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Immature and mature antibodies as defenders against cancer

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Cellular & Molecular Immunology 2023年第1期20卷 3-5页

作者： Robin V.Lacombe Sophie Sibéril jordan d.dimitrov Centre de Recherche des Cordeliers INSERMCNRSSorbonne UniversitéUniversitéParis CitéParisFrance

Antibodies(Abs)are glycoprotein molecules that represent an essential component of the adaptative immune *** are secreted in body fluids and act as a critical part of immune *** recognition of self-antigens by Abs is normally selected against during B-cell development,autoreactive Abs can be generated as a result of pathological immune responses,as observed in autoimmune *** can also be produced in cancer patients,where they may have beneficial roles[1].Indeed,the presence of intratumoral antibody-secreting cells(ASCs)and B-cell-rich tertiary lymphoid structures(TLSs)has been observed in many cancer types and generally correlates with a favorable clinical prognosis[2,3,4,5,6].The existence of specific antitumor antibody responses suggests that tumor cells express molecules that are recognized as nonself antigens by the immune system or that tolerance of self-antigens expressed on cancer cells is lost[1,4].The study of the origin of tumor-reactive Abs and their specificity and functions is of paramount importance for understanding the development of adaptive antitumor immune responses and for revealing novel therapeutic avenues.A recent publication in Cell by Mazor et al.[7]has provided an important advance in our understanding of antibody responses in *** particular,this work paves the way for the distinction between antibody-reactive tumors and antibody-nonreactive tumors,which is reminiscent of the dichotomy of the noninfiltrated“cold”tumor microenvironment(TME)in contrast with the highly infiltrated with immune cells“hot”TME[8].Moreover,an important finding of the study was the demonstration that tumor-directed autoreactivity may be either preexisting or induced by somatic hypermutations,a mechanism related to the chronicity of cancer.

关键词： cancer antibodies specificity

Noncanonical antibody strategy for broad and potent neutralization of influenza virus

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Cellular & Molecular Immunology 2021年第7期18卷 1615-1617页

作者： jordan d.dimitrov Centre de Recherche des Cordeliers INSERMSorbonne UniversitéUniversitéde ParisF-75006ParisFrance

Pathogens with high levels of genetic variability,such as HIV-1 and influenza virus,evade the immune system by constantly changing their proteins vulnerable to neutralization by antibodies Consequently,these highly evolvable viruses are notoriously elusive targets for *** rare cases,infection of humans with HIV-1 or influenza virus results in production of antibodies that can neutralize a very broad spectrum of viral *** antibodies are referred to as broadly neutralizing.

关键词： influenza antibodies neutral

Anti-IgE IgG autoantibodies isolated from therapeutic normal IgG intravenous immunoglobulin induce basophil activation

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Cellular & Molecular Immunology 2020年第4期17卷 426-429页

作者： Caroline Galeotti Anupama Karnam jordan d.dimitrov Alain Chevailler Srini V.Kaveri Jagadeesh Bayry Institut National de la Santéet de la Recherche Médicale/Centre de Recherche des Cordeliers Equipe-Immunopathologie et Immunointervention ThérapeutiqueSorbonne UniversitéParis F-75006France Service de Rhumatologie Pédiatrique Centre de Référence des Maladies Auto-Inflammatoires Rares et des AmylosesCHU de Bicêtrele Kremlin Bicêtre F-94270France UniversitéParis descartes Sorbonne Paris CitéParis F-75006France Laboratoire d’Immunologie et d’Allergologie/CHU d’Angers Universitéd’Angers/INSERM Unité1232/LabEx IGO“Immuno-Graft-Onco”Angers F-49933France

Basophils are rare *** representing only~0.5%of all leukocytes,basophils have several important physiological functions.1,2 Although basophils lack the classic features of professional antigen-presenting cells,3–7 through the secretion of cytokines,they orient the immune response by polarizing Th2 differentiation and supporting B-cell differentiation and class *** are also critical for mediating protection against helminth infection.1,2,8,9 Basophils receive activation signals from diverse *** is well recognized that cytokines such as IL-3,granulocyte–macrophage colony-stimulating factor(GM-CSF),thymic stromal lymphopoietin(TSLP)and IL-33;various toll-like receptor ligands;allergen-bound IgE provide activation signals to basophils and induce the release of inflammatory mediators.10–15 In addition,several reports have also demonstrated the existence of anti-IgE autoantibodies that possess the capacity to induce basophil activation in patients with chronic spontaneous urticaria(CSU),atopic or non-atopic asthma or autoimmune disease.16–21 However,isolation and functional exploration of such anti-IgE IgG autoantibodies from either healthy donors or patients have not been attempted *** using a pooled normal IgG preparation from healthy donors,specifically intravenous immunoglobulin G(IVIG)22 that represents the complete IgG repertoire of a normal individual,we attempted to address this outstanding question in the field.

关键词： activation attempted IgE

Aging impairs the osteocytic regulation of collagen integrity and bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha dole Nadja M.Maldonado Luna Natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina d.King jordan B.Burton Birgit Schilling Simon Melov Simon Tang Eric Schaible Tamara Alliston department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by *** hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material *** examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

EXISTENCE OF SOLUTIONS OF NONLOCAL PERTURBATIONS OF dIRICHLET dISCRETE NONLINEAR PROBLEMS

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Acta Mathematica Scientia 2017年第4期37卷 911-926页

作者： Alberto CABAdA Nikolay d.dimitrov Instituto de Matemdticas Facultade de MatemdticasUniversidade de Santiago de Compostela15782 Santiago de CompostelaSpain department of Mathematical Analysis University of Rousse7017 RousseBulgaria

This paper is devoted to the study of second order nonlinear difference equations. A Nonlocal Perturbation of a dirichlet Boundary Value Problem is considered. An exhaustive study of the related Green＇s function to the linear part is done. The exact expression of the function is given, moreover the range of parameter for which it has constant sign is obtained. Using this, some existence results for the nonlinear problem are deduced from monotone iterative techniques, the classical Krasnoselski fixed point theorem or by application of recent fixed point theorems that combine both theories.

关键词： dirichlet boundary value problem nonlocal perturbations Green's function parameter dependence

Cyclic patterns of incidence rate for skin malignant melanoma:association with heliogeophysical activity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 489-495页

作者： Borislav d.dimitrov Mariana I.RACHKOVA Penka A.ATANASSOVA BORdANI Alzano Lombardo(BG)24022ItalyDepartment of Social Medicine and Health ManagementMedical UniversityPlovdiv 4000Bulgaria ASSON-93 Research Co. Mount ProspectILL 60056USA department of Neurology Medical UniversityPlovdiv 4000Bulgaria

Background:Our previous studies revealed cyclicity in the incidence rate of skin malignant melanoma(SMM;ICd9,dx:172)in the Czech Republic(period T=7.50～7.63 years),UK(T=11.00 years)and Bulgaria(T=12.20 years).Incidences com- pared with the sunspot index Rz(lag-period dT=+2,+4,+6,+10 or+12 years)have indicated that maximal rates are most likely to appear on descending slopes of the 11-year solar cycle,i.e.,out of *** summarized and explored more deeply these cyclic variations and discussed their possible associations with heliogeophysical activity(HGA)components exhibiting similar cyclicity. Methods:Annual incidences of SMM from 5 countries(Czech Republic,UK,Bulgaria,USA and Canada)over various time spans during the years 1964～1992 were analyzed and their correlations with cyclic Rz(sunspot number)and aa(planetary geomagnetic activity)indices were *** regression analysis with trigonometric approximation and phase-correlation analysis were ***:Previous findings on SMM for the Czech Republic,UK and Bulgaria have been validated,and cyclic patterns have been revealed for USA(T=8.63 years,Pd Canada(Ontario,T=9.91 years,Pd(T=45.5,42.0,48.25,34.5 and 26.5 years,respectively)describing long-term cyclic incidence *** association of SMM for USA and Canada with Rz(dT=+6 and+7 years,respectively)and aa(dT=?10 and+9 years,respectively)was *** interactions of cyclic non-photic influences(UV irradiation,Schumann resonance signal,low-frequency geomagnetic fluctuations)with brain waves absorbance,neuronal calcium dynamics,neuro-endocrine axis modulation,melatonin/serotonin disbalance and skin neuro-immunity impairment as likely causal pathways in melanoma ap- pearance,were also ***:The above findings on cyclicity and temporal association of SMM with cyclic envi- ronmental factors could not only allow for better forecasting models but also lead to a bett

关键词：黑色素瘤皮肤活性手术治疗

The divergence of nearby trajectories in soft-sphere dEM

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Particuology 2022年第4期20卷 1-8页

作者： William d.Fullmer Roberto Porcu jordan Musser Ann S.Almgren Ishan Srivastava National Energy Technology Laboratory MorgantownWV 26507USA NETL Support Contractor MorgantownWV 26507USA Center for Computational Sciences and Engineering.Lawrence Berkeley National Laboratory BerkeleyCA 94720USA

The n-body instability is investigated with the soft-sphere discrete element *** divergence of nearby trajectories is quantifed by the dynamical memory *** the inverse proportionality between the dynamical memory time and the largest Lyapunov exponent,the soft-sphere discrete ele-ment method results are compared to previous hard-sphere molecular dynamics data for the first *** agreement is observed at low concentrations and the degree of instability is shown to increase asymptotically with increasing spring *** particle concentrations above 30%,the soft-sphere Lya-punov exponents increase faster than the corresponding hard-sphere *** paper concludes with a demonstration of how this case study may be used in conjunction with regression testing and code verification activities.

关键词： Soft-sphere dEM Chaos Lyapunov exponent

Fuzzy difference Equations in diagnoses of Glaucoma from Retinal Images Using deep Learning

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 801-816页

作者： d.dorathy Prema Kavitha L.Francis Raj Sandeep Kautish Abdulaziz S.Almazyad Karam M.Sallam Ali Wagdy Mohamed department of Mathematics Voorhees CollegeVelloreTamil NaduIndia Chandigarh Group of Colleges JhanjeriMohaliPunjabIndia department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Faculty of Science and Technology School of IT and SystemsUniversity of CanberraCanberraAustralia Operations Research department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied Science Research Center Applied Science Private UniversityAmman11937Jordan

The intuitive fuzzy set has found important application in decision-making and machine *** enrich and utilize the intuitive fuzzy set,this study designed and developed a deep neural network-based glaucoma eye detection using fuzzy difference equations in the domain where the retinal images *** image detections are categorized as normal eye recognition,suspected glaucomatous eye recognition,and glaucomatous eye *** degrees associated with weighted values are calculated to determine the level of concentration between the fuzzy partition and the retinal *** proposed model was used to diagnose glaucoma using retinal images and involved utilizing the Convolutional Neural Network(CNN)and deep learning to identify the fuzzy weighted regularization between *** methodology was used to clarify the input images and make them adequate for the process of glaucoma *** objective of this study was to propose a novel approach to the early diagnosis of glaucoma using the Fuzzy Expert System(FES)and Fuzzy differential equation(FdE).The intensities of the different regions in the images and their respective peak levels were *** the peak regions were identified,the recurrence relationships among those peaks were then *** partitioning was done due to varying degrees of similar and dissimilar concentrations in the *** and dissimilar concentration levels and spatial frequency generated a threshold image from the combined fuzzy matrix and *** distinguished between a normal and abnormal eye condition,thus detecting patients with glaucomatous eyes.

关键词： Convolutional Neural Network(CNN) glaucomatous eyes fuzzy difference equation intuitive fuzzy sets image segmentation retinal images

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Energy Management

Journal of Energy and Power Engineering 2024年第1期18卷 29-33页

作者： Khaled(Moh’d Khalaf)Soleiman Alnobani department of Chemical Engineering Jordan University of Science and TechnologyIrbid 22110Jordan

A new revised energy concept is proposed from relativistic approach using different kinds of *** is not always feasible to implement a project for saving *** is not merely heating a stream and cooling another *** study includes other considerations.A total feasibility study should be *** cost and the income should be *** this study it is shown how to perform such a feasibility study from scratch up to detailed *** is an investment *** are two energy balances:one thermal and the other *** are not separated but they complete each *** decision is upon rigorous energy *** the question where the energy will go shall be answered from 2nd law of thermodynamics.

关键词： Entropy energy feasibility study