The gut's feeling on bile acid signaling in NAFLD

作     者：John Y.L.Chiang 

作者机构：Department of Integrative Medical SciencesCollege of MedicineNortheast Ohio Medical UniversityRootstownOHUSA 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2018年第7卷第2期

页      面：151-153页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study is supported by grants DK58379 and DK44442 from the National Institute of Diabetes Digestive and Kidney Diseases 

主　　题：NAFLD metabolism bile 

摘      要：The gut to live axis plays a critical role in regulation of hepatic bile acid synthesis and metabolic homeostasis(1).Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease with a high prevalence of^35%in *** can progress from simple steatosis to non-alcoholic steatohepatitis(NASH),cirrhosis and hepatocellular *** is associated with insulin resistance,obesity and type 2 *** acid-activated farnesoid X receptor(FXR)and G protein-coupled bile acid receptor-1(Gpbar-1,aka TGR5)have been shown to regulate lipid,glucose and energy metabolism and activation of FXR by agonists have been shown to improve hepatic metabolism and metabolic disorder in several mouse models of NASH(2).However,the role of bile acid signaling in pathogenesis and treatment of NASH is not clear.