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Aerodynamics of a t.ndem-Bladed Axial Compressor Rot.r under Circumferent.al Dist.rt.on at.Different.Rot.t.onal Speeds

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Journal of t.ermal Science 2024年第4期33卷 1340-1356页

作者： Amit.KUMAR Jerry t.john A.M.PRADEEP R.A.DAKKERMANS Dragan KOZULOVIC Depart.ent.of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India Depart.ent.of Aut.mot.ve and Aeronaut.cal Engineering Hamburg University of Applied Sciences20099HamburgGermany Inst.t.t. of Jet.Propulsion Bundeswehr University Munich85577NeubibergGermany

For most.aircraft.engines,inflow.dist.rt.on is *** dist.rt.on is know. t. degrade t.e aerodynamic performance and st.ble operat.ng limit. of a *** rot.r configurat.on is an arrangement.t.at.effect.vely cont.ols t.e grow.0} of t.e boundary layer over t.e suct.on surface of t.e ***,a higher t.t.l pressure rise can be achieved t.rough t.is unconvent.onal design approach involving t.e split.ing of t.e blade int. forw.rd and aft.*** is expect.d t.at.t.e effect.of inlet.flow.dist.rt.on w.uld be more severe for a t.ndem-rot.r design due t. t.e great.r flow.t.rning inherent.in such ***,t.is aspect.needs t. be t.oroughly *** present.st.dy discusses t.e effect.of circumferent.al dist.rt.on on t.e t.ndem-rot.r at.different.rot.t.onal ***-annulus RANS simulat.ons using ANSYS CFX are used in t.e present.*** performance of t.e rot.r at.a part.cular flow.coefficient.and different.rot.t.onal speeds is *** t.t.l pressure and efficiency are observed t. drop at.low.r mass flow.rat.s under t.e influence of circumferent.al *** loss region in each blade passage is mainly associat.d w.t. t.e blade w.ke,t.p leakage vort.x,secondary flow.and boundary ***,t.eir cont.ibut.on varies from passage t. passage,part.cularly in t.e dist.rt.d *** t.e low.r span,t.e w.ke w.dt. is found t. be higher t.an t.at.at.a higher *** t. t.e redist.ibut.on of t.e mass flow.t.e circumferent.al ext.nt.reduces at.a higher *** t.e undist.rt.d sect.r,t.e st.engt. of t.e t.p leakage vort.x is significant.y higher at.t.e design rot.t.onal speed t.an at.low.r *** dist.rt.on near t.e t.p region promot.s an early vort.x breakdow. even at.t.e design operat.ng *** adversely affect. t.e t.t.l pressure,efficiency,and st.ll *** clean flow.condit.ons,t.is phenomenon is only observed near t.e st.ll *** t.e design operat.ng condit.on,t.e breakdow. of t.e forw.rd rot.r t.p l

关键词： t.ndem rot.r circumferent.al dist.rt.on loss t.p leakage vort.x vort.x breakdow. diffusion fact.r aerodynamics of compressor blade

Desialylat.d Plat.let.Clearance in t.e Liver is a Novel Mechanism of Syst.mic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： June Li Danielle Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni H.Yucel Sonya A.MacParland Haibo Zhang john w.Semple john Freedman Qizhen Shi Heyu Ni Depart.ent.of Laborat.ry Medicine and Pat.obiology University of TorontoTorontoONCanada t.ront. Plat.let.Immunobiology Group TorontoONCanada Keenan Research Cent.e for Biomedical Science of St.Michael's Hospit.l TorontoONCanada Canadian Blood Services Cent.e for Innovat.on TorontoONCanada Depart.ent. of Pediat.ics Medical College of WisconsinMilwaukeeWIUSA Blood Research Inst.t.t. Versiti WisconsinMilwaukeeWIUSA Depart.ent. of Opht.almology and Vision Sciences Medicine University of TorontoTorontoONCanada Facult. of Engineering and Archit.ct.ral Science Ryerson UniversityTorontoONCanada Mult.-Organ t.ansplant.Program Toronto General Hospital Research InstituteTorontoONCanada Depart.ent.of Immunology University of TorontoTorontoONCanada Crit.cal Care Medicine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada Depart.ent.of Physiology University of TorontoTorontoONCanada Depart.ent.of Pharmacology University of TorontoTorontoONCanada. Division of Hemat.logy and t.ansfusion Medicine Lund UniversityLundSweden clinical Immunology and t.ansfusion Medicine Ofice of Medical ServicesRegion SkaneLundSweden Depart.ent.of Medicine University of TorontoTorontoONCanada Children's Research Inst.t.t. Children's WisconsinWauwatosaWIUSA Midw.st.At.let.s Against.Childhood Cancer Fund Research Cent.r MilwaukeeWIUSA.

Plat.let. are small, versat.le blood cells t.at.are crit.cal for hemost.sis/t.rombosis. Local plat.let.accumulat.on is a know. cont.ibut.r t. proinflammat.on in various disease st.t.s. How.ver, t.e ant.-inflammat.ry/immunosuppressive pot.nt.al of plat.let. has been poorly explored. Here, w. uncovered, unexpect.dly, desialylat.d plat.let. (dPLt.) dow.-regulat.d immune responses against.bot. plat.let.associat.d and -independent.ant.gen challenges. Ut.lizing mult.spect.al phot.acoust.c t.mography, w. t.acked dPLt.t.afficking t. gut.vasculat.re and an exclusive Kupffer cell-mediat.d dPLt.clearance in t.e liver, a process t.at.w. ident.fied t. be synergist.cally dependent.on plat.let.glycoprot.in Ibα and hepat.c Ashw.ll–Morell recept.r. Mechanist.cally, Kupffer cell clearance of dPLt.pot.nt.at.d a syst.mic immunosuppressive st.t. w.t. increased ant.-inflammat.ry cyt.kines and circulat.ng CD4+ regulat.ry t.cells, abolishable by Kupffer cell deplet.on. Last. in a clinically relevant.model of hemophilia A, presensit.zat.on w.t. dPLt.at.enuat.d ant.-fact.r VIII ant.body product.on aft.r fact.r VIII ( infusion. As plat.let.desialylat.on commonly occurs in daily-aged and act.vat.d plat.let., t.ese findings open new.avenues t.w.rd underst.nding immune homeost.sis and pot.nt.at. t.e t.erapeut.c pot.nt.al of dPLt.and engineered dPLt.t.ansfusions in cont.olling aut.immune and alloimmune diseases.

关键词： Plat.let t.ansfusion homeost.sis

Experiment.l and analyt.cal invest.gat.on on frict.on resist.nce force bet.een buried coat.d pressurized st.el pipes and soil

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Front.ers of St.uct.ral and Civil Engineering 2024年第4期18卷 615-629页

作者： Shaurav ALAM t.nvir MANZUR john MAt.HEw. Chris BARt.Et. Erez ALLOUCHE Brent.KEIL john KRAFt Depart.ent.of Civil Engineering and Const.uct.on Engineering t.chnology Louisiana Tech UniversityRustonLA 71270USA Depart.ent.of Civil Engineering Bangladesh University of Engineering and TechnologyDhaka 1000Bangladesh Georgia t.ch Research Inst.t.t. AtlantaGA 30332USA St.nt.c Inc. Edmonton T5J0K4Canada Nort. w.st.Pipe Company VancouverWA 98684USA

t.is paper present. an analyt.cal approach for est.mat.ng frict.onal resist.nce t. pipe movement.at.soil and ext.rnal pipe surface of buried coat.d pressurized st.el pipes relat.ve t. t.e int.rnal t.rust.*** proposed analyt.cal met.od w.s developed based on 36 experiment.,w.ich involved t.ree coat.ng t.pes(cement.mort.r(CM),polyuret.ane t.pe-I(Pt.I),prefabricat.d plast.c t.pe(PPt.)on pipes’surfaces,t.ree different.soils(pea-gravel(PG),sand(S),silt.-clay(SC)),and four simulat.d over burden dept.s above t.e pipe’s *** show.d frict.onal resist.nce decreased w.t. increasing over burden dept. above t.e pipe’s *** degree of frict.onal resist.nce at.t.e pipe-soil int.rface w.s found t. be in t.e order of PG>SC>S for all coat.ng variat.ons and overburden *** coat.d pipe buried in all t.ree t.pes of soil produced significant.y higher frict.onal resist.nce as compared t. ot.er coat.ng *** on experiment.l dat.,t.e developed analyt.cal int.oduced a dimensionless fact.r“Z”,w.ich included effect. of t.pes of coat.ngs,soil,and overburden dept.s for simplified rapid *** show.d t.at.t.e met.od provided a bet.er predict.on of frict.onal resist.nce forces,in comparison t. previous analyt.cal met.ods,w.ich w.re barely close in predict.ng frict.on resist.nce for different.coat.ng variat.ons,soil t.pes,and overburden *** resist.nce force values report.d herein could be considered conservat.ve.

关键词： frict.on resist.nce force t.rust.force coat.d pressurized st.el pipe soil t.pe overburden dept.

Capacit.ve micromachined ult.asound t.ansducers for int.avascular ult.asound imaging

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Microsyst.ms & Nanoengineering 2020年第1期6卷 565-577页

作者： Jiaqi w.ng Zhou Zheng Jasmine Chan john t.w.yeow Depart.ent.of Syst.ms Design Engineering Faculty of EngineeringUniversity of WaterlooWaterlooON N2L 3G1Canada

Int.avascular ult.asound(IVUS)is a burgeoning imaging t.chnology t.at.provides vit.l informat.on for t.e diagnosis of coronary art.rial diseases.A significant.const.t.ent.t.at.enables t.e IVUS syst.m t. at.ain high-resolut.on images is t.e ult.asound t.ansducer,w.ich act. as bot. a t.ansmit.er t.at.sends acoust.c w.ves and a det.ct.r t.at.receives t.e ret.rning *** t.e most.mat.re form of ult.asound t.ansducer available in t.e market.piezoelect.ic t.ansducers have dominat.d t.e field of biomedical ***,t.ere are some draw.acks associat.d w.t. using t.e t.adit.onal piezoelect.ic ult.asound t.ansducers such as difficult.es in t.e fabricat.on of high-densit. arrays,w.ich w.uld aid in t.e accelerat.on of t.e imaging speed and alleviat. mot.on *** advent.of microelect.omechanical syst.m(MEMS)t.chnology has brought.about.t.e development.of micromachined ult.asound t.ansducers t.at.w.uld help t. address t.is *** from t.e advant.ge of being able t. be fabricat.d int. arrays w.t. lesser complicat.ons,t.e image qualit. of IVUS can be furt.er enhanced w.t. t.e easy int.grat.on of micromachined ult.asound t.ansducers w.t. complement.ry met.l-oxide-semiconduct.r(CMOS).t.is w.uld aid in t.e mit.gat.on of parasit.c capacit.nce,t.ereby improving t.e ***,t.ere are t.o commonly invest.gat.d micromachined ult.asound t.ansducers,piezoelect.ic micromachined ult.asound t.ansducers(PMUt.)and capacit.ve micromachined ult.asound t.ansducers(CMUt.).Current.y,PMUt. face a significant.challenge w.ere t.e fabricat.d PMUt. do not.funct.on as per t.eir ***,CMUt. w.t. different.array configurat.ons have been developed for *** t.is paper,t.e different.ult.asound t.ansducers,including convent.onal-piezoelect.ic t.ansducers,PMUt. and CMUt.,are review.d,and a summary of t.e recent.progress of CMUt. for IVUS is present.d.

关键词： piezoelect.ic t.ansducers t.ereby

Opt.mizing oncolyt.c virus design:a“Sw.ss army knife”approach t. creat. a syst.mically delivered t.erapeut.c

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Signal t.ansduct.on and t.rget.d t.erapy 2024年第5期9卷 1791-1792页

作者： Carolina S.Ilkow.john Cameron Bell Ot.aw. Hospit.l Research Inst.t.t. 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent.paper published in Nat.re Biot.chnology,Chen et.al.1 describe a mult.plex oncolyt.c virus plat.orm t.at.coupled w.t. adopt.ve t.cell t.erapy could solve t.e problem of repeat.syst.mic delivery of virus based *** is w.dely accept.d t.at.mult.-t.rget.d t.erapeut.c approaches at.acking several facet. of cancer biology are necessary t. effect.vely deal w.t. t.e t.mor het.rogeneit. t.at.exist. w.t.in and bet.een pat.ent..

关键词： t.erapeut.c al. t.rget.d

Development.validat.on,and t.ansport.bilit. of several machine-learned,non-exercise-based VO_(2max)predict.on models for older adult.

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Journal of Sport.and Healt. Science 2024年第5期13卷 611-620页

作者： Benjamin t.Schumacher Michael J.LaMont. Andrea Z.LaCroix Eleanor M.Simonsick St.ven P.Hooker Humbert. Parada Jr. john Bellet.iere Arun Kumar Herbert.w.rt.eim School of Public Healt. and Human Longevit. Science University of California San DiegoLa JollaCA 92093USA Depart.ent.of Epidemiology and Environment.l Healt. School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA t.anslat.onal Geront.logy Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Healt. and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biost.t.st.cs School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA Universit. of California San Diego Moores Cancer Cent.r La JollaCA 92093USA Comput.r Science and Engineering and Halicioglu Dat. Science Inst.t.t. University of California San DiegoLa JollaCA 92093USA

Background:t.ere exist.few.maximal oxygen upt.ke(VO_(2max))non-exercise-based predict.on equat.ons,few.r using machine learning(ML),and none specifically for older *** direct.measurement.of VO_(2max)is infeasible in large epidemiologic cohort.st.dies,w. sought.t. develop,validat.,compare,and assess t.e t.ansport.bilit. of several ML VO_(2max)predict.on ***:t.e Balt.more Longit.dinal St.dy of Aging(BLSA)part.cipant. w.t. valid VO2_(max)t.st. w.re included(n=1080).Least.absolut. shrinkage and select.on operat.r,linear-and t.ee-boost.d ext.eme gradient.boost.ng,random forest.and support.vect.r machine(SVM)algorit.ms w.re t.ained t. predict.VO_(2max)*** developed t.ese algorit.ms for:(a)t.e overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,w. quant.fied t.e associat.ons bet.een measured and predict.d VO_(2max)and ***:t.e age w.s 69.0±10.4 years(mean±SD)and t.e measured VO_(2max)w.s 21.6±5.9 mL/kg/*** absolut. shrinkage and select.on operat.r,linear-and t.ee-boost.d ext.eme gradient.boost.ng,random forest.and support.vect.r machine yielded root.mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quart.les of measured VO_(2max)show.d an inverse gradient.in mort.lit. *** VO_(2max)variables yielded similar effect.est.mat.s but.w.re not.robust.t. ***:Measured VO_(2max)is a st.ong predict.r of *** ML can improve t.e accuracy of predict.on as compared t. simpler approaches but.est.mat.s of associat.on w.t. mort.lit. remain sensit.ve t. *** st.dies should seek t. reproduce t.ese result. so t.at.VO_(2max),an import.nt.vit.l sign,can be more broadly st.died as a modifiable t.rget.for promot.ng funct.onal resiliency and healt.y aging.

关键词： Cardiorespirat.ry fit.ess Predict.on algorit.ms Epidemiology Mort.lit.

Experiment.l Validat.on of Nussbaum Gain Adapt.ve Cont.ol for a Polymer Composit. Based Elect.omagnet.c Micromirror

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Experimental Validation of Nussbaum Gain Adaptive Control fo...

Int.gral Sliding Mode Based Opt.mal Composit. Nonlinear Feedback Cont.ol for Capacit.ve Micromachined Ult.asonic t.ansducers（CMUt.） Syst.m

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作者： Jiazheng t.n w.ijie Sun john t.w.yeow Depart.ent.of Aut.mat.on Science and Engineering South China University of Technology Advanced Micro/Nano Devices Laborat.ry Systems Design EngineeringUniversity of Waterloo

ISBN: (纸本)9781538629185

In t.is art.cle, an adapt.ve cont.oller based on Nussbaum gain t.chnique and backst.pping met.od is designed for a polymer composit. based hard-magnet.c micromirror. w.t. t.e Nussbaum gain exploit.d, t.e unknow. cont.ol direct.on problem is solved. As a result. t.e closed-loop syst.m w.t. proposed cont.oller design is able t. t.ack t.e desired reference signal asympt.t.cally. t.e effect.veness of t.e adapt.ve cont.oller is verified by experiment.l result. on a micromirror-based plat.orm.

关键词： Nussbaum gain Backst.pping design Unknow. cont.ol direct.on Elect.omagnet.c micromirror

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Integral Sliding Mode Based Optimal Composite Nonlinear Feed...

t.e risk of prost.t. cancer on incident.l finding of an avid prost.t. upt.ke on 2-deoxy-2-[^(18)F]fluoro-D-glucose posit.on emission t.mography/comput.d t.mography for non-prost.t. cancer-relat.d pat.ology:A single cent.e ret.ospect.ve st.dy

第36届中国控制会议

作者： Yi Qin w.ijie Sun john t.w.yeow College of Aut.mat.on Science and Engineering South China University of Technology Syst.ms Design Engineering University of Waterloo

ISBN: (纸本)9781538629185

t.is paper originally applied an opt.mal sliding mode based opt.mal composit. nonlinear feedback（ISM-CNF） cont.ol st.at.gy t. t.e capacit.ve micromachined ult.asonic t.ansducers（CMUt.） syst.m. It.is know. t.at.CMUt. syst.m is inherent.y unst.ble w.ich result. in pull-in phenomenon and sensit.ve t. a small pert.rbat.ons. t.erefore t.e major problem is t. st.blize t.e CMUt. syst.m beyond t.e pull-in limit.w.t. t.e ext.rnal dist.rbances and input.sat.rat.on. w. verified t.e effect.veness by CNF and opt.mal ISM-CNF cont.ol met.ods t.rough ext.nding t.e t.avel range of t.e CMUt. gap. t.e simulat.on result. show.t.e opt.mal ISM-CNF cont.ol law.w.ich achieves robust.ess, quick response, negligible overshoot.and ext.nds t.e t.avel range t. 90% of t.e init.al gap is bet.er t.an CNF cont.ol law.in CMUt. syst.m.

关键词： CNF ISM MEMS CMUt. Robust Feedback Cont.ol

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Asian Journal of Urology 2024年第1期11卷 33-41页

作者： Ant.ony Franklin t.oy Gianduzzo Boon Kua David w.ng Louise McEw.n James w.lt.rs Rachel Esler Mat.hew.J.Robert. Geoff Coughlina john w.Yaxley Depart.ent.of Urology The Wesley HospitalBrisbaneQLDAustralia w.sley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia Depart.ent.of Radiology Wesley Medical ImagingBrisbaneQLDAustralia Depart.ent.of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Object.ve:t. review.t.e risk of prost.t. cancer(PCa)in men w.t. incident.lly report.d increased int.aprost.t.c upt.ke at.2-deoxy-2-[18F]fluoro-d-glucose posit.on emission t.mography/comput.d t.mography(18F-FDG PEt.Ct.ordered at.Depart.ent.of Urology,t.e w.sley Hospit.l,Brisbane,QLD,Aust.alia for non-PCa relat.d ***:Ret.ospect.ve analysis of consecut.ve men bet.een August.2014 and August.2019 present.ng t. a single inst.t.t.on for 18F-FDG PEt.Ct.for non-prost.t. relat.d condit.ons w.s *** w.re classified as benign,indet.rminat.,or malignant.depending of t.e result. of prost.t.-specific ant.gen(PSA),PSA velocit.,biopsy hist.pat.ology,and t.ree-t.sla(3 t.mult.paramet.ic MRI(mpMRI)Prost.t. Imaging Report.ng and Dat. Syst.m score,or gallium-68-prost.t.-specific membrane ant.gen(68Ga-PSMA)PEt.Ct.***:t.ree percent.273/9122)of men demonst.at.d 18F-FDG avidit. w.t.in t.e ***-five percent.231/273)w.re furt.er invest.gat.d,including w.t. PSA t.st.(227/231,98.3%),3 t.mpMRI(68/231,29.4%),68Ga-PSMA PEt.Ct.33/231,14.3%),and prost.t. biopsy(57/231,24.7%).Result. w.re considered benign in 130/231(56.3%),indet.rminat. in 31/231(13.4%),and malignant.in 70/231(30.3%).PCa w.s ident.fied in 51/57(89.5%)of t.e men w.o proceeded t. biopsy,including 26/27(96.3%)men w.t. Prost.t. Imaging Report.ng and Dat. Syst.m scores 4-5 mpMRI and six men w.t. a posit.ve 68Ga-PSMA PEt.*** most.common Gleason score on biopsy w.s great.r t.an or equal t. 4+5(14/51,27.5%).68Ga-PSMA PEt.Ct.w.s concordant.w.t. t.e 18F-FDG findings in 26/33(78.8%).All 13 men w.t. a posit.ve concordant.18F-FDG,3 t.mpMRI,and 68Ga-PSMA PEt.Ct.had PCa on *** w.s no st.t.st.cally significant.difference in t.e 18F-FDG maximum st.ndardized upt.ke value bet.een t.e benign or malignant.groups(5.7 vs.6.1;p=0.580).Conclusion:In t.is st.dy,aft.r an incident.l finding of an avid int.aprost.t.c lesion on 18F-FDG PEt.Ct.70 of t.e 231 cases(30.3%;0.8%of t.e ent.re cohort.had result. c

关键词： Prost.t.cancer Posit.onemission t.mography Mult.paramet.ic magnet.cresonance imaging Prost.t.biopsy