Anti-IgE IgG autoantibodies isolated from therapeutic normal IgG intravenous immunoglobulin induce basophil activation

作     者：Caroline Galeotti Anupama Karnam Jordan D.Dimitrov Alain Chevailler Srini V.Kaveri Jagadeesh Bayry 

作者机构：Institut National de la Santéet de la Recherche Médicale/Centre de Recherche des CordeliersEquipe-Immunopathologie et Immunointervention ThérapeutiqueSorbonne UniversitéParis F-75006France Service de Rhumatologie PédiatriqueCentre de Référence des Maladies Auto-Inflammatoires Rares et des AmylosesCHU de Bicêtrele Kremlin Bicêtre F-94270France UniversitéParis DescartesSorbonne Paris CitéParis F-75006France Laboratoire d’Immunologie et d’Allergologie/CHU d’AngersUniversitéd’Angers/INSERM Unité1232/LabEx IGO“Immuno-Graft-Onco”Angers F-49933France 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2020年第17卷第4期

页      面：426-429页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the Institut National de la Santéet de la Recherche Médicale(INSERM) Sorbonne Université,UniversitéParis Descartes,ANR-19-CE17-0021(BASIN) CSL Behring,Switzerland.C.G.and A.K.were the recipients of fellowships from La Fondation pour la Recherche Médicale(FDM20150633674 and FDT201805005552,respectively),France 

主　　题：activation attempted IgE 

摘      要：Basophils are rare *** representing only~0.5%of all leukocytes,basophils have several important physiological functions.1,2 Although basophils lack the classic features of professional antigen-presenting cells,3–7 through the secretion of cytokines,they orient the immune response by polarizing Th2 differentiation and supporting B-cell differentiation and class *** are also critical for mediating protection against helminth infection.1,2,8,9 Basophils receive activation signals from diverse *** is well recognized that cytokines such as IL-3,granulocyte–macrophage colony-stimulating factor(GM-CSF),thymic stromal lymphopoietin(TSLP)and IL-33;various toll-like receptor ligands;allergen-bound IgE provide activation signals to basophils and induce the release of inflammatory mediators.10–15 In addition,several reports have also demonstrated the existence of anti-IgE autoantibodies that possess the capacity to induce basophil activation in patients with chronic spontaneous urticaria(CSU),atopic or non-atopic asthma or autoimmune disease.16–21 However,isolation and functional exploration of such anti-IgE IgG autoantibodies from either healthy donors or patients have not been attempted *** using a pooled normal IgG preparation from healthy donors,specifically intravenous immunoglobulin G(IVIG)22 that represents the complete IgG repertoire of a normal individual,we attempted to address this outstanding question in the field.