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Effect of Hyperbaric Oxygen on the Growth of Intracranial Glioma in Rats

Chinese Medical Journal 2015年第23期128卷 3197-3203页

作者： jian-bo ding Jun-Rui Chen Hong-Zhi Xu Zhi-Yong Qin Department of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai 200040 China

Background： Numerous studies have confirmed that hyperbaric oxygen （Hbo） in combination with radiotherapy or chemotherapy may increase the efficacy of radiotherapy or chemotherapy in patients with glioma. However, whether Hbo therapy alone may inhibit or promote the growth of malignant tumors remains controversial. This study aimed to investigate the effect of Hbo on the growth of glioma in rats, and the impact of Hbo on the expression of vascular endothelial growth factor （VEGF） and hypoxia-inducible factor 1-alpha （HIF-1α）, angiogenesis, and apoptosis of glioma cells. Methods： Male Sprague-Dawley rats were treated with or without Hbo after glioma cell inoculation and followed for up to 16 days postinoculation. Rats were randomized to receive bilateral forelimb function tests （n = 20 per group） and head magnetic resonance imaging （n = 5 per group）. Differences between Hbo and control groups were tested using 2-sample independent t-tests and changes over time within treatment groups were analyzed using a repeated measurement analysis of variance with bonferroni correction. The effect of H bo on the expression of VEGF, HIF-1α, yon Willebrand factor, angiogenesis, and tumor cell apoptosis were also examined （n = 5 per group）. Results： Forelimb function scores were reduced in both Hbo-treated and control groups. Hbo-treated rats had significantly larger tumor volume and more water in the cerebellum compared with control rats. The intratumoral expression of VEGF was significantly higher in Hbo-treated rats compared with control rats （23.2% vs. 13.3%, P = 0.002）. HIF-1α was significantly increased in Hbo-treated rats compared with controls in the expression of both intratumoral （72.7% vs. 54.9%, P= 0.001） and peritumoral （2.6% vs. 1.9%, P = 0.003） cells. The intratumoral microvessel density （MVD） was significantly higher in the Hbo group （15.6 vessels/field vs. 4.4 vessels/field. P 〈 0.001 ）, and the peritumoral MVD was not significantly different between the two groups

关键词： Angiogenesis Apoptosis Glioma Hyperbaric Oxygen Rat

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The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian LI Jun WANG Xianhui CAO Laifu GONG jian LI bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

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基于Hilbert-Huang变换的管道超声检测信号处理

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上海交通大学学报 2016年第10期50卷 1646-1650页

作者：焦向东唐建戴波丁学鹏北京石油化工学院能源工程先进连接技术北京市高等学校工程研究中心北京102617 北京石油化工学院信息工程学院北京102617 北京华巨建筑设计有限公司北京100035

针对利用快速傅里叶变换法处理管道超声检测信号的转换精度不高、容易误判等问题,提出了基于Hilbert-Huang变换的非线性、非平稳信号处理方法.对原始管道超声回波信号进行经验模态分解,将复杂信号分解为有限的几个固有模态函数,对其进行... 详细信息

针对利用快速傅里叶变换法处理管道超声检测信号的转换精度不高、容易误判等问题,提出了基于Hilbert-Huang变换的非线性、非平稳信号处理方法.对原始管道超声回波信号进行经验模态分解,将复杂信号分解为有限的几个固有模态函数,对其进行Hilbert变换得到HilbertHuang幅值谱,再对时间进行积分得到Hilbert-Huang边际谱,从而获取管道壁厚对应的频率信息.结果表明,所提出的方法相较于快速傅里叶变换法的精度更高,并满足管道壁厚的检测要求.

关键词：管道超声检测信号处理 Hilbert-Huang变换经验模态分解

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Modularity of biomolecules and reusable designs of combinatorial transcriptional devices

Modularity of biomolecules and reusable designs of combinato...

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第一届全国生物物理化学会议暨生物物理化学发展战略研讨会

作者： Haiyan Liu~*,jian Zhan,bo ding School of Life Sciences,University of Science and Technology of China Hefei,Anhui,230026,China

＜正＞One outstanding property of biological systems in nature is their modular organization, namely,the build up of complex structures and functions from simpler *** modularity presents from the submolecular level up to the level of individual organisms,and may provide a guide to the design and engineering of synthetic biosystems of new(or

关键词： modularity molecular interactions computational design synthetic transcription factors

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数字公共性:数字乡村治理共同体的建构逻辑与优化路径

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西北农林科技大学学报（社会科学版） 2025年第1期25卷 10-16页

作者：丁波安徽大学社会与政治学院合肥230039

数字乡村建设以数字技术嵌入乡村社会,改变乡村社会的结构特征与治理模式,重构乡村治理共同体,形成具有数字公共性特征的数字乡村治理共同体。数字乡村治理共同体以数字主体、数字空间和数字场景的建构逻辑,培育数字参与理念、构建数字... 详细信息

数字乡村建设以数字技术嵌入乡村社会,改变乡村社会的结构特征与治理模式,重构乡村治理共同体,形成具有数字公共性特征的数字乡村治理共同体。数字乡村治理共同体以数字主体、数字空间和数字场景的建构逻辑,培育数字参与理念、构建数字联结纽带、搭建数字交往平台,实现数字公共性生产。数字乡村治理共同体通过治理主体的行动共建、治理方式的技术共治、治理资源的利益共享,推动乡村治理的数字赋权、数字赋能、数字赋利,有助于构建人人有责、人人尽责、人人享有的数字乡村治理共同体。

关键词：数字乡村建设数字公共性乡村治理数字乡村治理共同体

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A coordinated planning strategy of energy storage allocation and line upgrading to increase photovoltaic consumption with lowest planning cost

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Science China Technological Sciences 2025年

作者： bo ZHANG Yuqi JI Lu ZHANG Wei TANG Xiaohui ZHANG Liang WANG Haoran ding Hanchen MAO College of Information and Electrical Engineering China Agricultural University State Grid Heilongjiang Electric Power Research Institute State Grid Heilongjiang Electric Power Company Limited School of Electrical and Information Engineering Zhengzhou University of Light Industry

Random integration of massive distributed photovoltaic (PV) generation poses serious challenges to distribution networks. Voltage violations, line overloads, increased peak–valley differences, and power-flow reversals can occur at different locations, times, and severities. Traditional planning methods such as energy storage (ES) allocation and upgrading of lines may result in poor economics and low equipment utilization. This study proposes a distribution-network planning strategy that coordinates three planning mechanisms:ES allocation to substations and to feeders, and line upgrading. The proposed strategy achieved the lowest annual cost, considering the distribution network problems at different locations, times, and severities. A net load curve description method was first proposed considering economic planning and the uncertain distribution of loads and PVs. Second, a multistage optimization model for ES allocation and line upgrading was established based on the net load curves. Finally, an improved IEEE33 node system was used in the case study. The planning results show that the proposed coordinated planning strategy can address the problems caused by the random integration of massive distributed PVs, improve equipment utilization, and obtain the lowest total annual planning cost.

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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang ding Pan Pan Li bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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Evaluation on Common Hand, Foot and Mouth Disease Treated by Integrative Traditional Chinese Medicine and Western Medicine

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国际感染病学（电子版） 2013年第3期2卷 97-101页

作者： Guo-liang Zhang jian-bo ding Shuang-jie Li Xi Zhang Yi Xu Hua-sheng Yang Dan Wei Qin Li Qing-sheng Shi Qing-xiong Zhu Tong Yang Zi-qiang Zhuo Yi-mei Tian Hao-jie Zheng Liu-ping Tang Xin-ying Zou Tao Wen Xiu-hui Li Department of Infectious Diseases Anhui University of Traditional Chinese Medicine Department of Integrated TCM and Western medicine Beijing Youan Hospital affiliated to Capital Medical University Department of Communicable Diseases Children’s Hospital of Hunan Province Department of Pediatrics Kaifeng Children’s Hospital Department of Pediatrics Guangzhou Medical Center for Women & Children Department of Pediatrics First Hospital affiliated to Guangxi Medical University Department of Infectious Diseases Fuzhou Infectious Diseases Hospital Handan Maternal and Child Health Hospital Children’s Hospital of jiangxi Province The People’s Hospital of Liuzhou Department of Pediatrics Quanzhou Children’s Hospital Department of TCM the Fifth Hospital in Shijiazhuang Department of Pediatrics Liuzhou Worker’s Hospital Department of Pediatrics Shenzhen Maternal and Child Health Hospital Beijing Institute of Hepatology Beijing Youan Hospital affiliated to Capital Medical University

Objective To evaluate the efifcacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in the treatment of patients with common hand, foot and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial. Methods A total of 452 patients with common HFMD were randomly assigned to receive Western medicine alone (n=220) or combined with TCM (Reduning or Xiyanping injections) (n=232). The primary outcome was the incidence rate of rash/herpes disappearance within 5 days, while secondary outcomes included the incidence rate for fever, cough, lethargy, agitation, and vomiting clearance within 5 days. Results The rash/herpes disappearance rate was 45.5% (100/220) in Western medicine therapy group, and 67.2% (156/232) in TCM and Western medicine combined therapy group, with significant difference (P Conclusions It’s suggested that the integrative TCM and Western medicine therapy achieved a better therapeutic efficacy. TCM may become an important complementary therapy on relieving the symptoms of HFMD.

关键词： Hand,foot and mouth disease Traditional Chinese medicine Treatment Reduning injection Xiyanping injection

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等离子体改性聚酰亚胺热老化的分子模拟

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原子与分子物理学报 2025年第1期42卷 95-100页

作者：丁璨田浩博陈琛三峡大学电气与新能源学院宜昌443002

通过反应分子动力学方法模拟聚酰亚胺的热老化过程,以模拟仿真等离子体改性后的聚酰亚胺材料在热裂解后的性能变化情况.通过研究老化过程中气体产生的情况,研究发现随着温度升高,分子链之间的相互作用力减弱,导致材料的致密性下降,弹性... 详细信息

通过反应分子动力学方法模拟聚酰亚胺的热老化过程,以模拟仿真等离子体改性后的聚酰亚胺材料在热裂解后的性能变化情况.通过研究老化过程中气体产生的情况,研究发现随着温度升高,分子链之间的相互作用力减弱,导致材料的致密性下降,弹性模量降低,材料抵抗外应力的能力减弱.同时,由于温度升高使得聚酰亚胺材料相对介电常数上升,材料绝缘性能下降,击穿强度也被削弱.

关键词：反应分子动力学聚酰亚胺热老化

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The snowline in the protoplanetary disk and extrasolar planets

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Research in Astronomy and Astrophysics 2017年第8期17卷 13-22页

作者： Chun-jian Liu Zhen Yao Wen-bo ding College of Mathematics and Physics Bohai University College of Science Liaoning University of Technology

We investigate the behavior of the snowline in a protoplanetary disk and the relationship between the radius of the snowline and properties of molecular cloud *** our disk model,we consider mass influx from the gravitational collapse of a molecular cloud core,irradiation from the central star,and thermal radiation from the ambient molecular cloud *** the protoplanetary disk evolves,the radius of the snowline increases first to a maximum value Rmax,and then decreases in the late stage of evolution of the protoplanetary *** value of Rmaxis dependent on the properties of molecular cloud cores(mass M;,angular velocity ω and temperature T;).Many previous works found that solid material tends to accumulate at the location of the snowline,which suggests that the snowline is the preferred location for giant planet *** these conclusions,we compare the values of R;with semimajor axes of giant planets in extrasolar systems,and find that Rmaxmay provide an upper limit for the locations of the formation of giant planets which are formed by the core accretion model.

关键词： snowline—planets and satellites formation—protoplanetary disks

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