Tongdu Tiaoshen Acupuncture Method for Promoting Hippocampal Nerve Repair and Regeneration and Improving Learning and Memory Dysfunction in Stroke Model Rats
作者机构：Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China Fujian University of Traditional Chinese Medicine Fuzhou 350000 China
出 版 物：《Medicinal Plant》 (药用植物：英文版)
年 卷 期：2021年第12卷第2期
页 面：95-98,101页
学科分类：1006[医学-中西医结合] 1005[医学-中医学] 100502[医学-中医临床基础] 100602[医学-中西医结合临床] 10[医学]
主 题：Tongdu Tiaoshen Acupuncture Stroke Cognitive impairment Learning and memory function Hippocampal nerve
摘 要：[Objectives]To evaluate the effects of Tongdu Tiaoshen Acupuncture method on improving learning and memory function and hippocampal nerve regeneration and repair after stroke.[Methods]Animal models of cognitive impairment in the recovery phase of cerebral infarction in rats were prepared,and rats were randomly divided into control group,model group,donepezil group,and acupuncture *** water maze experiment was carried out to evaluate learning and memory *** staining,BrdU and DCX immunofluorescence staining were used to observe the number and morphological structure of neuronal pyramidal and granular cells in the dentate gyrus(DG)area of the hippocampus,as well as the proliferation and differentiation of neural progenitor *** method was used to detect cell apoptosis.[Results]Before intervention,the scores and ELP of the model group,donepezil group and acupuncture group were significantly higher than those of the blank group(P0.05),but it was still significantly higher than the blank group(P0.05).The results of BrdU and DCX immunofluorescence staining showed that there were only a few BrdU positive cells and DCX protein in the hippocampal DG area of mice in the blank group,and the positive cells in the model group were significantly increased(P0.05);donepezil group and acupuncture group showed significant increase compared with the model group(P0.05);compared with the blank group,the number of neurons in the hippocampal DG area of each group was significantly reduced(P0.01),and the neuronal apoptosis index was significantly increased(P0.01);compared with the blank group,the number of neurons in the hippocampal DG area of
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