Synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting

作     者：Yan-Long Ma Shi Yan Xiong-Jie Xu Hua Cao Ruibing Wang Yan-Long Ma;Shi Yan;Xiong-Jie Xu;Hua Cao;Ruibing Wang

作者机构：School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research CenterGuangdong Pharmaceutical UniversityZhongshan 528458China State Key Laboratory of Quality Research in Chinese Medicineand the Institute of Chinese Medical ScienceUniversity of MacaoMacao 999078China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第2期

页      面：44-56页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the Science and Technology Program of Guangzhou(No.202103000089) the National Natural Science Foundation of China(Nos.22271323 and 22071275) the Innovation Team Project of Universities in Guangdong Province(No.2020KCXTD009) the Scientific and Technological Innovation Leading Talent Project of Zhongshan City(No.LJ2021009) the Key Projects of Social Welfare and Basic Research of Zhongshan City(No.2021B2012) 

主　　题：Bioorthogonal chemistry Synthetic host-guest pairs Pre-targeting Molecular recognition Biomedical applications 

摘      要：Due to its simplicity, high efficiency, and chemo-selectivity, bioorthogonal chemistry has shown a great application potential in ***, four bioorthogonal pairs as targeting tools, including (strept)avidin/biotin, antibody/antigen, oligonucleotide hybridization and IEDDA tools, have been developed and applied in targeted ***, all of these tools still suffer from some limitations, such as difficult modification, biochemical fragility and larger molecular weight for biological association tools, as well as chemical instability for IEDDA *** host-guest pairs with relatively small molecular sizes not only possess strong chemical stability, but also have the features of fast conjugation rate, tunable binding affinity , easy modification, and high ***, they can be used as a novel non-covalent bioorthogonal tool for *** order to further promote the development of host-guest pairs as novel bioorthogonal tools for pre-targeted delivery, we firstly calculate their conversion rate to make researcher aware of their unique advantages;next, we summarize the recent research progress in this *** future perspectives and limitations of these unique tools will be *** review will provide a systemic overview of the development of synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting, and may serve as a “go for resort for researchers who are interested in searching for new synthetic tools to improve pre-targeting.