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Effects of intensive psychological intervention on treatment compliance,psychological status,and quality of life of patients with epilepsy

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World Journal of Psychiatry 2024年第5期14卷 670-677页

作者： Su-hua Zhang jie-hua wang Hong-Yu Liu Yue-Xia Zhang Ya-Ling Lin Bi-Yu Wu Department of Neurology Quanzhou First HospitalQuanzhou 362000Fujian ProvinceChina Department of Nursing Quanzhou First HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Epilepsy is a nervous system disease characterized by recurrent attacks,a long disease course,and an unfavorable *** is associated with an enduring therapeutic process,and finding a cure has been *** with epilepsy are predisposed to adverse moods,such as resistance,anxiety,nervousness,and anxiety,which compromise treatment compliance and overall *** To explored the influence of intensive psychological intervention on treatment compliance,psychological status,and quality of life(QOL)of patients with *** The clinical data of 105 patients with epilepsy admitted between December 2019 and July 2023 were retrospectively analyzed,including those of 50 patients who underwent routine intervention(control group)and 55 who underwent intensive psychological intervention(research group).Treatment compliance,psychological status based on the Self-Rating Anxiety Scale(SAS)and Depression Scale Self-Rating Depression Scale(SDS)scores,hope level assessed using the Herth Hope Scale(HHS),psychological resilience evaluated using the Psychological Resilience Scale,and QOL determined using the QOL in Epilepsy-31 Inventory(QOLIE-31)were comparatively *** Treatment compliance in the research group was 85.5%,which is significantly better than the 68.0%of the control *** notable intergroup differences in preinterventional SAS and SDS scores were identified(P>0.05);however,after the intervention,the SAS and SDS scores decreased significantly in the two groups,especially in the research group(P0.05).After 6 months of intervention,the research group showed evidently higher HHS,CD-RISC,tenacity,optimism,strength,and QOLIE-31 scores(P<0.05).CONCLUSION Intensive psychological intervention enhances treatment compliance,psychological status,and QOL of patients with epilepsy.

关键词： Intensive psychological intervention Epilepsy Treatment compliance Psychological status Quality of life

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Three-Dimensional Analysis of Rolling by Twin Shear Stress Yield Criterion

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Journal of Iron and Steel Research International 2006年第6期13卷 21-26页

作者： ZHAO De-wen XIE Ying-jie LIU Xiang-hua wang Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Using the twin shear stress yield criterion, the surface integral of the co-line vectors, and the integration depending on upper limit, Kobayashi＇s three-dimensional velocity field of rolling was analyzed and an analytical expression of rolling torque and single force was obtained. Through redoing the same experiment of rolling pure lead as Sims, the calculated results by the above expression were compared with those of Kobayashi and Sims formulae. The results show that the twin shear stress yield criterion is available for rolling analysis and the calculated results by the new formula are a little higher than those by Kobayashi and Sims ones if the reduction ratio is less than 30%.

关键词： twin shear stress yield criterion co-line vector integral three-dimensional rolling analytical solution

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High Expression of ERCC1 Is a Poor Prognostic Factor in Chinese Patients with Non-small Cell Lung Cancer Receiving Cisplatin-based Therapy

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Chinese Journal of Cancer Research 2010年第4期22卷 296-302页

作者： Qing-zhi Guo jie wang hua Bai Tong-tong An Meina Wu Jun Zhao Lu Yang Jian-chun Duan Yu-yan wang Zhi-jie wang Key laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Medical Oncology Peking University Cancer Hospital ＆ Institute Beijing 100142 China

Objective： to determine the role of excision repair cross-complementing group 1 gene （ERCC1） and ribonucleotide reductase subunit M1 （RRM1） expression in predicting response and survival in Chinese patients with advanced stage non-small cell lung cancer （NSCLC） treated with platinum-based chemotherapy. Methods： Formalin-fixed, paraffin-embedded biopsy tissues were retrospectively obtained from 160 advanced NSCLC patients. mRNA expression levels of ERCC1 and RRM1 were determined by real-time PCR. Results： Associations between mRNA expression level of ERCC1 and RRM1 and clinic-pathologic parameters were analyzed. One handred and forty two （88.75%） specimens were successfully amplified. mRNA expression level of ERCC1 and RRM1 was negatively associated with tumor response. ERCC1 expression levels ranged from 0.01 to 78.79 [median 0.63, mean 4.25 and standard deviation （SD） 9.23] and RRM1 from 0.00 to 30.91 （median 0.63, mean 0.87 and SD 3.36）. By adopting cut-off values according to median expression levels, we found that MST in patients with low ERCC1 mRNA levels was significantly longer in overall population than in patients with higher levels （18.63 versus 13.69 months, log-rank 5.73, P=0.017）, but we did not found the survival benefit of the patients with low expression level of RRM1. （19.07 versus 14.88, log-rank 1.66, P=0.197）. Further, in the multivariable Cox regression model analysis we found that low level of ERCC1 expression, the presence of weight loss and target therapy, were significant prognostic factors for survival. Conclusion： ERCC1 expression is associated with patients’ survival in Chinese advanced NSCLC patients treated with platinum-based regimen and may serve as a biomarker in predicting tumor response and clinical outcome in the patient population.

关键词： ERCC1 RRM1 NSCLC Platinum-based chemotherapy mRNA Realtime PCR

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Laser manufacturing of spatial resolution approaching quantum limit

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Light(Science & Applications) 2024年第3期13卷 421-428页

作者： Xiao-jie wang Hong-hua Fang Zhen-Ze Li Dan wang Hong-Bo Sun State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China

Atomic and close-to-atom scale manufacturing is a promising avenue toward single-photon emitters,single-electron transistors,single-atom memory,and quantum-bit devices for future communication,computation,and sensing *** manufacturing is outstanding to this end for ease of beam manipulation,batch production,and no requirement for *** is,however,suffering from optical diffraction ***,we report a spatial resolution improved to the quantum limit by exploiting a threshold tracing and lock-in method,whereby the two-order gap between atomic point defect complexes and optical diffraction limit is surpassed,and a feature size of<5 nm is *** underlying physics is that the uncertainty of local atom thermal motion dominates electron excitation,rather than the power density slope of the incident *** show that the colour centre yield in hexagonal boron nitride is transformed from stochastic to deterministic,and the emission from individual sites becomes polychromatic to *** a result,single colour centres in the regular array are deterministically created with a unity yield and high positional accuracy,serving as a step forward for integrated quantum technological applications.

关键词： quantum limit resolution

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Water-responsive 4D printing based on self-assembly of hydrophobic protein “Zein” for the control of degradation rate and drug release

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生物活性材料(英文) 2023年第5期23卷 343-352页

作者： Yubei Zhang Ali Raza Ya-Qi Xue Ganggang Yang Uzma Hayat Jingwen Yu Chang Liu hua-jie wang Jin-Ye wang School of Biomedical Engineering Shanghai Jiao Tong University800 Dongchuan RoadShanghai200240China Jiaxing Yaojiao Medical Device Co.Ltd. 321 Jiachuang RoadJiaxing314032China Department of Urology Tongren HospitalSchool of MedicineShanghai Jiao Tong University1111 Xianxia RoadShanghaiChina

Four-dimensional(4D)printing is a promising technology that provides solutions for compelling needs in various *** of the reported 4D printed systems are based on the temporal shape transformation of printed *** of temporal heterogenicity in functions in addition to shape may extend the scope of 4D ***,we report a 4D printing approach using plant protein(zein)gel inspired by the amyloid fibrils formation *** printing of zein gel in a specialized layered-Carbopol supporting bath with different water concentrations in an ethanol-water mixture modulates hydrophobic and hydrogen bonding that causes temporal changes in *** part of the construct printed in a supporting bath with higher water content exhibits higher drug loading,faster drug release and degradation than those printed in the supporting bath with lower water ***-segment conduit and butterfly-shaped construct with two asymmetrical wings are printed using this system to evaluate biomedical function as nerve conduit and drug delivery system.4D printed conduits are also effective as a drug-eluting urethral stent in the porcine ***,this study extends the concept of 4D printing beyond shape transformation and presents an approach of fabricating specialized baths for 4D printing that can also be extended to other materials to obtain 4D printed medical devices with translational potential.

关键词： Zein gels Water-driven 4D printing Protein self-assembly Tunable degradation Controlled drug release

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Micro segment analysis of supercritical methane thermal-hydraulic performance and pseudo-boiling in a PCHE straight channel

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Petroleum Science 2024年第2期21卷 1275-1289页

作者： Qian Li Zi-jie Lin Liu Yang Yue wang Yue Li Wei-hua Cai Laboratory of Thermo-Fluid Science and Nuclear Engineering Northeast Electric Power UniversityJilin132000JilinChina School of Energy and Power Engineering Northeast Electric Power UniversityJilin132000JilinChina

The printed circuit heat exchanger(PCHE) is receiving wide attention as a new kind of compact heat exchanger and is considered as a promising vaporizer in the LNG process. In this paper, a PCHE straight channel in the length of 500 mm is established, with a semicircular cross section in a diameter of 1.2 *** simulation is employed to investigate the flow and heat transfer performance of supercritical methane in the channel. The pseudo-boiling theory is adopted and the liquid-like, two-phase-like, and vapor-like regimes are divided for supercritical methane to analyze the heat transfer and flow *** results are presented in micro segment to show the local convective heat transfer coefficient and pressure drop. It shows that the convective heat transfer coefficient in segments along the channel has a significant peak feature near the pseudo-critical point and a heat transfer deterioration when the average fluid temperature in the segment is higher than the pseudo-critical point. The reason is explained with the generation of vapor-like film near the channel wall that the peak feature related to a nucleateboiling-like state and heat transfer deterioration related to a film-boiling-like state. The effects of parameters, including mass flow rate, pressure, and wall heat flux on flow and heat transfer were *** calculating of the averaged heat transfer coefficient of the whole channel, the traditional method shows significant deviation and the micro segment weighted average method is adopted. The pressure drop can mainly be affected by the mass flux and pressure and little affected by the wall heat flux. The peak of the convective heat transfer coefficient can only form at high mass flux, low wall heat flux, and near critical pressure, in which condition the nucleate-boiling-like state is easier to appear. Moreover,heat transfer deterioration will always appear, since the supercritical flow will finally develop into a filmboiling-like state. So hea

关键词： Printed circuit heat exchanger Vaporization Supercritical methane Pseudo-boiling Micro segment analysis

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Synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting

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Chinese Chemical Letters 2024年第2期35卷 44-56页

作者： Yan-Long Ma Shi Yan Xiong-jie Xu hua Cao Ruibing wang School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center Guangdong Pharmaceutical UniversityZhongshan 528458China State Key Laboratory of Quality Research in Chinese Medicine and the Institute of Chinese Medical ScienceUniversity of MacaoMacao 999078China

Due to its simplicity, high efficiency, and chemo-selectivity, bioorthogonal chemistry has shown a great application potential in ***, four bioorthogonal pairs as targeting tools, including (strept)avidin/biotin, antibody/antigen, oligonucleotide hybridization and IEDDA tools, have been developed and applied in targeted ***, all of these tools still suffer from some limitations, such as difficult modification, biochemical fragility and larger molecular weight for biological association tools, as well as chemical instability for IEDDA *** host-guest pairs with relatively small molecular sizes not only possess strong chemical stability, but also have the features of fast conjugation rate, tunable binding affinity , easy modification, and high ***, they can be used as a novel non-covalent bioorthogonal tool for *** order to further promote the development of host-guest pairs as novel bioorthogonal tools for pre-targeted delivery, we firstly calculate their conversion rate to make researcher aware of their unique advantages;next, we summarize the recent research progress in this *** future perspectives and limitations of these unique tools will be *** review will provide a systemic overview of the development of synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting, and may serve as a “go for” resort for researchers who are interested in searching for new synthetic tools to improve pre-targeting.

关键词： Bioorthogonal chemistry Synthetic host-guest pairs Pre-targeting Molecular recognition Biomedical applications

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Autofocus by Lissajous scanning in time reversal optical scanning holography

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Chinese Optics Letters 2024年第8期22卷 13-20页

作者： jie Liu Haiyan Ou hua wang Lin Peng Wei Shao Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518000China School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China Key Laboratory of Cognitive Radio and Information Processing Guilin University of Electronic TechnologyGuilin 541004China

In this Letter, an autofocusing method in optical scanning holography(OSH) system is proposed. By introducing Lissajous scanning into multiple signal classification(MUSIC) method in time-reversal(TR) OSH, the axial locations of the targets can be retrieved with better resolution and the peak prominence increases from 0.21 to 0.34. The feasibility of this method is confirmed by simulation as well as experiment.

关键词： digital holography Lissajous scanning image reconstruction axial localization

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A visual modeling method for spatiotemporal and multidimensional features in epidemiological analysis:Applied COVID-19 aggregated datasets

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Computational Visual Media 2024年第1期10卷 161-186页

作者： Yu Dong Christy jie Liang Yi Chen jie hua School of Computer Science University of Technology SydneySydneyNSW2007Australia Beijing Key Laboratory of Big Data Technology for Food Safety Beijing Technology and Business UniversityBeijing100048China

The visual modeling method enables flexible interactions with rich graphical depictions of data and supports the exploration of the complexities of epidemiological ***,most epidemiology visualizations do not support the combined analysis of objective factors that might influence the transmission situation,resulting in a lack of quantitative and qualitative *** address this issue,we developed a portrait-based visual modeling method called+*** method considers the spatiotemporal features of virus transmission patterns and multidimensional features of objective risk factors in communities,enabling portrait-based exploration and comparison in epidemiological *** applied+msRNAer to aggregate COVID-19-related datasets in New South Wales,Australia,combining COVID-19 case number trends,geo-information,intervention events,and expert-supervised risk factors extracted from local government area-based *** perfected the+msRNAer workflow with collaborative views and evaluated its feasibility,effectiveness,and usefulness through one user study and three subject-driven case *** feedback from experts indicates that+msRNAer provides a general understanding for analyzing comprehension that not only compares relationships between cases in time-varying and risk factors through portraits but also supports navigation in fundamental geographical,timeline,and other factor *** adopting interactions,experts discovered functional and practical implications for potential patterns of long-standing community factors regarding the vulnerability faced by the *** confirmed that+msRNAer is expected to deliver visual modeling benefits with spatiotemporal and multidimensional features in other epidemiological analysis scenarios.

关键词： visual modeling epidemiological analysis spatiotemporal multidimensional COVID-19

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A novel encoding mechanism for particle physics

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Nuclear Science and Techniques 2024年第8期35卷 153-166页

作者： Zhi‑Guang Tan Sheng‑jie wang You‑Neng Guo hua Zheng Aldo Bonasera School of Electronic Information and Electrical Engineering Changsha UniversityChangsha 410003China School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710119China Key Laboratory of Quark and Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA Laboratori Nazionali del Sud INFN95123 CataniaItaly

This study proposes a novel particle encoding mechanism that seamlessly incorporates the quantum properties of particles,with a specific emphasis on constituent *** primary objective of this mechanism is to facilitate the digital registration and identification of a wide range of particle *** design ensures easy integration with different event generators and digital simulations commonly used in high-energy ***,this innovative framework can be easily expanded to encode complex multi-quark states comprising up to nine valence quarks and accommodating an angular momentum of up to 99/*** versatility and scalability make it a valuable tool.

关键词： Multi-quark state Encoding mechanism Constituent quark Particle physics

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