Voltage-modulated polymer nanopore field-effect transistor for multi-sized nanoparticle detection

作     者：Zhou, Feng Li, Lin Xue, Qiannan 

作者机构：Tianjin Univ Sch Precis Instruments & Optoelect Engn State Key Lab Precis Measurement Technol & Instrum Tianjin 300072 Peoples R China 

出 版 物：《NANOTECHNOLOGY AND PRECISION ENGINEERING》 (纳米技术与精密工程（英文）)

年 卷 期：2024年第7卷第3期

页      面：79-89页

核心收录：

学科分类：080903[工学-微电子学与固体电子学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学] 

基　　金：National Natural Science Foundation of China [U2233206, 61674114, 91743110] National Key R&D Program of China [2021YFC3002204] Tianjin Applied Basic Research and Advanced Technology [17JCJQJC43600] The 111 Project [B07014] 

主　　题：Nanopipette Polymer nanopore Voltage modulation Nanoparticle detection DNA 

摘      要：Solid-state nanopores offer a range of distinct advantages over biological nanopores, such as structural diversity and greater stability and durability; this makes them highly promising for high-resolution nanoparticle sensing. Biological nanopores can exhibit gating characteristics with stress-responsive switches and can demonstrate specificity toward particular molecules. Drawing inspiration from biological nanopores, this paper introduces a novel polymer nanopore with field-effect characteristics, leveraging a conductive polymer in its construction to showcase intriguing gating behavior. Notably, in this device, the polymer layer serves as the gate, enabling precise control over the source-drain current response inside and outside the pore by simply adjusting the gate voltage. This unique feature allows fine-tuning of the nanopore s sensitivity to nanoparticles of varying sizes and facilitates its operation in multiple modes. Experimental results reveal that the developed polymer nanopore field-effect transistor demonstrates remarkable selectivity in detecting nanoparticles of various sizes under different applied voltages. The proposed single device demonstrates the exceptional ability to detect multiple types of nanoparticle, showcasing its immense potential for a wide range of applications in biological-particle analysis and medical diagnostics.