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Journal of Oceanology and limnology 2023年第1期41卷 327-341页

作者： Qi lIU Xi lUO Shulian XIE john Patrick KOCIOlEK School of life Science Shanxi UniversityTaiyuan 030006China Museum of Natural History University of ColoradoBoulderCO 80309USA Department of Ecology and Evolutionary Biology University of ColoradoBoulderCO 80309USA

We detailed the valve morphology of five new species of diatom genus Nupela from wetwall communities in Yunnan Province,China,with light and scanning electron *** five new species demonstrate great variability within the genus,as three of them are biraphid and two are *** addition,variation was noted in the structure of internal proximal raphe ends,with some species having anchor-shaped ends and other species have hooked *** genus Nupela has grown considerably in 30years since it was first proposed,going from a monotypic genus to over 85 *** of the genus is based on the presence of an external covering over the *** discussed the systematic placement of Nupela within the naviculoid *** Province appears to harbor many endemic diatom taxa,and many regions of the province have yet to be studied.

关键词： Nupela scanning electron microscope(SEM) Yunnan new species morphology China Bacillariophyceae

A little goes a long way: ClE peptides mediate phloem initiation

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Journal of Integrative Plant Biology 2019年第10期61卷 1034-1035页

作者： Amala john Zachary l.Nimchuk Department of Biology University of North Carolina at Chapel Hill

The root system of a tree can often extend many-fold the diameter of the tree;it provides physical support, dissolved minerals and water but relies on a constant supply of nutrients from photosynthetically active tissues in aboveground organs. The phloem is re-sponsible for such transport and the success of a plant relies heavily on the integrity of the phloem in its root system.

关键词： ClE peptides mediate initiation

Circadian rhythms in liver metabolism and disease

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Acta Pharmaceutica Sinica B 2015年第2期5卷 113-122页

作者： Jessica M.Ferrell john Y.l.Chiang Department of Integrative Medical Sciences Northeast Ohio Medical University

Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and ***, these associations are reviewed with respect to liver metabolism and disease.

关键词： Circadian rhythm liver Metabolic syndrome Type 2 diabetes

Synthesis and crystal structure of a neodymium coordination polymer with 2,6-anthraquinonedisulfonate

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Particuology 2010年第3期8卷 221-224页

作者： Jennifer l. Nicholls john Bacsa Andrew M. Fogg Department of Chemistry University of Liverpool Crown Street Liverpool L69 7ZD United Kingdom

The coordination polymer, （Nd（H2O）5）2（2,6-AQDS）3.2H2O where 2,6-AQDS = 2,6- anthraquinonedisulfonate, has been synthesised via a hydrothermal route. Structurally, it consists of layers of monomeric Nd polyhedra which are linked by 2,6-AQDS anions forming a polymeric, three-dimensional network. Each Nd atom is nine coordinate, bonding to five water molecules and to four oxygen atoms from four 2,6-AODS anions which in turn pillar the layers by bridging two Nd atoms in one layer, and coordinating to a single Nd in the other.

关键词： lanthanide layered materials Sulfonate Coordination polymer

Role of lPS/CD14/TlR4-mediated inflammation in necrotizing enterocolitis:Pathogenesis and therapeutic implications

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World Journal of Gastroenterology 2009年第38期15卷 4745-4752页

作者： Kwong l Chan Kwong F Wong john M luk Department of Surgery The University of Hong Kong Division of Paediatric Surgery Queen Mary Hospital Department of Pharmacology and Department of Surgery National University Health SystemNational University of SingaporeMD11 #05-1210 Medical Drive

AIM:To establish the roles of lipopolysaccharide (lPS)/CD14/toll-like receptor 4 (TlR4)-mediated inflammation in a rat model of human necrotizing enterocolitis (NEC).METHODS: Six pairs of intestinal samples from human NEC were collected before and after recovery for histological and molecular analysis of inflammatory cytokines and signaling components. In the rat NEC model, we isolated 10-cm jejunum segments and divided them into six groups (n=6) for sham operation, treatment with lPS, bowel distension, combined bowel distension and lPS stimulation, and two therapeutic groups. The potential eff icacy of a recombinant CD18 peptide and a monoclonal CD14 antibody was evaluated in the latter two groups. The serum and tissue levels of several inflammatory mediators were quantified by real-time polymerase chain reaction, ElISA and ***: Human acute phase NEC tissues displayed significant increases (Plevels of TlR4, CD14, myeloid differentiation protein (MD)-2, tumor necrosis factor (TNF)-α and nuclear factor-κB when compared to those after recovery. The histological and inflammatory picture of human NEC was reproduced in rats that were treated with combined bowel distension and lPS, but not in the sham-operated and other control rats. Serum levels of interleukin-6 and TNF-α were also elevated. The NEC pathology was attenuated by treating the NEC rats with a monoclonal CD14 antibody or an lPS-neutralizing ***:lPS and distension are required to produce the histological and inflammatory features of NEC. A potential treatment option is blocking lPS activation and leukocyte infi ltration.

关键词：小肠结肠炎发病机理坏死性治疗炎症

The role of organic electron donors in the initiation of BHAS base-induced coupling reactions between haloarenes and arenes

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Science China Chemistry 2019年第11期62卷 1425-1438页

作者： Andrew J.Smith Darren l.Poole john A.Murphy Department of Pure and Applied Chemistry University of StrathclydeStrathclydeGlasgow G11XLUnited Kingdom Flexible Discovery Unit GlaxoSmithKline Medicines Research CentreStevenageSG12NYUnited Kingdom

Coupling reactions between haloarenes and arenes(including heteroarenes)that are conducted without added transition metals but in the presence of KOtBu or NaOtBu,have been a topic of great interest since their discovery in *** organic structures act as additives that assist these *** additives are converted into organic electron donors by the butoxide base and this leads to initiation of the coupling reactions,which proceed by radical chain *** review provides an overview of the initiation stages of these reactions.

关键词： organic electron donor potassium tert-butoxide electron transfer base-promoted homolytic aromatic substitution(BHAS) coupling benzyne

Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017

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Journal of Integrative Medicine 2017年第6期15卷 411-425页

作者： arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang the american tcm association ViennaVA 22182USA the american society of acupuncturists ChicagoIL 60618USA the joint acupuncture opioid task force La VerneCA 91750USA pacific college of oriental medicine ChicagoIL 60601USA the acupuncture now foundation CA 91750USA the acupuncture evidence project ProvidenceRI 02860USA the acupuncture society of virginia ViennaVA 22182USA the national federation of chinese tcm organizations New YorkNY 11501USA the american alliance for professional acupuncture safety GreenwichCT 06878USA the american traditional chinese medicine society New YorkNY 11501USA highland hospital alameda health systemOaklandCA 94602USA indiana university school of medicine IndianapolisIN 46202USA university of california san diego school of medicineSan DiegoCA 92093USA

The United States （U.S.） is facing a national opioid epidemic, and medical systems are in need of non- pharmacologic strategies that can be employed to decrease the public＇s opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture＇s cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successfully and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care.

关键词： acupuncture opioid epidemic pain opiate dependency effectiveness safety cost-effectiveness mechanism United States

Growth and differentiation of human induced pluripotent stem cell(hiPSC)-derived kidney organoids using fully synthetic peptide hydrogels

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Bioactive Materials 2023年第3期21卷 142-156页

作者： Niall J.Treacy Shane Clerkin Jessica l.Davis Ciar´an Kennedy Aline F.Miller Alberto Saiani Jacek K.Wychowaniec Dermot F.Brougham john Crean Diabetes Complications Research Centre University College Dublin(UCD)Conway Institute of Biomolecular and Biomedical Research and BelfieldDublin 4Ireland UCD School of Biomolecular and Biomedical Science BelfieldDublin 4Ireland Department of Materials&Manchester Institute of Biotechnology(MIB) School of Natural SciencesFaculty of Science and EngineeringThe University of ManchesterUK UCD School of Chemistry University College DublinBelfieldDublin 4Ireland

Human induced pluripotent stem cell(hiPSC)-derived kidney organoids have prospective applications ranging from basic disease modelling to personalised ***,there remains a necessity to refine the bio-physical and biochemical parameters that govern kidney organoid *** within fully-controllable and physiologically relevant 3D growth environments will be critical to improving organoid reproducibility and ***,we matured hiPSC-derived kidney organoids within fully synthetic self-assembling peptide hydrogels(SAPHs)of variable stiffness(storage modulus,G′).The resulting organoids con-tained complex structures comparable to those differentiated within the animal-derived matrix,***-cell RNA sequencing(scRNA-seq)was then used to compare organoids matured within SAPHs to those grown within Matrigel or at the air-liquid interface.A total of 13,179 cells were analysed,revealing 14 distinct *** compositional analysis revealed a larger proportion of nephron cell types within Transwell-derived organoids,while SAPH-derived organoids were enriched for stromal-associated cell ***,dif-ferentiation within a higher G’SAPH generated podocytes with more mature gene expression ***-tionally,maturation within a 3D microenvironment significantly reduced the derivation of off-target cell types,which are a known limitation of current kidney organoid *** work demonstrates the utility of syn-thetic peptide-based hydrogels with a defined stiffness,as a minimally complex microenvironment for the selected differentiation of kidney organoids.

关键词： Human kidney organoids Fully synthetic matrices Self-assembling peptide hydrogels Single-cell RNA sequencing

A comprehensive review on bitter gourd (Momordica charantia l.) as a gold mine of functional bioactive components for therapeutic foods

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Food Production, Processing and Nutrition 2022年第1期4卷 107-120页

作者： K.S.Gayathry Jenny Ann john Faculty of Ocean Science and Technology Kerala(Department of Food Science and Technology)Kerala University of Fisheries and Ocean Studies(KUFOS)Panangad P.O.KochiKerala682506India

Bitter gourd is a tropical wine grown mainly in India, China and South East Asia. The plant is cultivated mainly for its fruit part which is edible. Bitter gourd is unaccepted widely due to its bitter taste. Nevertheless, the fruit is a source of several key nutrients. The plant, as a whole contains, more than 60 phyto-medicines that are active against more than 30 diseases, including cancer and diabetes. Currently, the incorporation of the bioactive compounds isolated from bitter gourd into functional foods and beverages finds a new horizon. Nanoencapsulation and novel green extraction methods can be employed to improve the yield and quality of extracted compounds and their stability while incorporation into food products. The present review is an attempt to throw light to nutritional aspects, various bioactive compounds present and important nutraceutical properties of the bitter gourd plant in detail.

关键词： Bitter gourd Bioactive Nutraceutical Extraction Encapsulation

The gut's feeling on bile acid signaling in NAFlD

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Hepatobiliary Surgery and Nutrition 2018年第2期7卷 151-153页

作者： john Y.l.Chiang Department of Integrative Medical Sciences College of MedicineNortheast Ohio Medical UniversityRootstownOHUSA

The gut to live axis plays a critical role in regulation of hepatic bile acid synthesis and metabolic homeostasis(1).Non-alcoholic fatty liver disease(NAFlD)is the most common chronic liver disease with a high prevalence of^35%in *** can progress from simple steatosis to non-alcoholic steatohepatitis(NASH),cirrhosis and hepatocellular *** is associated with insulin resistance,obesity and type 2 *** acid-activated farnesoid X receptor(FXR)and G protein-coupled bile acid receptor-1(Gpbar-1,aka TGR5)have been shown to regulate lipid,glucose and energy metabolism and activation of FXR by agonists have been shown to improve hepatic metabolism and metabolic disorder in several mouse models of NASH(2).However,the role of bile acid signaling in pathogenesis and treatment of NASH is not clear.

关键词： NAFlD metabolism bile