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团体认知行为治疗对广泛性焦虑障碍的临床疗效及其对患者执行功能的影响

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四川精神卫生 2024年第1期37卷 21-25页

作者：吕龙琴穆敬平廖恒刘丽珠王熙十堰市太和医院湖北医药学院附属医院湖北十堰442000 十堰市中西医结合医院湖北十堰442010

背景广泛性焦虑障碍(GAD)患者常存在执行功能损害。团体认知行为治疗(CBT)有助于改善GAD患者的负性情绪,但对执行功能的改善效果尚不明确。目的探讨团体CBT对GAD患者焦虑症状和执行功能的影响,以期为GAD患者的康复治疗提供参考。方法连... 详细信息

背景广泛性焦虑障碍(GAD)患者常存在执行功能损害。团体认知行为治疗(CBT)有助于改善GAD患者的负性情绪,但对执行功能的改善效果尚不明确。目的探讨团体CBT对GAD患者焦虑症状和执行功能的影响,以期为GAD患者的康复治疗提供参考。方法连续选取2021年3月—2022年8月在十堰市太和医院睡眠心身医学中心住院的、符合《精神障碍诊断与统计手册(第5版)》(DSM-5)中GAD诊断标准的80例患者为研究对象,采用随机数字表法分为研究组(n=40)和对照组(n=40)。两组均接受药物治疗及疾病健康教育,研究组在此基础上接受为期6周、每周1次、每次60~90 min的团体CBT。分别于治疗前和治疗6周后使用汉密尔顿焦虑量表(HAMA)评定焦虑症状,使用额叶功能评定量表(FAB)评定执行功能。结果重复测量方差分析结果显示,两组HAMA评分的时间效应有统计学意义(F=1870.320,P0.05)。两组FAB评分的时间效应、组间效应以及时间与组间的交互效应均有统计学意义(F=311.190、4.399、7.021,P<0.05或0.01)。进一步分析结果显示,治疗后,两组FAB评分均高于治疗前(t=200.569、115.401,P均<0.01),且研究组FBA评分高于对照组(t=-3.211,P<0.01)。结论团体CBT联合药物治疗可能有助于降低GAD患者焦虑水平,改善其执行功能。

关键词：团体认知行为治疗广泛性焦虑障碍执行功能

“补肾安神”针刺法治疗围绝经期失眠fNIRS初步研究

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辽宁中医药大学学报 2024年第9期26卷 91-95页

作者：代轶楠穆敬平郑苏王熙廖恒彭力十堰市太和医院湖北医药学院附属医院湖北十堰442000 湖北中医药大学湖北武汉430061 十堰市中西医结合医院湖北十堰442000 湖北中医药大学附属十堰市中医医院湖北十堰442000

目的探索补肾安神针刺法对围绝经期失眠(perimenopausal insomnia,PMI)患者前额叶功能活动的调节作用。方法将40例PMI患者随机分为两组,针刺组和药物组,针刺组穴取百会、照海、申脉、肾俞、三阴交、安眠、太溪,每日1次,每次30 min,治疗2... 详细信息

目的探索补肾安神针刺法对围绝经期失眠(perimenopausal insomnia,PMI)患者前额叶功能活动的调节作用。方法将40例PMI患者随机分为两组,针刺组和药物组,针刺组穴取百会、照海、申脉、肾俞、三阴交、安眠、太溪,每日1次,每次30 min,治疗2周;药物组口服佐匹克隆片,每次7.5 mg,每晚1次,治疗2周。同时招募与之相匹配的健康人20名设为健康组,采集患者治疗前后及健康人基线的匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)评分和功能性近红外光谱技术(functional near-infraredspectroscopy,fNIRS)数据,分析针刺对PMI患者前额叶功能活动的影响。结果治疗前,PMI患者额叶的前运动皮层区(BA6)的氧合血红蛋白(HbO)浓度明显高于健康组(P<0.05);背外侧前额叶区(BA9)、双侧额极区(BA10)的HbO浓度明显低于健康组(P<0.05)。治疗后,两组PMI患者额叶的前运动皮层区(BA6)的HbO浓度较前明显降低(P<0.05);双侧前额叶额极区(BA10)、左侧背外侧前额叶区(BA9)、腹外侧前额叶区(BA44、BA45)的HbO浓度明显升高(P<0.05)。治疗后组间比较,针刺组在左侧背外侧前额叶区(BA9)激活显著(P<0.05)。结论该研究为围绝经期失眠的过度觉醒假说提供了影像学依据,证明了前额叶在睡眠觉醒过程的重要作用,进一步揭示了补肾安神针刺治疗围绝经期失眠的脑功能机制,为治疗靶点的选择提供了新思路。

关键词：针灸围绝经期失眠近红外脑功能成像氧合血红蛋白机制

分期针刺联合步行训练对脑梗死后下肢运动功能的影响

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上海针灸杂志 2024年第6期43卷 627-633页

作者：郑苏穆敬平代轶楠谢谨金明滢李明芬十堰市太和医院(湖北医药学院附属医院) 十堰442000 湖北中医药大学武汉430061

目的观察分期针刺联合步行训练对脑梗死后下肢运动功能以及血清鸢尾素(irisin)和小而密低密度脂蛋白(small dense low density lipoprotein,sdLDL)含量的影响。方法采用随机数字表法将90例脑梗死患者分为A组、B组和C组,每组30例。A组予... 详细信息

目的观察分期针刺联合步行训练对脑梗死后下肢运动功能以及血清鸢尾素(irisin)和小而密低密度脂蛋白(small dense low density lipoprotein,sdLDL)含量的影响。方法采用随机数字表法将90例脑梗死患者分为A组、B组和C组,每组30例。A组予分期针刺治疗,B组予步行训练,C组予分期针刺联合步行训练治疗。于治疗前后分别采用Fugl-Meyer运动功能评定量表(Fugl-Meyer assessment,FMA)、Berg平衡量表(Berg balance scale,BBS)和改良Barthel指数(modified Bobath index,MBI)评定患者下肢运动功能、平衡协调能力和日常生活活动能力。使用数字化跑台步态分析系统(walkerview)采集时空参数、运动学参数和对称性参数,比较两组治疗前后的变化。检测并比较两组治疗前后血清irisin和sdLDL含量。结果治疗后,3组时空参数、运动学参数、对称性参数、FMA评分、MBI评分、BBS评分以及血清irisin和sdLDL含量均较治疗前改善(P<0.05),且C组上述指标均显著优于A组和B组(P<0.05)。结论分期针刺联合步行训练能改善脑梗死患者的下肢运动能力和日常生活活动能力,提高平衡协调能力,改善步态,降低sdLDL含量,促进irisin生成,联合治疗的疗效优于单一治疗。

关键词：针刺疗法康复训练脑梗死中风后遗症下肢功能障碍步态血脂

Effects of moxibustion on heat-shock protein 70 expression in the spinal cord and colonic mucosa in a rat model of ulcerative colitis

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Neural Regeneration Research 2010年第22期5卷 1717-1722页

作者： Li Qi Yin Shi Luyi Wu jingping mu Linying Tan Xiaopeng Ma Huirong Liu Shifen Xu Huangan Wu Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Key Laboratory of Acupuncture-moxibustion and Immunological Effects Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030 China Department of Acupuncture Taihe Hospital Affiliated to Yunyang Medical College Shiyan 442000 Hubei Province China

Pathological changes in the colon are closely associated with the spinal cord, and innervation of spinal cord can regulate cellular functions. Our previous studies verified that moxibustion protects and restores the colonic mucosa, but the mechanisms of action remain unknown. The present study observed the effects of moxibustion and salicylazosulfapyridine on expression of heat-shock protein 70 （HSP70） and its mRNA in the spinal cord and colonic mucosa of ulcerative colitis rats. Results demonstrated that moxibustion and salicylazosulfapyridine increased HSP70 mRNA expression in the spinal cord and colonic mucosa of ulcerative colitis rats. The decreased transcriptional activity of HSP70 in the spinal cord and colonic mucosa might participate in damage to the colonic mucosa in ulcerative colitis rats. Moxibustion exerted protective effects on colonic mucosa by up-regulating HSP70 transcriptional activity in the spinal cord and colonic mucosa.

关键词： heat-shock protein 70 moxibustion spinal cord colonic mucosa ulcerative colitis

Relationship between Serum Uric Acid Level and Clinical Symptom Improvement in Patients with Bipolar Disorder Type I in Their Manic Episode

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Medicinal Plant 2021年第6期12卷 56-57,59页

作者： Dongyu XIA Xiong CHEN Xi WANG jingping mu Sleep and Psychosomatic Health Medical Center Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China Mental Health Center Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China

[Objectives]To evaluate whether the level of serum uric acid in patients with bipolar disorder type I in their manic episode was different from that in healthy subjects,and to evaluate whether the level of serum uric acid is related to the severity of manic episode and the improvement of clinical symptoms.[Methods]A total of 70 patients with bipolar disorder type I in their manic episode were selected,their serum uric acid levels were measured at the beginning of the enrollment and at the end of the first,second and third week,and the clinical symptoms were evaluated with Young Mania Rating Scale(YMRS).65 healthy subjects were enrolled,and their serum uric acid levels were measured only at the beginning of the enrollment.[Results]The level of serum uric acid in patients with bipolar disorder type I in their manic episode was higher than that in healthy adults(t=8.153,p=0.039).At the end of the third week,the YMRS score and uric acid level of the patients were lower than those of the patients at the beginning of the enrollment(t=17.107,p=0.000;t=35.864,p=0.000).[Conclusions]The level of serum uric acid in patients with bipolar disorder type I in their manic episode was higher than that in healthy subjects,and the decrease of serum uric acid level may be related to the improvement of clinical symptoms.

关键词： Serum uric acid Bipolar disorder Manic episode

Experimental Study on the Repair Effect of Xianlinggubao Capsule on Osteoporotic Vertebral Compression Fracture in Rabbits

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Medicinal Plant 2023年第6期14卷 64-66,70页

作者： Lihong GUO Lizhu LIU Xi WANG Heng LIAO jingping mu Center for Sleep Psychosomatic Medicine Taihe Hospital of Shiyan City(Affiliated Hospital of Hubei University of Medicine)Shiyan 442000China

[Objectives]To observe the effect of Xianlinggubao Capsule on osteoporotic vertebral compression fracture(OVCF)in rabbits and the influence mechanism of the repair of fractures.[Methods]Female June age 30 rabbits were randomly divided into control group,model control group and Xianlinggubao *** bilateral ovariectomy,the model control group and Xianlinggubao group were injected with dexamethasone continuously for 4 weeks,and then the OVCF compound model was established by *** Xianlinggubao group was treated with Xianlinggubao at a dose of 300 mg/(kg·d)for 60 d,while the blank control group and the model control group were treated with the same amount of normal saline for 60 *** number of blood vessels and the expression of bone morphogenetic protein-2(BMP-2)were detected by immunohistochemical staining and the bone mineral density(BMD)in the callus of the third lumbar fracture area of rabbits was *** content of serum phosphorus(P),alkaline phosphatase(ALP)and total calcium(TCa)in rabbit venous blood were measured by automatic biochemical *** content of vascular endothelial growth factor(VEGF)and platelet-derived growth factor(PDGF)in rabbit venous blood were measured by ELISA kit.[Results]The number of blood vessels and the expression of BMP-2 in the callus of the third lumbar fracture area of rabbits was high in Xianlinggubao group,the content of serum P,ALP,TCa,VEGF and PDGF was obviously increased,BMD was obviously increased,the bone microstructure of the third lumbar vertebrae fracture area of rabbits was basically *** with the model control group(P<0.05),the difference was statistically significant.[Conclusions]Xianlinggubao Capsule can increase calcium and phosphorus deposition,promote the formation of blood vessels in the fracture area of OVCF in rabbits,and have a strong repair effect on OVCF in rabbits.

关键词： Rabbit Xianlinggubao Capsule Osteoporosis Compound model of vertebral compression fracture Repair

Evaluation of Clinical Efficacy of Combined Use of Acupuncture and Medicine in Treating Sleep Disorder in Patients with Anxiety Disorder

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Medicinal Plant 2021年第3期12卷 91-93页

作者： Xiangpu LIU jingping mu Xinhua YU Shun ZENG Nannan LIU Xiaohu ZHU Orthopedic Rehabilitation Ward 3 Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China Sleep Disorder Center Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China

[Objectives]To evaluate the clinical efficacy of combined acupuncture and medicine in the treatment of sleep disorders in patients with anxiety disorders.[Methods]A total of 300 anxiety patients with sleep disorders were randomly selected and divided into a research group and a control group,with 150 cases in each *** control group was administered with western medicine,and the research group was treated with acupuncture and medicine to compare their clinical treatment effects.[Results]The total effective rate of treatment in the research group was significantly higher than that in the control group;after treatment,both the PSQI and SAS scores of the two groups were significantly reduced,and the reduction degree of the research group was higher than that of the control group,the difference was statistically significant(P<0.05).[Conclusions]Combined use of acupuncture and medicine to treat sleep disorders in patients with anxiety disorders has better curative effect and fewer adverse reactions,so it has high clinical application value.

关键词： Combined use of acupuncture and medicine Anxiety disorder Sleep disorder

Tongdu Tiaoshen Acupuncture Method for Promoting Hippocampal Nerve Repair and Regeneration and Improving Learning and Memory Dysfunction in Stroke Model Rats

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Medicinal Plant 2021年第2期12卷 95-98,101页

作者： Jin XIE jingping mu Zhongmin HUANG Fangfang YANG Wanfen WANG Jimin LIU Jing TAO Lidian CHEN Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China Fujian University of Traditional Chinese Medicine Fuzhou 350000 China

[Objectives]To evaluate the effects of Tongdu Tiaoshen Acupuncture method on improving learning and memory function and hippocampal nerve regeneration and repair after stroke.[Methods]Animal models of cognitive impairment in the recovery phase of cerebral infarction in rats were prepared,and rats were randomly divided into control group,model group,donepezil group,and acupuncture *** water maze experiment was carried out to evaluate learning and memory *** staining,BrdU and DCX immunofluorescence staining were used to observe the number and morphological structure of neuronal pyramidal and granular cells in the dentate gyrus(DG)area of the hippocampus,as well as the proliferation and differentiation of neural progenitor *** method was used to detect cell apoptosis.[Results]Before intervention,the scores and ELP of the model group,donepezil group and acupuncture group were significantly higher than those of the blank group(P0.05),but it was still significantly higher than the blank group(Pmunofluorescence staining showed that there were only a few BrdU positive cells and DCX protein in the hippocampal DG area of mice in the blank group,and the positive cells in the model group were significantly increased(P<0.05);donepezil group and acupuncture group showed significant increase compared with the model group(P<0.05);compared with the blank group,the number of neurons in the hippocampal DG area of each group was significantly reduced(P<0.01),and the neuronal apoptosis index was significantly increased(P<0.01);compared with the blank group,the number of neurons in the hippocampal DG area of

关键词： Tongdu Tiaoshen Acupuncture Stroke Cognitive impairment Learning and memory function Hippocampal nerve

Present Situation of Enhanced Recovery after Surgery in Shiyan Taihe Hospital and Plan of Establishing Strategic Alliance with General Surgery Department

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Medicinal Plant 2021年第6期12卷 78-81页

作者： Yang YAO Shuwen WANG Chunming MA Chao YU Pengtao ZHOU Qing ZHAO Shuhang ZHANG jingping mu Department of Rehabilitation and Advancement Taihe Hospital Hubei University of Medicine Shiyan 442000 China Department of Otolaryngology Taihe Hospital Hubei University of Medicine Shiyan 442000 China Department of Rehabilitation Centre Taihe Hospital Hubei University of Medicine Shiyan 442000 China

The accelerated rehabilitation specialist surgery and general established strategic alliance plan of Taihe hospital is introduced in the *** background of strategic alliances established,and the political,environmental and technological factors are introduced,and stakeholder analysis and management plan,risk analysis and management plan are ***,a junior coalition problem that may occur in the process and the resulting deep thinking is analyzed,to provide the reference and enlightenment for the management of hospital and establishment of strategic alliance.

关键词： Enhanced recovery after surgery Medical services Strategic alliances Plan