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Long-and short-term outcomes for resectable gallbladder carcinoma patients treated with curative-intent laparoscopic versus open resection:a multicenter propensity score-matched comparative study

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 788-800,I0002页

作者： Zhi-Peng Liu Xing-Xing Su Long-Fei Chen xue-Lei Li Yi-Shi Yang Zhi-Long You Xiao-Lin Zhao Fan Huang Chao Yu Zhao-Ping Wu Wei Chen jin-xue zhou Wei Guo Da-Long Yin Ping Yue Rui Ding Yi Zhu Wei Chen Yan Jiang Jie Bai jing-jing Wang Yan-Qi Zhang Dong Zhang Hai-Su Dai Wan Yee Lau Zhi-Yu Chen The Biliary Surgery Branch of Elite Group of Chinese Digestive Surgery(EGCDS) Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Hepato-pancreato-biliary Center Tsinghua Changgung HospitalTsinghua UniversityBeijingChina Department of General Surgery Third Affiliated Hospital of Zunyi Medical UniversityZunyiChina Department of General Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Hepatobiliary Surgery Affiliated Hospital of Guizhou Medical UniversityGuiyangChina Department of Hepatopancreatobiliary Surgery Jiujiang First People’s HospitalJiujiangChina Department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Hepatopancreatobiliary Surgery Henan Provincial Tumor HospitalZhengzhouChina Department of General Surgery Capital Medical University Affiliated Beijing Friendship HospitalBeijingChina Department of Hepatobiliary Surgery First Affiliated Hospital of USTCHefeiChina Department of General Surgery Lanzhou University First Affiliated HospitalLanzhouChina Department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Air Force Medical UniversityXi’anChina Department of Hepatopancreatobiliary Surgery The Second Affiliated Hospital Zhejiang University School of MedicineHangzhouChina Department of Health Statistics College of Military Preventive MedicineThird Military Medical University(Army Medical University)ChongqingChina Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Faculty of Medicine the Chinese University of Hong KongHong KongChina 不详

Background:Gallbladder cancer(GBC)was once considered a contraindication for laparoscopic surgery,but it is becoming more common to use laparoscopic surgery for GBC *** aim of this study was to analyze the long-and short-term outcomes of patients with more advanced T-staged GBC treated with curative intent as defined by the National Comprehensive Cancer Network(NCCN)after laparoscopic resection(LR)versus open resection(OR).Methods:A multicenter database was used to select consecutive GBC patients treated with curative-intent resection as defined by the NCCN between 2016 and *** patients were divided into the LR group and the OR *** score matching(PSM)was used to eliminate selection *** endpoints were overall survival(OS),progression-free survival(PFS),and short-term *** factors that were independently associated with OS and PFS were ***:Of 626 GBC patients treated with curative-intent resection,after PSM,51 patients were in the LR group and 153 patients were in the OR *** LR group had more patients who were suitable to receive adjuvant chemotherapy(AC),a longer operation time,more harvested lymph nodes,and a lower overall morbidity *** rates of OS and PFS were not significantly different between the two *** was independently associated with better OS and ***:The overall morbidity of GBC patients after LR was lower,but the long-term outcomes between LR and OR were not significantly *** GBC patients treated with LR were more likely to receive AC,and the use of AC after curative-intent resection of GBC helped achieve better long-term survival outcomes.

关键词： Gallbladder cancer(GBC) laparoscopic resection(LR) morbidity survival adjuvant chemotherapy(AC)

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Design and validation of a variable camber wing structure

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Chinese Journal of Aeronautics 2024年第2期37卷 1-11页

作者： Xiasheng SUN jingfeng xue jin zhou Zhigang WANG Wenjuan WANG Mengjie ZHANG Chinese Aeronautical Establishment Beijing 100012China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Aircraft Strength Research Institute of China Xi’an 710065China Graduate School of Chinese Aeronautical Establishment Yangzhou 225002China

Variable camber wing technology is one of the important development trends of green aviation at *** smooth,seamless,continuous and adaptive change of wing camber,the aerodynamic performance is improved in achieving increase in lift and reduction in resistance and *** on the aerodynamic validation model CAE-AVM,Chinese Aeronautical Establishment(CAE)has carried out the design and validation of a variable camber wing,proposed an aerodynamic deformation matrix for the leading and trailing edges of aircraft wings in takeoff,landing and cruise *** structures and driving schemes are compared,and several key technology problems of leading and trailing edge deformation are solved.A full-size leading edge wind tunnel test piece with a span of 2.7 m and a trailing edge ground function test piece are *** deformation and shape maintenance capabilities of the leading edge is verified under real wind load conditions,and the load bearing and deformation capabilities of the trailing edge is verified under simulated follow-on *** results indicate that the leading and trailing edges of the variable camber wing can achieve the required deformation angle and have a certain load-bearing *** study can provide some insights into the application of variable camber wing technology for civil aircraft.

关键词： Variable camber wing Leading edge Trailing edge Structure Measurement and control Test

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Hypersensitive Spectrophotometric Determination of Trace Amounts of Tin ( Ⅳ ) with Salicylfluorone and Mixed Surfactants

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Chemical Research in Chinese Universities 1993年第2期9卷 154-160页

作者： XIE Zeng-hong, WANG Dong-jin, zhou xue-ying HU Xian-guo (Department of Chemistry, Fuzhou University, Fuzhou, 350002)

Introduction Since it was found that cetyltrimethylammonium bromide (CTMAB) can increase greatly the sensitivity of the tin (Ⅳ)-pyrocatechol violet (PV) system, the micellar speetrophotometric determination of tin (IV) has been developed extensⅣely. The most widely used acidity dyes are PV and Bromopyrogallol Red (BPR). They have

关键词： Spectrophotometry Tin Salicylfluorone

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Cracking on a nickel-based superalloy fabricated by direct energy deposition

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China Foundry 2024年第4期21卷 311-318页

作者： xue Zhang Ya-hang Mu Liang Ma jing-jing Liang Yi-zhou zhou Xiao-feng Sun jin-guo Li School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China

Cracks have consistently been a significant challenge limiting the development of additive manufactured nickel-based *** is essential to investigate the location of cracks and their forming *** study extensively examines the impact of solidification process,microstructural evolution,and stress concentration on crack initiation during direct energy deposition(DED).The results emphasize that the crack formation is significantly related to large-angle grain boundaries,rapid cooling *** caused by large-angle grain boundaries and a fast-cooling rate predominantly appear near the edge of the deposited *** cracks are more likely to form near the top of the deposited sample,due to the presence ofγ/γ'*** secondary dendritic arm and the carbides in the interdendritic regions can obstruct liquid flow during the final stage of solidification,which results in the formation of solidification cracks and *** work paves the way to avoid cracks in nickel-based superalloys fabricated by DED,thereby enhancing the performance of superalloys.

关键词： location cracks direct energy deposition nickel-based superalloys

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Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn

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Current Medical Science 2024年第2期44卷 369-379页

作者： Ji LUO jin zhou jing-zeng LUO Hai-long WANG xue-ling ZHAO Ru-dan zhou Department of Intensive Care Unit The First People's Hospital of ZiyangZiyang 641300China Department of Orthopedics Kunming Medical University Second Affiliated HospitalKunming 650033China Department of Orthopedics Kunming Medical University First Affiliated HospitalKunming 650032China Department of Orthopedics The Third People's Hospital of Yunnan ProvinceKunming 650200China

Objective:Matrix metalloproteinase 13(MMP13)is an extracellular matrix protease that affects the progression of atherosclerotic plaques and arterial thrombi by degrading collagens,modifying protein structures and regulating inflammatory responses,but its role in deep vein thrombosis(DVT)has not been *** purpose of this study was to investigate the potential effects of MMP13 and MMP13-related genes on the formation of ***:We altered the expression level of MMP13 in vivo and conducted a transcriptome study to examine the expression and relationship between MMP13 and MMP13-related genes in a mouse model of *** screening genes possibly related to MMP13 in DVT mice,the expression levels of candidate genes in human umbilical vein endothelial cells(HUVECs)and the venous wall were *** effect of MMP13 on platelet aggregation in HUVECs was investigated in ***:Among the differentially expressed genes,interleukin 1 beta,podoplanin(Pdpn),and factor VIII von Willebrand factor(F8VWF)were selected for analysis in *** MMP13 was inhibited,the expression level of PDPN decreased significantly in *** HUVECs,overexpression of MMP13 led to an increase in the expression level of PDPN and induced platelet aggregation,while transfection of PDPN-siRNA weakened the ability of MMP13 to increase platelet ***:Inhibiting the expression of MMP13 could reduce the burden of DVT in *** mechanism involves downregulating the expression of Pdpn through MMP13,which could provide a novel gene target for DVT diagnosis and treatment.

关键词： deep vein thrombosis matrix metalloproteinase 13 podoplanin

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Voltage-modulated polymer nanopore field-effect transistor for multi-sized nanoparticle detection

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Nanotechnology and Precision Engineering 2024年第3期7卷 79-89页

作者： Feng zhou Lin Li Qiannan xue State Key Laboratory of Precision Measurement Technology and Instruments School of Precision Instruments and Optoelectronics EngineeringTianjin UniversityTianjin 300072China

Solid-state nanopores offer a range of distinct advantages over biological nanopores,such as structural diversity and greater stability and durability;this makes them highly promising for high-resolution nanoparticle *** nanopores can exhibit gating characteristics with stress-responsive switches and can demonstrate specificity toward particular *** inspiration from biological nanopores,this paper introduces a novel polymer nanopore with field-effect characteristics,leveraging a conductive polymer in its construction to showcase intriguing gating ***,in this device,the polymer layer serves as the gate,enabling precise control over the source–drain current response inside and outside the pore by simply adjusting the gate *** unique feature allows fine-tuning of the nanopore’s sensitivity to nanoparticles of varying sizes and facilitates its operation in multiple *** results reveal that the developed polymer nanopore field-effect transistor demonstrates remarkable selectivity in detecting nanoparticles of various sizes under different applied *** proposed single device demonstrates the exceptional ability to detect multiple types of nanoparticle,showcasing its immense potential for a wide range of applications in biological-particle analysis and medical diagnostics.

关键词： Nanopipette Polymer nanopore Voltage modulation Nanoparticle detection

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Structural Engineering of Hierarchical Magnetic/Carbon Nanocomposites via In Situ Growth for High-Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2024年第9期16卷 262-278页

作者： Xianyuan Liu jinman zhou Ying xue Xianyong Lu Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

Materials exhibiting high-performance electromagnetic wave absorption have garnered considerable scientific and technological attention,yet encounter significant *** new materials and innovative structural design concepts is crucial for expanding the application field of electromagnetic wave ***,hierarchical structure engineering has emerged as a promising approach to enhance the physical and chemical properties of materials,providing immense potential for creating versatile electromagnetic wave absorption ***,an exceptional multi-dimensional hierarchical structure was meticulously devised,unleashing the full microwave attenuation capabilities through in situ growth,selfreduction,and multi-heterogeneous interface *** hierarchical structure features a three-dimensional carbon framework,where magnetic nanoparticles grow in situ on the carbon skeleton,creating a necklace-like ***,magnetic nanosheets assemble within this *** impedance matching was achieved by precisely adjusting component proportions,and intelligent integration of diverse interfaces bolstered dielectric *** obtain Fe_(3)O_(4)-Fe nanoparticles/carbon nanofibers/Al-Fe_(3)O_(4)-Fe nanosheets composites demonstrated outstanding performance with a minimum reflection loss(RLmin)value of−59.3 dB and an effective absorption bandwidth(RL≤−10 dB)extending up to 5.6 GHz at 2.2 *** notable accomplishments offer fresh insights into the precision design of high-efficient electromagnetic wave absorption materials.

关键词： Electromagnetic wave absorption Hierarchical structure In situ growth Self-reduction

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An Improved Bounded Conflict-Based Search for Multi-AGV Pathfinding in Automated Container Terminals

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2705-2727页

作者： Xinci zhou jin Zhu Shanghai Maritime University Logistics Science and Engineering Research InstituteShanghai200000China

As the number of automated guided vehicles(AGVs)within automated container terminals(ACT)continues to rise,conflicts have becomemore *** point and edge conflicts ofAGVs,amulti-AGVconflict-free path planning model has been formulated to minimize the total path length of AGVs between shore bridges and *** larger terminalmaps and complex environments,the grid method is employed to model AGVs’road *** improved bounded conflict-based search(IBCBS)algorithmtailored to ACT is proposed,leveraging the binary tree principle to resolve conflicts and employing focal search to expand the search *** experiments involving 60 AGVs indicate a reduction in computing time by 37.397%to 64.06%while maintaining the over cost within 1.019%.Numerical experiments validate the proposed algorithm’s efficacy in enhancing efficiency and ensuring solution quality.

关键词： Automated terminals multi-AGV multi-agent path finding(MAPF) conflict based search(CBS) AGV path planning

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Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： YANG Ying QU jin-yu GUO Hua zhou Hai-ying RUAN Xia PENG Ying-chun SHEN xue-fang XIONG jin WANG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of Neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dachangshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(HA),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(ELISA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

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Modeling and Validation of Diamagnetic Rotor Levitated by Permanent Magnetics

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 224-235页

作者： Yuanping Xu Yue Zhang jin zhou Chaowu jin College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

As an innovative,low-power consuming,and low-stiffness suspension approach,the diamagnetic levitation technique has attracted considerable interest because of its potential applicability in miniaturized mechanical *** foundation of a diamagnetic levitation system is mathematical modeling,which is essential for operating performance optimization and stability ***,few studies on systematic mathematical modeling have been *** this study,a systematic mathematical model for a disc-shaped diamagnetically levitated rotor on a permanent magnet array is *** on the proposed model,the magnetic field distribution characteristics,diamagnetic levitation force characteristics(i.e.,levitation height and stiffness),and optimized theoretical conditions for realizing stable levitation are *** are conducted to verify the feasibility of the proposed mathematical *** predictions and experimental results indicate that increasing the levitation height enlarges the stable ***,with a further increase in the rotor radius,the stable regions of the rotor gradually diminish and even ***,when the levitation height is fixed,a moderate rotor radius permits stable *** study proposes a mathematical modeling method for a diamagnetic levitation system that has potential applications in miniaturized mechanical systems.

关键词： Diamagnetic levitation Magnetic levitation Rotor Modeling Validation Stability

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