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A-kinase anchoring protein-mediated compartmentalization of pro-survival signaling in the retina

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Neural Regeneration Research 2025年第2期20卷 479-480页

作者： joanna Mackiewicz Tomasz Boczek Department of Molecular Neurochemistry Medical University of LodzLodzPoland

The retina plays a fundamental role in the process of vision,serving as the primary interface between external visual stimuli and the central nervous *** the retina is exposed to a variety of environmental stresses and deleterious insults,it is susceptible to a spectrum of pathological conditions that can detrimentally affect *** often leads to irreversible vision loss due to the injury of specific cell *** instance,inherited retinal degeneration and age-related macular degeneration can lead to the death of photoreceptors,while conditions like glaucoma and optic nerve injury can result in the loss of ganglion *** precise pathological mechanisms driving retinal degeneration remain largely elusive,although research utilizing mouse models suggests that disruptions in intracellular signal transduction pathways may play a pivotal *** pathways within the retina orchestrate various aspects of retinal physiology,including phototransduction,synaptic transmission,and neuronal survival.

关键词： degeneration utilizing irreversible

Response of soil catalase activity to chromium contamination

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Journal of Environmental Sciences 2009年第8期21卷 1142-1147页

作者： Zofia Stepniewska Agnieszka Wolińska joanna Ziomek Department of Biochemistry and Environmental Chemistry The John Paul II Catholic University of Lublin

The impact of chromium（Ⅲ） and （Ⅵ） forms on soil catalase activity was presented. The Orthic Podzol, Haplic Phaeozem and Mollic Gleysol from different depths were used in the experiment. The soil samples were amended with solution of Cr（Ⅲ） using CrCl3, and with Cr（Ⅵ） using K2Cr2O7 in the concentration range from 0 to 20 mg/kg, whereas the samples without the addition of chromium served as control. Catalase activity was assayed by one of the commonly used spectrophotometric methods. As it was demonstrated in the experiment, both Cr（Ⅲ） and Cr（Ⅵ） have an ability to reduce soil catalase activity. A chromium dosage of 20 mg/kg caused the inhibition of catalase activity and the corresponding contamination levels ranged from 75% to 92% for Cr（Ⅲ） and 68% to 76% for Cr（Ⅵ）, with relation to the control. Catalase activity reached maximum in the soil material from surface layers （0-25 cm）, typically characterized by the highest content of organic matter creating favorable conditions for microorganisms.

关键词： chromium catalase enzymatic activity inhibition

Nitrogen removal from wastewater and bacterial diversity in activated sludge at different COD/N ratios and dissolved oxygen concentrations

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Journal of Environmental Sciences 2012年第6期24卷 990-998页

作者： Magdalena Zielińska Katarzyna Bernat Agnieszka Cydzik-Kwiatkowska joanna Sobolewska Irena Wojnowska-Baryla Department of Environmental Biotechnology University of Warmia and Mazury in OlsztynS oneczna St.45G10-709 OlsztynPoland

The impact of the organic carbon to nitrogen ratio （chemical oxygen demand （COD）/N） in wastewater and dissolved oxygen （DO） concentration on carbon and nitrogen removal efficiency, and total bacteria and ammonia-oxidizing bacteria （AOB） communities in activated sludge in constantly aerated sequencing batch reactors （SBRs） was determined. At DO of 0.5 and 1.5 mg O2/L during the aeration phase, the efficiency of ammonia oxidation exceeded 90%, with nitrates as the main product. Nitrification and denitrification achieved under the same operating conditions suggested the simultaneous course of these processes. The most effective nitrogen elimination （above 50%） was obtained at the COD/N ratio of 6.8 and DO of 0.5 mg O2/L. Total bacterial diversity was similar in all experimental series, however, for both COD/N ratios of 6.8 and 0.7, higher values were observed at DO of 0.5 mg O2/L. The diversity and abundance of AOB were higher in the reactors with the COD/N ratio of 0.7 in comparison with the reactors with the COD/N of 6.8. For both COD/N ratios applied, the AOB population was not affected by oxygen concentration. Amplicons with sequences indicating membership of the genus Nitrosospira were the determinants of variable technological conditions.

关键词： nitrogen removal activated sludge COD/N ratio oxygen concentration ammonia-oxidizing bacteria microbial diversity

Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota-Key players in the pathogenesis of celiac disease

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World Journal of Gastroenterology 2017年第42期23卷 7505-7518页

作者： Bozena Cukrowska Agnieszka Sowińska joanna Beata Bierla Elzbieta Czarnowska Anna Rybak Urszula Grzybowska-Chlebowczyk Department of Pathology The Children's Memorial Health Institute Department of Gastroenterology Division of Neurogastroenterology and MotilityGreat Ormond Street Hospital Department of Pediatrics School of MedicineMedical University of Silesia

Celiac disease(CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred by the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase 2. As a result, they strongly bind to human leucocyte antigens(HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. This induces an inflammatory response, which results in small bowel enteropathy. Although gluten is the main external trigger activating both innate and adaptive(specific) immunity, its presence in the intestinal lumen does not fully explain CD pathogenesis. It has been hypothesized that an early disruption of the gut barrier in genetically susceptible individuals, which would result in an increased intestinal permeability, could precede the onset of gluten-induced immune events. The intestinal barrier is a complex functional structure, whose functioning is dependent on intestinal microbiotahomeostasis, epithelial layer integrity, and the gutassociated lymphoid tissue with its intraepithelial lymphocytes(IELs). The aim of this paper was to review the current literature and summarize the role of the gut microbiota, epithelial cells and their intercellular junctions, and IELs in CD development.

关键词： Celiac disease Intestinal microbiota Epithelium Intraepithelial lymphocytes Intestinal barrier

Community structure of Lumbricidae in beech woodland of the Bieszczady National Park, Southeast Poland

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Pedosphere 2021年第3期31卷 391-397页

作者： Anna MAZUR-PĄCZKA Grzegorz PĄCZKA joanna KOSTECKA Kevin R.BUTT Marcin JAROMIN Mariola GARCZYŃska Agnieszka PODOLAK University of Rzeszów Faculty of Biology and AgricultureDepartment of Natural Theories of Agriculture and Environmental Education1a Cwiklinskiej St.Rzeszów 35-959Poland University of Central Lancashire Forensic and Applied SciencesPreston PR12HEUK Rzeszów University of Technology Faculty of ChemistryDepartment of Biotechnology and Bioinformatics6 Powstancow Warszawy AvenueRzeszów 35-959Poland

As ecosystem engineers,earthworms play a key role in the soil ***,due to increasing anthropogenic pressure,soil organisms,including earthworms,are being threatened by habitat *** this study,we undertook a qualitative and quantitative investigation of earthworms of the family Lumbricidae in four types of Carpathian beech woodland(Fagetum carpaticum),characterized by their understory vegetation(I,*** drymejae;Ⅱ,***;Ⅲ,***;and IV,***),in the Bieszczady National Park(Eastern Carpathians,Southeast Poland).At each investigated site,soil monoliths(25 cm×25 cm×25 cm)were examined by hand *** were expelled from deep soil layers using a weak formalin solution(0.4%).Depending on the phytocoenosis,7 species of Lumbricidae were identified at each of the sites I,Ⅱ,andⅢand 10 at site *** IV(***)differed significantly(P<0.05)from the other three sites with respect to earthworm biomass(59.71±39.53 g m^(-2))and the Shannon-Wiener diversity index(0.52±0.12).Although present three decades ago,the deep-burrowing species Octodrilus transpadanus and the litter-dwelling species Dendrobaena octaedra were not found at site IV in the present *** suspect that these two species may have been displaced by the invasive Lumbricus terrestris,which was not found at the same site in the *** observations warrant further investigation to verify the predicted effects of an invasive earthworm,including the potential effects on soils and other fauna and flora,which have been documented in numerous countries.

关键词： beech forest earthworm invasive species Shannon-Wiener diversity index species diversity species dominance

Synchronous and metachronous neoplasms in gastric cancer patients:A 23-year study

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World Journal of Gastroenterology 2014年第23期20卷 7480-7487页

作者： Magorzata Lawniczak Alicja Gawin Halina Jaroszewicz-Heigelmann Wiesawa Rogoza-Mateja joanna Raszeja-Wyszomirska Andrzej Biaek Katarzyna Karpińska-Kaczmarczyk Teresa Starzyńska Department of Gastroenterology Pomeranian Medical University71-252 SzczecinPoland Liver Unit Pomeranian Medical University70-111 SzczecinPoland Department of Pathology Pomeranian Medical UniversityUnii Lubelskiej 171-252 SzczecinPoland

AIM: To determine the prevalence and characteristics of additional primary malignancies in gastric cancer (GC) patients.

关键词： Gastric cancer Multiple primary cancers Synchronous Metachronous Blood groups

Bioactive injectable composites based on insulin-functionalized silica particles reinforced polymeric hydrogels for potential applications in bone tissue engineering

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Journal of Materials Science & Technology 2022年第10期105卷 153-163页

作者： Aleksandra Krajcer joanna Klara Wojciech Horak joanna Lewandowska-Łańcucka Faculty of Chemistry Jagiellonian UniversityGronostajowa 2Kraków 30-387Poland AGH University of Science and Technology Faculty of Mechanical Engineering and RoboticsDepartment of Machine Design and TechnologyAl.Mickiewicza 30Kraków 30-059Poland

Novel bioactive injectable composites based on biopolymeric hydrogels reinforced with insulin-functionalized silica particles were *** insulin(INS)was immobilized on the surface of amine-modifed silica particles employing covalent attachment by EDC/NHS chemistry and via electrostatic *** resulting formulations were examined for the morphology(SEM),chemical composition(FTIR,XPS)as well as protein *** facilitate the injectability and support the bone regeneration,developed particles were dispersed in biopolymeric sol composed of collagen,chitosan and lysinemodifed hyaluronic acid and crosslinked with *** means of rheological study,the sol-gel in situ transition of obtained systems was *** was found in vitro study that MG-63 cells cultured on the developed composites exhibit signifcantly higher alkaline phosphatase(ALP)activity,compared to the pristine ***,the biomineralization ability in the simulated body fluid(SBF)model was also *** fndings suggest that proposed herein novel hydrogel-based composites might be the promising formulation for regeneration of bone defects,especially as a less-cost effective support/alternative for BMP-2 systems.

关键词： Injectable composites Biopolymers Insulin-functionalized silica particles Bone tissue engineering

Representative elementary volume analysis of polydisperse granular packings using discrete element method

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Particuology 2016年第4期14卷 88-94页

作者： joanna Wiacek Marek Molenda Institute of Agrophysics Polish Academy of Sciences Doswiadczalna 4 20-290 l.ublin Poland

The representative elementary volume （REV） for three-dimensional polydisperse granular packings was determined using discrete element method simulations. Granular mixtures of various sizes and particle size distributions were poured into a cuboid chamber and subjected to uniaxial compression, Findings showed that the minimum REV for porosity was larger compared with the REV for parameters such as coordination number, effective elastic modulus, and pressure ratio. The minimum REV for porosity and other parameters was found to equal 15,10, and 5 times the average grain diameter, respectively. A study of the influence of sample size on energy dissipation in random packing of spheres has also confirmed that the REV size is about 15 times the average grain diameter. The heterogeneity of systems was found to have no effect on the REV for the parameters of interest for the narrow range of coefficient of uniformity analyzed in this paper. As the REV approach is commonly applied in both experimental and numerical studies, determining minimum REV size for polydisperse granular packings remains a crucial issue.

关键词： Representative elementary volume Polydisperse packing Discrete element method Sample size effect

Effect of particle polydispersity on micromechanical properties and energy dissipation in granular mixtures

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Particuology 2014年第5期12卷 91-99页

作者： joanna Wiacek Marek Molenda Institute of Agrophysics Polish Academy of SciencesDoswiadczalna 420-290 Lublin 27Poland

A series of numerical tests was conducted to study the micromechanical properties and energy dissipation in polydisperse assemblies of spherical particles subjected to uniaxial compression. In general, distributed particle size assemblies with standard deviations ranging from 0% to 80% of the particle mean diameter were examined. The microscale analyses included the trace of the fabric tensor, magnitude and orien- tation of the contact forces, trace of stress, number of contacts and degree of mobilization of friction in contacts between particles. In polydisperse samples, the average coordination numbers were lower than in monodisperse assemblies, and the mobilization of friction was higher than in monodisperse assemblies due to the non-uniform spatial rearrangement of spheres in the samples and the smaller displacements of the particles. The effect of particle size heterogeneity on both the energy density and energy dissipation in systems was also investigated.

关键词： Polydisperse packing Discrete element method Micromechanics Energy dissipation