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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir john.potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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A Room of His Own

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中国翻译 1995年第2期 62-63页

作者： Mary E.potter

Unmistakable noises are coming throughmy bedroom wall. Now a scuffling, now abumping, a long, drawn-out scraping"john, are you moving furniture in there? A-gain?" I call. The wall muffles his "yes" butdoes not filter ... 详细信息

关键词： A Room of His Own

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A Standard of Excellence

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中国翻译 1995年第3期 61-62页

作者： Mary E. potter

My 14-year-old son, john, and I spotted thecoat simultaneously. It was hanging on a rack ata secondhand clothing store in Northampton,Mass., crammed in with shoddy trench coats andan assortment of sad, woollen overcoats—a roseamong thorns. While the other coats drooped, this onelooked as if it were holding itself up. The thick,black wool of the double-breasted chesterfieldwas soft and unworn, as though it had been pre-served in mothballs for years in dear old

关键词：盖茨比大衣普通名词英国历史美国小说生产厂家曼哈顿纽约市外交家再生

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成人结直肠癌发病呈低龄化趋势不良饮食、肥胖、缺少运动可能是主要原因

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英国医学杂志中文版 2020年第1期23卷 6-7页

作者： john D potter 张月宁(译) Centre for Public Health Research Massey University WellingtonNew Zealand Fred Hutchinson Cancer Research Center SeattleWAUSA 北京佑安医院肝病消化中心

早在2003年人们就已注意到50岁以下成人中结直肠癌发病率在上升,但直到最近才引起重视。为了解这种趋势背后的原因,应将其描述流行病学搞清楚,包括这种变化的性质及稳定性;年轻结直肠癌患者基于年龄、性别、种族及其他特征存在差异的证... 详细信息

早在2003年人们就已注意到50岁以下成人中结直肠癌发病率在上升,但直到最近才引起重视。为了解这种趋势背后的原因,应将其描述流行病学搞清楚,包括这种变化的性质及稳定性;年轻结直肠癌患者基于年龄、性别、种族及其他特征存在差异的证据;以及是否既往有其他我们较为了解的癌症出现类似变化的例子。

关键词：描述流行病学结直肠癌患者人结直肠癌低龄化趋势结直肠癌发病率不良饮食

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Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse

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Cellular & Molecular Immunology 2010年第3期7卷 211-220页

作者： Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun john A Gebe Gerald T Nepom Thomas N Wight Benaroya Research Institute SeattleWAUSA

Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and *** hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC *** primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA ***,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA *** effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th *** data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell *** also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen *** data point to a pivotal role for HA in DC–T cell interactions at the IS.

关键词： dendritic cell hyaluronan immune synapse pericellular matrix Th1

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Extraterrestrial Impacts and Geomagnetic Reversals

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Journal of Applied Mathematics and Physics 2022年第3期10卷 952-959页

作者： Pirooz Mohazzabi Michael J. Connolly Julia A. Jones john D. Skalbeck Nicholas A. potter Department of Mathematics and Physics University of Wisconsin-Parkside Kenosha WI USA Department of Geosciences University of Wisconsin-Parkside Kenosha WI USA

The existing data on the confirmed extraterrestrial impacts and geomagnetic reversals are examined. Differential rotation of the inner core of the Earth relative to the rest of the planet has been observed through seismic records. Differential rotation between the inner and outer core is thought to be related to the geomagnetic field of the Earth. Extraterrestrial impacts with the surface of the Earth have been shown to cause changes in this differential rotation. It is shown in this paper that there is a strong correlation between the dates of major impacts and geomagnetic reversals. This strongly supports the possibility of major extraterrestrial impacts being one of the causes of geomagnetic reversals as has been suggested previously.

关键词： Earth Extraterrestrial Impact Geomagnetic Reversal

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A Standard of Excellence

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语言教育 1995年第5期 36-37页

作者： Mary E.potter 陈可培

My 14-year-old son,john,and I spotted the coat *** was hanging on a rack at a secondhand clothing store inNorthampton,Mass,crammed in with shoddy trench coatsand an assortment of sad,woolen overcoats—a rose amongthorns.

关键词： hanging trench clothing store dinner looking beautiful something guess mistake

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Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry

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World Journal of Gastroenterology 2013年第21期19卷 3241-3248页

作者： Scott V Adams Dennis J Ahnen john A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor john D potter Polly A Newcomb Cancer Prevention Public Health SciencesFred Hutchinson Cancer Research CenterSeattleWA 98109United States Department of Medicine Denver VA Medical Center and University of Colorado School of MedicineDenverCO 80045United States Department of Medicine University of North CarolinaChapel HillNC 27599United States Epidemiology Research Program Department of Intramural ResearchAmerican Cancer SocietyAtlantaGA 30303United States Division of General Surgery University of TorontoTorontoON M5G2C4Canada Cancer Research Center of Hawaii University of HawaiiHonoluluHI 96813United States Department of Health Science Research Mayo Clinic ArizonaScottsdaleAZ 85259United States

AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC.

关键词： Colorectal cancer Inflammatory bowel disease Outcomes research Cancer survival Inflammation

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Phylogenetic inferences in Prunus （Rosaceae） using chloroplast ndhF and nuclear ribosomal ITS sequences

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植物分类学报 2008年第3期46卷 322-332页

作者： Jun WEN Scott T. BERGGREN Chung-Hee LEE Stefanie ICKERT-BOND Ting-Shuang YI Ki-Oug YOO Lei XIE Joey SHAW Dan potter Department of Botany National Museum of Natural History MRC 166 Smithsonian Institution Washington DC 20013-7012 USA Department of Biology Colorado State University Fort Collins CO 80523 USA Korean National Arboretum 51-7 Jikdongni Soheur-eup Pocheon-si Gyeonggi-do 487-821 Korea UA Museum of the North and Department of Biology and Wildlife University of Alaska Fairbanks Fairbanks AK 99775-6960 USA Key Laboratory of Plant Biodiversity and Biogeography Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China Division of Life Sciences Kangwon National University Chuncheon 200-701 Korea State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Beijing 100093 China Department of Biological and Environmental Sciences University of Tennessee Chattanooga TN 37403-2598 USA Department of Plant Sciences MS 2 University of California Davis CA 95616 USA

Sequences of the chloroplast ndhF gene and the nuclear ribosomal ITS regions are employed to recon-struct the phylogeny of Prunus (Rosaceae), and evaluate the classification schemes of this genus. The two data sets are congruent in that the genera Prunus s.l. and Maddenia form a monophyletic group, with Maddenia nested within Prunus. However, the ndhF data set is incongruent with the ITS data supporting two major groups within Prunus: one consisting of subgenera Laurocerasus (including Pygeum) and Padus as well as the genus Maddenia and another of subgenera Amygdalus, Cerasus, and Prunus. The ITS data, on the other hand, support a clade composed of subgenera Amygdalus and Prunus and Prunus sect. Microcerasus in addition to a paraphyletic grade of subgenera Laurocerasus and Padus (and the genus Maddenia) taxa. In general, the subgeneric classifications of Prunus s.l. are not supported. The ITS and ndhF phylogenies differ mainly in interspecific relationships and the relative position of the Padus/Laurocerasus group. Both ITS and ndhF data sets suggest that the formerly recog-nized genus Pygeum is polyphyletic and that the distinction of the subgenera Padus and Laurocerasus is not supported. The biogeographic interactions of the temperate and tropical members in the Padus/Laurocera- sus/Maddenia alliance including Pygeum are shown to be highly dynamic and complex.

关键词：系统发生学叶绿体核糖体层序核子

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红肉和加工肉及其与人类和地球的健康当代的肉类消费有害于人类健康，也不利于地球

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英国医学杂志中文版 2018年第5期21卷 246-247页

作者：童钰玲(译) 宋震亚(校) 浙江大学医学院附属第二医院全科医学科

美国国立健康研究院（the National Institutes of Health，NIH）先前的分析AARP研究发现，肉类摄人多的研究参与者病死率较高。Etemadi及其团队通过对超过750万人年的观察和进一步分析（doi：10．1136／bmj．j1957）发现，红肉和加工... 详细信息

美国国立健康研究院（the National Institutes of Health，NIH）先前的分析AARP研究发现，肉类摄人多的研究参与者病死率较高。Etemadi及其团队通过对超过750万人年的观察和进一步分析（doi：10．1136／bmj．j1957）发现，红肉和加工肉的高摄人与总病死率和主因病死率（心血管疾病、糖尿病、癌症和肝、肾、呼吸道疾病）升高相关。

关键词：红肉加工肉

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