The role of organic electron donors in the initiation of BHAS base-induced coupling reactions between haloarenes and arenes

作     者：Andrew J.Smith Darren L.Poole John A.Murphy 

作者机构：Department of Pure and Applied ChemistryUniversity of StrathclydeStrathclydeGlasgow G11XLUnited Kingdom Flexible Discovery UnitGlaxoSmithKline Medicines Research CentreStevenageSG12NYUnited Kingdom 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2019年第62卷第11期

页      面：1425-1438页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：EPSRC GSK the University of Strathclyde for funding(AJS) 

主　　题：organic electron donor potassium tert-butoxide electron transfer base-promoted homolytic aromatic substitution(BHAS) coupling benzyne 

摘      要：Coupling reactions between haloarenes and arenes(including heteroarenes)that are conducted without added transition metals but in the presence of KOtBu or NaOtBu,have been a topic of great interest since their discovery in *** organic structures act as additives that assist these *** additives are converted into organic electron donors by the butoxide base and this leads to initiation of the coupling reactions,which proceed by radical chain *** review provides an overview of the initiation stages of these reactions.