The role of BRCA1 in DNA damage response

作     者：Jiaxue Wu Lin-Yu Lu Xiaochun Yu 

作者机构：Division of Molecular Medicine and GeneticsDepartment of Internal MedicineUniversity of Michigan Medical SchoolAnn ArborMI 48109USA 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2010年第1卷第2期

页      面：117-123页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 0703[理学-化学] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学] 

基　　金：This work was supported in part by grants from the National Institutes of Health(CA132755 to XY) the Developmental fund from the University of Michigan Cancer Center 

主　　题：BRCA1 DNA damage response tumorigenesis 

摘      要：BRCA1 is a well-established tumor suppressor gene,which is frequently mutated in familial breast and ovarian *** gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability,including DNA damage-induced cell cycle checkpoint activation,DNA damage repair,protein ubiquitination,chromatin remodeling,as well as transcriptional regulation and *** this review,we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response,including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.