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Mitochondrial H_(2)S_(n)-Mediated Anti-Inflammatory Theranostics

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Nano-Micro Letters 2021年第12期13卷 1-13页

作者： Won Young kim Miae Won Seyoung Koo Xingcai Zhang jong Seung kim Department of Chemistry Korea UniversitySeoul 02841Korea John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

The insistent demand for space-controllable delivery,which reduces the side effects of non-steroidal antiinflammatory drugs(NSAIDs),has led to the development of a new theranostics-based approach for anti-inflammatory *** current anti-inflammatory treatments can be improved by designing a drug delivery system responsive to the inflammatory site biomarker,hydrogen polysulfide(H_(2)S_(n)).Here,we report a noveltheranostic agent 1(TA1),consisting of three parts:H_(2)S_(n)-mediated triggering part,a two-photon fluorophore bearing mitochondria targeting unit(Rhodol-TPP),and anti-inflammatory COX inhibitor(indomethacin).In vitro experiments showed that TA1 selectively reacts with H_(2)S_(n)to concomitantly release both Rhodol-TPP and ***-microscopy imaging of inflammation-inducedlive cells suggested that TA1 is localized in the mitochondria where the H_(2)S_(n)is *** TA1 reacted with H_(2)S_(n)in the endogenous and exogenous H_(2)S_(n)environments and in lipopolysaccharide treated inflammatory ***,TA1 suppressed COX-2 level in the inflammatory-induced cells and prostaglandin E 2(PGE2)level in blood serum from inflammation-induced mouse *** vivo experiments with inflammation-induced mouse models suggested that TA1 exhibits inflammation-site-elective drug release followed by significant therapeutic e ects,showing its function as a theranostic agent,capable of both anti-inflammatory therapy and precise *** behavior of TA1 is highly applicable in vivo model therapeutics for the inflammatory disease.

关键词： Theranostics Anti-inflammation Mitochondria Hydrogen polysulfides

Low-temperature crystalline lead-free piezoelectric thin films grown on 2D perovskite nanosheet for flexible electronic device applications

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Nano Research 2019年第10期12卷 2559-2567页

作者： jong-Hyun kim Sang Hyo Kweon Sahn Nahm KU-KIST Graduate School of Converging Science and Technology Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Material Science and Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Mechanical Engineering Kobe University1-1 Rokkodai-choNadaKobe 657-8501Japan

A monolayer of Sr2Nb3Oio(SNO)is deposited on the Pt/Ti/SiCWSi(Pt?Si)or Pt/Ti/polyimide(Pt-Pl)substrate by using the Langmuir-Blodgett method and employed as a seed-layer for the growth of a crystalline(Nai_xKx)NbO3(NKN)film at 350℃.The crystalline NKN film is grown along the[001]direction on the SNO/Pt-Si(or SNO/Pt-PI)*** to the presence of oxygen vacancies in the SNO seed-layer,the NKN film exhibits low ferroelectric properties and large leakage *** ameliorate these properties,the SNO/Pt-Si substrate is annealed in a 50 Torr oxygen atmosphere at 300℃,which removes the oxygen ***,the NKN film deposited on this substrate exhibits promising electrical properties,namely a dielectric constant of 278,dissipation factor of 1.7%,a piezoelectric 8nstant of 175 pm`V^-1,and a leakage current density of 6.47 x 10^-7 A cm^-2 at-0.2 MV *** electrical properties are obtained from the NKN film grown on the flexible SNO/Pt-PI substrate at 350°***,the NKN films grown on the SNO seed-layer at 350°C can be applied to electronic devices with flexible polymer substrates.

关键词： lead-free piezoelectric thin films low-temperature-deposition process two-dimensional(2D)nanosheet seed-layers polymer substrates

Degradation of malathion by Pseudomonas during activated sludge treatment system using principal component analysis (PCA)

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Journal of Environmental Sciences 2006年第4期18卷 797-804页

作者： Hashmi Imran Khan M Altaf kim jong-Guk Institute of Environmental Science and Engineering National University of S ciences and Technology Tamiz uddin Road Rawalpindi Pakistan Institute of E nvironmental Studies University of Karachi Karachi-75270 Pakistan Departm ent of Environmental Engineering Research Center of Industrial Technology Chon buk National University 664-14 Duckjin-Dong 1-Gu Chonju 560-756 South Korea

Popular descriptive multivariate statistical method currently employed is the principal component analyses （PCA） method. PCA is used to develop linear combinations that successively maximize the total variance of a sample where there is no known group structure. This study aimed at demonstrating the performance evaluation of pilot activated sludge treatment system by inoculating a strain of Pseudomonas capable of degrading malathion which was isolated by enrichment technique. An intensive analytical program was followed for evaluating the efficiency of biosimulator by maintaining the dissolved oxygen （DO） concentration at 4.0 mg/L. Analyses by high performance liquid chromatographic technique revealed that 90% of malathion removal was achieved within 29 h of treatment whereas COD got reduced considerably during the treatment process and mean removal efficiency was found to be 78%. The mean pH values increased gradually during the treatment process ranging from 7.36-8.54. Similarly the mean ammonia-nitrogen （NH3-N） values were found to be fluctuating between 19.425-28.488 mg/L, mean nitrite-nitrogen （NO3-N） ranging between 1.301- 2.940 mg/L and mean nitrate-nitrogen （NO3-N） ranging between 0.0071-0.0711 mg/L. The study revealed that inoculation of bacterial culture under laboratory conditions could be used in bioremediation of environmental pollution caused by xenobiotics. The PCA analyses showed that pH, COD, organic load and total malathion concentration were highly correlated and emerged as the variables controlling the first component, whereas dissolved oxygen, NO3-N and NH3-N governed the second component. The third component repeated the trend exhibited by the first two components.

关键词： activated sludge system malathion, principal component analyses (PCA) raw wastewater removal efficiency

Artificial synaptic and self-rectifying properties of crystalline(Na_(1-x)K_(x))NbO_(3)thin films grown on Sr_(2)Nb_(3)O_(10)nanosheet seed layers

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Journal of Materials Science & Technology 2022年第28期123卷 136-143页

作者： In-Su kim jong-Un Woo Hyun-Gyu Hwang Bumjoo kim Sahn Nahm Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

Crystalline(Na_(1-x)K_(x))NbO_(3)(NKN)thin films were deposited on Sr_(2)Nb_(3)O_(10)/TiN/Si(S-TS)substrates at 370°***_(2)Nb_(3)O_(10)(SNO)nanosheets served as a template for the formation of crystalline NKN films at low *** the NKN film was deposited on one SNO monolayer,the NKN memristor exhibited normal bipolar switching characteristics,which could be attributed to the formation and destruction of oxygen vacancy ***,the NKN memristor with one SNO monolayer exhibited artificial synaptic ***,the NKN memristor deposited on two SNO monolayers exhibited self-rectifying bipolar switching properties,with the two SNO monolayers acting as tunneling barriers in the *** conduction mechanism of the NKN memristor with two SNO monolayers in the highresistance state is attributed to Schottky emission,direct tunneling,and Fowler–Nordheim(FN)*** current conduction in this memristor in the low-resistance state was governed by direct tunneling and FN ***,the NKN memristor with two SNO monolayers exhibited large ON/OFF and rectification ratios and artificial synaptic ***,an NKN memristor with two SNO monolayers can be used for fabricating artificial synaptic devices with a cross-point array structure.

关键词： Bipolar switching properties Self-rectifying bipolar switching properties Artificial synaptic properties Crystalline NKN thin film Sr_(2)Nb_(3)O_(10)nanosheet seed layer

Microstructural evolution and grain growth mechanism of pre-twinned magnesium alloy during annealing

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Journal of Magnesium and Alloys 2021年第4期9卷 1238-1251页

作者： Ye Jin kim jong Un Lee Young Min kim Sung Hyuk Par School of Materials Science and Engineering Kyungpook National JJniversityDaegu 41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChanson 51508Republic of Korea

The microstructural evolution and underlying grain growth mechanism of a{1012}-twin-containing Mg alloy during annealing are investigated through quasi in situ electron backscatter diffraction measurements of a rolled AZ31 alloy subjected to precompression along the rolling direction(RD).The precompressed material shows a partially twinned structure consisting of a twinned region and a residual matrix region,and this structure changes to an almost twin-free structure consisting of grown grains with serrated grain boundaries in twinand matrix-originated regions after annealing at 250℃ for 1 *** addition,the average grain size almost doubles and the internal strain energy decreases significantly after *** microstructural variations are induced mainly by grain growth through the strain-induced migration of high-angle grain boundaries without the movement of twin *** twinned region of the precompressed material has higher stored strain energy than the residual matrix region because the crystallographic orientation of the former region is favorable for basal slip and because of the occurrence of the dislocation transmutation reaction in the *** reducing the total strain energy accumulated in the precompressed material,the residual matrix region—having lower stored strain energy—preferentially grows while consuming the twinned regions formed in the surrounding grains during *** a result,the area fraction of grains with a matrix texture increases whereas that of grains with a twin texture decreases after *** twin texture intensity increases significantly and this texture becomes more concentrated along the RD because the highly RD oriented twins tend to grow during annealing on account of their fairly low stored strain energy.

关键词： Magnesium Twin Annealing Grain growth Strain energy

Electrolyte accessibility of non-precious-metal catalysts with different spherical particle sizes under alkaline conditions for oxygen reduction reaction

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Journal of Energy Chemistry 2021年第1期30卷 326-331,I0011页

作者： Jiyeon Lee jong Gyeong kim Chanho Pak Graduate Program of Energy Technology School of Integrated TechnologyInstitute of Integrated TechnologyGwangju Institute of Science and TechnologyGwangju 61005Republic of Korea

Fuel cells are one of the most competitive alternative energy sources because their theoretical efficiency is~15%higher than that of internal combustion engines (ICEs) and they are considered cleaner and *** fuel cells are used to replace ICEs in cars and energy conversion systems,the system efficiency increases;furthermore,the process becomes more environmentally-friendly because fuel cells produce electricity by using only hydrogen and oxygen,obtained by purifying atmospheric air by filtering out dust and ***,their final product is only water,instead of pollutants like carboFuel cells are one of the most competitive alternative energy sources because their theoretical efficiency is~15%higher than that of internal combustion engines (ICEs) and they are considered cleaner and *** fuel cells are used to replace ICEs in cars and energy conversion systems,the system efficiency increases;furthermore,the process becomes more environmentally-friendly because fuel cells produce electricity by using only hydrogen and oxygen,obtained by purifying atmospheric air by filtering out dust and ***,their final product is only water,instead of pollutants like carbon dioxide.n dioxide.

关键词： Non-precious-metal catalyst Oxygen reduction reaction Size effect Electrolyte accessibility Alkaline fuel cell

Interfacial Behaviors of Basalt Fiber‑Reinforced Polymeric Composites: A Short Review

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Advanced Fiber Materials 2022年第6期4卷 1414-1433页

作者： Seong‑Hwang kim jong‑Hoon Lee jong‑Woo kim Seul‑Yi Lee Soo‑Jin Park Department of Chemistry Inha University100 InharoIncheon 22212South Korea

Basalt fibers(BFs)have emerged as a promising thermal insulation material for various applications,such as fireproof clothes/walls and protective equipment in military and civil *** have many desirable characteristics,such as low thermal conductivity,excellent flame resistance,exceptional mechanical strength,facile manipulability,environmental friendliness,and ***,the low intrinsic interfacial properties of BFs due to their chemical inertness and macro-scaled sizes have been a challenge for high performance of BFs-reinforced polymeric composites(BFRPs).Since the mechanical properties of BFRPs significantly depend on the interfacial interaction between the fibers and the matrix,it is critical to understand how incorporating BFs influences the properties of the *** this end,the aim of this review is to report on recent research progress with emphasis on the interfacial behavior in *** relationships between the fiber–matrix interfacial adhesion and the mechanical properties of the BFRPs are briefly described with systematic and up-to-date surface modification techniques summarized into two categories:surface modifications(“wet”and“dry”)and multi-scaled ***,several strategies for increasing the interfacial adhesion of BFs within the polymeric matrix to provide new ideas and insight for future research on the BFRPs are discussed.

关键词： Basalt fibers Polymeric matrix Surface modification Interface

Uncertainty analysis of flow rate measurement for multiphase flow using CFD

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Acta Mechanica Sinica 2015年第5期31卷 698-707页

作者： Joon-Hyung kim uk-Hee Jung Sung kim Joon-Yong Yoon Young-Seok Choi Department of Mechanical Design Engineering Hanyang University Thermal & Fluid System R&BD Group Korea Institute of Industrial Technology Energy System Engineering University of Science and Technology

The venturi meter has an advantage in its use,because it can measure flow without being much affected by the type of the measured fluid or flow ***,it has excellent versatility and is being widely applied in many *** flow of a liquid containing air is a representative example of a multiphase flow and exhibits complex flow *** particular,the greater the gas volume fraction（GVF）,the more inhomogeneous the flow *** a result,using a venturi meter to measure the rate of a flow that has a high GVF generates an *** this study,the cause of the error occurred in measuring the flow rate for the multiphase flow when using the venturi meter for analysis by *** ensure the reliability of this study,the accuracy of the multiphase flow models for numerical analysis was verified through comparison between the calculated results of numerical analysis and the experimental *** a result,the Grace model,which is a multiphase flow model established by an experiment with water and air,was confirmed to have the highest ***,the characteristics of the internal flow Held about the multiphase flow analysis result generated by applying the Grace model were analyzed to find the cause of the uncertainty occurring when measuring the flow rate of the multiphase flow using the venturi meter.A phase separation phenomenon occurred due to a density difference of water and air inside the venturi,and flow inhomogeneity happened according to the flow velocity difference of each *** was confirmed that this flow inhomogeneity increased as the GVF increased due to the uncertainty of the flow measurement.

关键词： Multiphase flow Measurement Numerical analysis Venturi meter Gas volume fraction(GVF) Uncertainty Multiphase flow model Grace model

Design,Fabrication,and Analysis of Flapping and Folding Wing Mechanism for a Robotic Bird

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Journal of Bionic Engineering 2020年第2期17卷 229-240页

作者： Seung Wan Ryu jong Gu Lee Hyoun Jin kim Department of Mechanical&Aerospace Engineering and Automation Systems Research Institute Seoul National UniversitySeoul 08826Republic of Korea

Emulating periodic main wing movement of a bird for generating lift and thrust remains a significant challenge in developing a robotic *** sequences of main wing motion are comprised of flapping,folding,bending,and *** this paper,we concentrate on the flapping and folding motion,and design two wing mechanisms based on a 4-bar linkage structure:one is only for Flapping Motion(FM)and the other is for simultaneous Flapping and Folding Motion(FFM)during a wing *** derive relationships between length and angle of links to analyze kinematic characteristics of the mechanisms and conduct an optimization to select the length parameters of links that allow maximization of the flapping *** run a simulation to confirm the performance of the optimized parameters by examining physical properties,and fabricate two wing mechanisms *** particular,the folding motion is achieved without using an additional *** measurements to investigate a lift profile of each mechanism and their quantitative comparison of the performance of both types confirm the benefits of the folding motion in the perspectives of wing frequency and *** expect that our kinematic formulation,design procedures,and comparative measurement results can help develop a wing mechanism to create a truly biomimetic robotic bird.

关键词： biomimetic robotic bird flapping and folding wing mechanism wing kinematics force measurement