Non-invasive markers of gut wall integrity in health and disease

作     者：Joep PM Derikx Misha DP Luyer Erik Heineman Wim A Buurman 

作者机构：Department of SurgeryUniversity Hospital Maastricht & Nutrition and Toxicology Research InstituteMaastricht UniversityMaastricht6200 MDThe Netherlands Department of SurgeryOrbis Medical Centre Sittard6162 BGThe Netherlands Department of SurgeryUniversity Medical Centre Groningen9713 GZThe Netherlands 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第42期

页      面：5272-5279页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Grants from AGIKO-stipendium 920-03-271(to Luyer MDP) 920-03-438(to Derikx JPM)from the Nether-lands Organisation for Health Research and Development 

主　　题：Intestinal damage Markers Human Gut wall integrity 

摘      要：The intestinal mucosa is responsible for the absorption of nutrients from the lumen and for the separation of the potentially toxic luminal content(external environment) from the host(internal environment).Disruption of this delicate balance at the mucosal interface is the basis for numerous(intestinal) *** animal studies have shown that gut wall integrity loss is involved in the development of various inflammatory syndromes,including post-operative or post-traumatic systemic inflammatory response syndrome,sepsis,and multiple organ *** of gut wall integrity in clinical practice is still a challenge,as it is difficult to evaluate the condition of the gut non-invasively with currently available diagnostic ***,non-invasive,rapid diagnostic means to assess intestinal condition are needed to evaluate the effects of treatment of intestinal *** review provides a survey of non-invasive tests and newly identified markers that can be used to assess gut wall integrity.