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Littoral landforms of Lake Hulun and Lake Buir(China and Mongolia):Wind-driven hydro-sedimentary dynamics and resulting clastics distribution

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Journal of Palaeogeography 2024年第2期13卷 309-326页

作者： Li Wang Mathieu Schuster Shi-Wei Xin Florin Zainescu Xin-Yu Xue joep storms Jan-Hendrik May Alexis Nutz Helena van der Vegt Guilherme Bozetti Zai-Xing Jiang School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Universite de Strasbourg CNRSENGEESInstitut Terre et Environnement de StrasbourgUMR 70635 Rue DescartesStrasbourgFrance Tamsag Mongolia(XIX)Ltd. PetroChinaDaqing 163000China CEREGE Aix-Marseille UniversitéCNESIRDCollege de FranceINRAAix en ProvenceFrance School of Marine Science Sun Yat-sen UniversityZhuhai 519083China Delft University of Technology Department of Geoscience and EngineeringDelfthe Netherlands School of Geography Earth and Atmospheric SciencesUniversity of Melbourne253 Elgin St.CarltonVIC 3053Australia Deltares Delfthe Netherlands SCMF Faculty of GeographyUniversity of Bucharest1 N.Balcescu Blv.BucharestRomania

Two rectangular-shaped lakes,Lake Hulun and Lake Buir,located at the boundary between China and Mongolia,only c.75 km apart and therefore experiencing similar wind fields,have been studied based on satellite images and field surveys in order to compare their geomorphological and sedimentological *** wind-driven hydrodynamics,which have a significant effect on the development of littoral landforms and on sediment distribution,have been discussed for the two similar lakes that experienced a prevailing wind perpendicular to their long axis.A conceptual model related to wind-driven water bodies and sediment distribution is ***-influenced to wave-dominated deltas,beaches,spits,and eolian dune deposits develop around these two lakes,with a strikingly similar distribution *** features locally inform the longshore drift and help reconstruct the water circulation induced by wind *** the NW prevailing wind regime,the spits developed on the SW coast with a NW—SE extension,which was influenced by the NW—SE longshore *** same influence was observed in the delta extension in the NE *** differences lie in the presence of fan deltas in the NW region of Lake Hulun,but not in Lake ***,the width of the beach and eolian deposits on the downwind coast of Lake Hulun is three times greater than that of Lake Buir which were caused by the differences in sediment supply and wind fetch between the two *** Hulun and Lake Buir provide two reliable examples to understand the relationship among the wind field,provenance,hydrodynamics,landforms,and asymmetrical distribution of clastics in elongated *** also represent relevant modern analogs,which may also be of guiding significance to wind-driven sand body prediction in lacustrine basins.

关键词： Wind-driven lakes Fetch Sedimentary facies Hydrodynamics Geomorphology Spits Shoreline Lake Hulun Lake Buir

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Generic and disease-specific health-related quality of life in patients with Hirschsprung disease:A systematic review and meta-analysis

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World Journal of Gastroenterology 2022年第13期28卷 1362-1376页

作者： Veerle Huizer Naveen Wijekoon Daniëlle Roorda Jaap Oosterlaan Marc A Benninga LW Ernest van Heurn Shaman Rajindrajith joep PM Derikx Department of Pediatric Surgery Emma Children's HospitalAmsterdam UMCUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdam Reproduction and DevelopmentAmsterdam 1105 AZNetherlands Department of Surgery University of Colombo and Department of Paediatric SurgeryLady Ridgeway Hospital for ChildrenColombo 00800Sri Lanka Department of Pediatrics Emma Children's HospitalAmsterdam UMCUniversity of AmsterdamEmma Neuroscience GroupAmsterdam Reproduction and DevelopmentAmsterdam 1105 AZNetherlands Department of Pediatrics Lady Ridgeway Hospital for ChildrenColombo 00800Sri Lanka

BACKGROUND Patients with Hirschsprung disease(HD)are at risk of persistent constipation,fecal incontinence or recurrent enterocolitis after surgical treatment,which in turn may impact physical and psychosocial *** health-related quality of life(HRQoL)and disease-specific health-related quality of life are relevant outcome measures to assess the impact of HD on the QoL of these *** To summarize all available evidence on HRQoL of patients with HD after surgery and the impact of possible moderating *** Pubmed,Web of Sciences,Psyc Info and Embase were searched with search terms related to’Hirschsprung disease’,’Pediatrics’and’Quality of life’.Mean and standard deviation of generic HRQoL overall and domain scores were extracted from each study,as well as data describing potential factors associated with *** effect models were used for meta-analytic aggregation of generic HRQoL ***-regression was used to assess the relationship between patient and clinical characteristics and generic ***-specific HRQoL outcomes of patients with HD were systematically *** Seventeen articles were included in the systematic review(n=1137 patients)and 15 in the quantitative meta-analysis(n=1024 patients).Four studies reported disease-specific ***’s age ranged between 0 and 21 ***-analytic aggregation showed a nonsignificantly impaired generic HRQoL(d=-0.168[95%CI:-0.481;0.145],P=0.293,I^(2)=94.9)in patients with HD compared to healthy ***(d=-0.042[95%CI:-0.419;0.335],P=0.829,I^(2)=95.1),psychosocial(d=-0.159[95%CI:-0.458;0.141],P=0.299,I^(2)=93.6)and social HRQoL(d=-0.092[95%CI:-0.642;0.457],P=0.742,I^(2)=92.3)were also not significantly lower compared to healthy *** was no relation between health-related outcomes and the sex of the patients and whether generic HRQoL was measured by parental proxy or ***-specific complaints of patients with HD impaired physical

关键词： Hirschsprung disease Health-related quality of life Meta-analysis Systematic review Pediatrics

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Should primary anastomosis be considered more?A retrospective analysis of anastomotic complications in young children

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World Journal of Pediatric Surgery 2023年第4期6卷 224-230页

作者： Laurens D.Eeftinck Schattenkerk Gijsbert D.Musters Wouter J.de Jonge L.W.(Ernest)van Heurn joep PM Derikx Department of Pediatric Surgery Emma Children’s HospitalAmsterdam UMCUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdamThe Netherlands Tytgat Institute for Liver and Intestinal Research Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands Department of General VisceralThoracic and Vascular SurgeryUniversity Hospital BonnBonnGermany

Objective Little is known about intestinal anastomotic leakage and stenosis in young children(≤3 years of age).The purpose of this study is to answer the following questions:(1)what is the incidence of anastomotic stenosis and leakage in infants?(2)which surgical diseases entail the highest incidence of anastomotic stenosis and leakage?(3)what are perioperative factors associated with anastomotic stenosis and leakage?Methods Patients who underwent an intestinal anastomosis during primary abdominal surgery in our tertiary referral centre between 1998 and 2018 were retrospectively *** general incidence and incidence per disease of anastomotic complications were *** risk factors(location and type of anastomosis,mode of suturing,and suture resorption time)were evaluated by multivariate Cox regression for anastomotic *** and American Society of Anaesthesiology(ASA)score of≥Ⅲwere evaluated byχ^(2)test for anastomotic *** In total,477 patients underwent an *** most prominent diseases are intestinal atresia(30%),Hirschsprung’s disease(29%),and necrotizing enterocolitis(14%).Anastomotic stenosis developed in 7%(34/468)of the patients with highest occurrence in necrotizing enterocolitis(14%,9/65).Colonic anastomosis was associated with an increased risk of anastomotic stenosis(hazard ratio(HR)=3.6,95%CI 1.8 to 7.5).No technical features(type of anastomosis,suture resorption time and mode of suturing)were significantly associated with stenosis *** leakage developed in 5%(22/477)of the patients,with the highest occurrence in patients with intestinal atresia(6%,9/143).An ASA score of≥Ⅲ(p=0.03)and male gender(p=0.03)were significantly associated with anastomotic *** Both anastomotic stenosis and leakage are major surgical *** more patient specific factors can result in better treatment selection,which should not solely be based on the type of disease.

关键词： anastomosis anastomotic complications

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Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.G.van Gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos Ronald Cornet Bruna dos Santos Vieira Nawel Lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart Esther van Enckevort Chris T.Evelo Alasdair J.G.Gray Marc Hanauer Kristina Hettne joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon L.Willighagen Mascha Jansen Barend Mons Marco Roos Annika Jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The Leiden Academic Center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

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Governance interactions of spatial data infrastructures: an agent-based modelling approach

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International Journal of Digital Earth 2021年第6期14卷 696-713页

作者： Jaap-Willem Sjoukema Jalal Samia Arnold K.Bregt joep Crompvoets Laboratory of Geo-Information Science and Remote Sensing Wageningen University&ResearchWageningenThe Netherlands KU Leuven Public Governance Institute LeuvenBelgium Department of Geography and Urban Planning University of MazandaranBabolsarIran

In order to facilitate and coordinate spatial data sharing and exchange,many organisations have developed spatial data infrastructures(SDIs).SDI governance plays a pivotal role in the development and evolution of an SDI,but as SDIs are complex adaptive systems,governing is a *** research therefore proposes a complexity perspective to SDI governance by exploring the use of agent-based modelling to simulate and examine SDI governance *** this agent-based simulation,we examine interactions between SDI stakeholders,data availability and the effects of different governance styles(hierarchical,network and laissez-faire governance)and budget *** simulation shows that it is possible to mimic SDI governance dynamics through agent-based *** running different scenarios,it appears that a network approach is more successful compared to a hierarchical or laissez-faire *** validation shows that overall the results of the simulation are credible and insightful,although improvements can be made to make the model more *** agent-based modelling,SDI governance becomes more tangible and visible,which facilitates discussion and ***-based modelling therefore appears to be a helpful new approach in a better understanding of the complexities and dynamics of SDI governance.

关键词： Governance spatial data infrastructure(SDI) agentbased modelling funding models complex adaptive systems

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Analysing spatial data performance in inter-organisational processes

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International Journal of Digital Earth 2015年第5期8卷 403-420页

作者： Ezra Dessers Glenn Vancauwenberghe Danny Vandenbroucke joep Crompvoets Geert Van Hootegem Centre for Sociological Research KU LeuvenLeuvenBelgium Spatial Applications Division Leuven KU LeuvenLeuvenBelgium Public Governance Institute KU LeuvenLeuvenBelgium

The use of spatial data has become a key factor in numerous public sector ***,recent evidence suggests that the seemingly obvious benefits of spatial data use and sharing often stay beyond *** paper examines whether the performance of spatial data in inter-organisational processes depends on the structural characteristics of the process *** structure here refers to the way in which tasks are divided and coordinated between the organisations in a process chain,and to the allocation of the spatial data handling tasks in that *** data performance describes the level of access,use and sharing of spatial data in the *** paper presents the results of a comparative case study of interorganisational public sector processes in the fields of urban planning,flood management,population registration,environmental permit delivery and road safety *** findings suggest that spatial data performance in inter-organisational processes depends on the interplay between the structural characteristics of the *** processes with embedded activities that are related to spatial data are apparently linked to a high level of spatial data performance,while fragmented processes without centralised coordination,or processes in which the spatial datarelated activities are separated from the actual process,seem to relate to lower levels of spatial data performance.

关键词： spatial data performance public sector coordination task division

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Human small intestine is capable of restoring barrier function after short ischemic periods

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World Journal of Gastroenterology 2017年第48期23卷 8452-8464页

作者： Dirk HSM Schellekens Inca HR Hundscheid Claire AJI Leenarts joep Grootjans Kaatje Lenaerts Wim A Buurman Cornelis HC Dejong joep PM Derikx Department of Surgery Maastricht University Medical Center NUTRIM School for Nutrition and Translational Research in MetabolismMaastricht University Department of Gastroenterology Academic Medical Center MHeNs School of Mental Health and Neuroscience Maastricht University Medical Center Pediatric Surgical Center of Amsterdam Emma Children’s Hospital Academic Medical Center and VU University Medical Center

AIM To assess intestinal barrier function during human intestinal ischemia and reperfusion(IR).METHODS In a human experimental model,6 cm of jejunum was selectively exposed to 30 min of ischemia(I) followed by 30 and 120 min of reperfusion(R). A sham procedure was also performed. Blood and tissue was sampled at all-time points. Functional barrier function was assessed using dual-sugar absorption tests with lactulose(L) and rhamnose(R). Plasma concentrations of citrulline,an amino acid described as marker for enterocyte function were measured as marker of metabolic enterocytes restoration. Damage to the epithelial lining was assessed by immunohistochemistry for tight junctions( TJs),by plasma marker for enterocytes damage(I-FABP) and analyzed by electron microscopy(EM) using lanthanum nitrate as an electrondense *** Plasma L/R ratio's were significantly increased after 30 min of ischemia(30 I) followed by 30 min of reperfusion(30 R) compared to control(0.75 ± 0.10 vs 0.20 ± 0.09,P < 0.05). At 120 min of reperfusion(120 R),ratio's normalized(0.17 ± 0.06) and were not significantly different from control. Plasma levels of I-FABP correlated with plasma L/R ratios measured at the same time points(correlation: 0.467,P < 0.01). TJs staining shows distortion of staining at 30 I. An intact lining of TJs was again observed at 30 I120 R. Electron microscopy analysis revealed disrupted TJs after 30 I with paracellular leakage of lanthanum nitrate,which restored after 30 I120 R. Furthermore,citrulline concentrations closely paralleled the histological perturbations during intestinal *** This study directly correlates histological data with intestinal permeability tests,revealing that the human gut has the ability of to withstand short episodes of ischemia,with morphological and functional recovery of the intestinal barrier within 120 min of reperfusion.

关键词： Intestinal ischemia-reperfusion Intestinal barrier function Intestinal permeability Human Dualsugar absorption test Tight Junctions Citrulline

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Non-invasive markers of gut wall integrity in health and disease

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World Journal of Gastroenterology 2010年第42期16卷 5272-5279页

作者： joep PM Derikx Misha DP Luyer Erik Heineman Wim A Buurman Department of Surgery University Hospital Maastricht & Nutrition and Toxicology Research InstituteMaastricht UniversityMaastricht6200 MDThe Netherlands Department of Surgery Orbis Medical Centre Sittard6162 BGThe Netherlands Department of Surgery University Medical Centre Groningen9713 GZThe Netherlands

The intestinal mucosa is responsible for the absorption of nutrients from the lumen and for the separation of the potentially toxic luminal content(external environment) from the host(internal environment).Disruption of this delicate balance at the mucosal interface is the basis for numerous(intestinal) *** animal studies have shown that gut wall integrity loss is involved in the development of various inflammatory syndromes,including post-operative or post-traumatic systemic inflammatory response syndrome,sepsis,and multiple organ *** of gut wall integrity in clinical practice is still a challenge,as it is difficult to evaluate the condition of the gut non-invasively with currently available diagnostic ***,non-invasive,rapid diagnostic means to assess intestinal condition are needed to evaluate the effects of treatment of intestinal *** review provides a survey of non-invasive tests and newly identified markers that can be used to assess gut wall integrity.

关键词： Intestinal damage Markers Human Gut wall integrity

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A History of Fischer-Tropsch Wax Upgrading at BP-from Catalyst Screening Studies to Full Scale Demonstration in Alaska

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Journal of Natural Gas Chemistry 2006年第1期15卷 1-10页

作者： John P. Collins joep J. H. M. Font Freide Barry Nay BP Exploration America Inc. BP Exploration Operating Company

Conversion of Fischer-Tropsch wax into high quality synthetic crude or finished transportation fuels such as premium diesel has been studied over the past 15 years within BP. Catalyst screening and selection was carried out in dedicated micro-reactors and pilot plants, whose designs are critical to the performance selection. Variation in catalyst composition and defining the gas to oil feed ratios with the operating temperature are a few of the parameters studied. Product selection and maximizing diesel yield combined with stability （catalyst life） were the ultimate drivers. The selected catalyst was then tested under commercial conditions in a dedicated 300 barrel per day demonstration plant. The products were also tested in engines to assess their combustion characteristics.

关键词： Fischer-Tropsch wax upgrading hydrocracking synthetic crude diesel naphtha engine emission

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Botulinum toxin injections after surgery for Hirschsprung disease:Systematic review and meta-analysis

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World Journal of Gastroenterology 2019年第25期25卷 3268-3280页

作者： Danielle Roorda Zarah AM Abeln Jaap Oosterlaan Lodewijk WE van Heurn joep PM Derikx Department of Pediatric Surgery Emma Children’s HospitalAmsterdam UMCUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdam Reproduction and DevelopmentAmsterdam 1105 AZNetherlands Department of Pediatrics Emma Children’s HospitalAmsterdam UMCUniversity of AmsterdamEmma Neuroscience GroupAmsterdam Reproduction and DevelopmentAmsterdam 1105 AZNetherlands Department of Pediatric Surgery Emma Children’s HospitalAmsterdam UMCUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdam Gastroenterology and MetabolismAmsterdam 1105 AZNetherlands

BACKGROUND A large proportion of patients with Hirschsprung disease experience persistent obstructive symptoms after corrective *** obstructive symptoms may result in faecal stasis that can develop into Hirschsprung-associated enterocolitis,a potential life-threatening *** treatment to improve faecal passage is internal anal sphincter relaxation using botulinum toxin *** To give an overview of all empirical evidence on the effectiveness of botulinum toxin injections in patients with Hirschsprung *** A systematic review and meta-analysis was done by searching PubMed,EMBASE and the Cochrane Library,using entry terms related to:(1)Hirschsprung disease;and(2)Botulinum toxin injections.14 studies representing 278 patients met eligibility *** that were extracted were proportion of patients with improvement of obstructive symptoms or less enterocolitis after injection,proportion of patients with adverse effects and data on type botulinum toxin,mean dose,average age at first injection and patients with associated ***-effects meta-analysis was used to aggregate effects and random-effects meta-regression was used to test for possible confounding *** Botulinum toxin injections are effective in treating obstructive symptoms in on average 66%of patients[event rate(ER)=0.66,P=0.004,I2=49.5,n=278 patients].Type of botulinum toxin,average dose,average age at first injections and proportion of patients with associated syndromes were not predictive for this *** 7 duration of improvement after one botulinum toxin injections was 6.4 mo and patients needed on average 2.6 *** was a significant higher response rate within one month after botulinum toxin injections compared to more than one month after Botulinum toxin injections(ER=0.79,vs ER=0.46,Q=19.37,P<0.001).Botulinum toxin injections were not effective in treating enterocolitis(ER 0.58,P=0.65,I2=71.0,n=52 patients).There wer

关键词： Hirschsprung disease Botulinum toxin Internal anal sphincter Obstructive symptoms Enterocolitis Adverse effects

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