using machine learning in analysis is its ability to cluster samples across multi-dimensional(i.e.,multi-element)*** NAIP data set is manipulated using Principal Component Analysis(PCA)and t-Distributed Stochastic Neighbour Embedding(t-SNE)techniques to increase separability in the data alongside clustering using the k-means *** new multi-element classification is compared to the original geographic classification to assess the performance of both *** workflow provides a means for creating an objective high-dimensional investigation on a geochemical data set and particularly enhances the identification of metallogenic anomalies across the *** techniques used highlight three distinct multi-element end-members which successfully capture the variability of the majority of elements included as input *** end-members are seen to fluctuate in prominence throughout the NAIP,which we propose reflects the changing geodynamic environment and melting ***,the variability of Pt and Pd are not reflected in mLA-based clustering trends,suggesting that they vary independently through controls not readily demonstrated by the NAIP major or trace element data structure(i.e.,other proxies for magmatic differe

关键词： Platinum-group elements machine learning Plume Geochemistry metallogenesis mantle

Sleep disturbances as an adverse effect of propranolol use in children with infantile hemangioma

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World Journal of Pediatrics 2020年第5期16卷 537-538页

作者： Ellen m.S.Xerfan monica L.andersen Anamaria S.Facina Sergio Tufik Jane Tomimori Programa de Pós-Gradua(c)(a)o em medicina Translacional Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departamento de Dermatologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departamento de Psicobiologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil

Infantile hemangiomas(IHs)are the most prevalent benign vascular tumor in children,with an estimated rate of 5-10%.most IHs resolve spontaneously after the proliferation stage,but about 12-24%develop with sequelae and complications which require pharmacological interventions[1].The beta blocker propranolol is considered as the first-line treatment for complicated cases of IHs[2].

关键词： propranolol children effect

Pit-and trench-forming osteoclasts:a distinction that matters

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Bone Research 2015年第4期3卷 199-209页

作者： Ditte mH merrild Dinisha C Pirapaharan Christina m Andreasen Per Kjxrsgaard-andersen Anas mJ mùller ming Ding Jean-marie Delaissé Kent Sùe Department of Clinical Cell Biology Vejle Hospital/Lillebaelt HospitalInstitute of Regional Health ResearchUniversity of Southern Denmark Orthopaedic Research Laboratory Department of Orthopedic Surgery and TraumatologyOdense University HospitalUniversity of Southern Denmark Department of Orthopedic Surgery Vejle Hospital/Lillebaelt Hospital

Osteoclasts（OCs）seeded on bone slices either drill round pits or dig long *** pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption *** is unknown whether the distinction between pits and trenches has any biological *** OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench *** formation went along with high collagenolytic activity and high cathepsin K（CatK）expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of *** obtained from bone marrow were more prone to generate trenches than those obtained from *** electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in *** conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic *** indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption.

关键词： trench cathepsin collagen faster prone assembly highlights thereby correspond apparatus

Safety and efficacy of Profermin~to induce remission in ulcerative colitis

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World Journal of Gastroenterology 2012年第15期18卷 1773-1780页

作者： Aleksander Krag Hans Israelsen Bjrn von Ryberg Klaus K andersen Flemming Bendtsen Gastrounit Medical Devision 360Copenhagen University Hospital Hvidovre Faculty of Health Sciences Copenhagen UniversityDK-2650 HvidovreDenmark Nordisk Rebalance A/S M.D.Madsensvej 14-16DK-3450 AllerdDenmark Statistics Section Informatics and Mathematical ModellingTechnical University of DenmarkDK-2800 LyngbyDenmark

AIm:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).mETHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 andmedian:7.5),who were treated open-label with Profermintwice daily for 24 *** SCCAI was reported observer blinded via the ***:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in *** secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,Pmated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to *** was generally well ***:Profermin is safe and may be effective in inducing remission of active UC.

关键词：溃疡性结肠炎安全性诱导疗效平均时间回归分析重复测量活动期

First record of stable isotopes(δ^(13)C, δ^(18)O) and element ratios(mg/Ca, Sr/Ca) of middle to Late Jurassic belemnites from the Indian Himalayas and their potential for palaeoenvironmental reconstructions

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Journal of Palaeogeography 2021年第3期10卷 416-437页

作者： matthias Alberti Franz T.Fursich Dhirendra K.Pandey Nils andersen Dieter Garbe-Schonberg Suraj Bhosale Ketan Chaskar Jorg m.Habermann State Key Laboratory for mineral Deposits Research School of Earth Sciences and EngineeringCenter for Research and Education on Biological Evolution and Environment and Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023Jiangsu ProvinceChina GeoZentrum Nordbayern Friedrich-Alexander-Universität Erlangen-NürnbergLoewenichstraße 2891054 ErlangenGermany Department of Geology School of EarthBiological and Environmental ScienceCentral University of South Bihar SH 7Gaya-Panchanpur RoadVillage KarharaPost FatehpurGaya 824236(Bihar)India Department of Earth and Environmental Science KSKV Kachchh UniversityBhujIndia Leibniz Laboratory for Radiometric Dating and Stable Isotope Research Christian-Albrechts-Universität zu KielMax-Eyth-Straße 1124118 KielGermany Institut für Geowissenschaften Christian-Albrechts-Universität zu KielLudewig-Meyn-Straße 1024118 KielGermany

middle to Late Jurassic belemnites from the Spiti and Zanskar valleys in the Indian Himalayas were used for stable isotope(δ^(13)C, δ^(18)O) and element(mg/Ca, Sr/Ca) analyses. Although the Himalayan orogeny deformed and altered a large portion of the collected fossils, cathodoluminescence and scanning electron microscopy in combination with analyses of iron and manganese contents allowed the identification of belemnites believed to still retain their original chemical composition. Results indicate a long-term temperature decrease from the middle Callovian–Oxfordian to the Tithonian, which is proposed to have been caused by a concomitant drift of eastern Gondwana into higher palaeolatitudes. Reconstructed absolute temperatures depend on the used equation and assumed δ^(18)O value of seawater, but most likely varied between 17.6 ℃ to 27.6℃ in the Kimmeridgian and Tithonian with average values between 22 ℃ to 24 ℃. This way, temperatures were similar to slightly warmer than today at comparable latitudes. The reconstruction of absolute temperatures for the middle Callovian–Oxfordian was hindered by a larger number of poorly preserved belemnites representing this time interval.

关键词： Jurassic Palaeoclimate Water temperature Spiti Zanskar India Tethyan Himalaya Eastern Gondwana