Levels of L-carnitine in human seminal plasma are associated with sperm fatty acid composition
作者机构：FertilitetssenteretOslo 0176Norway Department of Life Sciences and HealthOsloMet-Oslo Metropolitan UniversityOslo 0130Norway
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2022年第24卷第5期
页 面：451-457页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：founded by The Research Council of Norway and Fertilitetssenteret Oslo Norway
主 题：body mass index L-carnitine male fertility semen quality sperm fatty acids spermatozoa
摘 要：The fatty acid composition of spermatozoa has been shown to be important for their function,and L-carnitine is crucial for fatty acid *** levels in the seminal plasma positively correlate with semen quality,whereas high body mass index(BMI)is associated with both reduced semen quality and altered sperm fatty acid ***,we examined the associations between free seminal L-carnitine levels and sperm fatty acid composition as well as *** samples were collected and analyzed from 128 men with unknown fertility status and with BMI ranging from 19 kg m^(−2) to 63 kg m^(−2).Sperm fatty acid composition was assessed by gas chromatography,while free seminal L-carnitine analysis was performed using high-performance liquid *** linear regression analysis showed a positive correlation of free seminal L-carnitine levels with the amount of sperm palmitic acid(β=0.21;P=0.014),docosahexaenoic acid(DHA;β=0.23;P=0.007),and total n-3 polyunsaturated fatty acids(β=0.23;P=0.008)and a negative correlation of free seminal L-carnitine levels with lignoceric acid(β=−0.29;P=0.001)and total n-6 polyunsaturated fatty acids(β=−0.24;P=0.012)when adjusted for *** was no relationship between free seminal L-carnitine levels and *** free seminal L-carnitine levels are associated with semen quality,the absence of a correlation with BMI suggests that reduced semen quality in obese men is independent of seminal L-carnitine.
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