Evaluation on Common Hand, Foot and Mouth Disease Treated by Integrative Traditional Chinese Medicine and Western Medicine

作     者：Guo-liang Zhang Jian-bo Ding Shuang-jie Li Xi Zhang Yi Xu Hua-sheng Yang Dan Wei Qin Li Qing-sheng Shi Qing-xiong Zhu Tong Yang Zi-qiang Zhuo Yi-mei Tian Hao-jie Zheng Liu-ping Tang Xin-ying Zou Tao Wen Xiu-hui Li 

作者机构：Department of Infectious DiseasesAnhui University of Traditional Chinese Medicine Department of Integrated TCM and Western medicineBeijing Youan Hospital affiliated to Capital Medical University Department of Communicable DiseasesChildren’s Hospital of Hunan Province Department of PediatricsKaifeng Children’s Hospital Department of PediatricsGuangzhou Medical Center for Women & Children Department of PediatricsFirst Hospital affiliated to Guangxi Medical University Department of Infectious DiseasesFuzhou Infectious Diseases Hospital Handan Maternal and Child Health Hospital Children’s Hospital of Jiangxi Province The People’s Hospital of Liuzhou Department of Pediatrics Quanzhou Children’s Hospital Department of TCM the Fifth Hospital in Shijiazhuang Department of Pediatrics Liuzhou Worker’s Hospital Department of Pediatrics Shenzhen Maternal and Child Health Hospital Beijing Institute of HepatologyBeijing Youan Hospital affiliated to Capital Medical University 

出 版 物：《国际感染病学（电子版）》 (Infection International(Electronic Edition))

年 卷 期：2013年第2卷第3期

页      面：97-101页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：supported by State Administration of Traditional Chinese Medicine of China Research Project (200907001-3) 

主　　题：Hand,foot and mouth disease Traditional Chinese medicine Treatment Reduning injection Xiyanping injection 

摘      要：Objective To evaluate the efifcacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in the treatment of patients with common hand, foot and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial. Methods A total of 452 patients with common HFMD were randomly assigned to receive Western medicine alone (n=220) or combined with TCM (Reduning or Xiyanping injections) (n=232). The primary outcome was the incidence rate of rash/herpes disappearance within 5 days, while secondary outcomes included the incidence rate for fever, cough, lethargy, agitation, and vomiting clearance within 5 days. Results The rash/herpes disappearance rate was 45.5% (100/220) in Western medicine therapy group, and 67.2% (156/232) in TCM and Western medicine combined therapy group, with significant difference (P0.001). Moreover, TCM remarkably increased the incidence rate of secondary disappearance, which was 56.4%in Western medicine therapy group and 71.4%in TCM and Western medicine combined therapy group (P=0.001). No drug-related adverse events were observed. Conclusions It’s suggested that the integrative TCM and Western medicine therapy achieved a better therapeutic efficacy. TCM may become an important complementary therapy on relieving the symptoms of HFMD.