Injectable Fiber Electronics for Tumor Treatment
作者机构：State Key Laboratory of Molecular Engineering of PolymersDepartment of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China The State Key Laboratory of Genetic EngineeringSchool of Life ScienceZhongshan HospitalFudan UniversityShanghai 200438China National Laboratory of Solid State MicrostructuresJiangsu Key Laboratory of Artifcial Functional Materialsand College of Engineering and Applied SciencesNanjing UniversityNanjing 210023China
出 版 物：《Advanced Fiber Materials》 (先进纤维材料（英文）)
年 卷 期：2022年第4卷第2期
页 面：246-255页
核心收录：
学科分类：0821[工学-纺织科学与工程] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by MOST(2016YFA0203302),NSFC(21634003,22075050),STCSM(20JC1414902),SHMEC(2017-01-07-00-07-E00062) the National Postdoctoral Program for Innovative Talents(BX2021245) the Fundamental Research Funds for the Central Universities
主 题：Flexible Biocompatible Implantable Fiber device Tumor therapy
摘 要：Electrochemical therapy emerged as a low-cost and efective method for tumor ***,it has challenges such as the production of toxic byproducts and the use of rigid electrodes that damage soft ***,we report a new injectable and tissue-compatible fber therapeutic electronics for safe and efcient tumor *** design of aligned carbon nanotube(CNT)fber as electrodes endowed the device with high softness and enabled mini-invasive implantation through *** a mild voltage(1.2 V),the fber device released hydroxyl ions to alter the local chemical environment of the tissues without additional toxic products/gases,leading to immediate death of tumor *** fexible fber device could form stable interface with tissues and showed good biocompatibility after implantation for 30 *** in vitro experimental results showed the fber device could efciently kill 90.9%of QGY-7703 cancer cells after a single treatment in a few *** tumor-bearing animal models proved that the fber therapeutic device could efectively inhibit the growth of tumor tissues,indicating it is a safe,efective,controllable and low-cost method for tumor therapy.
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