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Nearly lattice-defect-free MOF membranes

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Science China Chemistry 2024年第3期67卷 741-743页

作者： Yuzhang Zhu Yang liu Jian jin i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Membrane technology has widely accepted as the most energy efficient technology for the separation of ions or molecules. As the core of the membrane technology, the chemical and structure nature of membrane materials determines the application and energy-efficiency of the technology. An advanced membrane that has a remarkable ability to selectively differentiate ions and molecules can significantly enhance the separation technology and revolutionize industrial separation processes.

关键词： processes. separation defect

Nano-Bacillus Calmette-Guérin immunotherapies for improved bladder cancer treatment

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 557-567页

作者： sheng ZENG Shaoqiang XING Yifei ZHANG Haifeng WANG Qian liu Department of Urology Tianjin First Central HospitalTianjin 300192China Department of Urology First Central Clinical CollegeTianjin Medical UniversityTianjin 300192China

Cancer immunotherapy has rapidly become the fourth mainstream treatment alternative after surgery,radiotherapy,and chemotherapy,with some promising *** aims to kill tumor cells by mobilizing or stimulating cytotoxic immune ***,the clinical applications of tumor immunotherapies are limited owing to a lack of adequate delivery pathways and high ***,nanomaterials and genetic engineering have shown great potential in overcoming these limitations by protecting the delivery of antigens,activating targeted T cells,modulating the immunosuppressive tumor microenvironment,and improving the treatment *** Calmette-Gué;rin(BCG)is a live attenuated Mycobacterium bovis vaccine used to prevent tuberculosis,which was first reported to have antitumor activity in *** therapy can activate the immune system by inducing various cytokines and chemokines,and its specific immune and inflammatory responses exert antitumor *** was first used during the 1970s as an intravesical treatment agent for bladder cancer,which effectively improved immune antitumor activity and prevented tumor *** recently,nano-BCG and genetically engineered BCG have been proposed as treatment alternatives for bladder cancer due to their ability to induce stronger and more stable immune *** this study,we outline the development of nano-BCG and genetically engineered BCG for bladder cancer immunotherapy and review their potential and associated challenges.

关键词： Bladder cancer Bacillus Calmette-Gué rin vaccine Nanocarrier Genetic engineering Immunotherapy

A continuous-wave Nd:YVO_(4)-KGW intracavity Raman laser with over 34% diode-to-Stokes optical efficiency

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High Power Laser Science and Engineering 2024年第2期12卷 62-68页

作者： Quan sheng jingni Geng Tianchang liu Shijie Fu Wei Shi Jianquan Yao Institute of Laser and Optoelectronics School of Precision Instrument and Optoelectronics EngineeringTianjin UniversityTianjinChina Key Laboratory of Optoelectronic Information Technology(Ministry of Education) Tianjin UniversityTianjinChina

We demonstrate a continuous-wave(CW)Nd:YVO_(4)-potassium gadolinium tungstate(KGW)intracavity Raman laser with a diode-to-Stokes optical efficiency of 34.2%.By optimizing the cavity arrangement and reducing the cavity losses,8.47 W Stokes output at 1177 nm was obtained under an incident 878.6 nm diode pump power of 24.8 *** influence of cavity losses on the power and efficiency of the CW Raman laser,as well as the potential for further optimization,was investigated based on the numerical *** observation of thermally-induced output rollover was well explained by the calculation of the thermal lensing and cavity stability,indicating that the end-face curvature played an important role when the end-face of the crystal was highly reflective coated to make the cavity.A 10.9 W Stokes output under 40.9 W incident pump was also demonstrated with a cavity arrangement less sensitive to the end-face curvature,which is the highest output power of CW intracavity Raman lasers reported.

关键词： continuous wave intracavity Raman laser KGW crystal thermal lens

Interface healing mechanism of fine-grained Ni-Co-based superalloy during hot-compression bonding

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Journal of Materials Science & Technology 2024年第6期173卷 45-53页

作者： Shaofei Ren Xiaolong Bai sheng liu Mingyue Sun Bin Xu Chuanyong Cui Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China China United Gas Turbine Technology Co. Ltd.Beijing 100016China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The interface healing mechanism of fine-grained Ni-Co-based superalloy during hot-compression bonding(HCB)is *** HCB,the incompatibility of deformation between theγand the primary γ′leads to a large number of dislocation pairs(DP),stacking faults(SF),and micro-twins(MT)in the primary γ′.These defects act as fast channels for elemental diffusion,leading to supersaturation of the primary γ′and promoting the growth of the γ-*** the one hand,the primary γ′with a γ-shell moves towards the bonding interface due to anomalous yielding phenomena of the primary γ′and plastic flow during HCB *** increase in the number of defects leads to the growth of γ-γ′heterogeneous epitaxial recrystallization(HERX)grain with coherent structure at the bonding interface,which promotes the bulge of the interface grain boundaries(IGBs).On the other hand,the nucleation and growth of a necklace-like distribution of discontinuous dynamic recrystallization(DDRX)grain at the interface lead to the healing of *** the synergistic action of DDRX and HERX,the mechanical properties of Ni-Co-based superalloy joints through HCB achieve the same level as the base *** finding further enriches the theory of interface healing in HCB.

关键词： Hot-compression bonding Ni-Co-based superalloy Discontinuous dynamic recrystallization Heterogeneous epitaxial recrystallization

A novel Fluorescent Protein Chromophore Analogue to simultaneously probe lysosome viscosity and β-Amyloid fibrils

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A novel Fluorescent Protein Chromophore Analogue to simultan...

CAGCN:Centrality-Aware Graph Convolution Network for Anomaly Detection in Industrial Control Systems

第十一届全国化学生物学学术会议

作者： Han Sun Hua-xiang Leng jin-sheng liu jin-wu Yan School of Biology and Biological Engineering South China University of Technology

Alzheimer’s disease（AD） is an incurable neurodegenerative disease. To improve the diagnostic level of AD is essential to early treatment and effectively utilizes disease-modifying drugs. The amyloid cascade hypothesis and its revised version identify insoluble β-amyloid deposition as a good diagnostic biomarker for AD. We hypothesized that lysosomal viscosity may be an auxiliary biomarker for AD based on literature research. Herein, we have successfully developed the FP chromophore analogue C25 as a dual-functional fluorescent probe which respond to Aβ fibrils and viscosity in lysosome with distinguishable turn-on fluorescence signals around 570 nm and 600 nm, respectively. The probe C25 can also monitor the process of digesting Aβ in lysosome. The probe C25 can serve as a promising tool for developing the early diagnosis and innovative therapeutics of AD.

关键词： Alzheimer’s Disease Aβ fibrils lysosomal viscosity dual-functional fluorescent probe FP chromophore

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Journal of Computer Science & Technology 2024年第4期39卷 967-983页

作者： Jun Yang Yi-Qiang sheng jin-Lin Wang Hong Ni National Network New Media Engineering Research Center Institute of AcousticsChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

In industrial control systems,the utilization of deep learning based methods achieves improvements for anomaly ***,most current methods ignore the association of inner components in industrial control *** industrial control systems,an anomaly component may affect the neighboring components;therefore,the connective relationship can help us to detect anomalies *** this paper,we propose a centrality-aware graph convolution network(CAGCN)for anomaly detection in industrial control *** the traditional graph convolution network(GCN)model,we utilize the concept of centrality to enhance the ability of graph convolution networks to deal with the inner relationship in industrial control *** experiments show that compared with GCN,our CAGCN has a better ability to utilize this relationship between components in industrial control *** performances of the model are evaluated on the Secure Water Treatment(SWaT)dataset and the Water Distribution(WADI)dataset,the two most common industrial control systems datasets in the field of industrial anomaly *** experimental results show that our CAGCN achieves better results on precision,recall,and F1 score than the state-of-the-art methods.

关键词： graph convolution network(GCN) data mining network centrality anomaly detection industrial control system

Toxicity of the disinfectant benzalkonium chloride(C_(14))towards cyanobacterium Microcystis results from its impact on the photosynthetic apparatus and cell metabolism

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Journal of Environmental Sciences 2024年第1期135卷 198-209页

作者： Yunlu Jia Yi Huang jin Ma Shangwei Zhang jin liu Tianli Li Lirong Song Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China School of Environmental Studies China University of GeosciencesWuhan 430074China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China

Quaternary ammonium compounds(QACs)are commonly used in a variety of consumer and commercial products,typically as a component of *** the COVID-19 pandemic,QACs became one of the primary agents utilized to inactivate the SARS CoV-2 virus on ***,the ecotoxicological effects of QACs upon aquatic organisms have not been fully *** this study,we examined the effects of a widely used QAC(benzalkonium chloride-C_(14),BAC-14)on two toxigenic Microcystis strains and one non-toxigenic freshwater Microcystis strain and carried out an analysis focused on primary,adaptive and compensatory stress responses at apical(growth and photosynthesis)and metabolic *** analysis revealed that the two toxic Microcystis strains were more tolerant than the non-toxic strain,with 96 hr-EC_(50)values of 0.70,0.76,and 0.38 mg/L BAC-14 for toxigenic *** FACHB-905,toxigenic *** FACHB-469,and non-toxigenic *** FACHB-908,*** photosynthetic activities of the Microcystis,assessed via F_(v)/F_(m) values,were significantly suppressed under 0.4 mg/L ***,this analysis revealed that BAC-14 altered 14,12,and 8 metabolic pathways in *** FACHB-905,*** FACHB-469,and *** FACHB-908,*** is noteworthy that BAC-14 enhanced the level of extracellular microcystin production in the toxigenic Microcystis strains,although cell growth was not significantly ***,these data show that BAC-14 disrupted the physiological and metabolic status of Microcystis cells and stimulated the production and release of microcystin,which could result in damage to aquatic systems.

关键词： Disinfectants Quaternary ammonium compounds Microcystis Cyanotoxin Metabolomics Chlorophyll fluorescence

Development and performance evaluation of high temperature resistant strong adsorption rigid blocking agent

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Petroleum Science 2024年第4期21卷 2650-2662页

作者： Zhe Xu jin-sheng Sun jing-Ping liu Kai-He Lv Xiao-Dong Dong Zong-Lun Wang Tai-Feng Zhang Yuan-Wei Sun Zhi-Wen Dai School of Petroleum Engineering China University of Petroleum (East China) CNPC Engineering Technology R&D Company Limited

As drilling wells continue to move into deep ultra-deep layers, the requirements for temperature resistance of drilling fluid treatments are getting higher and higher. Among them, blocking agent, as one of the key treatment agents, has also become a hot spot of research. In this study, a high temperature resistant strong adsorption rigid blocking agent(QW-1) was prepared using KH570 modified silica,acrylamide(AM) and allyltrimethylammonium chloride(TMAAC). QW-1 has good thermal stability,average particle size of 1.46 μm, water contact angle of 10.5., has a strong hydrophilicity, can be well dispersed in water. The experimental results showed that when 2 wt% QW-1 was added to recipe A(4 wt% bentonite slurry+0.5 wt% DSP-1(filtration loss depressant)), the API filtration loss decreased from 7.8to 6.4 m L. After aging at 240.C, the API loss of filtration was reduced from 21 to 14 m L, which has certain performance of high temperature loss of filtration. At the same time, it is effective in sealing 80-100mesh and 100-120 mesh sand beds as well as 3 and 5 μm ceramic sand discs. Under the same conditions,the blocking performance was superior to silica(5 μm) and calcium carbonate(2.6 μm). In addition, the mechanism of action of QW-1 was further investigated. The results show that QW-1 with amide and quaternary ammonium groups on the molecular chain can be adsorbed onto the surface of clay particles through hydrogen bonding and electrostatic interaction to form a dense blocking layer, thus preventing further intrusion of drilling fluid into the formation.

关键词： High adsorption Rigid microsphere High temperature resistance Blocking performance

Boundary Regularity of Isometries Between Infinitely Flat Complex Domains

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1375-1387页

作者： jin Song liu Fei TAO Hong Yu WANG Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China Beijing International Center for Mathematical Research Peking UniversityBeijing 100871P.R.China School of Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China Key Laboratory of Mathematics and Information Networks(Beijing University of Posts and Telecommunications) Ministry of EducationBeijing 100876P.R.China

In this paper we prove that isometries with respect to the Kobayashi metric between certain domains having boundary points at which the boundary is infinitely flat extend continuously to the *** strategy is to reestab... 详细信息

关键词： Boundary extension Kobayashi metric isometries