Characterization of TGFβ-specific CD4+T cells through the modulation of TGFβexpression in malignant myeloid cells

作     者：Rasmus Erik Johansson Mortensen Morten Orebo Holmström Mads Hald Andersen 

作者机构：National Center for Cancer Immune TherapyDepartment of OncologyCopenhagen University HospitalHerlevDenmark Institute for Immunology and MicrobiologyCopenhagen UniversityCopenhagenDenmark 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第11期

页      面：2575-2577页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：This project was supported by Danish Health Authority grant“Empowering Cancer Immunotherapy in Denmark”(grant number 4-1612-236/8) the Copenhagen University Hospital Herlev and Gentofte and through a research funding agreement between IO Biotech ApS and the National Center for Cancer Immune Therapy(CCIT-DK).We greatly appreciate the tremendous technical support from Merete Jonassen 

主　　题：TGFβ malignant myeloid 

摘      要：Transforming growth factor beta(TGFβ)is a pleiotropic cytokine with functions related to angiogenesis,tumor suppression,and immune tolerance[1].TGFβis involved in tumor immune escape and is a target for cancer immune therapy[1].We have reported that healthy donors and cancer patients harbor CD8^(+)cytotoxic T lymphocytes(CTLs)that are specific to TGFβ-derived epitopes and that these CD8^(+)CTLs kill malignant myeloid cells in a TGFβ-dependent manner[2].