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Community structure and carbon metabolism functions of bacterioplankton in the Guangdong coastal zone

Marine Life Science & Technology 2024年第3期6卷 547-561页

作者： Ziqi Peng Pandeng Wang Xiaoqing Luo Qiqi Deng Ziwen Yang jiaxue wu Wendong Xian Weicong Yan Xiaozhen Mou Yang Yuan Wenjun Li Jialing Li State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant Stress BiologySchool of Marine SciencesSchool of EcologySchool of Life SciencesSun Yat-Sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Department of Biological Sciences Kent State UniversityKentOH 44242USA Marine Microorganism Ecological&Application Lab Marine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316000China

Coastal ecosystems are an important region for biogeochemical cycling,are a hotspot of anthropogenic disturbance and play a crucial role in global carbon cycling through the metabolic activities of *** can be broadly classified into two lifestyles:free-living(FL)and particle-attached(PA).However,how coastal bacterioplankton the community structure,co-occurrence networks and carbon metabolic functions with different lifestyles are differentiated is still largely *** these processes is necessary to better determine the contributions of coastal bacterioplankton to carbon ***,the characteristics of community structure and carbon metabolism function of bacterioplankton with two lifestyles in the coastal areas of Guangdong Province were investigated using amplicon sequencing,metagenomic,and metatranscriptomic *** results show that the main bacterioplankton responsible for carbon metabolism were the Pseudomonadota,Bacteroidota,and *** microbial community structure,carbon metabolic function,and environmental preferences differ between different *** and PA bacteria exhibited higher carbon fixation and degradation potentials,respectively.A range of environmental factors,such as dissolved oxygen,pH,and temperature,were associated with the community structure and carbon metabolic functions of the *** activities,such as nutrient discharge,may affect the distribution of functional genes and enhance the carbon degradation functions of *** conclusion,this study increased the understanding of the role of microorganisms in regulating carbon export in coastal ecosystems with intense human activity.

关键词： Particle-attached and free-living bacterioplankton Community structure Carbon metabolism Coastal ecosystem

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Mulberry Biomass-Derived Nanomedicines Mitigate Colitis through Improved Inflamed Mucosa Accumulation and Intestinal Microenvironment Modulation

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Research 2024年第1期2023卷 791-807页

作者： Wenjing Yang Ya Ma Haiting Xu Zhenhua Zhu jiaxue wu Cheng Xu Wei Sun Erhu Zhao Min Wang Rui L.Reis Subhas C.Kundu Xiaoxiao Shi Bo Xiao State Key Laboratory of Silkworm Genome Biology College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarco 4805-017GuimaraesPortugal ICVS/3B’s-PT Government Associate Laboratory BragaGuimarãesPortugal

The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory ***,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.

关键词： fluorine sizes Biomass

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基于小波变换的全息图压缩编码比较研究

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应用光学 2024年第1期45卷 99-106页

作者：付泰陈艾帅胡磊桂进斌吴佳雪王晓诗许路昕昆明理工大学理学院云南昆明650500

在全息三维显示及全息视频应用中,减少全息图的信息量、满足通信带宽的要求是一项重要的研究工作。使用小波阈值和量化的方法有损压缩全息图,对比分析使用不同小波基阈值对全息图再现像质量和全息图压缩比的影响。研究结果表明,对离轴... 详细信息

在全息三维显示及全息视频应用中,减少全息图的信息量、满足通信带宽的要求是一项重要的研究工作。使用小波阈值和量化的方法有损压缩全息图,对比分析使用不同小波基阈值对全息图再现像质量和全息图压缩比的影响。研究结果表明,对离轴数字全息图小波阈值有损压缩后,Haar和db5小波基得到的再现像质量最高,其峰值信噪比(PSNR)达到了26.38 dB,使用sym2和db2小波得到的压缩比最高,达到了6.68。相息图小波阈值有损压缩后,Haar和Daubechies小波得到的再现像质量最高,其PSNR达到了32.32 dB,使用Biorthogonal小波得到的压缩比最高,达到了4.47。研究结果可为如何有效使用小波变换实现全息图的压缩提供参考。

关键词：全息小波阈值图像压缩全息编码

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The role of BRCA1 in DNA damage response

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Protein & Cell 2010年第2期1卷 117-123页

作者： jiaxue wu Lin-Yu Lu Xiaochun Yu Division of Molecular Medicine and Genetics Department of Internal MedicineUniversity of Michigan Medical SchoolAnn ArborMI 48109USA

BRCA1 is a well-established tumor suppressor gene,which is frequently mutated in familial breast and ovarian *** gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability,including DNA damage-induced cell cycle checkpoint activation,DNA damage repair,protein ubiquitination,chromatin remodeling,as well as transcriptional regulation and *** this review,we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response,including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.

关键词： BRCA1 DNA damage response tumorigenesis

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真实世界中含恩沃利单抗方案治疗消化道腺癌患者的安全性及疗效研究

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现代消化及介入诊疗 2024年第7期29卷 778-783,788页

作者：武稼雪赵健王育生山西医科大学 030001 山西省肿瘤医院 030013 山西医科大学第一医院 030001

目的回顾性分析真实世界中含恩沃利单抗的治疗方案治疗消化道腺癌的安全性和有效性数据。方法回顾性收集2021年12月至2023年7月在山西省肿瘤医院接受含恩沃利单抗方案治疗的35例消化道腺癌患者的治疗信息。应用IBM SPSS Statistics 2... 详细信息

目的回顾性分析真实世界中含恩沃利单抗的治疗方案治疗消化道腺癌的安全性和有效性数据。方法回顾性收集2021年12月至2023年7月在山西省肿瘤医院接受含恩沃利单抗方案治疗的35例消化道腺癌患者的治疗信息。应用IBM SPSS Statistics 27统计学软件分析数据,对定量数据用均数±标准差或中位数表示,定性数据用频率和百分比表示,通过Kaplan-Meier (KM)法分析生存状况,使用GraphPad Prism 9.5.1制作图像。结果 108例患者中,35例符合入组标准。24(68.6%)例发生1~3级不良事件(AE),无4、5级AE发生。免疫治疗可能相关不良事件发生率为31.4%。总体不良事件发生的中位时间为4.8个月。35例患者中有23例至少接受了一次疗效评估,5例达到部分缓解(PR),15例达到病情稳定(SD),无患者达到完全缓解(CR),客观缓解率(ORR)为21.7%,疾病控制率(DCR)为87.0%。在6例错配修复蛋白缺失/微卫星高度不稳定性(dMMR/MSI-H)病变患者中,ORR为50%,DCR为100%。在17例错配修复功能完整/微卫星稳定(pMMR/MSS)病变患者中,ORR为11.8%,DCR为82.4%。结论真实世界中含恩沃利单抗的方案治疗消化道腺癌显示出良好的安全性,同时具有较好的疗效。

关键词：恩沃利单抗消化道腺癌不良事件(AE) 安全性 PD-L1抑制剂

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Variations of mesoscale eddy SST fronts based on an automatic detection method in the northern South China Sea

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Acta Oceanologica Sinica 2020年第11期39卷 82-90页

作者： Chunhua Qiu Juan Ouyang Jiancheng Yu Huabin Mao Yongfeng Qi jiaxue wu Danyi Su School of Marine Sciences Sun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519020China State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China

SST fronts at the mesoscale eddy edge(ME fronts)were investigated from 2007–2017 in the northern South China Sea(NSCS)based on an automatic method using satellite sea level anomaly(SLA)and SST *** relative probabilities between the number of anticyclonic/cyclonic ME fronts(AEF/CEF)and the number of anticyclones/cyclones reached 20%.The northeastern and southwestern parts of these anticyclones had more fronts than the northwestern and southeastern parts,although CEFs were nearly equally distributed in all *** number of ME fronts had remarkable seasonal variations,while the eddy kinetic energy(EKE)showed no seasonal *** total EKE at the ME fronts was three times of that within the MEs,and it was much stronger in AEFs than in *** interannual variability in the number of ME fronts and EKE had no significant correlation with the El Ni?o-Southern Oscillation(ENSO)*** mechanisms of ME fronts were discussed,but the contributions of mesoscale eddies to SST fronts need to be quantified in future studies.

关键词： detection method mesoscale eddy SST front northern South China Sea

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The Mechanism Driving a HAB-Induced SST Warming Anomaly: A Case Study in the Beibu Gulf

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Ocean-Land-Atmosphere Research 2023年第1期2卷 84-94页

作者： Shaoqiong Fu Jingsong Yang Xiulin Lou Dingtian Fu jiaxue wu State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Fourth Institute of Oceanography Ministry of Natural ResourcesBeihai 536000China Marine Monitoring and Forecasting Center of Zhejiang Province Hangzhou 310007China

Water temperature is one of the most important factors that affect the occurrence of harmful algal blooms(HABs).Characteristics of sea surface temperature(SST)variability related to a Noctiluca scintillans bloom were analyzed with Himawari-8 data in the Beibu Gulf during mid-February *** SST warming anomaly was found around the bloom area from 10:00 to 19:00 local time,with a peak temperature of 24.3℃at 15:00,which was 2.9℃higher than the surrounding normal sea *** possible formation mechanism of the HAB-induced SST anomaly was studied in this work by integrating meteorological,ocean dynamics,and ecological *** the HAB event,the sea surface was covered by biological mucilage.A model that considered the net heat flux,heat capacity,density of seawater,and temperature variation was established to estimate the thickness changes(ΔH)in the marine heating layer during the HAB *** model results show that the heating layer thickness of the HAB area(ΔH between 0.76 m and 0.91 m)was smaller than that of the non-HAB area(ΔH>1.19 m).The SST anomaly in this study might be caused by a thinner and warmer marine heating layer that is related to the biological mucilage on the surface of the HAB area.

关键词： integrating meteorological bloom

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Pan-cancer analysis identifies RNA helicase DDX1 as a prognostic marker

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Phenomics 2022年第1期2卷 33-49页

作者： Baocai Gao Xiangnan Li Shujie Li Sen Wang jiaxue wu Jixi Li State Key Laboratory of Genetic Engineering School of Life SciencesMOE Engineering Research Center of Gene TechnologyShanghai Engineering Research Center of Industrial MicroorganismsFudan UniversityShanghai 200438China Kunming Institute of Physics Kunming 650223China

The DEAD-box RNA helicase(DDX)family plays a critical role in the growth and development of multiple ***1 is involved in mRNA/rRNA processing and mature,virus replication and transcription,hormone metabolism,tumo-rigenesis,and tumor ***,how DDX1 functions in various cancers remains ***,we explored the potential oncogenic roles of DDX1 across 33 tumors with The Cancer Genome Atlas(TCGA)and the Genotype-Tissue Expression(GTEx)***1 is highly expressed in breast cancer(BRCA),cholangiocarcinoma(CHOL),and colon adenocarcinoma(COAD),but it is lowly expressed in renal cancers,including kidney renal clear cell carcinoma(KIRC),kidney chromophobe(KICH),and kidney renal papillary cell carcinoma(KIRP).Low expression of DDX1 in KIRC is cor-related with a good prognosis of overall survival(OS)and disease-free survival(DFS).Highly expressed DDX1 is linked to a poor prognosis of OS for adrenocortical carcinoma(ACC),bladder urothelial carcinoma(BLCA),KICH,and liver hepatocellular carcinoma(LIHC).Also,the residue Ser481 of DDX1 had an enhanced phosphorylation level in BRCA and ovarian cancer(OV)but decreased in *** infiltration analysis exhibited that DDX1 expression affected CD8+T cells,and it was significantly associated with MSI(microsatellite instability),TMB(tumor mutational burden),and ICT(immune checkpoint blockade therapy)in *** addition,the depletion of DDX1 dramatically affected the cell viability of human tumor-derived cell ***1 could affect the DNA repair pathway and the RNA transport/DNA replication processes during tumorigenesis by analyzing the CancerSEA ***,our pan-cancer analysis revealed that DDX1 had complicated impacts on different cancers and might act as a prognostic marker for cancers such as renal cancer.

关键词： RNA helicase DDX1 Pan-cancer analysis Survival analysis Prognostic marker

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Injectable Fiber Electronics for Tumor Treatment

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Advanced Fiber Materials 2022年第2期4卷 246-255页

作者： Yang Zhao Chuanrui Chen Yangyang Qiu Tenglong Mei Lei Ye Huan Feng Ye Zhang Liyuan Wang Yue Guo Xuemei Sun jiaxue wu Huisheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China The State Key Laboratory of Genetic Engineering School of Life ScienceZhongshan HospitalFudan UniversityShanghai 200438China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artifcial Functional Materialsand College of Engineering and Applied SciencesNanjing UniversityNanjing 210023China

Electrochemical therapy emerged as a low-cost and efective method for tumor ***,it has challenges such as the production of toxic byproducts and the use of rigid electrodes that damage soft ***,we report a new injectable and tissue-compatible fber therapeutic electronics for safe and efcient tumor *** design of aligned carbon nanotube(CNT)fber as electrodes endowed the device with high softness and enabled mini-invasive implantation through *** a mild voltage(1.2 V),the fber device released hydroxyl ions to alter the local chemical environment of the tissues without additional toxic products/gases,leading to immediate death of tumor *** fexible fber device could form stable interface with tissues and showed good biocompatibility after implantation for 30 *** in vitro experimental results showed the fber device could efciently kill 90.9%of QGY-7703 cancer cells after a single treatment in a few *** tumor-bearing animal models proved that the fber therapeutic device could efectively inhibit the growth of tumor tissues,indicating it is a safe,efective,controllable and low-cost method for tumor therapy.

关键词： Flexible Biocompatible Implantable Fiber device Tumor therapy

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RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells

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Cancer Communications 2021年第2期41卷 187-191页

作者： Yahui Zhao Xiao Liang Li Wei Yao Liu Juan Liu Huan Feng Fen Zheng Ying Wang Haijie Ma jiaxue wu State Key Laboratory of Genetic Engineering Zhongshan Hospital and School of Life SciencesFudan UniversityShanghai 200438P.R.China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032P.R.China Department of Oncology No.971 Hospital of PLA NavyQingdaoShandong 266071P.R.China Laboratory of Cytobiology and Molecular Biology the Affiliated Zhoushan Hospital of Wenzhou Medical UniversityZhoushanZhejiang 316000P.R.China

Dear editor,ADP-ribosylation is a post-translational modification catalysed by poly(ADP-ribose)polymerases(PARPs)and plays important roles in diverse biological processes,such as DNA repair,chromatin remodelling,telomere homeostasis,transcription,chromosome segregation,cell proliferation,and cell death[1,2].While much is known about the cellular roles of PARPs that catalyse polyADP ribosylation,the function of the PARPs that catalyse monoADP ribosylation is substantially less understood.

关键词： PARP1 editor homeostasis

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